35 completed. 35 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 35 | Completed 35 |
Follow Menstruation Disturbances: new trials by email Literature Review of Menstruation Disturbances trials Research Report on Menstruation Disturbances
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Myo-Inositol and D-Chiro-Inositol for Menstrual Irregularities and Hormone Changes in Women With Polycystic Ovarian Syndrome Myo-Inositol and D-Chiro-Inositol Combination Therapy, placebo (folic acid) - Polycystic Ovary Syndrome (PCOS), Myo-inositol | Phase 4 | Completed | Nishtar Medical University | 60 | 2025-06-01 | 2026-07-14 |
| Non-Steroidal Anti-Inflammatory Drug (NSAID) Response and Central Sensitization of Pain in Women With Dysmenorrhea Sodium Naproxen, Placebo - Dysmenorrhea, Menstrual Pain | Phase 4 | Completed | Mclean Hospital | 70 | 2024-03-25 | 2026-09-22 |
| Effectiveness of PEA Compared to Placebo on Acute Menstrual Pain Levagen+, Microcrystalline cellulose - Menstrual Pain | Phase 4 | Completed | RDC Clinical Pty Ltd | 80 | 2023-05-19 | 2024-11-14 |
| Alternate Day Versus Daily Oral Iron Therapy in Adolescents Ferrous sulfate - Iron Deficiency Anemia, Heavy Menstrual Bleeding | Phase 4 | Completed | Baylor College of Medicine | 13 | 2020-12-21 | 2023-09-13 |
| Mechanistic Characterization of Uterine Pain Naproxen Sodium, Placebo - Dysmenorrhea (Disorder), Dysmenorrhea Primary | Phase 4 | Completed | Endeavor Health | 183 | 2019-10-25 | 2026-09-23 |
| A Study to Evaluate the Safety and Efficacy of Elagolix for the Management of Heavy Menstrual Bleeding Associated With Uterine Fibroids in Premenopausal Women Elagolix, Placebo - Uterine Fibroids | Phase 4 | Completed | AbbVie | 82 | 2019-04-12 | 2022-03-31 |
| Examining the Role of Improved NSAID Management in Treating Dysmenorrhea and Bladder Pain Naproxen - Dysmenorrhea, Pain | Phase 4 | Completed | Endeavor Health | 26 | 2018-05-09 | 2023-10-18 |
| Intravenous Tramadol Versus Intravenous Paracetamol in Patients With Dysmenorrhea tramadol, paracetamol - Dysmenorrhea | Phase 4 | Completed | Cairo University | 100 | 2018-04-25 | 2020-06-16 |
| A Study to Assess Menstrual Cramp Pain Associated With Primary Dysmenorrhea Naproxen Sodium, (Aleve, BAY117031), Acetaminophen (Tylenol Extra Strength) - Dysmenorrhea | Phase 4 | Completed | Bayer | 201 | 2018-04-05 | 2019-10-28 |
| Treatment of Heavy Menstrual Bleeding in Women With Uterine Fibroids Levonorgestrel IUS, Tranexamic Acid - Heavy Menstrual Bleeding, Menorrhagia | Phase 4 | Completed | Shannon K. Laughlin-Tommaso | 18 | 2017-11-14 | 2021-12-08 |
| Tamoxifen to Reduce Unscheduled Bleeding in New Users of the Levonorgestrel-releasing Intrauterine System (LNG-IUS) Tamoxifen, Placebo (for Tamoxifen) - Menorrhagia, Metrorrhagia | Phase 4 | Completed | Oregon Health and Science University | 42 | 2016-09-06 | 2019-06-04 |
| Stress & Premenstrual Symptoms Study Sertraline - PMDD, Stress | Phase 4 | Completed | Johns Hopkins University | 84 | 2016-04-01 | 2025-06-12 |
| Copper IUD Treatment Observation Study Naproxen, Placebo - Menorrhagia | Phase 4 | Completed | University of Washington | 34 | 2016-02-01 | 2020-10-14 |
| Ulipristal for Endometriosis-related Pelvic Pain Ulipristal - Endometriosis | Phase 4 | Completed | Northwestern University | 1 | 2015-02-01 | 2024-05-16 |
| Effectiveness of IV Acetaminophen and IV Ibuprofen in Reducing Post Procedural Pain in the UFE Procedure IV Ibuprofen, IV Acetaminophen, Intravenous placebo/Intravenous placebo - Symptomatic Uterine Fibroids and Adenomyosis | Phase 4 | Completed | University of California, Los Angeles | 40 | 2014-08-01 | 2018-06-08 |
| Chronic Pain Risk Associated With Menstrual Period Pain cyclic microgestin 1/20, continuous microgestin 1/20 - Cystitis, Interstitial, Dysmenorrhea | Phase 4 | Completed | Endeavor Health | 353 | 2014-07-01 | 2023-06-18 |
| Tamoxifen for the Treatment of Unfavorable Bleeding in Contraceptive Implant Users Tamoxifen, Placebo - Menstruation Disturbances | Phase 4 | Completed | Oregon Health and Science University | 56 | 2014-02-01 | 2017-07-02 |
| A Comparison of Analgesic İmpacts of Piroxicam and Diclofenac Sodium in the Treatment of Primary Dysmenorrhea Piroxicam, Diclofenac Sodium - Primary Dysmenorrhea | Phase 4 | Completed | Pamukkale University | 400 | 2013-05-01 | 2014-10-01 |
| Tranexamic Acid in Adolescents With Heavy Menstrual Bleeding Tranexamic Acid - Heavy Menstrual Bleeding | Phase 4 | Completed | Nationwide Children's Hospital | 32 | 2013-04-01 | 2018-10-24 |
| Premenstrual Symptoms Treatment Comparing Between Oral Contraceptives Containing Desogestrel and Drospirenone EE 20 microgram with desogestrel 150 mg, EE 20 microgram with drospirenone 3 mg - Premenstrual Syndrome | Phase 4 | Completed | Chulalongkorn University | 90 | 2011-06-01 | 2012-03-14 |
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Menorrhagia (15) · Dysmenorrhea (10) · Premenstrual Syndrome (7) · Leiomyoma (5) · Premenstrual Dysphoric Disorder (5) · Metrorrhagia (4) · Hemorrhage (3) · Pain (3) · Amenorrhea (2) · Endometriosis (2) · Visceral Pain (2) · Adenomyosis (1) · Anemia, Iron-Deficiency (1) · Chronic Pain (1)
Pathologic Processes (35) · Pathological Conditions, Signs and Symptoms (35) · Female Urogenital Diseases (18) · Female Urogenital Diseases and Pregnancy Complications (18) · Genital Diseases (18) · Genital Diseases, Female (18) · Urogenital Diseases (18) · Uterine Diseases (15) · Uterine Hemorrhage (15) · Hemorrhage (13) · Neurologic Manifestations (11) · Signs and Symptoms (11) · Pelvic Pain (9) · Pain (8)
Naproxen (6) · Tranexamic Acid (4) · Acetaminophen (3) · Sertraline (3) · Levonorgestrel (2) · Piroxicam (2) · Tamoxifen (2) · drospirenone and ethinyl estradiol combination (2) · Desogestrel (1) · Diclofenac (1) · Estradiol (1) · Ethinyl Estradiol-Norgestrel Combination (1) · Fluoxetine (1) · Flutamide (1) · Folic Acid (1)
Endeavor Health (3) · Bayer (2) · Oregon Health and Science University (2) · AbbVie (1) · Abimbola Famuyide (1) · Baylor College of Medicine (1) · Boston Scientific Corporation (1) · Cairo University (1) · Central South University (1) · Chulalongkorn University (1) · CooperSurgical Inc. (1) · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (1) · Ferring Pharmaceuticals (1) · Johns Hopkins University (1) · K. Sue Robinson (1)
United States (23) · Sweden (2) · Australia (1) · Austria (1) · Brazil (1) · China (1) · Egypt (1) · Finland (1) · France (1) · Ireland (1) · Pakistan (1) · Puerto Rico (1) · Thailand (1) · Turkey (Türkiye) (1)
Frank Tu, MD, MPH (2) · Margaret Altemus, MD (2) · Abimbola O. Famuyide, MBBS (1) · Ahmed Ali, mbbch (1) · Amanda Rao, PhD (1) · Beda W. Hartmann, Univ.-Doz. (1) · Cheryl H Hoffman, MD (1) · Christopher C Destephano, MD, MPH (1) · Cynthia N Epperson, MD (1) · Ellen W Freeman, PhD (1) · Emily Godfrey, MD,MPH (1)
PMID 19414713, PMID 19955104, PMID 20378611, PMID 20472114, PMID 22393222, PMID 24682613, PMID 24788209, PMID 26351969, PMID 28715852, PMID 29141040, PMID 31226322, PMID 31397597, PMID 34292344, PMID 37212651, PMID 37226937, PMID 37769311, PMID 38091917, PMID 39096755
2017 (1), K23MH107831 (1), R01DK100368 (1), R01HD098193 (1), R01MH072955 (1), R01MH081837 (1), R21HD091337 (1), R34MH072878 (1)