18 completed, 7 unknown, 5 recruiting, 4 terminated. 38 Phase 3, 4 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 38 | Completed 18, Unknown 7, Recruiting 5, Terminated 4, Active not recruiting 2, Withdrawn 2 |
| Phase 2 | 4 | Completed 2, Recruiting 1, Unknown 1 |
Follow Paranasal Sinus Diseases: new trials by email Literature Review of Paranasal Sinus Diseases trials Research Report on Paranasal Sinus Diseases
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study to Assess the Efficacy and Safety of GSK5784283 (Felcorekibart) in Participants With Chronic Rhinosinusitis With Nasal Polyps (CRSwNP) GSK5784283, Placebo, Standard of Care - Nasal Polyps | Phase 3 | Recruiting | GlaxoSmithKline | 218 | 2026-09-28 | 2026-10-14 |
| A Study to Assess the Efficacy and Safety of GSK5784283 (Felcorekibart) Compared With Placebo in Participants With Chronic Rhinosinusitis With Nasal Polyps (CRSwNP) GSK5784283, Placebo, Standard of Care - Nasal Polyps | Phase 3 | Recruiting | GlaxoSmithKline | 218 | 2026-09-03 | 2026-10-09 |
| The Efficacy and Safety of Raphamin in the Treatment of Acute Rhinosinusitis in Adult Patients Raphamin, Placebo - Rhinosinusitis, Rhinosinusitis Acute | Phase 3 | Recruiting | Materia Medica Holding | 552 | 2025-04-03 | 2026-03-16 |
| A Study to Investigate Changes in Symptoms in Adult Participants With Chronic Rhinosinusitis With Nasal Polyposis Initiating Treatment With Tezepelumab Tezepelumab - Chronic Rhinosinusitis With Nasal Polyps | Phase 3 | Active not recruiting | AstraZeneca | 181 | 2024-12-03 | 2026-10-07 |
| A Study to Evaluate 611 in Patients With Chronic Rhinosinusitis With Nasal Polyps 611, Placebo - Sinusitis, Nasal Polyps | Phase 3 | Active not recruiting | Sunshine Guojian Pharmaceutical (Shanghai) Co., Ltd. | 243 | 2024-11-22 | 2025-12-03 |
| Bupivacaine and Epinephrine Injection Study Sensorcaine with Epinephrine, Sham injection - Sinus Disease, Anesthesia | Phase 2 / Phase 3 | Recruiting | Amin Javer | 80 | 2024-11-15 | 2025-05-15 |
| Study of Dupilumab 300 mg Every Other Week After Endoscopic Sinus Surgery in Patients With Allergic Fungal Rhinosinusitis (AFRS) on a Background Therapy With Intranasal Corticosteroid Spray Dupilumab - Allergic Fungal Rhinosinusitis (AFRS), Chronic Rhinosinusitis (CRS) | Phase 3 | Withdrawn | National Institute on Deafness and Other Communication Disorders (NIDCD) | 2024-07-17 | 2024-07-25 | |
| Add-on Dupilumab for AFRS as Postoperative Therapy (ADAPT) Dupilumab, Placebo, Intranasal Corticosteroid Sprays (INCS) - Allergic Fungal Rhinosinusitis | Phase 3 | Terminated | Emory University | 5 | 2023-10-26 | 2025-05-08 |
| Evaluation of the Efficacy of Azithromycin in Idiopathic Purulent Oedematous Sinusitis in Adults Azithromycin Oral Tablet, Placebo - Sinusitis, Chronic, Sinus Infection Chronic | Phase 3 | Recruiting | Centre Hospitalier Intercommunal Creteil | 230 | 2022-11-21 | 2025-08-29 |
| Establishment of Precise Diagnosis and Treatment System for Refractory Chronic Rhinosinusitis Mometasone furoate nasal spray hormone, Mometasone furoate nasal spray hormone + oral hormone, Mometasone furoate nasal spray hormone + omalizumab - Sinusitis | Phase 3 | Unknown | Beijing Tongren Hospital | 87 | 2022-05-25 | 2022-05-25 |
| Dupilumab in Allergic Fungal Rhinosinusitis (AFRS) Dupilumab SAR231893, Placebo - Allergic Fungal Rhinosinusitis | Phase 3 | Completed | Sanofi | 62 | 2020-12-01 | 2026-09-03 |
| Efficacy and Safety of Acetylcysteine for the Treatment of Acute Uncomplicated Rhinosinusitis acetylcysteine, Placebo - Rhinosinusitis | Phase 3 | Completed | Sandoz | 944 | 2020-10-22 | 2021-11-19 |
| Investigating the Effect of Herbal Medicine Nasal Irrigation on Treatment of Chronic Rhinitis and Sinusitis Taiwan Scientific" noninvasive blood pressure meter TS-0411, Meridian Energy Analysis Device(MEAD), bacteria culture - Nasal Disease | Phase 2 / Phase 3 | Unknown | Chang Gung Memorial Hospital | 250 | 2019-12-31 | 2020-06-22 |
| Efficacy and Safety of Modified Release Cefpodoxime Formulation in the Treatment of Acute Sinusitis. Infex 400 MR, Infex 200 IR - Sinusitis, Sinusitis, Acute | Phase 3 | Unknown | Neutec Ar-Ge San ve Tic A.Ş | 100 | 2019-05-15 | 2023-01-05 |
| Xylitol for Chronic Sinusitis Xylitol, Saline - Chronic Rhinosinusitis, Rhinosinusitis | Phase 2 / Phase 3 | Completed | Ochsner Health System | 1 | 2018-03-01 | 2023-04-07 |
| Tobramycin Delivered by Nebulized Sonic Aerosol for Chronic Rhinosinusitis Treatment of Cystic Fibrosis Patients Tobramycin nebulized nasally, Physiologic serum nebulized nasally - Cystic Fibrosis, Rhinosinusitis | Phase 3 | Terminated | Virginie ESCABASSE | 86 | 2017-02-16 | 2023-02-15 |
| Effect of Reslizumab in Chronic Rhinosinusitis Reslizumab, Placebo - Sinusitis | Phase 3 | Unknown | Joshua S. Jacobs | 30 | 2016-06-01 | 2018-02-01 |
| Efficacy of Antibiotics in Children With Acute Sinusitis: Which Subgroups Benefit? Amoxicillin-clavulanate, Placebo - Sinusitis, Respiratory Tract Infections | Phase 3 | Completed | Nader Shaikh | 515 | 2016-02-01 | 2023-06-29 |
| Rates of Middle Meatus Synechiae Formation Post Endoscopic Sinus Surgery Restora™ Steroid eluting spacer, Silastic Silicone Spacer - Sinusitis | Phase 3 | Terminated | Cedars-Sinai Medical Center | 3 | 2015-12-01 | 2017-11-17 |
| Prednisone in Chronic Rhinosinusitis Without Nasal Polyps Prednisone, Placebo - Sinusitis, Chronic Rhinosinusitis | Phase 3 | Unknown | University of Chile | 90 | 2015-06-01 | 2015-06-04 |
Showing 20 of 38. Sign in to see all of them.
Sinusitis (23) · Rhinosinusitis (8) · Nasal Polyps (5) · Maxillary Sinusitis (4) · Respiratory Tract Infections (4) · Rhinitis (4) · Allergic Fungal Sinusitis (3) · Cystic Fibrosis (3) · Infections (3) · Bronchiolitis Obliterans Syndrome (2) · Nose Diseases (2) · Asthma (1) · Bronchiolitis (1) · Constipation (1)
Otorhinolaryngologic Diseases (38) · Respiratory Tract Diseases (37) · Nose Diseases (36) · Infections (31) · Respiratory Tract Infections (30) · Sinusitis (11) · Rhinitis (8) · Pathological Conditions, Signs and Symptoms (7) · Immune System Diseases (6) · Lung Diseases (6) · Pathological Conditions, Anatomical (5) · Polyps (5) · Bronchial Diseases (4) · Hypersensitivity (4)
Levofloxacin (4) · Sodium Chloride (3) · dupilumab (3) · Amoxicillin-Potassium Clavulanate Combination (2) · Anti-Bacterial Agents (2) · Azithromycin (2) · Standard of Care (2) · dornase alfa (2) · telithromycin (2) · Acetylcysteine (1) · Amoxicillin (1) · Budesonide (1) · Bupivacaine (1) · Cisplatin (1) · Docetaxel (1)
GlaxoSmithKline (3) · Johnson & Johnson Pharmaceutical Research & Development, L.L.C. (3) · Sanofi (3) · Amin Javer (1) · AstraZeneca (1) · Bayer (1) · Beijing Tongren Hospital (1) · Cedars-Sinai Medical Center (1) · Centre Hospitalier Intercommunal Creteil (1) · Chang Gung Memorial Hospital (1) · Cliniques universitaires Saint-Luc- Université Catholique de Louvain (1) · Emory University (1) · Integra LifeSciences Corporation (1) · Joshua S. Jacobs (1) · Materia Medica Holding (1)
United States (15) · France (4) · Germany (4) · Russia (4) · Canada (3) · China (3) · Japan (3) · Argentina (2) · Bulgaria (2) · Chile (2) · India (2) · Poland (2) · Spain (2) · Turkey (Türkiye) (2) · Australia (1)
Babak Saedi, professor (1) · Christopher Church, MD (1) · Constanza J Valdes, MD (1) · Coralie Colbrant, PT (1) · Ellen R Wald, MD (1) · Enrico Heffler, MD, PhD (1) · Everett Vokes, M.D. (1) · Gregory Reychler, PhD (1) · Jochen Mainz, M.D. (1) · Joshua Jacobs, MD (1)
PMID 15023840, PMID 15316237, PMID 15510034, PMID 17178300, PMID 17405780, PMID 17882910, PMID 20422704, PMID 20500134, PMID 21994147, PMID 22287332, PMID 22764607, PMID 22887970, PMID 23378777, PMID 23785241, PMID 24594542, PMID 24610673, PMID 24753507, PMID 24889751, PMID 27394715, PMID 28390807, PMID 35390177, PMID 37490085, PMID 42498125, PMID 8281565, PMID 9755259
2019 (1), U01AI118506 (1)