4 completed, 3 recruiting, 2 terminated, 2 unknown. 11 Not applicable, 1 Phase 1, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 11 | Completed 3, Recruiting 3, Terminated 2, Unknown 2, Active not recruiting 1 |
| Phase 1 | 1 | Enrolling by invitation 1 |
| Phase 2 | 1 | Suspended 1 |
Follow Mild Neurocognitive Disorder: new trials by email Literature Review of Mild Neurocognitive Disorder trials Research Report on Mild Neurocognitive Disorder
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Pramipexole Versus Escitalopram to Treat Major Depressive Disorder (MDD) and Comorbid MDD With Mild Neurocognitive Disorder (MND) in Persons With HIV Pramipexole ER, Escitalopram - Major Depressive Disorder, Mild Neurocognitive Disorder | Phase 2 | Suspended | National Institute of Allergy and Infectious Diseases (NIAID) | 186 | 2026-05-17 | 2026-07-14 |
| Brain Stimulation and Cognitive Training for MCI Accelerated iTBS, Computerized Cognitive Training, Sham Computerized Cognitive Training - Mild Cognitive Impairment (MCI), Mild Neurocognitive Disorder | Not applicable | Recruiting | Medical University of South Carolina | 50 | 2026-03-16 | 2026-05-22 |
| Deep rTMS for Mild Neurocognitive Disorder in Older Adults Brainsway H1-Coil Deep TMS System, Brainsway H4-Coil Deep TMS System, Brainsway H7-Coil Deep TMS System - Mild Neurocognitive Disorder | Not applicable | Recruiting | St. Joseph's Healthcare Hamilton | 30 | 2025-08-26 | 2025-10-06 |
| tFUS for Memory in mNCD and Healthy Adults Transcranial Focused Ultrasound - Mild Neurocognitive Disorder, Healthy Aging | Phase 1 | Enrolling by invitation | Medical University of South Carolina | 25 | 2025-03-30 | 2025-11-24 |
| Endovascular Therapy Versus Best Medical Treatment for Acute Large Vessel Occlusion Stroke With Low NIHSS Endovascular therapy, Best medical management - Acute Ischemic Stroke, Mild Neurocognitive Disorder | Not applicable | Recruiting | First Affiliated Hospital of Wannan Medical College | 264 | 2024-01-21 | 2026-09-25 |
| Impact of Intensive Computerized Cognitive Training Cognitive Computerized Training - Acquired Brain Injury, Mild Cognitive Impairment | Not applicable | Active not recruiting | Brigham and Women's Hospital | 30 | 2023-10-01 | 2026-10-01 |
| C-SMART: Cognitive Strategies, Mindfulness, and Rehabilitation Therapy for Patients With Primary Brain Tumors C-SMART - Glioma, Mixed, Mild Neurocognitive Disorder | Completed | Virginia Commonwealth University | 32 | 2023-09-15 | 2026-02-20 | |
| Long Term Transcranial Pulse Stimulation (TPS) on Older Adults With Mild Neurocognitive Disorder (NCD) Transcranial Pulse Stimulation (TPS), Treatment as usual (TAU) - Mild Neurocognitive Disorder | Not applicable | Unknown | The University of Hong Kong | 22 | 2022-11-25 | 2023-07-27 |
| Effectiveness of a Novel Exergame-Based Training Concept for Older Adults With Mild Neurocognitive Disorder Exergame training according to the 'Brain-IT' exergame-based training concept, Usual Care - Mild Neurocognitive Disorder | Not applicable | Completed | Eling DeBruin | 41 | 2022-06-22 | 2024-06-04 |
| Feasibility of a Novel Exergame-Based Training Concept for Older Adults With Mild Neurocognitive Disorder Exergame, Usual Care - Mild Neurocognitive Disorder | Not applicable | Completed | Eling DeBruin | 18 | 2021-07-12 | 2023-10-12 |
| Transcranial Pulse Stimulation Open-label Self-controlled Trial For Mild Neurocognitive Disorder Transcranial Pulse Stimulation (TPS) - Mild Neurocognitive Disorder | Not applicable | Unknown | The University of Hong Kong | 20 | 2020-01-20 | 2022-04-15 |
| Noninvasive Brain Stimulation for Mild Cognitive Impairment Active rTMS (Bilateral DLPFC), Active rTMS (Bilateral LPC), Placebo rTMS (Inactive) - Mild Cognitive Impairment, Mild Neurocognitive Disorder | Not applicable | Completed | Palo Alto Veterans Institute for Research | 69 | 2018-06-15 | 2025-09-03 |
| Physical Exercise And Cognitive Engagement Outcomes for Mild Neurocognitive Disorder Computerized brain fitness training, Yoga, Wellness Education - Mild Cognitive Impairment, Memory Disorders | Not applicable | Terminated | University of Florida | 5 | 2017-03-23 | 2022-07-06 |
| Cognitive Training With and Without tDCS to Improve Cognition in HIV Transcranial direct current stimulation, Cognitive training, Sham transcranial direct current stimulation - HIV, Mild Neurocognitive Disorder | Not applicable | Terminated | Nova Southeastern University | 21 | 2015-09-01 | 2021-06-22 |
Neurocognitive Disorders (14) · Cognitive Dysfunction (5) · Memory Disorders (3) · Cognition Disorders (2) · Brain Injuries (1) · Brain Neoplasms (1) · Dementia (1) · Depressive Disorder, Major (1) · Glioma (1) · Ischemic Stroke (1) · Motor Activity (1)
Mental Disorders (14) · Nervous System Diseases (6) · Brain Diseases (4) · Central Nervous System Diseases (4) · Cognition Disorders (3) · Neurobehavioral Manifestations (3) · Neurologic Manifestations (3) · Pathological Conditions, Signs and Symptoms (3) · Signs and Symptoms (3) · Behavior (1) · Cardiovascular Diseases (1) · Central Nervous System Neoplasms (1) · Cerebrovascular Disorders (1) · Craniocerebral Trauma (1) · Depressive Disorder (1)
Cognitive Training (2) · Transcranial Magnetic Stimulation (2) · Escitalopram (1) · Exergaming (1) · Self-Help Groups (1) · Therapeutics (1) · Transcranial Direct Current Stimulation (1) · Yoga (1)
Eling DeBruin (2) · Medical University of South Carolina (2) · The University of Hong Kong (2) · Brigham and Women's Hospital (1) · First Affiliated Hospital of Wannan Medical College (1) · National Institute of Allergy and Infectious Diseases (NIAID) (1) · Nova Southeastern University (1) · Palo Alto Veterans Institute for Research (1) · St. Joseph's Healthcare Hamilton (1) · University of Florida (1) · Virginia Commonwealth University (1)
United States (8) · Hong Kong (2) · Switzerland (2) · Botswana (1) · Brazil (1) · Canada (1) · China (1) · India (1) · Kenya (1) · Malawi (1) · Mexico (1) · Peru (1) · Philippines (1) · South Africa (1) · Thailand (1)
Eling D de Bruin, PhD (2) · Calvin PW Cheng, MBBS (HKU) (1) · Calvin Pak Wing Cheng, MBBS (HKU) (1) · Glenn Smith, Ph. D (1) · Joy L Taylor, Ph.D. (1) · Kevin Caulfield, PhD (1) · Kim C Willment, PhD (1) · Kirk R Daffner, MD (1) · Raymond L Ownby, MD, PhD (1) · Sarah E Braun, PhD (1) · Scott Letendre, MD (1) · Stephanie Aghamoosa (1) · William R Short, MD (1)
PMID 30340619, PMID 31842821, PMID 36745483, PMID 37810620, PMID 38809948, PMID 40916053, PMID 42773385
K23AG090691 (1), R01AG055526 (1)