9 completed, 5 unknown, 4 recruiting, 1 not yet recruiting. 8 Not applicable, 1 Phase 2, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 8 | Recruiting 3, Completed 2, Unknown 2, Not yet recruiting 1 |
| Phase 2 | 1 | Completed 1 |
| Phase 3 | 1 | Completed 1 |
Follow Adrenocortical Adenoma: new trials by email Literature Review of Adrenocortical Adenoma trials Research Report on Adrenocortical Adenoma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Endoscopic Ultrasound-Guided Ethanol Ablation for Aldosterone-Producing Adenoma Endoscopic Ultrasound-Guided Ethanol Ablation - Primary Aldosteronism, Aldosterone-Producing Adenoma | Not applicable | Not yet recruiting | Chongqing Medical University | 30 | 2026-07-15 | 2026-07-14 |
| Radiofrequency Ablation Versus Adrenalectomy for Adenoma in Patients With Primary Aldosteronism and Hypertension RFA -radiofrequency ablation, Adrenalectomy - Primary Aldosteronism Due to Conn Adenoma, Radiofrequency Ablation Treatment | Not applicable | Recruiting | University Hospital, Toulouse | 134 | 2026-06-05 | 2026-06-11 |
| PETAL Trial: Impact of Gallium-68 Pentixafor PET-CT on Surgical Outcomes in Primary Aldosteronism 68Ga-pentixafor PET/CT - Primary Aldosteronism, Secondary Hypertension | Not applicable | Recruiting | Seoul National University Hospital | 90 | 2025-06-25 | 2025-06-18 |
| Surgical Treatment of Adrenal Diseases- Laparoscopic vs. Robotic-assisted Adrenalectomy Adrenal Tumor, Adrenal Disease | Unknown | University Hospital Olomouc | 100 | 2023-09-03 | 2023-09-22 | |
| CXCR4 Targeted PET Imaging in APA Preoperative Localization Diagnosis CXCR4 - Aldosterone-Producing Adenoma | Not applicable | Unknown | Zhongnan Hospital | 50 | 2023-05-30 | 2023-07-17 |
| [18F]AlF-NOTA-pentixather PET/CT in Patients With Suspected Primary Hyperaldosteronism [18F]AlF-NOTA-pentixather PET/CT - Primary Hyperaldosteronism, Aldosterone-Producing Adenoma | Not applicable | Completed | Sichuan Provincial People's Hospital | 20 | 2023-01-07 | 2026-08-18 |
| The Plasma Metabolomics Profiling of Primary Aldosteronism liquid chromatography-mass spectrometry (LC/MS) - Primary Aldosteronism, Essential Hypertension | Completed | Third Military Medical University | 95 | 2022-08-15 | 2024-07-15 | |
| Endoscopic Ultrasound-guided Radiofrequency Ablation in Primary Aldosteronism EUS-RFA of left adrenal tumour in PA with AVS-verified left lateralisation, EUS-RFA of left adrenal tumour in PA, "debulking group", EUS-RFA of left adrenal tumour in MACS with AVS-verified left lateralisation - Primary Aldosteronism, Aldosterone-Producing Adenoma | Not applicable | Recruiting | Haukeland University Hospital | 60 | 2022-06-03 | 2026-05-08 |
| Effect of Adrenocorticotropic Hormone Stimulation During Adrenal Vein Sampling in Primary Aldosteronism Primary Aldosteronism, Aldosterone-Producing Adenoma | Unknown | The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School | 59 | 2021-09-01 | 2023-04-24 | |
| Water and Electrolytes Content in HYpertension (WHYSKI) in the SKIn Skin Biopsy, Video-laparoscopic adrenalectomy - Hyperaldosteronism, Hypertension | Unknown | University Hospital Padova | 35 | 2021-01-01 | 2024-03-19 | |
| Multifaceted Comparison of Ultrasound-guided Ablation and Laparoscopic Adrenalectomy for Aldosterone-producing Adenoma radiofrequency ablation, laparoscopic adrenalectomy, Hypotensive Drugs - Aldosterone-producing Adenoma, Radiofrequency Ablation | Recruiting | Third Affiliated Hospital, Sun Yat-Sen University | 45 | 2020-01-01 | 2023-08-15 | |
| Prevention of Conversion in Posterior Retroperitoneal Adrenalectomy by Measuring Preoperative Anatomical Conditions Posterior retroperitoneal adrenalectomy (PRA), Lateral transperitoneal adrenalectomy (LTA) - Adrenal Tumor, Adrenal Mass | Completed | University of Basel | 14 | 2018-11-19 | 2019-08-28 | |
| Predicting Reduction of Hypertension After Adrenalectomy for Primary Aldosteronism: a Multicenter Analysis Unilateral adrenalectomy - Primary Aldosteronism Due to Aldosterone Producing Adenoma, Primary Aldosteronism | Completed | UMC Utrecht | 514 | 2016-03-26 | 2021-02-18 | |
| Prevalence of Primary Aldosteronism in Hypertensive Patients Presenting With Atrial Flutter or Fibrillation Atrial Fibrillation, Atrial Flutter | Completed | University Hospital Padova | 411 | 2015-01-01 | 2019-06-07 | |
| Medical Safety Follow-up Study for Patients Who Received More Than 28 Days of Total Exposure to BGG492 MRI, CT or ultrasound was permitted if MRI was contraindicated, Dexamethasone Supression Test, Sonogram - Adrenocortical Adenoma, Endometrial Stromal Sarcomas | Phase 2 | Completed | Novartis Pharmaceuticals | 59 | 2014-08-01 | 2016-12-05 |
| Laparoscopic Adrenalectomy Versus Radiofrequency Ablation Radiofrequency Ablation, Laparoscopic Adrenalectomy - Hyperaldosteronism, Conn Syndrome | Not applicable | Unknown | Chinese University of Hong Kong | 36 | 2013-01-01 | 2017-04-25 |
| 11C-Metomidate PET Versus Adrenal Vein Sampling in Primary Aldosteronism 11C-Metomidate Positron Emission Tomography - Primary Hyperaldosteronism | Not applicable | Completed | Helsinki University Central Hospital | 40 | 2012-02-01 | 2019-03-11 |
| SPARTACUS: Subtyping Primary Aldosteronism: a Randomized Trial Comparing Adrenal Vein Sampling and Computed Tomography Scan. Ct-scan or adrenal vein sampling - Hyperaldosteronism | Phase 3 | Completed | Radboud University Medical Center | 200 | 2010-07-01 | 2015-07-16 |
| Adrenal Vein Sampling International Study (AVIS Study) Hyperaldosteronism | Completed | University Hospital Padova | 2604 | 2010-05-01 | 2013-01-15 |
Hyperaldosteronism (14) · Hypertension (3) · Adrenal Gland Neoplasms (2) · Adrenal Hyperplasia, Congenital (2) · Cushing Syndrome (2) · Essential Hypertension (2) · Hypokalemia (2) · Pheochromocytoma (2) · ACTH Syndrome, Ectopic (1) · Adrenal Cortex Diseases (1) · Adrenal Cortex Neoplasms (1) · Adrenal Gland Diseases (1) · Adrenocortical Carcinoma (1) · Atrial Fibrillation (1)
Endocrine Gland Neoplasms (19) · Endocrine System Diseases (19) · Neoplasms (19) · Neoplasms by Site (19) · Adrenal Cortex Diseases (18) · Adrenal Cortex Neoplasms (18) · Adrenal Gland Diseases (18) · Adrenal Gland Neoplasms (17) · Adrenocortical Hyperfunction (15) · Cardiovascular Diseases (5) · Metabolic Diseases (4) · Nutritional and Metabolic Diseases (4) · Vascular Diseases (4) · Female Urogenital Diseases (3) · Female Urogenital Diseases and Pregnancy Complications (3)
Radiofrequency Ablation (2) · Adrenalectomy (1) · Antihypertensive Agents (1) · Biopsy (1) · High-Energy Shock Waves (1) · Magnetic Resonance Spectroscopy (1) · Postmortem Imaging (1) · selurampanel (1)
University Hospital Padova (3) · Chinese University of Hong Kong (1) · Chongqing Medical University (1) · Haukeland University Hospital (1) · Helsinki University Central Hospital (1) · Novartis Pharmaceuticals (1) · Radboud University Medical Center (1) · Seoul National University Hospital (1) · Sichuan Provincial People's Hospital (1) · The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School (1) · Third Affiliated Hospital, Sun Yat-Sen University (1) · Third Military Medical University (1) · UMC Utrecht (1) · University Hospital Olomouc (1) · University Hospital, Toulouse (1)
China (6) · Italy (5) · Netherlands (3) · United States (3) · Australia (2) · Canada (2) · Czechia (2) · France (2) · Germany (2) · South Korea (2) · Finland (1) · Hong Kong (1) · Hungary (1) · Japan (1) · Norway (1)
Christian A Nebiker, PD Dr. med. (1) · Enders KW Ng, MB ChB (1) · Gerlof D Valk, MD (1) · Gian Paolo Rossi, MD, FAHA (1) · GianPaolo Rossi, MD, FACC (1) · Jacob Deinum, Dr. (1) · Liang Deng, MD, PhD (1) · MUDr. Igor Hartmann Ph.D. (1) · Marianne Grytaas, MD phd (1) · Mengyin Cai, Dr (1) · Menno R Vriens, MD (1) · Niina Matikainen, M.D., Ph.D. (1) · Shirley YW Liu, MB ChB (1) · Shumin Yang, MD, PhD (1)
PMID 32206838, PMID 22399502, PMID 27325147, PMID 29099925, PMID 29279316, PMID 30042959, PMID 30810749, PMID 31053245, PMID 31270571, PMID 31476901, PMID 31536622, PMID 31834121, PMID 31849839, PMID 32025781, PMID 34212188, PMID 34878892, PMID 35998969, PMID 37317838, PMID 38123759, PMID 38525605, PMID 39355924, PMID 42276127