48 completed, 13 unknown, 12 recruiting, 5 active not recruiting. 63 Not applicable, 9 Phase 2, 4 Phase 3, 3 Early Phase 1, 3 Phase 1.
Follow Muscle Atrophy: new trials by email Literature Review of Muscle Atrophy trials Research Report on Muscle Atrophy
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Weaning Assessment by Peripheral Muscle Ultrasonography Ultrasonography of peripheral muscle (rectus femoris or vastus intermedius), Ultrasonography of diaphragma - ICU Stay, Muscle Atrophy | Not yet recruiting | Taksim Egitim ve Arastirma Hastanesi | 100 | 2026-09-25 | 2026-10-06 | |
| Protein Supplementation During Luteal Phase to Stop Protein Degradation protein supplement, Placebo - Muscle Atrophy | Not applicable | Recruiting | Sam Houston State University | 34 | 2026-08-04 | 2026-09-25 |
| Effect of Knee Position on Muscle Loss During Leg Immobilization Knee immobilization brace (0°) for 5 days, Knee immobilization brace (60°) for 5 days - Muscle Atrophy, Disuse Atrophy | Not applicable | Not yet recruiting | Wageningen University | 30 | 2026-08-01 | 2026-07-08 |
| Effects of Cyclical Blood Flow Restriction Exercise on Muscle Hypertrophy and Capillaries in Older Adults Blood Flow Restriction (BFR), Conventional Low-Load Resistance Exercise - Sarcopenia in Elderly, Muscle Atrophy | Not applicable | Completed | Akdeniz University | 31 | 2026-02-01 | 2026-07-08 |
| Electromyostimulation (EMS) of Astronauts in Spaceflight (Easymotion-2) Electromyostimulation (EMS), Myoton, Electromyography (EMG) - Muscle Atrophy, Myotonia | Not applicable | Enrolling by invitation | Charite University, Berlin, Germany | 12 | 2025-09-15 | 2026-03-23 |
| Intertrochanteric Femur Fracture Patients Who Receive Metformin With a Placebo Placebo, Metformin - Intertrochanteric Femur Fracture, Muscle Atrophy | Early Phase 1 | Enrolling by invitation | University of Utah | 60 | 2025-09-04 | 2026-04-29 |
| Identifying Fundamental Mechanisms of Skeletal Muscle Ageing in Older Men Undergoing Androgen Deprivation Therapy: a Feasibility Study Sarcopenia, Prostate Cancer | Not yet recruiting | Guy's and St Thomas' NHS Foundation Trust | 20 | 2025-09-01 | 2025-08-21 | |
| Continuous Passive Motion to Prevent Ankle Contracture and Muscle Atrophy in Ventilated Patients Continuous Passive Motion - Ankle Contracture, Critically Ill Intensive Care Unit Patients | Not applicable | Not yet recruiting | Shin Kong Wu Ho-Su Memorial Hospital | 20 | 2025-06-25 | 2025-06-29 |
| Effects of Overground Robot-Assisted Gait Training on Stroke-Related Sarcopenia Overground Robot-Assisted Gait Training (o-RAGT), Recumbent Bicycle Training - Stroke, Sarcopenia | Not applicable | Completed | Sahmyook University | 53 | 2025-06-09 | 2026-05-01 |
| Postoperative Electrical Muscle Stimulation Two Neuromuscular Electrical Stimulation, Protein supplement drink - Surgery, Colorectal Cancer | Not applicable | Recruiting | University of Nottingham | 45 | 2025-06-05 | 2026-06-15 |
| Achilles Tendon Rupture - Intervention With Electrical Stimulation Neuromuscular Electrical Stimulation - Achilles Tendon Ruptures, Immobilization | Not applicable | Not yet recruiting | Karolinska University Hospital | 220 | 2025-01-15 | 2024-09-19 |
| Using Continuous Passive Motion to Prevent Ankle Problems in ICU Patients Continuous Passive Motion (CPM) - Joint Contracture, Mechanical Ventilation | Not applicable | Completed | Shin Kong Wu Ho-Su Memorial Hospital | 12 | 2024-11-20 | 2025-04-25 |
| FIT Exercise in 30d of ULLS-induced Muscle Disuse velocity-based FIT (VBFIT), No Exercise - Muscle Atrophy, Muscle Weakness | Not applicable | Recruiting | Lance Bollinger | 16 | 2024-10-23 | 2025-10-24 |
| Impact of Urolithin A (Mitopure) on Mitochondrial Quality in Muscle of Frail Older Adults Mitopure (Urolithin A), Placebo - Frailty, Sarcopenia | Not applicable | Completed | Amazentis SA | 26 | 2024-08-15 | 2025-05-28 |
| Essential Amino Acid Supplementation for Femoral Fragility Fractures Essential Amino Acid Supplementation - Femoral Fracture, Fragility Fracture | Phase 2 | Recruiting | Michael C Willey | 60 | 2024-06-17 | 2026-10-07 |
| Muscle Wasting and Rheumatoid Arthritis Flares Amino Acid Supplement - Rheumatoid Arthritis, Muscle Atrophy | Not applicable | Unknown | Leeds Beckett University | 40 | 2024-05-13 | 2024-05-06 |
| Molecular Mechanisms Underlying Anabolic Resistance to Protein Intake During Muscle Disuse Unilateral leg immobilization, Contralateral active leg - Atrophy, Disuse, Muscle Atrophy | Not applicable | Completed | United States Army Research Institute of Environmental Medicine | 12 | 2024-02-20 | 2024-12-02 |
| Changes in Skeletal Muscle Thickness in Patients With Acute Heart Failure BodyMetrix Body Composition Ultrasound - Heart Failure, Muscle Atrophy | Recruiting | Tufts Medical Center | 60 | 2024-02-19 | 2026-10-26 | |
| Neuromodulation for Prevention of Intensive Care Unit Acquired Weakness and Post Intensive Care Syndrome Intervention Group, Control Group - Muscle Atrophy, Muscle Weakness | Not applicable | Active not recruiting | Bijan Najafi, PhD | 25 | 2023-08-28 | 2024-12-30 |
| Improved Muscle Metabolism by Combination of Muscle Activation and Protein Substitution ( IMEMPRO ) Dietary Supplement: additional substitution of protein, Neuromuscular electrical stimulation, Early Mobilization - ICU Acquired Weakness, Muscle Atrophy | Not applicable | Recruiting | Technical University of Munich | 40 | 2023-06-27 | 2026-03-03 |
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Muscular Atrophy (93) · Sarcopenia (13) · Muscle Weakness (12) · Critical Illness (8) · Motor Activity (6) · Muscular Disorders, Atrophic (6) · Insulin Resistance (4) · Sedentary Behavior (4) · COVID-19 (3) · Cachexia (3) · Pulmonary Disease, Chronic Obstructive (3) · Atrophy (2) · Frailty (2) · Heart Failure (2) · Inflammation (2)
Nervous System Diseases (93) · Neurologic Manifestations (93) · Neuromuscular Manifestations (93) · Pathological Conditions, Anatomical (93) · Pathological Conditions, Signs and Symptoms (93) · Signs and Symptoms (93) · Atrophy (91) · Pathologic Processes (30) · Musculoskeletal Diseases (23) · Muscular Diseases (16) · Disease Attributes (11) · Behavior (10) · Nutritional and Metabolic Diseases (10) · Wounds and Injuries (9) · Cardiovascular Diseases (8)
Blood Flow Restriction Therapy (4) · Electric Stimulation (4) · Bed Rest (3) · Resistance Training (3) · Immobilization (2) · Leucine (2) · Magnetic Resonance Imaging (2) · Metformin (2) · Motion Therapy, Continuous Passive (2) · Sodium Chloride (2) · Testosterone (2) · testosterone enanthate (2) · 3,8-dihydroxy-6H-dibenzo(b,d)pyran-6-one (1) · Alanine (1) · Amino Acids (1)
University of Nottingham (6) · McMaster University (5) · McGill University (3) · University of Exeter (3) · University of Utah (3) · Baylor College of Medicine (2) · Concordia University, Montreal (2) · Guy's and St Thomas' NHS Foundation Trust (2) · King's College London (2) · Sahlgrenska University Hospital (2) · Shin Kong Wu Ho-Su Memorial Hospital (2) · Tufts Medical Center (2) · University Hospital, Bonn (2) · University of Erlangen-Nürnberg Medical School (2) · University of Saskatchewan (2)
United States (26) · United Kingdom (17) · Canada (13) · Germany (6) · Austria (2) · Belgium (2) · Brazil (2) · Denmark (2) · France (2) · Sweden (2) · Switzerland (2) · Taiwan (2) · Chile (1) · Egypt (1) · Lithuania (1)
Stuart M Phillips, PhD (4) · Oliver Witard, PhD (2) · Aivaras Ratkevicius, Dr. (1) · Angelika Hammerer, MD (1) · Carolyn Greig, PhD (1) · Christian Mueller, MD (1) · Corbin Griffen, MSc (1) · Danielle E Bear, MRes (1) · Darren Candow, Ph.D. (1) · David A Patch, MD (1) · David Green, PhD (1) · Derek Renshaw, PhD (1) · Dieter Blottner, PhD (1) · Elham Sobhy (1)
PMID 32469388, PMID 36905161, PMID 10747199, PMID 10816184, PMID 1108172, PMID 12472328, PMID 15699838, PMID 16040540, PMID 16040545, PMID 16215380, PMID 17855814, PMID 18191684, PMID 18414231, PMID 18511703, PMID 18955382, PMID 19661454, PMID 19886379, PMID 19893999, PMID 20333769, PMID 2055867, PMID 21475676, PMID 22068603, PMID 2240202, PMID 23550781, PMID 23917769, PMID 23948422, PMID 24012740, PMID 24108315, PMID 24135505, PMID 24168489, PMID 24215591, PMID 24251881, PMID 24326421, PMID 24371120, PMID 24919692, PMID 25296344, PMID 25457674, PMID 25481088, PMID 26578714, PMID 26733251, PMID 26814772, PMID 26829246, PMID 27279248, PMID 27358494, PMID 27779600, PMID 28377156, PMID 28716003, PMID 28840147, PMID 29403389, PMID 29539414
R01AG031255 (1), R01AG046401 (1), R01HL167113 (1), R21AT010847 (1)