13 completed, 7 unknown, 2 not yet recruiting, 1 recruiting. 16 Not applicable, 4 Phase 4, 1 Early Phase 1, 1 Phase 1, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 16 | Completed 11, Unknown 4, Not yet recruiting 1 |
| Phase 4 | 4 | Unknown 3, Completed 1 |
| Early Phase 1 | 1 | Not yet recruiting 1 |
| Phase 1 | 1 | Completed 1 |
| Phase 2 | 1 | Recruiting 1 |
Follow Molar, Third: new trials by email Literature Review of Molar, Third trials Research Report on Molar, Third
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A First-in-Human Study of a Novel 3rd Molar Tooth Bud Ablation Procedure Zero3 System - Molar, Third | Not applicable | Not yet recruiting | TriAgenics Inc | 35 | 2026-09-01 | 2026-09-25 |
| A Study of LY4515100 in Participants With Pain Following Third Molar Removal LY4515100, Placebo - Acute Pain, Molar | Phase 2 | Recruiting | Eli Lilly and Company | 212 | 2026-04-01 | 2026-05-01 |
| Comparison of Computer-Assisted and Conventional Local Anesthesia Methods in Mandibular Impacted Third Molar Surgery Computer-Assisted Local Anesthesia, Conventional Local Anesthesia - Molar, Third, Surgery, Oral | Not applicable | Completed | Afyonkarahisar Health Sciences University | 40 | 2025-03-01 | 2025-12-10 |
| Efficacy of Artificial Intelligence-Generated Music Therapy in Reducing Dental Anxiety Among Adults Undergoing Impacted Third Molar Extraction Music therapy - Tooth Extraction, Molar, Third | Not applicable | Completed | University of Coimbra | 40 | 2024-12-04 | 2025-05-31 |
| LED Therapy for Third Molar Surgery photobiomodulation, Antibiotic - Molar, Third, Photobiomodulation | Early Phase 1 | Not yet recruiting | Huashan Hospital | 50 | 2024-10-14 | 2024-10-15 |
| Evaluation the Effect of Coenzyme Q10 on Tissue Healing Process in Patients Undergoing Wisdom Tooth Extraction Coenzyme Q10 100 MG Oral Tablet, Placebo - Molar, Third, Temporomandibular Joint Disorders | Phase 4 | Unknown | Zahra Nejati | 70 | 2024-07-01 | 2024-06-11 |
| Preventive Effect of Photobiomodulation in the Postoperative Period of Extractions of Retained Lower Third Molars Photobiomodulation, Placebo Corticosteroid, Simulation Photobiomodulation - Molar, Third, Photobiomodulation | Not applicable | Completed | University of Nove de Julho | 30 | 2023-11-20 | 2026-07-29 |
| Pain and Trismus Control in Third Molar Surgery: Ibuprofen, Ketamine, and Their Combination Impacted third molar surgey - Molar, Third | Not applicable | Unknown | Cihan Topan | 100 | 2023-03-01 | 2023-09-07 |
| The Use of Injectable-Platelet Rich Fibrin (i-PRF) in the Lower Third Molar Extraction Extraction of mandibular third molar, i-PRF - Molar, Third, Postoperative Complications | Not applicable | Unknown | University of Naples | 40 | 2023-02-27 | 2023-12-21 |
| Evaluation of a New Technique for Periodontal Pocket Reduction in the Extraction of Wisdom Teeth "Distal Flap Reduction" Group, "Only Exodontia" Group - Molar, Third, Periodontal Pocket | Not applicable | Completed | Universidad Rey Juan Carlos | 72 | 2022-09-12 | 2026-05-05 |
| 3D Evaluation of Postoperative Edema After Third Molar Surgery Combination of corticosteroid (methylprednisolone - Medrol, 16mg Pfizer Laboratories) therapy and non-steroidal anti-inflammatory (Ibuprofen 600mg Mylan) therapy, Non-steroidal anti-inflammatory therapy (Ibuprofen 600mg Mylan) - Molar, Third, Third Molar Surgery | Phase 4 | Unknown | Implantology Institute | 40 | 2022-07-01 | 2023-07-12 |
| "Effectiveness of Dual-Wavelength Laser Therapy in Third Molar Extraction Pain, Swelling, and Trismus" Dual wavelength low level laser, Placebo - Molar, Third, Low-level Laser Therapy | Not applicable | Completed | Tokat Gaziosmanpasa University | 40 | 2021-10-18 | 2024-09-26 |
| Oral Flap Outline and Local Blood Supply After Surgical Removal of Lower Third Molar Teeth Sulcular flap elevation for wisdom tooth removal, Three-cornered flap elevation for wisdom tooth removal - Surgical Flaps, Oral Surgical Procedures | Not applicable | Completed | Betül Taş Özyurtseven | 56 | 2020-11-09 | 2026-08-11 |
| 92/5000 Preoperative Efficacy of Traumeel Versus Dexamethasone in the Control of Pain, Swelling and Trismus Dexamethasone, Traumeel S - Molar, Third, Surgery | Not applicable | Unknown | Federal University of the Valleys of Jequitinhonha and Mucuri | 17 | 2018-04-02 | 2018-06-25 |
| Influence of CYP2C9 Genotype on Clinical Efficacy of Tenoxicam Tenoxicam - Molar, Third, Pain | Phase 4 | Completed | University of Sao Paulo | 89 | 2018-03-01 | 2019-12-02 |
| Prevention of Mandibular Third Molar Extraction- Associated Periodontal Defects Using Platelet-Rich Fibrin extraction of mandibular third molar - Periodontal; Lesion, Periodontal Pocket | Not applicable | Completed | University of Naples | 18 | 2018-01-07 | 2020-03-25 |
| Acupuncture on Anxiety and Inflammatory Events Following Surgery of Mandibular Third Molars Acupuncture - Tooth Extraction, Molar, Third | Not applicable | Completed | Federal University of the Valleys of Jequitinhonha and Mucuri | 18 | 2016-08-01 | 2018-06-04 |
| Effects of the Use of Platelet-rich Fibrin on Bone Regeneration After Impacted Third Molar Surgery Platelet-rich fibrin, Control group - Fibrin/Therapeutic Use, Blood Platelets | Not applicable | Completed | Rio de Janeiro State University | 20 | 2016-08-01 | 2017-04-12 |
| Probiotic Intervention After Surgical Removal of Mandibular Third Molars Probiotic AB-DENTALAC, Placebo, Surgical removal of mandibular third molars at baseline - Surgery--Complications, Molar, Third | Not applicable | Completed | AB Biotics, SA | 38 | 2016-06-01 | 2020-05-06 |
| Effect of Hilotherm Therapy on Post-operative Pain and Swelling Following Surgical Wisdom Tooth Removal Hilotherm cooling face mask - Molar, Third, Wisdom Teeth | Not applicable | Unknown | King's College Hospital NHS Trust | 30 | 2015-08-01 | 2015-09-03 |
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Pain (7) · Edema (4) · Anxiety Disorders (3) · Tooth, Impacted (3) · Trismus (3) · Agnosia (2) · Pain, Postoperative (2) · Periodontal Pocket (2) · Acute Pain (1) · Dry Socket (1) · Postoperative Complications (1) · Temporomandibular Joint Disorders (1)
Neurologic Manifestations (10) · Pathological Conditions, Signs and Symptoms (10) · Signs and Symptoms (10) · Stomatognathic Diseases (6) · Nervous System Diseases (4) · Mental Disorders (3) · Mouth Diseases (3) · Neuromuscular Manifestations (3) · Pathologic Processes (3) · Spasm (3) · Tooth Diseases (3) · Neurobehavioral Manifestations (2) · Pain (2) · Perceptual Disorders (2) · Periodontal Diseases (2)
Ibuprofen (2) · Low-Level Light Therapy (2) · 21-benzyloxy-9alpha-fluoro-16alpha-methylpregna-1,4-dien-11beta,17alpha-diol-3,20-dione (1) · Acupuncture Therapy (1) · Adrenal Cortex Hormones (1) · Anti-Bacterial Agents (1) · Anti-Inflammatory Agents, Non-Steroidal (1) · Calcium Dobesilate (1) · Carticaine (1) · Control Groups (1) · Dexamethasone (1) · Epinephrine (1) · Music Therapy (1) · Orthodontics (1) · Tablets (1)
Federal University of the Valleys of Jequitinhonha and Mucuri (2) · University of Naples (2) · AB Biotics, SA (1) · Afyonkarahisar Health Sciences University (1) · Betül Taş Özyurtseven (1) · Cihan Topan (1) · Eli Lilly and Company (1) · Huashan Hospital (1) · Implantology Institute (1) · King's College Hospital NHS Trust (1) · Mohammad Javad Shirani (1) · National Taiwan University Hospital (1) · Rio de Janeiro State University (1) · Tokat Gaziosmanpasa University (1) · TriAgenics Inc (1)
Brazil (4) · Turkey (Türkiye) (4) · Spain (3) · Italy (2) · China (1) · Iran (1) · Panama (1) · Portugal (1) · Taiwan (1) · United Kingdom (1) · United States (1)
Gilberto Sammartino, Professor (2) · Anna Catharina V Armond (1) · Bijan Movahedian, Oral and maxillofacial surgeon (1) · Catarina Pinto, DDS (1) · Chung-Chen Yao, DDS, PhD (1) · Eduard Ferres Padro, MD (1) · Helena Francisco, DDS PhD (1) · Jordi Espadaler Mazo, PhD (1) · Jose Antonio B Rueda, PhD (1) · Kathy Fan, PhD, FDSRSC, FRCSEd, FRCS OMFS (1)
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