62 completed, 21 unknown, 8 recruiting, 3 enrolling by invitation. 51 Not applicable, 9 Phase 2, 5 Phase 3, 4 Phase 1, 2 Phase 4.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Clinical Trial of the Cryosa System for the Treatment of Obstructive Sleep Apnea (OASIS) Cryosa Procedure - Obstructive Sleep Apnea (OSA), Sleep Apnea - Obstructive | Not applicable | Not yet recruiting | Cryosa, Inc. | 130 | 2026-10-01 | 2026-07-22 |
| PMOS in OSA Pilot Study Continuous Positive Airway Pressure (CPAP) - PCOS, PCOS (Polycystic Ovary Syndrome) | Not applicable | Recruiting | University of Chicago | 10 | 2026-10-01 | 2026-10-13 |
| Automated Manual Lymphatic Drainage Therapy to Improve Glymphatic Function in OSA Patients Automated manual lymphatic drainage therapy (AMLDT) device - Obstructive Sleep Apnea (OSA), OSA | Not applicable | Enrolling by invitation | Mayo Clinic | 15 | 2025-11-24 | 2026-09-10 |
| MEA DPA Hypoxic Event Reductions DPA, OPA - Hypoxia, OSA | Not applicable | Withdrawn | Stanford University | 2025-11-01 | 2026-05-07 | |
| Impact of Muscle Training Device on Non-Severe OSA DidgeriTU, Sham device - OSA, Obstructive Sleep Apnea | Not applicable | Recruiting | Thammasat University Hospital | 76 | 2025-05-01 | 2026-01-21 |
| The Use of Entropy to Assess Sleep Disordered Breathing in Chronic Respiratory Disease Bronchial Asthma, Bronchiectasis | Recruiting | University College, London | 120 | 2025-04-30 | 2025-07-11 | |
| Diagnosing Obstructive Sleep Apnea Using Electromyography of the Muscles of the Mouth Electromyography (EMG) of the Oropharynx - Obstructive Sleep Apnea (OSA), OSA | Recruiting | University of California, San Diego | 60 | 2025-03-24 | 2025-04-25 | |
| A Master Protocol for Orforglipron in Participants With Obstructive Sleep Apnea and Obesity or Overweight Orforglipron, Placebo - OSA, Overweight or Obesity | Phase 3 | Completed | Eli Lilly and Company | 712 | 2024-10-22 | 2026-09-14 |
| Inspire Singapore Study Inspire System - Obstructive Sleep Apnea, OSA | Not applicable | Completed | Inspire Medical Systems, Inc. | 44 | 2024-07-25 | 2026-05-22 |
| Detecting Heart Rate, Respiration, and Sleep With the Sleeptracker-AI Under-mattress Monitor Sleeptracker-AI - OSA | Recruiting | Woolcock Institute of Medical Research | 100 | 2024-07-10 | 2025-03-28 | |
| Lifestyle Changes in PCOS with OSA and NAFLD diet restriction and exercise, diet restriction - PCOS, NAFLD | Not applicable | Unknown | Cairo University | 40 | 2024-07-05 | 2024-09-19 |
| Continuation Protocol for Obstructive Sleep Apnea (OSA) Aroxybutynin and Atomoxetine - OSA | Phase 3 | Enrolling by invitation | Apnimed | 1280 | 2024-07-03 | 2025-05-13 |
| Study That Tests AD109 in Patients Taking GLP-1 Drugs AD109 - OSA | Phase 2 | Completed | Apnimed | 40 | 2024-05-20 | 2025-02-19 |
| Reversible Effect of Falling Ventilatory Drive in Drive-dependent OSA Dynamic CO2, Sham CO2 - OSA | Not applicable | Recruiting | Brigham and Women's Hospital | 36 | 2024-03-27 | 2025-03-19 |
| Prevalence of OSA and Diagnostic Accuracy of Type 3 Home Sleep Test in Difficult-to-treat Asthma home sleep test - OSA | Not applicable | Active not recruiting | Chulalongkorn University | 37 | 2024-02-07 | 2025-06-25 |
| Acetazolamide as a Means to Mitigate Falling Ventilatory Drive and Drive-dependent OSA Acetazolamide, Placebo - OSA | Phase 1 / Phase 2 | Recruiting | Brigham and Women's Hospital | 36 | 2024-01-31 | 2024-03-04 |
| Hypoxic Burden and Sleepiness in Treated OSA Patients Impact of hypoxic burden on objective and subjective sleepiness in patients treated for Obstructive Sleep apnea - Obstructive Sleep, OSA | Completed | Hospices Civils de Lyon | 141 | 2024-01-01 | 2024-11-22 | |
| Mandibular Advancement Device and Changes in Nocturia Somnodent Classic - Obstructive Sleep Apnea, Nocturia | Not applicable | Completed | Isabel Moreno Hay | 11 | 2023-12-11 | 2026-08-27 |
| Pharyngeal Muscle Control Mechanisms of Atomoxetine-plus-oxybutynin in Obstructive Sleep Apnea Atomoxetine 80 mg plus Oxybutynin 5 mg, Atomoxetine 80 MG, Placebo - OSA | Phase 1 / Phase 2 | Completed | Brigham and Women's Hospital | 27 | 2023-12-01 | 2025-12-17 |
| Biomarkers of Dementia in Chronic Sleep and Breathing Disorders High density electroencephalogram (HdEEG), Functional near infrared spectroscopy (fNIRS), Magnetic resonance imaging (MRI) - COPD, Overlap Syndrome | Unknown | Woolcock Institute of Medical Research | 104 | 2023-12-01 | 2024-04-22 |
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Sleep Apnea, Obstructive (35) · Pulmonary Disease, Chronic Obstructive (13) · Sleep Apnea Syndromes (11) · Apnea (3) · Asthma (3) · Obesity (3) · Respiratory Insufficiency (3) · Sleep Wake Disorders (3) · Hypoxia (2) · Nocturia (2) · Patient Compliance (2) · Snoring (2) · Acute Coronary Syndrome (1) · Airway Remodeling (1) · Alzheimer Disease (1)
Respiratory Tract Diseases (56) · Respiration Disorders (45) · Nervous System Diseases (42) · Dyssomnias (40) · Sleep Disorders, Intrinsic (40) · Apnea (37) · Sleep Wake Disorders (37) · Pathological Conditions, Signs and Symptoms (32) · Sleep Apnea Syndromes (29) · Signs and Symptoms (19) · Lung Diseases (15) · Lung Diseases, Obstructive (15) · Pathologic Processes (14) · Chronic Disease (13) · Disease Attributes (13)
Exercise (4) · Continuous Positive Airway Pressure (3) · Polysomnography (3) · Acetazolamide (2) · Atomoxetine Hydrochloride (2) · Blood Specimen Collection (2) · Surveys and Questionnaires (2) · Aging (1) · Dimethyl Fumarate (1) · Electromyography (1) · Eszopiclone (1) · Fentanyl (1) · Fractional Exhaled Nitric Oxide Testing (1) · Information Motivation Behavioral Skills Model (1) · Magnetic Resonance Imaging (1)
Apnimed (5) · Chinese University of Hong Kong (4) · University of California, San Diego (4) · Brigham and Women's Hospital (3) · Chang Gung Memorial Hospital (3) · Chulalongkorn University (3) · Assiut University (2) · Cairo University (2) · Guy's and St Thomas' NHS Foundation Trust (2) · Hillel Yaffe Medical Center (2) · Hospital Universitario Araba (2) · Institut für Pneumologie Hagen Ambrock eV (2) · Mahidol University (2) · Mansoura University (2) · Mayo Clinic (2)
United States (33) · Taiwan (8) · Thailand (8) · Egypt (6) · Belgium (5) · Spain (5) · Brazil (4) · China (4) · Germany (4) · Australia (3) · Canada (3) · France (3) · United Kingdom (3) · Hong Kong (2) · Italy (2)
Dillon Gilbertson (3) · Atul Malhotra, MD (2) · Joaquin Duran-Cantolla, MD (2) · Scott Sands, PhD (2) · Abdulghani Sankari, MD PhD (1) · Alex Pearce (1) · Annick AB Bruwier (1) · Antonio Spanevello, Prof MD (1) · Arnaud Prigent, Dr (1) · B. Tucker Woodson, MD (1) · Carolina Lombardi, Prof. (1) · Cheryl CH Yang, professor (1)
PMID 21461326, PMID 23997699, PMID 25766689, PMID 28824451, PMID 29602814, PMID 29609706, PMID 29800466, PMID 29992713, PMID 30795760, PMID 32356074, PMID 33888576, PMID 34053151, PMID 34728052, PMID 35613672, PMID 36447027, PMID 37349132, PMID 37858599, PMID 38325913, PMID 39454998, PMID 39514000, PMID 39897118, PMID 40135690, PMID 40360261, PMID 40914728, PMID 40946231, PMID 41025403, PMID 42008810, PMID 42148495, PMID 42149813, PMID 42257317, PMID 42383207
1IK2RX003535 (1), R42HL176325 (1)