125 completed, 73 recruiting, 63 unknown, 16 not yet recruiting. 67 Not applicable, 40 Phase 2, 20 Phase 4, 15 Phase 3, 9 Phase 1.
Follow Adrenocortical Hyperfunction: new trials by email Literature Review of Adrenocortical Hyperfunction trials Research Report on Adrenocortical Hyperfunction
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| SPIRO-First: A Pragmatic Primary Care-Embedded Pilot Trial of Renin-Guided First-Line Antihypertensive Therapy Spironolactone (drug), Candesartan 8mg, Hydrochlorothiazide (HCTZ) 25 milligrams. - Hypertension | Phase 4 | Not yet recruiting | Ottawa Hospital Research Institute | 30 | 2027-01-01 | 2026-10-14 |
| [11C]Metomidate PET-CT vs Usual Care for People With Primary Aldosteronism: a Proof-of-concept Study [11C] Metomidate PETCT, Adrenal Venous Sampling - Primary Aldosteronism | Not applicable | Recruiting | Chinese University of Hong Kong | 32 | 2026-11-01 | 2026-10-26 |
| Metyrapone Study for Patients Diagnosed With Mild Autonomous Cortisol Secretion - MACS Metyrapone 250 mg Oral Tablets, Placebo - Mild Autonomous Cortisol Secretion (MACS), Autonomous Cortisol Secretion (ACS) | Phase 2 | Recruiting | Mayo Clinic | 90 | 2026-10-01 | 2026-09-25 |
| Comparing Inclisiran Versus Statin for Primary Aldosteronism inclisiran, Lipophilic statins (such as Simvastatin, Atorvastatin, Fluvastatin, Lovastatin,Pitavastatin), Spironolactone (drug) - Primary Aldosteronism | Not applicable | Recruiting | Third Military Medical University | 50 | 2026-10-01 | 2026-10-21 |
| Regular Sauna Use to Lower Blood Pressure in Primary Aldosteronism sauna session - Primary Aldosteronism, Hypertension | Not applicable | Not yet recruiting | University of Calgary | 10 | 2026-09-30 | 2026-08-31 |
| Baxdrostat and Molecular Imaging of Adrenal Cytoreduction in Primary Aldosteronism baxdrostat - Primary Aldosteronism | Not applicable | Not yet recruiting | Queen Mary University of London | 30 | 2026-09-15 | 2026-09-02 |
| Osilodrostat in Patients With Hypertension Caused by Hypercortisolaemia Due to Cushing's Syndrome Osilodrostat, Placebo - Hypertension, Hypercortisolemia | Phase 4 | Recruiting | RECORDATI GROUP | 63 | 2026-08-26 | 2026-10-28 |
| Endoscopic Ultrasound-Guided Ethanol Ablation for Aldosterone-Producing Adenoma Endoscopic Ultrasound-Guided Ethanol Ablation - Primary Aldosteronism, Aldosterone-Producing Adenoma | Not applicable | Not yet recruiting | Chongqing Medical University | 30 | 2026-07-15 | 2026-07-14 |
| Intensive vs. Standard Blood Pressure Control in Primary Aldosteronism Intensive BP control, Standard BP control - Primary Aldosteronism | Not applicable | Recruiting | Chongqing Medical University | 3830 | 2026-07-07 | 2026-09-21 |
| EndoSense: Continuous Real-Time Monitoring of Health Markers in Endocrine and Metabolic Disorders Sequential Dietary Sodium Modulation - Endocrine Disorders, Hypertension | Not applicable | Active not recruiting | Felix Beuschlein | 100 | 2026-07-03 | 2026-07-27 |
| A Phase II Clinical Trial of Efficacy and Safety of SAL0140 at Different Doses in Patients With Primary Aldosteronism SAL0140 Tablets, SAL0140 placebo - Primary Aldosteronism | Phase 2 | Not yet recruiting | Shenzhen Salubris Pharmaceuticals Co., Ltd. | 50 | 2026-06-12 | 2026-06-12 |
| Radiofrequency Ablation Versus Adrenalectomy for Adenoma in Patients With Primary Aldosteronism and Hypertension RFA -radiofrequency ablation, Adrenalectomy - Primary Aldosteronism Due to Conn Adenoma, Radiofrequency Ablation Treatment | Not applicable | Recruiting | University Hospital, Toulouse | 134 | 2026-06-05 | 2026-06-11 |
| Study of QLS1410 in the Treatment of Primary Aldosteronism. QLS1410, Placebo - Primary Aldosteronism | Phase 2 | Not yet recruiting | Qilu Pharmaceutical Co., Ltd. | 60 | 2026-06-01 | 2026-04-24 |
| A Phase II Clinical Study on the Efficacy and Safety of HRS-1780 in Participants With Primary Aldosteronism HRS-1780 Tablets, Placebo - Primary Aldosteronism | Phase 2 | Active not recruiting | Shandong Suncadia Medicine Co., Ltd. | 61 | 2026-04-23 | 2026-10-13 |
| Effects of Glucocorticoid Therapy on Renal Function in Patients With PA Complicated by CKD After Adrenalectomy: A Multicenter RCT Intervention_1 - Primary Aldosteronism Due to Adrenal Hyperplasia | Phase 4 | Not yet recruiting | Ruijin Hospital | 90 | 2026-04-22 | 2026-04-30 |
| Efficacy and Safety of Finerenone Compared to Spironolactone in Treatment of Primary Aldosteronism Finerenone - Primary Aldosteronism, Endocrine Hypertension | Not applicable | Recruiting | Bangladesh Medical University | 104 | 2026-04-15 | 2026-07-07 |
| Study on Cutoff Revision Effects and Evaluation of NNT in Primary Aldosteronism Saline Infusion Test - Primary Aldosteronism | Recruiting | Seoul National University Hospital | 150 | 2026-04-01 | 2026-06-02 | |
| Virtual Twins as Tools for Personalized Clinical Care in Renal Denervation - Pilot Study Data collection in order to train the digital twin - Hypertension | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 60 | 2026-04-01 | 2026-03-10 | |
| IMPACT-MACS: Adrenalectomy vs Semaglutide for Metabolic Outcomes in Mild Autonomous Cortisol Secretion Intervention 1: Adrenalectomy, Intervention 2: Semaglutide - Mild Autonomous Cortisol Secretion (MACS), Autonomous Cortisol Secretion (ACS) | Not applicable | Recruiting | University of Texas Southwestern Medical Center | 75 | 2026-03-05 | 2026-03-27 |
| Myokines as Potential Biomarkers and Drivers of Sarcopenia in Metabolic and Endocrine Diseases GLP-1 Receptor Agonists - Diabetes, Obesity & Overweight | Recruiting | Cliniques universitaires Saint-Luc- Université Catholique de Louvain | 100 | 2026-02-19 | 2026-07-14 |
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Hyperaldosteronism (191) · Cushing Syndrome (117) · Hypertension (59) · ACTH Syndrome, Ectopic (27) · Pituitary ACTH Hypersecretion (21) · Adrenocortical Adenoma (15) · Endocrine System Diseases (14) · Adrenal Insufficiency (13) · Pheochromocytoma (13) · Adrenal incidentaloma (11) · Adrenal Gland Neoplasms (10) · Adrenal Cortex Neoplasms (9) · Adrenal Hyperplasia, Congenital (9) · Adrenocortical Carcinoma (9)
Adrenal Gland Diseases (302) · Endocrine System Diseases (295) · Cardiovascular Diseases (72) · Neoplasms (70) · Vascular Diseases (68) · Pathological Conditions, Signs and Symptoms (50) · Neoplasms by Site (48) · Endocrine Gland Neoplasms (45) · Nutritional and Metabolic Diseases (44) · Nervous System Diseases (42) · Brain Diseases (37) · Central Nervous System Diseases (37) · Metabolic Diseases (36) · Pathologic Processes (31)
Spironolactone (16) · Osilodrostat (11) · Adrenalectomy (10) · Eplerenone (8) · Mifepristone (7) · Amlodipine (6) · Mineralocorticoid Receptor Antagonists (6) · finerenone (6) · relacorilant (6) · Dexamethasone (5) · Blood Specimen Collection (4) · Metyrapone (4) · Nifedipine (4) · Corlux (3) · Hydrochlorothiazide (3)
Corcept Therapeutics (16) · Chongqing Medical University (13) · Third Military Medical University (10) · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (9) · Qifu Li (8) · Haukeland University Hospital (7) · Changi General Hospital (6) · National Taiwan University Hospital (6) · RECORDATI GROUP (6) · University Hospital Padova (6) · Assistance Publique - Hôpitaux de Paris (5) · Brigham and Women's Hospital (5) · Chinese Academy of Medical Sciences, Fuwai Hospital (5) · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (5) · Novartis Pharmaceuticals (5)
United States (83) · China (77) · Italy (36) · France (34) · United Kingdom (22) · Netherlands (20) · Germany (17) · Canada (16) · Spain (13) · Israel (10) · Poland (9) · Bulgaria (8) · Romania (8) · Singapore (8) · South Korea (8)
Lynnette K Nieman, M.D. (7) · Irina Bancos, MD (3) · Xiongjing Jiang, MD (3) · Andreas G Moraitis, MD (2) · Andreas Moraitis, MD (2) · Coleman Gross, MD (2) · Deborah P Merke, M.D. (2) · Gian Paolo Rossi, MD (2) · Hui Dong, MD (2) · Irina Bancos, MD, MS (2) · Kwan-Dun Wu, MD, PhD (2) · Martin Fassnacht, MD (2) · Monica N. Starkman (2) · Ping Li (2)
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