50 completed, 28 recruiting, 20 unknown, 7 terminated. 22 Phase 2, 17 Not applicable, 9 Phase 3, 5 Phase 4, 4 Phase 1.
Follow Cushing Syndrome: new trials by email Literature Review of Cushing Syndrome trials Research Report on Cushing Syndrome
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Metyrapone Study for Patients Diagnosed With Mild Autonomous Cortisol Secretion - MACS Metyrapone 250 mg Oral Tablets, Placebo - Mild Autonomous Cortisol Secretion (MACS), Autonomous Cortisol Secretion (ACS) | Phase 2 | Recruiting | Mayo Clinic | 90 | 2026-10-01 | 2026-09-25 |
| Osilodrostat in Patients With Hypertension Caused by Hypercortisolaemia Due to Cushing's Syndrome Osilodrostat, Placebo - Hypertension, Hypercortisolemia | Phase 4 | Not yet recruiting | RECORDATI GROUP | 63 | 2026-08-01 | 2025-12-10 |
| IMPACT-MACS: Adrenalectomy vs Semaglutide for Metabolic Outcomes in Mild Autonomous Cortisol Secretion Intervention 1: Adrenalectomy, Intervention 2: Semaglutide - Mild Autonomous Cortisol Secretion (MACS), Autonomous Cortisol Secretion (ACS) | Not applicable | Recruiting | University of Texas Southwestern Medical Center | 75 | 2026-03-05 | 2026-03-27 |
| Myokines as Potential Biomarkers and Drivers of Sarcopenia in Metabolic and Endocrine Diseases GLP-1 Receptor Agonists - Diabetes, Obesity & Overweight | Recruiting | Cliniques universitaires Saint-Luc- Université Catholique de Louvain | 100 | 2026-02-19 | 2026-07-14 | |
| Impact of 1 mg Osilodrostat Therapy on Mild Autonomous Cortisol Secretion (MACS) Osilodrostat 1 MG - Mild Autonomous Cortisol Secretion, Autonomous Cortisol Secretion (ACS) | Phase 2 | Recruiting | Mayo Clinic | 15 | 2026-01-14 | 2026-02-11 |
| REMS25: Study on the Use of REMS Technology in Diseases Commonly Associated With Reduced Bone Mineral Density (BMD) REMS - Osteogenesis Imperfecta, Osteoporosis | Not applicable | Recruiting | Meyer Children's Hospital IRCCS | 100 | 2025-12-04 | 2026-02-17 |
| Trial Against INtractable Type 2 Diabetes (CAPTAIN-T2D) clofutriben, Placebo - Type 2 Diabetes, Cortisol Excess | Phase 2 | Recruiting | Sparrow Pharmaceuticals | 1500 | 2025-11-29 | 2026-10-06 |
| Salivary Cortisol and Hypercortisolism in Type 2 Diabetes Hypercortisolism, Type 2 Diabetes (T2DM) | Recruiting | Shanghai 6th People's Hospital | 500 | 2025-09-11 | 2026-07-27 | |
| Establishment and Clinical Application of Reference Intervals of Salivary Cortisol Healthy Adult, Cushing Syndrome | Recruiting | Shanghai 6th People's Hospital | 220 | 2025-09-01 | 2025-09-11 | |
| Continuous Steroid Monitoring in Interstitial Fluid With Wearable and Nanoparticle-enhanced Biosensors for Improved Management of Adrenal Disorders Participants will use the biossensor for 48 h - Cushing Syndrome, Primary Aldosteronism | Not applicable | Not yet recruiting | University of Sao Paulo General Hospital | 246 | 2025-06-01 | 2025-05-20 |
| Study of the Prevalence of Endogenous Hypercortisolism in Patients With Resistant Hypertension (MOMENTUM) Resistant Hypertension, Hypercortisolism | Completed | Corcept Therapeutics | 1143 | 2025-03-28 | 2026-02-17 | |
| Desmopressin Stimulation Test Performance in ACTH-Dependent Cushing Syndrome Desmopressin, Dexamethasone - Cushing Syndrome | Phase 2 | Recruiting | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | 140 | 2024-12-12 | 2026-08-31 |
| Osilodrostat Therapy and 11C-methionine PET to Improve Corticotroph Adenoma Detection 11C-Methionine PET/CT - Cushing's Disease, Hypercortisolism | Not yet recruiting | Imperial College London | 15 | 2024-12-03 | 2024-12-03 | |
| Evaluating the Functional Status of the Adrenal Glands With [68Ga]Ga-PentixaFor in Hyperaldosteronism and Hypercortisolism [68Ga]Ga-PentixaFor - Hyperaldosteronism, Hypercortisolism | Phase 2 | Recruiting | National Cancer Institute (NCI) | 80 | 2024-09-23 | 2026-10-22 |
| A Block-and-Replace Therapy With Osilodrostat and Concomitant Glucocorticoid Replacement Osilodrostat - Endogenous Cushing Syndrome, Adrenal Insufficiency | Recruiting | University of Michigan | 12 | 2024-07-19 | 2026-09-09 | |
| Institutional Registry of Rare Diseases Rare Diseases, Amyloidosis | Recruiting | Hospital Italiano de Buenos Aires | 380 | 2024-07-01 | 2026-01-14 | |
| Neuroendocrine Mechanisms in Adiposity: An Integrated Approach to the Characterization of Potential Pharmacological Novel Targets Based on Experimental and Clinical Models Endocrine Disorders, Adiposity | Not yet recruiting | IRCCS San Raffaele | 200 | 2024-07-01 | 2024-06-11 | |
| Dynamic Hormone Profiling and Multimodal Data Capture in Primary Aldosteronism dynamic microdialysis sampling - Mineralocorticoid Excess, Primary Aldosteronism | Recruiting | Haukeland University Hospital | 80 | 2024-06-01 | 2024-07-11 | |
| A Single Center Randomized Controlled Study on the Promotion of Rapid Recovery Tubeless laparoscopic adrenalectomy, Drainage tube - Nonfunctional Adrenal Cortex Adenoma, Primary Aldosteronism | Not applicable | Recruiting | Zhe Meng | 200 | 2024-01-03 | 2024-02-13 |
| Metyrapone for Mild Autonomous Cortisol Secretion (MACS) Metyrapone - Autonomous Cortisol Secretion, Mild Autonomous Cortisol Secretion (MACS) | Phase 2 | Active not recruiting | Mayo Clinic | 30 | 2023-12-19 | 2026-09-25 |
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ACTH Syndrome, Ectopic (22) · Pituitary ACTH Hypersecretion (18) · Hyperaldosteronism (14) · Adrenal Insufficiency (10) · Adrenal incidentaloma (10) · Endocrine System Diseases (10) · Pheochromocytoma (10) · Adrenal Cortex Neoplasms (9) · Adrenocortical Carcinoma (9) · Diabetes Mellitus, Type 2 (8) · Hypertension (8) · Adrenal Gland Neoplasms (7) · Adrenal Hyperplasia, Congenital (7) · Obesity (7)
Adrenal Gland Diseases (113) · Adrenocortical Hyperfunction (113) · Endocrine System Diseases (107) · Neoplasms (41) · Nutritional and Metabolic Diseases (29) · Nervous System Diseases (28) · Brain Diseases (26) · Central Nervous System Diseases (26) · Hypothalamic Diseases (25) · Endocrine Gland Neoplasms (24) · Neoplasms by Site (24) · Metabolic Diseases (23) · Pathological Conditions, Signs and Symptoms (23) · Paraneoplastic Endocrine Syndromes (22) · Paraneoplastic Syndromes (22)
Osilodrostat (8) · Mifepristone (7) · relacorilant (6) · Metyrapone (4) · Corlux (3) · Adrenalectomy (2) · Blood Specimen Collection (2) · Surgical Procedures, Operative (2) · fluorodopa F 18 (2) · 4-amino-4'-hydroxylaminodiphenylsulfone (1) · ASP3662 (1) · Abiraterone Acetate (1) · Absorptiometry, Photon (1) · Adiposity (1) · Aftercare (1)
Corcept Therapeutics (16) · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (9) · Haukeland University Hospital (5) · RECORDATI GROUP (5) · Mayo Clinic (4) · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (4) · HRA Pharma (3) · Istituto Auxologico Italiano (3) · National Center for Research Resources (NCRR) (3) · National Institute of Mental Health (NIMH) (3) · Seoul National University Hospital (3) · University of Roma La Sapienza (3) · Assistance Publique - Hôpitaux de Paris (2) · Cliniques universitaires Saint-Luc- Université Catholique de Louvain (2) · Cortendo AB (2)
United States (55) · Italy (21) · France (15) · Spain (10) · Germany (9) · Netherlands (9) · Poland (8) · Bulgaria (7) · China (7) · Romania (7) · Israel (6) · Belgium (5) · Norway (5) · South Korea (5) · United Kingdom (5)
Lynnette K Nieman, M.D. (7) · Andreas G Moraitis, MD (2) · Andreas Moraitis, MD (2) · Coleman Gross, MD (2) · Deborah P Merke, M.D. (2) · Irina Bancos, MD (2) · Irina Bancos, MD, MS (2) · Martin Fassnacht, MD (2) · Monica N. Starkman (2) · Adrian Gadano, MD (1) · Andrea M Isidori, MD, PHD (1) · Andrea M Isidori, MD, PhD (1) · Andreas Moraitis, M.D. (1)
PMID 22154461, PMID 25013998, PMID 25968622, PMID 26507877, PMID 35058882, PMID 11745214, PMID 12044826, PMID 1478121, PMID 14985252, PMID 16172198, PMID 16342272, PMID 16580903, PMID 16670169, PMID 18426820, PMID 18509277, PMID 18619560, PMID 18923576, PMID 18957506, PMID 19223900, PMID 19500762, PMID 19759515, PMID 19783236, PMID 20164322, PMID 20631206, PMID 21220434, PMID 21392121, PMID 21612468, PMID 22466348, PMID 2268888, PMID 22739109, PMID 22890008, PMID 22997446, PMID 23000592, PMID 23470964, PMID 23733748, PMID 23970725, PMID 24210085, PMID 24268504, PMID 24482099, PMID 24571724, PMID 24939997, PMID 25243546, PMID 25822102, PMID 26067718, PMID 26156970, PMID 26188235, PMID 26353009, PMID 27389594, PMID 29189215, PMID 30137397
2015 (1), 2016 (1), 2018 (1), 2025 (1), K23DK142038 (1), ZIADK075121 (1)