18 completed. 18 Phase 3, 2 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 18 | Completed 18 |
| Phase 2 | 2 | Completed 2 |
Follow Paranasal Sinus Diseases: new trials by email Literature Review of Paranasal Sinus Diseases trials Research Report on Paranasal Sinus Diseases
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Dupilumab in Allergic Fungal Rhinosinusitis (AFRS) Dupilumab SAR231893, Placebo - Allergic Fungal Rhinosinusitis | Phase 3 | Completed | Sanofi | 62 | 2020-12-01 | 2026-09-03 |
| Efficacy and Safety of Acetylcysteine for the Treatment of Acute Uncomplicated Rhinosinusitis acetylcysteine, Placebo - Rhinosinusitis | Phase 3 | Completed | Sandoz | 944 | 2020-10-22 | 2021-11-19 |
| Xylitol for Chronic Sinusitis Xylitol, Saline - Chronic Rhinosinusitis, Rhinosinusitis | Phase 2 / Phase 3 | Completed | Ochsner Health System | 1 | 2018-03-01 | 2023-04-07 |
| Efficacy of Antibiotics in Children With Acute Sinusitis: Which Subgroups Benefit? Amoxicillin-clavulanate, Placebo - Sinusitis, Respiratory Tract Infections | Phase 3 | Completed | Nader Shaikh | 515 | 2016-02-01 | 2023-06-29 |
| Study to Assess the Efficacy and Safety of Potassium Clavulanate/Amoxicillin in Children With Acute Bacterial Rhinosinusitis Amoxicillin-Potassium Clavulanate Combination - Sinusitis, Acute | Phase 3 | Completed | GlaxoSmithKline | 27 | 2013-08-30 | 2017-07-11 |
| Evaluation of Inhaled Treatment in Sinusitis methylprednisolone, Budesonide - Sinusitis | Phase 2 / Phase 3 | Completed | Cliniques universitaires Saint-Luc- Université Catholique de Louvain | 50 | 2013-07-01 | 2014-01-27 |
| Nasal Inhalation of Pulmozyme in Patients With Cystic Fibrosis and Chronic Rhinosinusitis Dornase alfa (Pulmozyme), isotonic saline - Cystic Fibrosis, Rhinosinusitis | Phase 3 | Completed | University of Jena | 23 | 2007-09-01 | 2014-12-04 |
| Clinical Evaluation to Confirm Safety and Efficacy of Sinuplasty in the Paranasal Sinuses (CLEAR) Sinuplasty - Chronic Sinusitis | Phase 3 | Completed | Integra LifeSciences Corporation | 115 | 2005-04-01 | 2024-08-06 |
| BAY12-8039: 5 Days for Sinusitis vs Placebo Moxifloxacin (Avelox, BAY12-8039), Placebo - Sinusitis | Phase 3 | Completed | Bayer | 374 | 2005-01-01 | 2013-11-26 |
| Antibiotics Versus Therapeutic Ultrasound for Sinusitis Antibiotic (Amoxicillin), Therapeutic ultrasound - Sinusitis | Phase 3 | Completed | Norwegian University of Science and Technology | 48 | 2005-01-01 | 2013-10-29 |
| Docetaxel Based Chemotherapy Plus or Minus Induction Chemotherapy to Decrease Events in Head and Neck Cancer (DeCIDE) docetaxel, cisplatin, hydroxyurea - Cancer of the Pharynx, Cancer of the Larynx | Phase 3 | Completed | University of Chicago | 285 | 2004-11-01 | 2018-04-09 |
| Japanese Study Evaluating Safety, Efficacy and Acceptability of Telithromycin in Children With Infections telithromycin (HMR3647) - Infections, Child | Phase 3 | Completed | Sanofi | 111 | 2004-08-01 | 2009-04-03 |
| A Study Evaluating the Safety and Efficacy of Treating Sinus Infection With Levofloxacin 750 mg for 5 Days. levofloxacin - Maxillary Sinusitis | Phase 3 | Completed | Johnson & Johnson Pharmaceutical Research & Development, L.L.C. | 18 | 2003-11-01 | 2011-06-10 |
| A Multicenter, Randomized, Double-Blind, Double-Dummy Trial of Azithromycin SR Compared With Levofloxacin for the Treatment of Sinus Infections in Adults azithromycin SR (Zithromax; compound: CP-62,993), placebo, levofloxacin - Maxillary Sinusitis | Phase 3 | Completed | Pfizer | 541 | 2003-01-01 | 2011-05-11 |
| AMS VS MOXI Ketek vs Avelox in AMS Telithromycin - Maxillary Sinusitis | Phase 3 | Completed | Sanofi | 351 | 2002-12-01 | 2012-02-17 |
| A Comparison of the Safety and Efficacy of Two Different Regimens of Levofloxacin in the Treatment of Acute Bacterial Sinusitis(Sinus Infection) in Adults. levofloxacin - Sinusitis | Phase 3 | Completed | Johnson & Johnson Pharmaceutical Research & Development, L.L.C. | 784 | 2002-10-01 | 2011-06-10 |
| A Trial of Point of Care Information in Ambulatory Pediatrics Electronic point-of-care delivery system - Acute Otitis Media, Allergic Rhinitis | Phase 3 | Completed | University of Washington | 44 | 1999-11-01 | 2006-08-29 |
| A Study of the Safety and Effectiveness of Levofloxacin Compared With Amoxicillin/Clavulanate Potassium in the Treatment of Adults With Rapid Onset of Severe Inflammation/Infection of the Sinuses levofloxacin - Sinusitis, Maxillary Sinusitis | Phase 3 | Completed | Johnson & Johnson Pharmaceutical Research & Development, L.L.C. | 614 | 1993-08-01 | 2011-06-10 |
Sinusitis (11) · Maxillary Sinusitis (4) · Respiratory Tract Infections (4) · Infections (3) · Rhinosinusitis (3) · Allergic Fungal Sinusitis (1) · Bronchiolitis (1) · Constipation (1) · Croup (1) · Cystic Fibrosis (1) · Laryngeal Neoplasms (1) · Nose Diseases (1) · Otitis Media (1) · Paranasal Sinus Neoplasms (1)
Otorhinolaryngologic Diseases (18) · Nose Diseases (17) · Respiratory Tract Diseases (17) · Infections (14) · Respiratory Tract Infections (13) · Sinusitis (6) · Rhinitis (4) · Hypersensitivity (2) · Hypersensitivity, Immediate (2) · Immune System Diseases (2) · Laryngeal Diseases (2) · Lung Diseases (2) · Pharyngeal Diseases (2) · Respiratory Hypersensitivity (2)
Levofloxacin (4) · Amoxicillin-Potassium Clavulanate Combination (2) · Sodium Chloride (2) · telithromycin (2) · Acetylcysteine (1) · Amoxicillin (1) · Anti-Bacterial Agents (1) · Azithromycin (1) · Budesonide (1) · Cisplatin (1) · Docetaxel (1) · Drug Therapy (1) · Fluorouracil (1) · Hydroxyurea (1) · Methylprednisolone (1)
Johnson & Johnson Pharmaceutical Research & Development, L.L.C. (3) · Sanofi (3) · Bayer (1) · Cliniques universitaires Saint-Luc- Université Catholique de Louvain (1) · GlaxoSmithKline (1) · Integra LifeSciences Corporation (1) · Nader Shaikh (1) · Norwegian University of Science and Technology (1) · Ochsner Health System (1) · Pfizer (1) · Sandoz (1) · University of Chicago (1) · University of Jena (1) · University of Washington (1)
United States (8) · Germany (3) · Japan (3) · Russia (3) · Argentina (2) · India (2) · Bulgaria (1) · Canada (1) · Chile (1) · China (1) · Costa Rica (1) · Croatia (1) · Czechia (1) · Estonia (1) · France (1)
Christopher Church, MD (1) · Coralie Colbrant, PT (1) · Ellen R Wald, MD (1) · Everett Vokes, M.D. (1) · Gregory Reychler, PhD (1) · Jochen Mainz, M.D. (1) · Nader Shaikh, MPH, MD (1) · Norifumi Yamamoto (1) · Ottar Vasseljen, PhD (1)
PMID 15023840, PMID 15316237, PMID 15510034, PMID 17178300, PMID 17405780, PMID 17882910, PMID 20422704, PMID 20500134, PMID 21994147, PMID 23378777, PMID 23785241, PMID 24594542, PMID 27394715, PMID 28390807, PMID 37490085, PMID 42498125, PMID 8281565, PMID 9755259
2019 (1), U01AI118506 (1)