12 completed, 4 not yet recruiting, 4 recruiting, 2 unknown. 23 Phase 1, 6 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 23 | Completed 12, Not yet recruiting 4, Recruiting 4, Unknown 2, Withdrawn 1 |
| Phase 2 | 6 | Completed 4, Unknown 1, Withdrawn 1 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Consciousness and Psilocybin Effects on Well-Being: The CoPEWell Study Psilocybin, Saline Placebo, Clonidine - Well-Being, Psychological, Psychedelic Experiences | Phase 1 | Not yet recruiting | University of Wisconsin, Madison | 120 | 2027-02-01 | 2026-10-30 |
| AI-DBT For Serious Illness AI DBT - Serious Illness, Distress, Emotional | Phase 1 | Not yet recruiting | Rutgers, The State University of New Jersey | 80 | 2026-10-01 | 2026-08-05 |
| Alaska Alliance for Community Engagement Phase II: Partnership for Action Toward Health Tools for Arctic Health Promotion - Chronic Disease, Mental Health | Phase 1 | Not yet recruiting | University of Alaska Fairbanks | 360 | 2026-09-21 | 2026-09-03 |
| Yoga for Black and Brown Women Who Have Experienced Abuse From an Intimate Partner Culturally-Tailored, Trauma-Informed Yoga (CT-TIY), Enhanced Care as Usual (ECU) - Intimate Partner Violence (IPV), Psychological Well Being | Phase 1 | Recruiting | The University of Akron | 40 | 2026-05-15 | 2026-04-28 |
| Remote Medical Monitoring of Patients With Depression Use of ThIA Medical Device - Depression Chronic, Depression and Quality of Life | Phase 1 | Recruiting | ThIA Santé Mentale | 608 | 2026-04-01 | 2026-10-16 |
| MDMA-Assisted Therapy for Mental Healthcare Providers MDMA Hydrochloride - Mental Wellbeing | Phase 1 | Recruiting | Rachel Yehuda | 30 | 2026-02-11 | 2026-03-27 |
| Evaluating the Efficacy and Safety of PROSOMNIA Sleep Therapy™ in Patients With Sleep Deprivation and Chronic Insomnia PROSOMNIA Sleep Therapy™ (PSTx), Anesthesia-Induced Sleep Therapy, Diprivan (propofol), Astra-Zeneca - Chronic Insomnia, Sleep Deprivation | Phase 1 | Not yet recruiting | Nyree Penn | 100 | 2025-11-01 | 2025-05-28 |
| A Robot-assisted Tailored Activity Programme for People With Dementia and Their Caregivers Intervention, Control - Dementia, Caregiver | Phase 1 | Recruiting | The Hong Kong Polytechnic University | 60 | 2025-09-01 | 2025-12-18 |
| Self-Management Program for AIS D SCI SCI Self-Management for AIS D - Psychological Well-Being, Spinal Cord Injuries | Phase 1 / Phase 2 | Withdrawn | VA Office of Research and Development | 2024-05-01 | 2026-03-13 | |
| Oral Supplement in Older Adults to Support Physical Fitness and Mental Well-being Q-actin, Placebo - Osteo-arthritis | Phase 1 | Unknown | Aberystwyth University | 50 | 2023-04-22 | 2023-05-26 |
| Safety, Tolerability, and Pharmacokinetics of Naltrexone Implant (DLP-160) Combination Product: Naltrexone - Opiod Use Disorder | Phase 1 | Completed | Delpor, Inc. | 10 | 2022-03-22 | 2025-02-13 |
| Strengths-based Linkage to Alcohol Care (SLAC) for Hazardous Drinkers in Primary Care Strengths-based linkage to alcohol care, Usual care - Alcohol-induced Disorders, Alcohol Drinking | Phase 1 | Completed | VA Office of Research and Development | 140 | 2021-01-01 | 2026-01-13 |
| rTMS for Emotional Difficulties in Verterans Repetitive Transcranial Magnetic Stimulation (rTMS) - Mental Health, Depression | Phase 1 | Completed | VA Office of Research and Development | 21 | 2019-02-01 | 2023-11-09 |
| Treatment Outcome in Major Depressive Disorder Escitalopram, Duloxetine - Major Depressive Disorder | Phase 1 | Completed | Copenhagen University Hospital, Rigshospitalet | 100 | 2016-08-01 | 2019-10-16 |
| Enhancing Delivery of Problem Solving Therapy Using SmartPhone Technology Problem Solving Therapy plus Moving Forward, Problem Solving Therapy - Depression, Anxiety | Phase 1 / Phase 2 | Completed | VA Office of Research and Development | 33 | 2014-04-01 | 2016-11-28 |
| Testing a Promising Treatment for Youth Substance Abuse in a Community Setting Contingency Management-Family Engagement, Treatment as Usual - Substance Abuse, Delinquency | Phase 1 / Phase 2 | Completed | Medical University of South Carolina | 101 | 2014-04-01 | 2018-07-06 |
| Comparing Interventions To Improve The Well-Being Of Custodial Grandfamilies Behavioral Parent Training, Cognitive Behavioral Therapy, Psychosocial-Informational support - Custodial Grandparents | Phase 1 / Phase 2 | Completed | Kent State University | 343 | 2012-01-01 | 2020-10-19 |
| Eliciting Affect in Teens in a Virtual World (Project AVATAR) Virtual Reality, Health Promotion - HIV Infections | Phase 1 / Phase 2 | Completed | Rhode Island Hospital | 196 | 2010-05-01 | 2016-04-06 |
| ENGAGE - Meeting Mental Health Needs of Complex Comorbid Patients Cognitive behavioural therapy, Standard treatment - Comorbidity, Substance Abuse | Phase 1 / Phase 2 | Unknown | University of Glasgow | 30 | 2009-11-01 | 2010-06-28 |
| Effectiveness of an Internet-Based Self-Management Program in Treating Prolonged Grief Disorder Internet-Based Self-Management for Prolonged Grief Symptoms - Grief, Mental Health | Phase 1 | Completed | Boston University | 135 | 2009-08-01 | 2013-06-24 |
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Psychological Well-Being (22) · Depression (5) · Anxiety Disorders (4) · Substance-Related Disorders (3) · Sleep Initiation and Maintenance Disorders (2) · Stress Disorders, Post-Traumatic (2) · Alcohol Drinking (1) · Alcohol-Induced Disorders (1) · Alzheimer Disease (1) · Autistic Disorder (1) · Behavior, Addictive (1) · Brain Injuries (1) · Cancer Pain (1) · Cerebral Palsy (1) · Chronic Disease (1)
Behavior (23) · Mental Disorders (12) · Behavioral Symptoms (6) · Nervous System Diseases (5) · Central Nervous System Diseases (4) · Chemically-Induced Disorders (4) · Brain Diseases (3) · Pathological Conditions, Signs and Symptoms (3) · Stress Disorders, Traumatic (3) · Trauma and Stressor Related Disorders (3) · Dyssomnias (2) · Neurocognitive Disorders (2) · Neurologic Manifestations (2) · Pathologic Processes (2)
Cognitive Behavioral Therapy (3) · (tris(diphenylphosphinomethyl)phenylborate)(p-tolylnitrido)iron(I) (1) · Behavior Therapy (1) · Clonidine (1) · Duloxetine Hydrochloride (1) · Electroencephalography (1) · Escitalopram (1) · Ethanol (1) · Health Promotion (1) · Methods (1) · Propofol (1) · Psilocybin (1) · Self-Help Groups (1) · Therapeutics (1) · Transcranial Magnetic Stimulation (1)
VA Office of Research and Development (4) · Aberystwyth University (1) · Boston University (1) · Children's Treatment Network (1) · Copenhagen University Hospital, Rigshospitalet (1) · Delpor, Inc. (1) · Kent State University (1) · Medical University of South Carolina (1) · Nyree Penn (1) · Rachel Yehuda (1) · Rhode Island Hospital (1) · Rutgers, The State University of New Jersey (1) · ThIA Santé Mentale (1) · The Hong Kong Polytechnic University (1) · The University of Akron (1)
United States (15) · United Kingdom (2) · Australia (1) · Canada (1) · Denmark (1) · France (1) · Hong Kong (1)
Alex Choo, MD (1) · Amanda Jane J Lloyd, PhD, BSc (1) · Bert Hayslip, Ph.D. (1) · Brett T. Litz, PhD (1) · Charles Raison, MD (1) · Gitte M Knudsen, MD,Prof. (1) · Gregory Smith, Ed.D. (1) · Karie Feldman, Ph.D. (1) · Kate M Davidson, PhD (1) · Kathleen M Grubbs, PhD (1) · Keith N. Humphreys, PhD MA (1) · Lisa M. McTeague, PhD (1) · Michael A Cucciare, PhD (1) · Nancy M. Petry, PhD (1) · Nyree Penn, MHSc., CAA, Master of Health Science (1)
PMID 30188171, PMID 32792991, PMID 33393377, PMID 33884617, PMID 33910154, PMID 35549538, PMID 36347845, PMID 36763929, PMID 36863106, PMID 37169780, PMID 37592359, PMID 38100057, PMID 40421033, PMID 40656082
I21RX004417 (1), P50DA009241 (1), R01MH060417 (1), R01NR012256 (1), R34MH079884 (1), R42MH087322 (1), U54AG093230 (1)