21 completed, 4 recruiting, 3 unknown. 28 Phase 1, 6 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 28 | Completed 21, Recruiting 4, Unknown 3 |
| Phase 2 | 6 | Completed 4, Unknown 2 |
Follow Menopause: new trials by email Literature Review of Menopause trials Research Report on Menopause
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study to Assess the Skin Irritation and Sensitization of Estradiol/Levonorgestrel TDS in Healthy Postmenopausal Subjects Estradiol/Levonorgestrel Transdermal System - Menopause, Healthy Female Participants | Phase 1 | Recruiting | Corium Innovations, Inc. | 250 | 2026-08-10 | 2026-09-10 |
| Blackcurrants Modify Gut Microbiota and Reduce Osteoporosis Risk in Postmenopausal Females Blackcurrant (BC) extract, Placebo - Postmenopausal Osteoporosis, Gut Microbiome | Phase 1 | Recruiting | University of Connecticut | 159 | 2026-07-01 | 2026-07-23 |
| COmmencing Menopausal HOrmone Replacement Therapy and the Effect on Metabolic-dysfunction Associated Steatotic Liver Disease: a Pilot Mechanistic Study Menopausal hormone therapy - Menopause, Metabolic Dysfunction Associated Steatotic Liver Disease | Phase 1 | Recruiting | University of Oxford | 10 | 2025-01-01 | 2025-01-13 |
| Affect of Duavive on Mood & Anxiety Symptoms Duavive 0.45Mg-20Mg Tablet - Menopause, Depression, Anxiety | Phase 1 | Recruiting | St. Joseph's Healthcare Hamilton | 30 | 2024-07-03 | 2024-12-03 |
| Stem Cell Therapy and Growth Factor Ovarian in Vitro Activation SEGOVA procedure - Menopause, Menopause Ovarian Failure | Phase 1 / Phase 2 | Unknown | Forever Young d.o.o. | 100 | 2019-06-01 | 2020-08-06 |
| A Neurosteroid Intervention for Menopausal and Perimenopausal Depression Pregnenolone, Placebo - Major Depressive Disorder, Menopause | Phase 1 / Phase 2 | Completed | University of Texas Southwestern Medical Center | 73 | 2018-09-01 | 2026-01-22 |
| Study to Investigate the Pharmacokinetics & Safety Following One Application of 3 Different Doses 0.5,0.75,& 1.25 gm,a Transdermal Estradiol Cream (VML-0203), in Comparison to a Single Dose of EstroGel 1.25 gm to Healthy Post-menopausal Women. Estrogel - Menopause | Phase 1 | Unknown | Viramal Limited | 20 | 2018-05-22 | 2022-04-27 |
| Inovium Ovarian Rejuvenation Trials Autologous PRP injection into human ovarian tissue - Perimenopausal Disorder, Menopause | Phase 1 | Completed | Ascendance Biomedical | 200 | 2017-06-01 | 2020-04-20 |
| Use of Estriol at Distal Third of Vagina Improving Coital Pain in Post-menopause Women Estriol, Distal estriol, Vaginal Gel - Dyspareunia, Menopause | Phase 1 | Completed | University of Sao Paulo | 125 | 2017-06-01 | 2024-10-16 |
| Safety, Tolerability and Pharmacokinetics of Estetrol (E4) After Single and Multiple Oral Doses in Healthy Female Volunteers 5 mg E4 single-dose, 15 mg E4 single-dose, 45 mg E4 single-dose - Contraception, Menopause | Phase 1 | Completed | Estetra | 31 | 2017-01-31 | 2017-09-08 |
| Evaluation of the Effect of Transcutaneous Electrical Nerve Stimulation (TENS) in Postmenopausal Women Transcutaneous Elevtrical Nerve Stimulation - Menopause | Phase 1 / Phase 2 | Unknown | Secretaria Municipal de Saúde de Rolante | 30 | 2017-01-01 | 2017-01-26 |
| Pharmacokinetics and Pharmacodynamics of 3 Dosages of Estriol After Continuous Vaginal Administration for 21 Days Estriol 0.125 mg/day, Estriol 0.250 mg/day, Estriol 0.500 mg/day - Menopause | Phase 1 | Completed | Galeno Desenvolvimento de Pesquisas Clínicas | 31 | 2016-09-23 | 2017-12-06 |
| Study Conducted to Further Understand the Elimination Pathways, Metabolite Profile and PK Profile of 14C-estetrol Estetrol - Contraception, Menopause | Phase 1 | Completed | Estetra | 6 | 2016-02-01 | 2019-02-15 |
| Evaluation of Periodontal Response to Non Surgical Therapy in Pre and Post Menopausal Women With Periodontitis scaling and root planing (srp) - Periodontitis, Menopause | Phase 1 / Phase 2 | Completed | Panineeya Mahavidyalaya Institute of Dental Sciences & Research Centre | 60 | 2015-01-01 | 2016-03-24 |
| Pharmacokinetics Study of Qing'E Pill Qing'E pill - Menopause | Phase 1 | Completed | Shanghai University of Traditional Chinese Medicine | 24 | 2013-08-01 | 2022-05-05 |
| A Study To Compare The Amount Of Premarin Components That Is Absorbed Into The Blood Of Japanese Healthy Postmenopausal Women Following Oral Administration Of Two Different Tablets Of Premarin Under Fast and Fed Conditions. Premarin reference tablet (fasted), Premarin new tablet (fasted), Premarin reference tablet (fed) - Primary Ovarian Insufficiency, Vaginitis | Phase 1 | Completed | Pfizer | 72 | 2011-10-01 | 2012-03-15 |
| Pharmacokinetics of Injectable Estradiol and Progesterone Microspheres Suspension Estradiol + Progesterone - Menopause | Phase 1 | Completed | Productos Científicos S. A. de C. V. | 30 | 2011-02-01 | 2011-10-13 |
| Comparison of Two Vaginal Tablets, Produced at Different Sites, in Postmenopausal Women With Atrophic Vaginitis estradiol, 25 mcg - Menopause, Postmenopausal Vaginal Atrophy | Phase 1 | Completed | Novo Nordisk A/S | 70 | 2010-03-01 | 2014-06-26 |
| A Pharmacokinetic Evaluation of Bioidentical Compounded Estrogen Cream and Natural Progesterone bioidentical hormone (Biest), bioidentical hormone (Vivelle-Dot) - Menopause | Phase 1 | Completed | Mayo Clinic | 40 | 2008-06-01 | 2012-01-16 |
| Study Comparing 3 New Formulations of Premarin® 0.625 mg/MPA 2.5 mg With a Reference Formulation Premarin®/MPA formulation A, Premarin®/MPA formulation B, Premarin®/MPA formulation C - Menopause | Phase 1 | Completed | Wyeth is now a wholly owned subsidiary of Pfizer | 76 | 2008-02-01 | 2009-02-04 |
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Hot Flashes (3) · Primary Ovarian Insufficiency (3) · Menopause, Premature (2) · Ovarian Dysgenesis 2 (2) · Premature Ovarian Failure 2a (2) · Premature Ovarian Failure 3 (2) · Premature Ovarian Failure 5 (2) · Premature Ovarian Failure 6 (2) · Premature Ovarian Failure 7 (2) · Anxiety Disorders (1) · Breast Neoplasms (1) · Depression (1) · Depressive Disorder, Major (1) · Dyspareunia (1) · Fatty Liver (1)
Pathological Conditions, Signs and Symptoms (5) · Female Urogenital Diseases (4) · Female Urogenital Diseases and Pregnancy Complications (4) · Genital Diseases (4) · Genital Diseases, Female (4) · Urogenital Diseases (4) · Adnexal Diseases (3) · Endocrine System Diseases (3) · Gonadal Disorders (3) · Mental Disorders (3) · Ovarian Diseases (3) · Signs and Symptoms (3) · Pathologic Processes (2) · Behavior (1) · Behavioral Symptoms (1)
Estradiol (8) · Estetrol (2) · Estriol (2) · Estrogens, Conjugated (USP) (2) · Norethindrone Acetate (2) · bazedoxifene (2) · black cohosh root extract (2) · Hormone Replacement Therapy (1) · Mindfulness (1) · Pregnenolone (1) · Progesterone (1) · Qing'e pill (1) · Root Planing (1) · Tablets (1) · Tooth Exfoliation (1)
Novo Nordisk A/S (4) · Wyeth is now a wholly owned subsidiary of Pfizer (3) · Estetra (2) · National Center for Complementary and Integrative Health (NCCIH) (2) · Ascendance Biomedical (1) · Corium Innovations, Inc. (1) · Forever Young d.o.o. (1) · Galeno Desenvolvimento de Pesquisas Clínicas (1) · Mayo Clinic (1) · Panineeya Mahavidyalaya Institute of Dental Sciences & Research Centre (1) · Pfizer (1) · Productos Científicos S. A. de C. V. (1) · Secretaria Municipal de Saúde de Rolante (1) · Shanghai University of Traditional Chinese Medicine (1) · St. Joseph's Healthcare Hamilton (1)
United States (7) · Germany (4) · Brazil (3) · United Kingdom (3) · Bulgaria (1) · Canada (1) · China (1) · India (1) · Japan (1) · Malta (1) · Mexico (1) · North Macedonia (1) · Serbia (1)
Aleksandar Ljubic, MD, PhD (1) · Alison Shea, MD (1) · Dobrin Sviranov, Prof (1) · Dr Simona Fiore, MD (1) · E Scott Sills, MD PhD (1) · Edward Sauter, MD (1) · Gilberto De Nucci, MD (1) · Litza McKenzie, MBChB (1) · Marlene Freeman, MD (1) · Ock Chun, PhD (1) · Richa Sood, MD (1) · Roberto Bernardo, MSc (1)
PMID 37619252, PMID 10782451, PMID 12050564, PMID 14583935, PMID 15189832, PMID 15804736, PMID 17262148, PMID 19170834, PMID 20423242, PMID 23384975, PMID 23848490, PMID 29486615, PMID 30796792, PMID 32195207, PMID 34155864, PMID 3425152, PMID 3793432, PMID 6880820
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