5 completed, 4 terminated, 3 active not recruiting, 1 recruiting. 6 Not applicable, 2 Phase 4, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 6 | Active not recruiting 2, Completed 2, Terminated 2 |
| Phase 4 | 2 | Completed 1, Recruiting 1 |
| Phase 3 | 1 | Completed 1 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Study Comparing Avance Nerve Graft and Autograft for Functional Recovery Following Mixed and Motor Peripheral Nerve Reconstruction Avance Nerve Graft, Sural nerve autograft - Peripheral Nerve Injury, Peripheral Nerve Discontinuity | Phase 4 | Recruiting | Axogen Corporation | 178 | 2026-06-11 | 2026-10-08 |
| Axoguard HA Plus Nerve Protector to Reduce Post-operative Neck and Shoulder Dysfunction in Patients Undergoing Neck Dissection Spinal Accessory Nerve Protection utilizing Axoguard HA+ - Head and Neck Cancer, Neck Dissection | Not applicable | Active not recruiting | Matthew Spector | 90 | 2025-12-09 | 2026-05-12 |
| Nerve Protection Evaluation: Revision Cubital Tunnel Syndrome Decompression Axoguard HA+ Nerve Protector™ - Recurrent Cubital Tunnel Syndrome, Recalcitrant Cubital Tunnel Syndrome | Not applicable | Completed | Axogen Corporation | 19 | 2023-10-19 | 2026-10-13 |
| Tolerability and Feasibility Pilot Clinical Study of a Large-Diameter Nerve Cap for Protecting and Preserving Terminated Nerve Ends Axoguard Nerve Cap® - Symptomatic Neuroma, Amputation | Not applicable | Active not recruiting | Axogen Corporation | 15 | 2022-03-02 | 2026-06-03 |
| Sensory Restoration After DIEP Flap Neurotization DIEP Flap Neurotization - Breast Cancer, Breast Reconstruction | Not applicable | Terminated | Johns Hopkins University | 156 | 2020-12-01 | 2025-04-11 |
| Surgical Treatment of Chronic Neuropathic Pain Surgical Management of Neuroma - Chronic Neuropathic Pain | Terminated | Axogen Corporation | 8 | 2020-02-19 | 2024-03-26 | |
| Registry of Avive® Soft Tissue Membrane Utilization in Selected Applications of Acute Trauma of the Upper Extremity Minimally Processed Human Umbilical Cord Membrane, Standard Surgical Procedures - Acute Upper Extremity Trauma | Terminated | Axogen Corporation | 7 | 2018-12-01 | 2025-08-20 | |
| Study of AxoGuard® Nerve Cap and Neurectomy for Treatment of Symptomatic Neuroma & Prevention of Recurrent Neuroma Pain AxoGuard® Nerve Cap, Standard Neurectomy - Symptomatic Neuroma, Morton's Neuroma | Not applicable | Completed | Axogen Corporation | 86 | 2018-10-10 | 2025-01-09 |
| Non-Invasive Neurosensory Testing For Chemotherapy-Induced Peripheral Neuropathy Neurosensory testing with Pressure-Specified Sensory Device - Cancer, Malignancy | Completed | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | 26 | 2017-11-29 | 2019-11-27 | |
| Comparison of Processed Nerve Allograft and Collagen Nerve Cuffs for Peripheral Nerve Repair Processed Nerve Allograft (human), Collagen Nerve Cuff - Peripheral Nerve Discontinuities | Phase 3 | Completed | Axogen Corporation | 220 | 2015-06-01 | 2023-07-12 |
| Study of Nerve Reconstruction Using AVANCE in Subjects Who Undergo Robotic Assisted Prostatectomy for Treatment of Prostate Cancer Processed Human Nerve Tissue Scaffold - Peripheral Nerve Injury, Prostate Cancer | Phase 4 | Completed | Axogen Corporation | 12 | 2009-08-01 | 2024-08-12 |
| A Comparative Post-marketing Study of Commercially Available Peripheral Nerve Gap Repair Options Hollow tube nerve conduit, synthetic or biosynthetic, Processed Human Nerve Tissue - Traumatic Nerve Injury | Not applicable | Terminated | Axogen Corporation | 23 | 2009-06-01 | 2020-12-01 |
| Registry of Avance® Nerve Graft's Utilization and Recovery Outcomes Post Peripheral Nerve Reconstruction Processed Human Nerve Graft, Standard Treatment, Autogenous Nerve Graft, Direct Suture, etc., Autogenous Nerve Graft - Peripheral Nerve Injuries | Active not recruiting | Axogen Corporation | 3126 | 2008-11-01 | 2026-01-26 |
Peripheral Nerve Injuries (7) · Peripheral Nervous System Diseases (3) · Nervous System Diseases (2) · Neuralgia (2) · Neuroma (2) · Trauma, Nervous System (2) · Breast Neoplasms (1) · Chronic Pain (1) · Cubital Tunnel Syndrome (1) · Head and Neck Neoplasms (1) · Morton Neuroma (1) · Neoplasms (1) · Prostatic Neoplasms (1) · Wounds and Injuries (1)
Nerve Transfer (1)
United States (13) · Austria (1) · Canada (1) · United Kingdom (1)
Daniel Zandberg (1) · Erick W DeVinney (1) · Gedge D Rosson, MD (1) · Jonathan E Isaacs, MD (1) · Joseph J Smith, MD (1) · L. Scott Levin, MD FACS (1) · Nina Wagner-Johnston, MD (1) · R. Glenn Gaston, MD (1)