9 completed, 5 recruiting, 2 terminated, 2 unknown. 6 Not applicable, 1 Phase 2, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 6 | Recruiting 2, Completed 1, Enrolling by invitation 1, Terminated 1, Unknown 1 |
| Phase 2 | 1 | Terminated 1 |
| Phase 4 | 1 | Recruiting 1 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Radiofrequency Ablation Versus Adrenalectomy for Adenoma in Patients With Primary Aldosteronism and Hypertension RFA -radiofrequency ablation, Adrenalectomy - Primary Aldosteronism Due to Conn Adenoma, Radiofrequency Ablation Treatment | Not applicable | Recruiting | University Hospital, Toulouse | 134 | 2026-06-05 | 2026-06-11 |
| Benign and Malignant Adrenal Gland Surgery: Single Center Experience Surgery with and without the aid of Indocyanine Green (ICG) - Adrenal Gland Disease | Not yet recruiting | University of Roma La Sapienza | 12 | 2026-05-03 | 2026-05-11 | |
| Genetic Predisposition to High Blood Pressure Adrenalectomy - Hypertension, Primary Aldosteronism | Not applicable | Enrolling by invitation | Linkoeping University | 76 | 2026-01-01 | 2026-02-02 |
| Metyrapone Versus Osilodrostat in Patients With Metabolic Autonomous Cortisol Secretion (MACS) Metyrapone 250 mg Oral Tablets, Osilodrostat 1 MG, adrenalectomy - Mild Autonomous Cortisol Secretion (MACS) | Phase 4 | Recruiting | Laikο General Hospital, Athens | 150 | 2025-12-01 | 2025-12-05 |
| Cardiovascular Complications After Adrenalectomy for Pheochromocytoma and Non-secreting Tumors adrenalectomy - Pheochromocytoma, Cardiovascular Complication | Recruiting | Central Hospital, Nancy, France | 522 | 2025-10-01 | 2026-10-22 | |
| Primary Aldosteronism: Superselective Embolization vs. Laparoscopic Endocrine Curative Therapy Superselective adrenal artery embolization or adrenalectomy - Primary Aldosteronism, Suprarenalectomy | Not applicable | Recruiting | Xinjiang Medical University | 570 | 2024-08-01 | 2025-04-15 |
| European Multicenter Study on Role of Lymph Node Dissection in Surgical Management of Adrenal Cortical Carcinoma Adrenalectomy with or without lymphadenectomy - Adrenocortical Carcinoma | Unknown | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 90 | 2022-12-15 | 2023-03-20 | |
| Textbook Outcome in Adrenal Neoplasms Adrenalectomy - Outcome Assessment, Adrenal Neoplasm | Completed | Hospital General Universitario de Alicante | 105 | 2022-09-01 | 2023-06-22 | |
| Investigating Salt Taste Threshold in Patients Being Investigated for Primary Hyperaldosteronism Before and After Treatment. adrenalectomy, Aldosterone Antagonist - Hyperaldosteronism; Primary, Hypertension | Withdrawn | Imperial College London | 2021-01-01 | 2024-05-10 | ||
| Efficacy and Safety of Clinical Telesurgery Using Chinese Independently Developed Surgical Robot System adrenalectomy for adrenal adenoma - Renal Cell Carcinoma, Bladder Cancer | Not applicable | Completed | The Affiliated Hospital of Qingdao University | 1 | 2020-08-27 | 2022-02-16 |
| Impact of Adrenal IncidenTalomas and Possible Autonomous Cortisol Secretion on Cardiovascular and Metabolic Alterations Adrenalectomy - Adrenal Incidentaloma, Hypercortisolism | Recruiting | University of Roma La Sapienza | 68 | 2019-01-02 | 2025-03-28 | |
| Tissue K+ in Primary Hyperaldosteronism Surgical Treatment of Primary Aldosteronism, Drug treatment of Primary Aldosteronism - Primary Hyperaldosteronism, Electrolyte Disturbance | Completed | University of Erlangen-Nürnberg Medical School | 21 | 2018-01-01 | 2025-11-25 | |
| Prospective Study Assessing Blood Pressure and Other Outcomes Post-treatment in Patients With Primary Aldosteronism Adrenalectomy, Mineralocorticoid Receptor Antagonists - Primary Aldosteronism, Primary Aldosteronism Due to Aldosterone Producing Adenoma | Completed | Changi General Hospital | 57 | 2017-02-20 | 2022-05-20 | |
| IS Metomidate PET-CT Superior to Adrenal Venous Sampling in Predicting Outcome From Adrenalectomy in Patients With Primary Hyperaldosteronism adrenalectomy - Primary Aldosteronism, Hyperaldosteronism | Completed | Queen Mary University of London | 190 | 2016-12-01 | 2025-03-10 | |
| Effect of Surgical or Conservative Approach in Patients With Adrenal Incidentalomas adrenalectomy - Adrenal Incidentaloma, Subclinical Hypercortisolism | Not applicable | Unknown | Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico | 61 | 2016-09-29 | 2021-04-26 |
| Readmission After Adrenalectomy adrenalectomy - Adrenalectomy | Completed | Zagazig University | 346 | 2016-09-01 | 2024-11-20 | |
| Intraoperative Hemodynamic Instability During Unilateral Adrenalectomy for Pheochromocytoma adrenalectomy - Pheochromocytoma, Non-Secretory Adrenal Adenoma | Completed | Central Hospital, Nancy, France | 60 | 2015-09-01 | 2025-02-13 | |
| Glucose Metabolism in Subjects With Aldosterone-Producing Adenomas Adrenalectomy, mineralocorticoid receptor antagonist - Primary Aldosteronism | Completed | Vanderbilt University | 10 | 2015-01-01 | 2021-05-04 | |
| Long-term Blood Pressure Outcome After Unilateral Adrenalectomy for Primary Hyperaldosteronism adrenalectomy for primary addosteronism - Adrenalectomy; Status | Completed | Centre Hospitalier Universitaire, Amiens | 43 | 2013-12-01 | 2026-06-16 | |
| Study of Adrenalectomy Versus Observation for Subclinical Hypercortisolism Adrenalectomy, Observation - Subclinical Hypercortisolism, Cushing Syndrome | Phase 2 | Terminated | National Cancer Institute (NCI) | 4 | 2013-11-27 | 2018-06-14 |
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Hyperaldosteronism (8) · Adrenal Gland Neoplasms (5) · Adrenal incidentaloma (4) · Hypertension (4) · Cushing Syndrome (2) · Pheochromocytoma (2) · Adrenal Gland Diseases (1) · Adrenocortical Adenoma (1) · Adrenocortical Carcinoma (1) · Carcinoma, Renal Cell (1) · Diabetes Mellitus (1) · Feeding and Eating Disorders (1) · Genetic Predisposition to Disease (1) · Hypercholesterolemia (1) · Hypokalemia (1)
Central Hospital, Nancy, France (2) · University of Roma La Sapienza (2) · Centre Hospitalier Universitaire, Amiens (1) · Changi General Hospital (1) · Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico (1) · Fondazione Policlinico Universitario Agostino Gemelli IRCCS (1) · Hospital General Universitario de Alicante (1) · Imperial College London (1) · Laikο General Hospital, Athens (1) · Linkoeping University (1) · National Cancer Institute (NCI) (1) · Queen Mary University of London (1) · Region Skane (1) · The Affiliated Hospital of Qingdao University (1) · University Hospital, Toulouse (1)
France (4) · Italy (3) · China (2) · Sweden (2) · United Kingdom (2) · United States (2) · Denmark (1) · Germany (1) · Greece (1) · Norway (1) · Singapore (1) · Spain (1)
Anders OJ Bergenfelz, MD, PhD (1) · Andrea M Isidori, MD, PHD (1) · Christoph Kopp, MD (1) · Dhaval T Patel, M.D. (1) · Fabien Saint, MD, PhD (1) · Haitao Niu, PhD (1) · Iacopo Chiodini, Professor (1) · James M Luther, MD (1) · Laurent Brunaud (1) · Marco Raffaelli, Prof (1) · Troy Puar, MRCP (UK) (1) · Ying-Ying Zheng, PhD (1)
PMID 11923603, PMID 12136861, PMID 18295861, PMID 18803341, PMID 19222048, PMID 22146510, PMID 25840895, PMID 25968622, PMID 26293795, PMID 26433570, PMID 26934393, PMID 27123543, PMID 27194259, PMID 27649314, PMID 30624247, PMID 31714582, PMID 32172621, PMID 33583202, PMID 35721734, PMID 35846272, PMID 36646800, PMID 38316738, PMID 40030172, PMID 40600855, PMID 41572809, PMID 41773968, PMID 41940913
R01DK096994 (1)