42 completed, 35 recruiting, 25 unknown, 9 not yet recruiting. 31 Not applicable, 12 Phase 2, 8 Phase 4, 3 Phase 3, 2 Phase 1.
Follow Primary Aldosteronism: new trials by email Literature Review of Primary Aldosteronism trials Research Report on Primary Aldosteronism
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| [11C]Metomidate PET-CT vs Usual Care for People With Primary Aldosteronism: a Proof-of-concept Study [11C] Metomidate PETCT, Adrenal Venous Sampling - Primary Aldosteronism | Not applicable | Recruiting | Chinese University of Hong Kong | 32 | 2026-11-01 | 2026-10-26 |
| Comparing Inclisiran Versus Statin for Primary Aldosteronism inclisiran, Lipophilic statins (such as Simvastatin, Atorvastatin, Fluvastatin, Lovastatin,Pitavastatin), Spironolactone (drug) - Primary Aldosteronism | Not applicable | Recruiting | Third Military Medical University | 50 | 2026-10-01 | 2026-10-21 |
| Regular Sauna Use to Lower Blood Pressure in Primary Aldosteronism sauna session - Primary Aldosteronism, Hypertension | Not applicable | Not yet recruiting | University of Calgary | 10 | 2026-09-30 | 2026-08-31 |
| Baxdrostat and Molecular Imaging of Adrenal Cytoreduction in Primary Aldosteronism baxdrostat - Primary Aldosteronism | Not applicable | Not yet recruiting | Queen Mary University of London | 30 | 2026-09-15 | 2026-09-02 |
| Endoscopic Ultrasound-Guided Ethanol Ablation for Aldosterone-Producing Adenoma Endoscopic Ultrasound-Guided Ethanol Ablation - Primary Aldosteronism, Aldosterone-Producing Adenoma | Not applicable | Not yet recruiting | Chongqing Medical University | 30 | 2026-07-15 | 2026-07-14 |
| Intensive vs. Standard Blood Pressure Control in Primary Aldosteronism Intensive BP control, Standard BP control - Primary Aldosteronism | Not applicable | Recruiting | Chongqing Medical University | 3830 | 2026-07-07 | 2026-09-21 |
| EndoSense: Continuous Real-Time Monitoring of Health Markers in Endocrine and Metabolic Disorders Sequential Dietary Sodium Modulation - Endocrine Disorders, Hypertension | Not applicable | Active not recruiting | Felix Beuschlein | 100 | 2026-07-03 | 2026-07-27 |
| A Phase II Clinical Trial of Efficacy and Safety of SAL0140 at Different Doses in Patients With Primary Aldosteronism SAL0140 Tablets, SAL0140 placebo - Primary Aldosteronism | Phase 2 | Not yet recruiting | Shenzhen Salubris Pharmaceuticals Co., Ltd. | 50 | 2026-06-12 | 2026-06-12 |
| Study of QLS1410 in the Treatment of Primary Aldosteronism. QLS1410, Placebo - Primary Aldosteronism | Phase 2 | Not yet recruiting | Qilu Pharmaceutical Co., Ltd. | 60 | 2026-06-01 | 2026-04-24 |
| A Phase II Clinical Study on the Efficacy and Safety of HRS-1780 in Participants With Primary Aldosteronism HRS-1780 Tablets, Placebo - Primary Aldosteronism | Phase 2 | Active not recruiting | Shandong Suncadia Medicine Co., Ltd. | 61 | 2026-04-23 | 2026-10-13 |
| Efficacy and Safety of Finerenone Compared to Spironolactone in Treatment of Primary Aldosteronism Finerenone - Primary Aldosteronism, Endocrine Hypertension | Not applicable | Recruiting | Bangladesh Medical University | 104 | 2026-04-15 | 2026-07-07 |
| Study on Cutoff Revision Effects and Evaluation of NNT in Primary Aldosteronism Saline Infusion Test - Primary Aldosteronism | Recruiting | Seoul National University Hospital | 150 | 2026-04-01 | 2026-06-02 | |
| Prognosis of Primary Aldosteronism: A Prospective Cohort Study Primary Aldosteronism | Recruiting | Xinjiang Medical University | 5000 | 2026-01-30 | 2026-02-03 | |
| Genetic Predisposition to High Blood Pressure Adrenalectomy - Hypertension, Primary Aldosteronism | Not applicable | Enrolling by invitation | Linkoeping University | 76 | 2026-01-01 | 2026-02-02 |
| The Association Between Primary Aldosteronism and Cognitive Dysfunction Primary Aldosteronism, Cognitive Dysfunction | Recruiting | Xinjiang Medical University | 1000 | 2025-12-31 | 2026-01-05 | |
| Sequential Combined Versus Single-Strategy Adrenal Venous Sampling for Primary Aldosteronism(SCOPE) sequential combined AVS - Primary Aldosteronism | Not applicable | Recruiting | Shumin Yang | 456 | 2025-12-25 | 2025-12-24 |
| Multi-omics Studies of Primary Aldosteronism Without intervention - Primary Aldosteronism | Recruiting | Peking University First Hospital | 400 | 2025-08-15 | 2025-12-09 | |
| PETAL Trial: Impact of Gallium-68 Pentixafor PET-CT on Surgical Outcomes in Primary Aldosteronism 68Ga-pentixafor PET/CT - Primary Aldosteronism, Secondary Hypertension | Not applicable | Recruiting | Seoul National University Hospital | 90 | 2025-06-25 | 2025-06-18 |
| Continuous Steroid Monitoring in Interstitial Fluid With Wearable and Nanoparticle-enhanced Biosensors for Improved Management of Adrenal Disorders Participants will use the biossensor for 48 h - Cushing Syndrome, Primary Aldosteronism | Not applicable | Not yet recruiting | University of Sao Paulo General Hospital | 246 | 2025-06-01 | 2025-05-20 |
| Study on the Application of Liquid Chromatography-Tandem Mass Spectrometry for the Determination of Aldosterone and Renin Activity in the Diagnosis of Primary Aldosteronism by Captopril Test Captopril inhibition test(CCT) - Primary Aldosteronism | Recruiting | Peking Union Medical College Hospital | 800 | 2025-04-28 | 2026-07-09 |
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Hyperaldosteronism (119) · Hypertension (27) · Adrenocortical Adenoma (6) · Cushing Syndrome (5) · Disease (5) · ACTH Syndrome, Ectopic (4) · Atrial Fibrillation (4) · Adrenal Gland Neoplasms (3) · Essential Hypertension (3) · Pheochromocytoma (3) · Adrenal Insufficiency (2) · Endocrine System Diseases (2) · Hypokalemia (2) · Renal Insufficiency, Chronic (2) · AIDS-Related Complex (1)
Adrenal Gland Diseases (119) · Adrenocortical Hyperfunction (119) · Endocrine System Diseases (117) · Cardiovascular Diseases (32) · Vascular Diseases (30) · Pathological Conditions, Signs and Symptoms (16) · Neoplasms (15) · Pathologic Processes (14) · Neoplasms by Site (12) · Endocrine Gland Neoplasms (11) · Adrenal Cortex Diseases (7) · Adrenal Cortex Neoplasms (7) · Adrenal Gland Neoplasms (6) · Heart Diseases (6) · Arrhythmias, Cardiac (4)
Spironolactone (10) · finerenone (6) · Adrenalectomy (5) · Amlodipine (3) · Eplerenone (3) · Mineralocorticoid Receptor Antagonists (3) · Dexamethasone (2) · Mass Screening (2) · Nifedipine (2) · ALN-PCS (1) · Adrenocorticotropic Hormone (1) · Amiloride (1) · Atorvastatin (1) · Cinnarizine (1) · Everolimus (1)
Chongqing Medical University (13) · Third Military Medical University (8) · Changi General Hospital (5) · Peking Union Medical College Hospital (5) · Qifu Li (5) · Queen Mary University of London (5) · Xinjiang Medical University (4) · Brigham and Women's Hospital (3) · Seoul National University Hospital (3) · The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School (3) · University of Calgary (3) · First Affiliated Hospital of Chengdu Medical College (2) · Haukeland University Hospital (2) · National Taiwan University Hospital (2) · Peking University First Hospital (2)
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