71 completed, 50 recruiting, 46 unknown, 15 not yet recruiting. 54 Not applicable, 17 Phase 2, 16 Phase 4, 5 Phase 3, 3 Phase 1.
Follow Hyperaldosteronism: new trials by email Literature Review of Hyperaldosteronism trials Research Report on Hyperaldosteronism
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| SPIRO-First: A Pragmatic Primary Care-Embedded Pilot Trial of Renin-Guided First-Line Antihypertensive Therapy Spironolactone (drug), Candesartan 8mg, Hydrochlorothiazide (HCTZ) 25 milligrams. - Hypertension | Phase 4 | Not yet recruiting | Ottawa Hospital Research Institute | 30 | 2027-01-01 | 2026-10-14 |
| Comparing Inclisiran Versus Statin for Primary Aldosteronism inclisiran, Lipophilic statins (such as Simvastatin, Atorvastatin, Fluvastatin, Lovastatin,Pitavastatin), Spironolactone (drug) - Primary Aldosteronism | Not applicable | Recruiting | Third Military Medical University | 50 | 2026-11-15 | 2026-11-12 |
| SYH2072 Tablets in Participants With Primary Aldosteronism SYH2072 tablets, Placebo - Primary Aldosteronism | Phase 2 | Not yet recruiting | InnovStone Therapeutics Limited | 60 | 2026-11-13 | 2026-11-06 |
| [11C]Metomidate PET-CT vs Usual Care for People With Primary Aldosteronism: a Proof-of-concept Study [11C] Metomidate PETCT, Adrenal Venous Sampling - Primary Aldosteronism | Not applicable | Recruiting | Chinese University of Hong Kong | 32 | 2026-11-01 | 2026-10-26 |
| Regular Sauna Use to Lower Blood Pressure in Primary Aldosteronism sauna session - Primary Aldosteronism, Hypertension | Not applicable | Not yet recruiting | University of Calgary | 10 | 2026-09-30 | 2026-08-31 |
| Baxdrostat and Molecular Imaging of Adrenal Cytoreduction in Primary Aldosteronism baxdrostat - Primary Aldosteronism | Not applicable | Not yet recruiting | Queen Mary University of London | 30 | 2026-09-15 | 2026-09-02 |
| Kidney Stiffness Measured by Ultrasound in Patients With High Blood Pressure and Healthy Volunteers Arterial Hypertension, Chronic Kidney Disease, Primary Aldosteronism | Recruiting | Azienda Ospedaliera di Padova | 240 | 2026-08-11 | 2026-11-03 | |
| Endoscopic Ultrasound-Guided Ethanol Ablation for Aldosterone-Producing Adenoma Endoscopic Ultrasound-Guided Ethanol Ablation - Primary Aldosteronism, Aldosterone-Producing Adenoma | Not applicable | Not yet recruiting | Chongqing Medical University | 30 | 2026-07-15 | 2026-07-14 |
| Adrenal Diseases in the Population of Modena: A Clinical-Epidemiological Database of Patients Referred to the Adrenal Disorders Outpatient Clinic of the Clinical Unit of Endocrinology at the Modena University Hospital (AOU Modena) Cushing s Syndrome, Cushing Disease | Recruiting | Azienda Ospedaliero-Universitaria di Modena | 2000 | 2026-07-09 | 2026-11-09 | |
| Intensive vs. Standard Blood Pressure Control in Primary Aldosteronism Intensive BP control, Standard BP control - Primary Aldosteronism | Not applicable | Recruiting | Chongqing Medical University | 3830 | 2026-07-07 | 2026-09-21 |
| EndoSense: Continuous Real-Time Monitoring of Health Markers in Endocrine and Metabolic Disorders Sequential Dietary Sodium Modulation - Endocrine Disorders, Hypertension | Not applicable | Active not recruiting | Felix Beuschlein | 100 | 2026-07-03 | 2026-07-27 |
| A Phase II Clinical Trial of Efficacy and Safety of SAL0140 at Different Doses in Patients With Primary Aldosteronism SAL0140 Tablets, SAL0140 placebo - Primary Aldosteronism | Phase 2 | Not yet recruiting | Shenzhen Salubris Pharmaceuticals Co., Ltd. | 50 | 2026-06-12 | 2026-06-12 |
| Radiofrequency Ablation Versus Adrenalectomy for Adenoma in Patients With Primary Aldosteronism and Hypertension RFA -radiofrequency ablation, Adrenalectomy - Primary Aldosteronism Due to Conn Adenoma, Radiofrequency Ablation Treatment | Not applicable | Recruiting | University Hospital, Toulouse | 134 | 2026-06-05 | 2026-06-11 |
| Study of QLS1410 in the Treatment of Primary Aldosteronism. QLS1410, Placebo - Primary Aldosteronism | Phase 2 | Not yet recruiting | Qilu Pharmaceutical Co., Ltd. | 60 | 2026-06-01 | 2026-04-24 |
| A Phase II Clinical Study on the Efficacy and Safety of HRS-1780 in Participants With Primary Aldosteronism HRS-1780 Tablets, Placebo - Primary Aldosteronism | Phase 2 | Active not recruiting | Shandong Suncadia Medicine Co., Ltd. | 61 | 2026-04-23 | 2026-10-13 |
| Effects of Glucocorticoid Therapy on Renal Function in Patients With PA Complicated by CKD After Adrenalectomy: A Multicenter RCT Intervention_1 - Primary Aldosteronism Due to Adrenal Hyperplasia | Phase 4 | Not yet recruiting | Ruijin Hospital | 90 | 2026-04-22 | 2026-04-30 |
| Efficacy and Safety of Finerenone Compared to Spironolactone in Treatment of Primary Aldosteronism Finerenone - Primary Aldosteronism, Endocrine Hypertension | Not applicable | Recruiting | Bangladesh Medical University | 104 | 2026-04-15 | 2026-07-07 |
| Study on Cutoff Revision Effects and Evaluation of NNT in Primary Aldosteronism Saline Infusion Test - Primary Aldosteronism | Recruiting | Seoul National University Hospital | 150 | 2026-04-01 | 2026-06-02 | |
| Virtual Twins as Tools for Personalized Clinical Care in Renal Denervation - Pilot Study Data collection in order to train the digital twin - Hypertension | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 60 | 2026-04-01 | 2026-03-10 | |
| Prognosis of Primary Aldosteronism: A Prospective Cohort Study Primary Aldosteronism | Recruiting | Xinjiang Medical University | 5000 | 2026-01-30 | 2026-02-03 |
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Hypertension (53) · Adrenocortical Adenoma (14) · Cushing Syndrome (14) · Pheochromocytoma (11) · ACTH Syndrome, Ectopic (8) · Adrenal Insufficiency (7) · Essential Hypertension (7) · Hypokalemia (7) · Adrenal Gland Neoplasms (6) · Disease (6) · Atrial Fibrillation (5) · Adrenal incidentaloma (4) · Arrhythmias, Cardiac (4) · Bartter Syndrome (4)
Adrenocortical Hyperfunction (198) · Adrenal Gland Diseases (196) · Endocrine System Diseases (196) · Cardiovascular Diseases (63) · Vascular Diseases (60) · Neoplasms (37) · Neoplasms by Site (29) · Pathological Conditions, Signs and Symptoms (27) · Endocrine Gland Neoplasms (26) · Pathologic Processes (24) · Adrenal Cortex Diseases (19) · Adrenal Cortex Neoplasms (17) · Adrenal Gland Neoplasms (17) · Urogenital Diseases (17) · Neoplasms by Histologic Type (16)
Spironolactone (16) · Adrenalectomy (8) · Eplerenone (8) · Amlodipine (6) · Mineralocorticoid Receptor Antagonists (6) · finerenone (6) · Dexamethasone (4) · Nifedipine (4) · Hydrochlorothiazide (3) · Pharmaceutical Preparations (3) · Aminocaproic Acid (2) · Blood Specimen Collection (2) · Bosentan (2) · Cefepime (2) · Fosfomycin (2)
Chongqing Medical University (13) · Third Military Medical University (10) · Qifu Li (8) · Changi General Hospital (6) · National Taiwan University Hospital (6) · University Hospital Padova (6) · Brigham and Women's Hospital (5) · Chinese Academy of Medical Sciences, Fuwai Hospital (5) · Haukeland University Hospital (5) · Peking Union Medical College Hospital (5) · Queen Mary University of London (5) · Seoul National University Hospital (5) · Radboud University Medical Center (4) · Xinjiang Medical University (4) · Assistance Publique - Hôpitaux de Paris (3)
China (73) · United States (20) · United Kingdom (17) · France (14) · Italy (12) · Canada (10) · Netherlands (8) · Singapore (8) · Taiwan (7) · Germany (6) · Norway (5) · South Korea (5) · Sweden (4) · Australia (3) · Finland (3)
Xiongjing Jiang, MD (3) · Gian Paolo Rossi, MD (2) · Hui Dong, MD (2) · Kwan-Dun Wu, MD, PhD (2) · Ping Li (2) · Qifu Li (2) · Qifu Li, PhD (2) · Shumin Yang (2) · Shumin Yang, MD, PhD (2) · Vin-Cent Wu, MD (2) · Xiang Xie, PhD (2) · Zhiming Zhu, MD (2) · A.H. van den Meiracker, MD, PhD (1) · Alexander Leung, Asst. Prof (1)
PMID 26934393, PMID 32327102, PMID 17161262, PMID 15657580, PMID 28385310, PMID 28576687, PMID 29279316, PMID 35218017, PMID 36795418, PMID 21828936, PMID 29987110, PMID 32206838, PMID 32890265, PMID 35418526, PMID 16508586, PMID 16670162, PMID 18539224, PMID 19349554, PMID 21270113, PMID 22146510, PMID 22743644, PMID 25002246, PMID 27315757, PMID 27325147, PMID 29129575, PMID 30255616, PMID 30590677, PMID 31476901, PMID 31536622, PMID 33196558, PMID 33447758, PMID 33605538, PMID 33796078, PMID 34398686, PMID 36974473, PMID 37870836, PMID 10641708, PMID 11074243, PMID 12468575, PMID 12517689, PMID 12676966, PMID 12756408, PMID 15001583, PMID 15356010, PMID 15480108, PMID 15591226, PMID 15681560, PMID 15808809, PMID 15808810, PMID 15947891
2023 (2), 2018 (1), 2025 (1), R01DK096994 (1), R01HL075614 (1), R01HL153004 (1)