11 completed. 11 Phase 1, 5 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 11 | Completed 11 |
| Phase 2 | 5 | Completed 5 |
Follow Postoperative Nausea and Vomiting: new trials by email Literature Review of Postoperative Nausea and Vomiting trials Research Report on Postoperative Nausea and Vomiting
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Phase I PK and Safety Study of Ondansetron Inhalation Powder LPI-1503, Matching Placebo of LPI-1503, IV Ondansetron - Postoperative Nausea and Vomiting | Phase 1 | Completed | Luxena Pharmaceuticals, Inc. | 24 | 2025-03-13 | 2026-03-27 |
| Effect of Magnesium Sulfate on Hemodynamics on Laparoscopic Cholecystectomy Patients Placebo, Magnesium - Hemodynamics Instability, Pain After Surgery | Phase 1 / Phase 2 | Completed | Ziauddin University | 60 | 2025-01-06 | 2026-09-02 |
| Effect of Dexmedetomidine on Prevention of Postoperative Nausea and Vomiting in Children Dexamethasone, Ondansetron, Dexmedetomidine - Postoperative Nausea and Vomiting, Post Operative Pain | Phase 1 | Completed | Tanta University | 4 | 2021-10-27 | 2022-04-05 |
| Olanzapine for the Prevention of Postoperative Nausea and Vomiting Placebo, 5 mg Olanzapine Tablets, 10 mg Olanzapine Tablets - Postoperative Nausea | Phase 1 / Phase 2 | Completed | Amani Hassan Abdel-Wahab | 132 | 2021-03-15 | 2023-03-09 |
| Study of APD421 With and Without Ondansetron APD421, Placebo, Ondansetron - Postoperative Nausea and Vomiting | Phase 1 | Completed | Acacia Pharma Ltd | 30 | 2018-07-17 | 2018-10-01 |
| How Pregnant Women and Their Babies Metabolize Ondansetron Compared to a Group of Non-pregnant Women Ondansetron - Postoperative Nausea | Phase 1 / Phase 2 | Completed | Stanford University | 100 | 2013-01-01 | 2015-06-01 |
| 10% Carbohydrate Drink for Preventing Post-operative Nausea and Vomiting (PONV) After Spinal Morphine 10% carbohydrate drink - Nausea and Vomiting, Postoperative | Phase 1 | Completed | Mahidol University | 120 | 2011-02-01 | 2013-07-19 |
| A Study of Aprepitant (MK-0869) in Pediatric Participants Undergoing Surgery (MK-0869-148) Aprepitant, Ondansetron - Postoperative Nausea and Vomiting | Phase 1 | Completed | Merck Sharp & Dohme LLC | 98 | 2009-01-26 | 2021-01-26 |
| Crossover Study Comparing Ondansetron Orally Dissolving Film Strip (ODFS) With Zofran Orally Disintegrating Tablets Ondansetron (ODFS), Zofran (ODT) - Nausea and Vomiting, Postoperative, Nausea With Vomiting Chemotherapy-Induced | Phase 1 / Phase 2 | Completed | MonoSol Rx | 48 | 2008-09-16 | 2020-07-29 |
| Osteopathic Manipulative Treatment for Post-Operative Nausea and Vomiting Osteopathic Manipulative Treatment - Postoperative Nausea and Vomiting | Phase 1 / Phase 2 | Completed | University of North Texas Health Science Center | 20 | 2006-12-01 | 2011-01-12 |
| A Study to Investigate the Safety and Tolerability of MK-0517 in Healthy Subjects (MK-0517-012) 90 mg MK-0517 (PS80), 100 mg MK-0517 (PS80), 100 MK-0517 (PS80) + 2 mg midazolam - Chemotherapy-Induced Nausea and Vomiting, Postoperative Nausea and Vomiting | Phase 1 | Completed | Merck Sharp & Dohme LLC | 188 | 2005-01-01 | 2015-08-19 |
Nausea (2) · Vomiting (2) · Emergence Delirium (1) · Pain (1) · Pain, Postoperative (1) · Pneumoperitoneum (1)
Pathologic Processes (11) · Pathological Conditions, Signs and Symptoms (11) · Postoperative Complications (11) · Signs and Symptoms (11) · Signs and Symptoms, Digestive (11) · Nausea (9) · Vomiting (9) · Neurologic Manifestations (2) · Confusion (1) · Delirium (1) · Digestive System Diseases (1) · Mental Disorders (1) · Nervous System Diseases (1) · Neurobehavioral Manifestations (1) · Neurocognitive Disorders (1)
Ondansetron (6) · Aprepitant (2) · Control Groups (1) · Dexamethasone (1) · Dexmedetomidine (1) · Magnesium (1) · Magnesium Sulfate (1) · Manipulation, Osteopathic (1) · Midazolam (1) · Olanzapine (1) · Saline Solution (1)
Merck Sharp & Dohme LLC (2) · Acacia Pharma Ltd (1) · Amani Hassan Abdel-Wahab (1) · Luxena Pharmaceuticals, Inc. (1) · Mahidol University (1) · MonoSol Rx (1) · Stanford University (1) · Tanta University (1) · University of North Texas Health Science Center (1) · Ziauddin University (1)
United States (2) · Brazil (1) · Canada (1) · Egypt (1) · India (1) · Mexico (1) · Pakistan (1) · Saudi Arabia (1) · Spain (1) · Thailand (1) · Turkey (Türkiye) (1) · United Kingdom (1)
Amani H Abdel-wahab, MD (1) · David R. Drover, MD (1) · Dr Asma A Salam, MBBS, FCPS (1) · Hollis H King, DO, PhD (1) · Manee Raksakietisak, MD (1) · Muna Albayaty (1) · Simon L Schrick-Senasac, OMS-IV, PDF (1) · Sudershan Vishwanath, MD (1)
PMID 17513629, PMID 19617379, PMID 22096279, PMID 23904932, PMID 25670522, PMID 25885838, PMID 31303716, PMID 31862004, PMID 31913911, PMID 32839657
2008 (1)