27 completed, 5 terminated, 3 active not recruiting, 3 recruiting. 43 Phase 2, 10 Phase 1, 4 Phase 3.
Follow Paranasal Sinus Diseases: new trials by email Literature Review of Paranasal Sinus Diseases trials Research Report on Paranasal Sinus Diseases
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Docetaxel and SX-682 in Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma, Salivary Gland Carcinoma, and Advanced Prostate Cancer SX-682, DTX - Head and Neck Cancer, Head and Neck Squamous Cell Carcinoma | Phase 1 / Phase 2 | Recruiting | National Cancer Institute (NCI) | 120 | 2026-11-04 | 2026-10-30 |
| Toripalimab With Chemotherapy for Sinus Cancer Toripalimab, Carboplatin, Docetaxel - Sinonasal Cancer, Paranasal Sinus Neoplasms | Phase 2 | Recruiting | Dana-Farber Cancer Institute | 20 | 2025-06-17 | 2026-08-31 |
| Bupivacaine and Epinephrine Injection Study Sensorcaine with Epinephrine, Sham injection - Sinus Disease, Anesthesia | Phase 2 / Phase 3 | Recruiting | Amin Javer | 80 | 2024-11-15 | 2025-05-15 |
| Evaluation of Nitric Oxide Nasal Spray (NONS) for Treatment of Recurrent Acute Rhinosinusitis Nitric Oxide Releasing Solution, Nasal spray with isotonic saline - Recurrent Acute Rhinosinusitis | Phase 2 | Completed | Sanotize Research and Development corp. | 162 | 2024-01-16 | 2026-04-22 |
| A Clinical Study of TQH2722 Injection in the Treatment of Chronic Sinusitis With or Without Nasal Polyps. 300mg of TQH2722 injection, 600mg of TQH2722 injection, TQH2722 injection matching placebo - Sinusitis | Phase 2 | Completed | Chia Tai Tianqing Pharmaceutical Group Nanjing Shunxin Pharmaceutical Co., Ltd. | 160 | 2023-12-28 | 2026-10-22 |
| A Study to Investigate the Efficacy and Safety of Verekitug (UPB-101) in Participants With Chronic Rhinosinusitis With Nasal Polyps Verekitug (UPB-101), Placebo - Chronic Rhinosinusitis With Nasal Polyps | Phase 2 | Completed | Upstream Bio Inc. | 81 | 2023-12-18 | 2026-09-18 |
| A Study to Evaluate 611 in Patients With Chronic Rhinosinusitis With Nasal Polyps 611, Placebo - Sinusitis, Nasal Polyps | Phase 2 | Unknown | Sunshine Guojian Pharmaceutical (Shanghai) Co., Ltd. | 90 | 2023-06-30 | 2024-01-12 |
| Intensity Modulated Proton or X-Ray Therapy After Surgery for Treatment of Head and Neck Cancer, the HEADLIGHT Study Cisplatin, Intensity-Modulated Proton Therapy, Quality-of-Life Assessment - Head and Neck Carcinoma, Head and Neck Carcinoma of Unknown Primary | Phase 2 | Active not recruiting | Mayo Clinic | 174 | 2022-02-16 | 2026-07-16 |
| Customized 3D Printed Oral Stents During Head and Neck Radiotherapy Best Practice, Medical Device Usage and Evaluation - Head and Neck Carcinoma, Malignant Parotid Gland Neoplasm | Phase 2 | Active not recruiting | M.D. Anderson Cancer Center | 88 | 2021-05-26 | 2026-10-06 |
| Camrelizumab Plus Chemoradiotherapy for Patients With Locoregional Cancer of Nasal Cavity and Paranasal Sinuses camrelizumab - Nasal Cavity Cancer, Paranasal Sinus Cancer | Phase 2 | Unknown | Sun Yat-sen University | 57 | 2021-04-16 | 2021-11-10 |
| Dupilumab in CRSsNP Dupilumab SAR231893, Placebo - Chronic Rhinosinusitis Without Nasal Polyps, Sinusitis | Phase 2 | Completed | Sanofi | 71 | 2020-12-02 | 2026-07-30 |
| Efficacy of Dupilumab for Patients With Chronic Rhinosinusitis Without Nasal Polyps (CRSsNP) dupilumab, placebo - Chronic Sinusitis | Phase 2 | Completed | Johns Hopkins University | 33 | 2020-10-15 | 2025-11-03 |
| Investigating the Effect of Herbal Medicine Nasal Irrigation on Treatment of Chronic Rhinitis and Sinusitis Taiwan Scientific" noninvasive blood pressure meter TS-0411, Meridian Energy Analysis Device(MEAD), bacteria culture - Nasal Disease | Phase 2 / Phase 3 | Unknown | Chang Gung Memorial Hospital | 250 | 2019-12-31 | 2020-06-22 |
| Celecoxib Through Surgery and Radiation Therapy for the Treatment of Advanced Head and Neck Cancer Celecoxib, Placebo, Quality-of-Life Assessment - Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, Clinical Stage IV HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8 | Phase 2 | Terminated | University of Utah | 13 | 2019-11-27 | 2025-02-12 |
| Nitric Oxide Releasing Sinus Irrigation (NOSi) to Treat Recalcitrant Chronic Rhinosinusitis (RCRS) Nitric Oxide, Budesonide - Chronic Sinusitis | Phase 2 | Completed | Sanotize Research and Development corp. | 56 | 2019-10-27 | 2022-06-30 |
| Xylitol for Chronic Sinusitis Xylitol, Saline - Chronic Rhinosinusitis, Rhinosinusitis | Phase 2 / Phase 3 | Completed | Ochsner Health System | 1 | 2018-03-01 | 2023-04-07 |
| A Clinical Trial of Endoscopic Surgery Followed by Chemotherapy and Proton Radiation for the Treatment of Tumors in the Sinus and Nasal Passages Cisplatin, Adjuvant Proton Radiotherapy, Endoscopic Resection - Paranasal Sinus Cancer, Nasal Cavity Tumor | Phase 2 | Completed | Memorial Sloan Kettering Cancer Center | 3 | 2017-09-01 | 2025-05-16 |
| SynRinse Irrigation Pilot (SIP) Trial Synrinse - Sinusitis, Chronic, Cystic Fibrosis With Other Manifestations | Phase 1 / Phase 2 | Completed | University of Washington | 30 | 2017-06-06 | 2018-10-17 |
| Adaptive Radiotherapy for Head and Neck Cancer Adaptive Radiotherapy - Head and Neck Cancer, Paranasal Sinus Cancer | Phase 2 | Completed | Memorial Sloan Kettering Cancer Center | 64 | 2017-03-15 | 2021-10-26 |
| Nivolumab and Ipilimumab in Treating Patients With Rare Tumors Biospecimen Collection, Computed Tomography, Echocardiography Test - Acinar Cell Carcinoma, Adenoid Cystic Carcinoma | Phase 2 | Active not recruiting | National Cancer Institute (NCI) | 798 | 2017-01-30 | 2026-06-17 |
Showing 20 of 43. Sign in to see all of them.
Sinusitis (20) · Paranasal Sinus Neoplasms (13) · Rhinosinusitis (10) · Laryngeal Neoplasms (8) · Mouth Neoplasms (7) · Head and Neck Neoplasms (6) · Hypopharyngeal Neoplasms (6) · Oropharyngeal Neoplasms (5) · Nasal Polyps (4) · Salivary Gland Neoplasms (4) · Carcinoma, Adenoid Cystic (3) · Nasopharyngeal Neoplasms (3) · Asthma (2) · Bronchiolitis Obliterans Syndrome (2)
Otorhinolaryngologic Diseases (42) · Respiratory Tract Diseases (42) · Nose Diseases (41) · Infections (27) · Respiratory Tract Infections (27) · Neoplasms (14) · Neoplasms by Site (14) · Otorhinolaryngologic Neoplasms (14) · Respiratory Tract Neoplasms (14) · Nose Neoplasms (13) · Pharyngeal Diseases (10) · Rhinitis (10) · Stomatognathic Diseases (10) · Pathological Conditions, Signs and Symptoms (9)
Budesonide (5) · Cisplatin (4) · Radiotherapy (3) · 1,2-diaminocyclohexaneplatinum II citrate (2) · Carboplatin (2) · Celecoxib (2) · Docetaxel (2) · Fluorouracil (2) · Magnetic Resonance Spectroscopy (2) · Platinum (2) · Sodium Chloride (2) · Specimen Handling (2) · dupilumab (2) · Azithromycin (1) · BID protein, human (1)
Johnny Kao (2) · M.D. Anderson Cancer Center (2) · Memorial Sloan Kettering Cancer Center (2) · National Cancer Institute (NCI) (2) · Pari Pharma GmbH (2) · Sanotize Research and Development corp. (2) · Amin Javer (1) · Burzynski Research Institute (1) · Centre hospitalier de l'Université de Montréal (CHUM) (1) · Chang Gung Memorial Hospital (1) · Chia Tai Tianqing Pharmaceutical Group Nanjing Shunxin Pharmaceutical Co., Ltd. (1) · Cliniques universitaires Saint-Luc- Université Catholique de Louvain (1) · Dana-Farber Cancer Institute (1) · Entellus Medical, Inc. (1) · GlaxoSmithKline (1)
United States (26) · Canada (8) · Germany (5) · China (4) · Spain (3) · Belgium (2) · Czechia (2) · Poland (2) · Russia (2) · Sweden (2) · Ukraine (2) · Argentina (1) · Bulgaria (1) · Chile (1) · Estonia (1)
Adam M Zanation, MD (1) · Amin Javer, MD (1) · Amin R Javer, MD, FRCSC (1) · Amit Agrawal (1) · Andrew M Wilson (1) · Anna Lee (1) · C. Jillian Tsai, MD (1) · Charalampos Floudas, M.D. (1) · Claus Bachert, MD, PhD (1) · Coralie Colbrant, PT (1) · Ehab Y Hanna (1) · Greg Davis, MD (1) · Gregory Reychler, PhD (1)
PMID 15023840, PMID 15125017, PMID 15316237, PMID 15510034, PMID 17405780, PMID 17882910, PMID 19419611, PMID 19559969, PMID 19794023, PMID 20830768, PMID 21246519, PMID 21994147, PMID 23378777, PMID 23785241, PMID 27394715, PMID 28390807, PMID 29178954, PMID 31969335, PMID 33362722, PMID 33735508, PMID 33882143, PMID 34380663, PMID 34716198, PMID 38243705, PMID 38358334, PMID 39067873, PMID 39343510, PMID 39393433, PMID 39417692, PMID 39583952, PMID 39856213, PMID 40402690, PMID 40588371, PMID 41672597, PMID 41892875, PMID 41995270, PMID 42499790, PMID 8281565, PMID 9755259
2023 (1), P30CA042014 (1), U10CA180888 (1)