15 completed, 6 unknown, 1 enrolling by invitation, 1 not yet recruiting. 13 Not applicable, 4 Phase 2, 3 Phase 1, 1 Early Phase 1, 1 Phase 4.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| NAC-REPAIR for Post-surgical Pain NAC, NAC 0mg/day (Placebo) - Carpal Tunnel Surgery, Trigger Finger Disorder | Phase 2 | Not yet recruiting | University of Arizona | 80 | 2026-10-15 | 2026-07-17 |
| Morton's Toe and Neuromuscular Performance Foot Morphology, Morton Toe | Completed | Giresun University | 47 | 2026-01-10 | 2026-10-26 | |
| Resiniferatoxin for the Management of Refractory Morton s Neuroma Pain Resiniferatoxin - Morton's Neuroma | Phase 1 | Completed | National Institutes of Health Clinical Center (CC) | 3 | 2025-03-13 | 2026-04-13 |
| Radiofrequency Before to Surgical Removal of a Recalcitrant Morton´s Neuroma Radiofrequency - Morton Neuroma, Radriofrequency | Not applicable | Unknown | Universidad de Extremadura | 34 | 2022-10-15 | 2023-05-10 |
| Cryoanalgesia for the Treatment of Pain in Subjects With Morton's Neuroma Cryoanalgesia (iovera°®) - Morton's Neuroma, Pain Management | Not applicable | Unknown | Northern California Research Trials, Inc. | 5 | 2022-08-22 | 2022-11-21 |
| Comparative Effectiveness of Cryoablation Versus Steroid and Lidocaine Alone for Treatment of Morton's Neuroma Cryoablation, Nerve block - Morton Neuroma | Not applicable | Recruiting | Oregon Health and Science University | 32 | 2022-07-25 | 2025-10-16 |
| A Test of Efficacy and Foot Position Alteration in Patients Wearing Good Feet Arch Supports for the Treatment of Pain Arch supports - Plantar Fasciitis of Both Feet, Metatarsalgia | Completed | Massachusetts General Hospital | 43 | 2022-06-13 | 2025-08-08 | |
| Investigation of the Effect of Custom Made Insoles on Foot Pressure Distribution and Gait Parameters in Patients With Morton's Neuroma Custom made orthosis - Morton Neuroma | Not applicable | Unknown | Acibadem University | 35 | 2022-06-01 | 2022-06-09 |
| Comparison of the Effects of Morton's Neuroma on Foot Pressure Distribution and Gait Parameters in Pes Planus and Pes Cavus Patients Comparison of gait and foot pressure - Morton Neuroma, Pes Planus | Completed | Acibadem University | 40 | 2021-07-01 | 2021-10-26 | |
| US and MRI of the Forefoot: Intermetatarsal Bursitis or Morton's Neuroma MRI with contrast, Ultrasound - Intermetatarsal Bursitis, Morton Neuroma | Not applicable | Enrolling by invitation | Copenhagen University Hospital, Rigshospitalet | 75 | 2021-06-14 | 2024-11-15 |
| Study of AxoGuard® Nerve Cap and Neurectomy for Treatment of Symptomatic Neuroma & Prevention of Recurrent Neuroma Pain AxoGuard® Nerve Cap, Standard Neurectomy - Symptomatic Neuroma, Morton's Neuroma | Not applicable | Completed | Axogen Corporation | 86 | 2018-10-10 | 2025-01-09 |
| Feasibility of Specific Anesthesia of the Forefoot Preserving the Sensitivity of the Heel for Foot Surgery Specific block of medial and lateral plantar nerves - Hallux Valgus and Bunion (Disorder), Morton Neuroma | Not applicable | Completed | CMC Ambroise Paré | 27 | 2018-06-25 | 2026-06-12 |
| Compare Ultrasound Assisted Cold Therapy and Lidocaine Injection to Treat Morton's Neuroma Cryoablation, Lidocaine, Saline - Intermetatarsal Neuroma | Phase 1 | Completed | Icahn School of Medicine at Mount Sinai | 10 | 2016-07-01 | 2018-11-06 |
| Blind and Ultrasound Guided Injection in Morton Neuroma blind injection of Morton neuroma, blind injection of Mepivacaine, blind injection of Triamcinolone - Morton Neuroma | Phase 4 | Unknown | Complejo Hospitalario Universitario de Granada | 100 | 2016-01-01 | 2017-10-18 |
| A Study to Evaluate the Safety and Efficacy of CNTX-4975 in Subjects With Painful Intermetatarsal Neuroma (Morton's Neuroma) CNTX-4975 - Morton's Neuroma | Phase 2 | Completed | Centrexion Therapeutics | 67 | 2015-12-01 | 2018-05-09 |
| Insole on Morton's Neuroma Insole, Placebo Insole - Morton Neuroma | Not applicable | Completed | Federal University of São Paulo | 72 | 2015-06-01 | 2018-04-30 |
| A Study to Evaluate the Efficacy and Safety of CNTX-4975 in Subjects With Painful Intermetatarsal Neuroma (Morton's Neuroma) CNTX-4975, Placebo - Painful Intermetatarsal Neuroma (Morton's Neuroma) | Phase 2 | Completed | Centrexion Therapeutics | 119 | 2014-10-01 | 2016-12-06 |
| Morton's Neuroma: Manipulation Versus Steroid Injection methylprednisolone, manual manipulation - Morton Neuroma | Not applicable | Completed | Dundee Podiatry Clinic | 62 | 2014-09-01 | 2023-02-01 |
| Study to Evaluate the Safety and Tolerability of CNTX-4975 in Subjects With Painful Intermetatarsal Neuroma (Morton's Neuroma) CTNX-4975 - Morton's Neuroma | Phase 1 | Completed | Centrexion Therapeutics | 11 | 2014-02-01 | 2015-09-15 |
| Study Evaluating Treatment of Forefoot Pain Related to Nerve Entrapment Using the Cryo-Touch III Device Cryo-Touch III Device - Entrapment Neuropathy | Not applicable | Completed | Pacira Pharmaceuticals, Inc | 7 | 2012-11-01 | 2014-01-29 |
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Metatarsalgia (2) · Nerve Compression Syndromes (2) · Agnosia (1) · Bunion (1) · Charcot-Marie-Tooth Disease (1) · Dupuytren Contracture (1) · Fasciitis, Plantar (1) · Flatfoot (1) · Foot Injuries (1) · Hallux Valgus (1) · Low Back Pain (1) · Nails, Ingrown (1) · Nervous System Diseases (1) · Neuroma (1)
Foot Diseases (25) · Joint Diseases (25) · Musculoskeletal Diseases (25) · Neuralgia (25) · Neurologic Manifestations (25) · Neuromuscular Diseases (25) · Pathological Conditions, Signs and Symptoms (25) · Signs and Symptoms (25) · Nervous System Diseases (24) · Pain (24) · Peripheral Nervous System Diseases (24) · Metatarsalgia (23) · Congenital Abnormalities (2) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (2) · Foot Deformities (2)
Lidocaine (3) · CNTX-4975 (2) · Cryosurgery (2) · Ethanol (2) · Foot Orthoses (2) · Capsaicin (1) · High-Energy Shock Waves (1) · Magnetic Resonance Imaging (1) · Magnetic Resonance Spectroscopy (1) · Methylprednisolone (1) · Methylprednisolone Acetate (1) · Musculoskeletal Manipulations (1) · Nerve Block (1) · Saline Solution (1) · Sodium Chloride (1)
Centrexion Therapeutics (3) · Acibadem University (2) · AlgoRx Pharmaceuticals (1) · AstraZeneca (1) · Axogen Corporation (1) · Brown University (1) · CMC Ambroise Paré (1) · Complejo Hospitalario Universitario de Granada (1) · Copenhagen University Hospital, Rigshospitalet (1) · Dundee Podiatry Clinic (1) · Federal University of São Paulo (1) · Giresun University (1) · Icahn School of Medicine at Mount Sinai (1) · Lowcountry Infectious Diseases (1) · Massachusetts General Hospital (1)
United States (13) · Turkey (Türkiye) (3) · Spain (2) · Denmark (1) · France (1) · Sweden (1) · United Kingdom (1)
Adam S Landsman, DPM, PhD (1) · Andrew J Mannes, M.D. (1) · Bror Jonzon, MD, PhD (1) · Christopher Digiovanni, MD (1) · Claire Kaufman (1) · David G Cashley, BSc(Hons)Pod (1) · David Spinner, DO (1) · Eric Diamond, D.P.M. (1) · Jonah Mullens, DPM (1) · Kevin M Miller, DPM, FACPM, FFPM (1) · Ludwig A Lettau, MD (1) · Rene Verdonk, MD, PhD (1) · Srinivas Nalamachu, MD (1)