38 completed, 6 recruiting, 5 unknown, 2 not yet recruiting. 56 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 56 | Completed 38, Recruiting 6, Unknown 5, Not yet recruiting 2, Terminated 2, Active not recruiting 1, Enrolling by invitation 1, Withdrawn 1 |
Follow Menopause: new trials by email Literature Review of Menopause trials Research Report on Menopause
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Hormone thERapy Effects on BRAin-HEART Health During the Menopausal Transition Transdermal estradiol, Standard of care - non hormonal - Menopause, Perimenopause | Phase 4 | Not yet recruiting | McGill University Health Centre/Research Institute of the McGill University Health Centre | 100 | 2026-11-01 | 2026-07-29 |
| Cyclic vs. Constant Estradiol: Regimens' Effects on Brain Health Cyclic Estradiol, Continuous Estradiol - Menopause, Healthy Adult | Phase 4 | Recruiting | University of Colorado, Denver | 40 | 2026-07-15 | 2026-09-21 |
| Menopausal HT for Women Living With HIV (HoT) Transdermal estradiol gel, Micronized Progesterone, Placebo for estradiol gel - HIV Infection, Menopause | Phase 4 | Recruiting | Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections | 105 | 2026-04-09 | 2026-05-22 |
| No More Sleepless Nights in Perimenopause Cognitive Behavioural Therapy for Insomnia (CBT-I), Hormone Replacement Therapy (HRT), Sleep Hygiene - Insomnia, Menopause | Phase 4 | Recruiting | Insel Gruppe AG, University Hospital Bern | 54 | 2026-01-01 | 2026-01-13 |
| Sleeping Through Menopause Estrogens and Progestogens, Cognitive behavioral therapy for insomnia (CBTi), and circadian rhythm therapy - Menopause, Insomnia | Phase 4 | Not yet recruiting | VU University of Amsterdam | 222 | 2025-10-01 | 2025-08-24 |
| Post-Menopause Skin Rejuvenation Study Restylane SkinBoosters Vital, Sculptra Aesthetic - Aesthetic, Menopause | Phase 4 | Completed | Erevna Innovations Inc. | 50 | 2025-08-14 | 2026-10-26 |
| Effect of Vaginal Estrogen on Alterations in the Urine Microbiome of Menopausal Women With Overactive Bladder 17β-estradiol 10 mcg - Overactive Bladder (OAB), Menopause | Phase 4 | Completed | Mahidol University | 30 | 2025-06-27 | 2026-02-09 |
| Aging Well: Targeting Obesity With GLP-1 Agonists to Enhance Physical and Vascular Health in Postmenopausal Women semaglutide or tirzepatide, Lifestyle modification intervention - Obesity, Menopause | Phase 4 | Enrolling by invitation | Mayo Clinic | 30 | 2025-05-01 | 2026-07-20 |
| Role of Menopause in Thermoregulation Elagolix Oral Tablet, Estradiol patch, cellulose placebo - Menopause, Aging | Phase 4 | Recruiting | Penn State University | 24 | 2025-03-01 | 2026-10-02 |
| Cardiometabolic Consequences of the Loss of Ovarian Function Degarelix, Transdermal Estradiol Patch, Transdermal Placebo Patch - Menopause, Estrogen Deficiency | Phase 4 | Recruiting | University of Colorado, Denver | 100 | 2024-06-01 | 2024-06-20 |
| the Effects of Different Therapy Regimens on Menopausal Sleep Disorders Tibolone, Xiangshao granules, Tibolone plus Xiangshao granules - Menopause, Sleep Disorder | Phase 4 | Unknown | Peking Union Medical College Hospital | 180 | 2023-12-30 | 2024-01-02 |
| Rhythmic Estradiol and Bone Health Estradiol patch, Progesterone - Osteoporosis Risk, Menopause | Phase 4 | Completed | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | 48 | 2023-07-19 | 2026-10-16 |
| Treating Insomnia and Improving Metabolic Health in Midlife Women With Insomnia Suvorexant, Placebo - Insomnia, Metabolic Health | Phase 4 | Completed | Brigham and Women's Hospital | 31 | 2023-01-06 | 2026-04-16 |
| Estrogen Variability and Irritability During the Menopause Transition Estradiol Patch, 0.1 mg/24 Hours Weekly Transdermal Film, Extended Release, Placebo, Progesterone 200 mg - Menopause, Irritable Mood | Phase 4 | Completed | University of North Carolina, Chapel Hill | 40 | 2022-06-15 | 2025-11-26 |
| Effects of Xiangshao Granules on Anxiety in Menopausal Women. Xiangshao Granules, Xiangshao Granules Placebo - Anxiety, Menopause | Phase 4 | Completed | Peking Union Medical College Hospital | 360 | 2021-12-23 | 2026-11-03 |
| Ovarian Hormone Regulation of Central and Cerebrovascular Hemodynamics (NoMEN Study) GnRH antagonist - Menopause, Estrogen Deficiency | Phase 4 | Active not recruiting | University of Colorado, Denver | 55 | 2021-11-22 | 2025-03-27 |
| Accelerated Genital Tract Aging in HIV: Estradiol Clinical Trial Estradiol Vaginal Insert - HIV Infection, Vaginal Atrophy | Phase 4 | Completed | Kerry Murphy | 60 | 2020-09-01 | 2025-03-14 |
| A New Hormone Replacement Paradigm: Physiologic Restoration Study Compounded topical estradiol and compounded topical progesterone in a carrier cream - Menopause, Perimenopausal Disorder | Phase 4 | Unknown | Women's Hormone Network | 100 | 2020-06-01 | 2020-04-01 |
| Discontinuation of Postmenopausal Hormone Therapy: Impact on the Cardiovascular System and Quality of Life Estradiol, Placebo - Menopause, Atherosclerosis | Phase 4 | Unknown | Hanna Savolainen-Peltonen | 150 | 2020-02-19 | 2021-02-15 |
| Progesterone and Resting Energy Expenditure Utrogestan - Menopause, Progesterone | Phase 4 | Terminated | Insel Gruppe AG, University Hospital Bern | 2 | 2019-11-01 | 2022-03-31 |
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Depression (6) · Hot Flashes (5) · Anxiety Disorders (3) · Obesity (3) · Sleep Initiation and Maintenance Disorders (3) · Weight Gain (3) · Atrophic Vaginitis (2) · Cardiovascular Diseases (2) · Depressive Disorder, Major (2) · Diabetes Mellitus, Type 2 (2) · HIV Infections (2) · Hypertension (2) · Osteoporosis (2) · Parasomnias (2) · Aging, Premature (1)
Pathological Conditions, Signs and Symptoms (16) · Signs and Symptoms (14) · Mental Disorders (13) · Behavior (7) · Nervous System Diseases (7) · Nutritional and Metabolic Diseases (7) · Behavioral Symptoms (6) · Body Weight (6) · Sleep Wake Disorders (6) · Urogenital Diseases (6) · Dyssomnias (4) · Female Urogenital Diseases (4) · Female Urogenital Diseases and Pregnancy Complications (4) · Genital Diseases (4) · Metabolic Diseases (4)
Estradiol (9) · Progesterone (5) · Estrogens, Conjugated (USP) (4) · Estrogens (3) · LHRH, Ac-Nal(1)-Cpa(2)-Trp(3)-Arg(6)-Ala(10)- (3) · Ortho Evra (3) · acetyl-2-naphthylalanyl-3-chlorophenylalanyl-1-oxohexadecyl-seryl-4-aminophenylalanyl(hydroorotyl)-4-aminophenylalanyl(carbamoyl)-leucyl-ILys-prolyl-alaninamide (3) · tibolone (3) · Cognitive Behavioral Therapy (2) · Hormone Replacement Therapy (2) · Leuprolide (2) · estradiol, norethindrone drug combination (2) · 2-chloroethyl ethyl sulfide (1) · Administration, Cutaneous (1) · Contraceptives, Oral (1)
Massachusetts General Hospital (5) · University of Colorado, Denver (4) · University of Pennsylvania (3) · Brigham and Women's Hospital (2) · Insel Gruppe AG, University Hospital Bern (2) · Peking Union Medical College Hospital (2) · Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) (1) · Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections (1) · Anna Posadzy-Małaczyńska (1) · Baskent University (1) · Bezmialem Vakif University (1) · Casa de Saúde santa Marcelina (1) · Centro de Diabetes Curitiba Ltda (1) · Derming SRL (1) · Erevna Innovations Inc. (1)
United States (28) · Brazil (4) · Italy (3) · Canada (2) · Switzerland (2) · China (1) · Finland (1) · Germany (1) · Hungary (1) · Netherlands (1) · Norway (1) · Spain (1) · Sweden (1) · Thailand (1) · Turkey (Türkiye) (1)
Marlene P Freeman, MD (2) · Adele Sparavigna, Physician (1) · Andre GD Vianna, MD (1) · Andreas Nikolis, MD, PhD (1) · Benedito F Reis, Prof (1) · Birit Broekman, Prof. (1) · Cornelia U von Hagens, MD (1) · Cynthia N Epperson, MD (1) · Cynthia Neill Epperson, M.D. (1) · Dennis M Black, PhD (1) · Deslyn Hobson, M.D. (1) · Elizabeth Andersen, PhD (1) · Eus van Someren, Prof. (1) · Frederick Naftolin, MD, PhD (1)
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U54AG062319 (2), 2004 (1), 2018 (1), 2019 (1), 2023 (1), K23AG062400 (1), R01AG053838 (1), R01MH082922 (1), R21AT002289 (1), R21MH128241 (1), UM1AI068636 (1)