253 completed, 27 unknown, 19 recruiting, 15 terminated. 78 Phase 3, 74 Phase 2, 64 Not applicable, 50 Phase 1, 46 Phase 4.
Follow Keratosis, Actinic: new trials by email Literature Review of Keratosis, Actinic trials Research Report on Keratosis, Actinic
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Efficacy and Safety of Cryotherapy Followed by Tirbanibulin Ointment for Actinic Keratosis on the Scalp and Forehead Cryotherapy + Tirbanibulin - Keratosis, Actinic Keratoses | Phase 3 | Not yet recruiting | University Hospital, Lille | 59 | 2026-11-30 | 2026-05-22 |
| Therapeutic Induction of Dermal Remodeling in Veterans to Prevent Actinic Neoplasia Caused by Chronic Environmental Exposure to Ultraviolet Radiation Microneedling, Trichloroacetic acid peel - Nonmelanoma Skin Cancer, Actinic Keratosis | Not applicable | Not yet recruiting | VA Office of Research and Development | 96 | 2026-11-01 | 2026-10-06 |
| Basal Cell Carcinoma Chemoprevention Trial 5% Imiquimod cream, Placebo Vehicle Control Cream - Basal Cell Carcinoma | Phase 3 | Recruiting | VA Office of Research and Development | 1630 | 2026-10-06 | 2026-10-19 |
| Multimodal Laser Treatment of Photodamaged Skin 1927-nm thulium laser, 1550-nm Er:Glass laser, Intense Pulsed Light - Photo-damage, Actinic Keratosis (AK) | Not applicable | Recruiting | Merete Haedersdal | 35 | 2026-09-01 | 2026-09-09 |
| 5-Fluorouracil and Calcipotriene for Field Treatment of Actinic Keratoses Combination field therapy with 5-fluorouracil and calcipotriene (5FU/C) - Actinic Keratoses | Phase 1 | Not yet recruiting | Cedars-Sinai Medical Center | 96 | 2026-09-01 | 2026-10-05 |
| An Open-Label Pharmacokinetic Study for Patients With Actinic Keratosis on the Upper Extremities or the Face Investigational drug, Photodynamic therapy - Actinic Keratosis (AK) | Phase 1 | Recruiting | Sun Pharmaceutical Industries Limited | 48 | 2026-08-04 | 2026-08-13 |
| PDT vs Peels for Treatment of Actinic Keratoses Photodynamic Therapy, Chemical Peels - Actinic Keratoses | Phase 2 | Not yet recruiting | Northwestern University | 60 | 2026-08-01 | 2026-07-01 |
| A Phase 2 Study of HW211026 HW211026 - Actinic Keratosis | Phase 2 | Not yet recruiting | Hubei Bio-Pharmaceutical Industrial Technological Institute Inc. | 80 | 2026-07-01 | 2026-07-09 |
| A Randomized Controlled Trial of Topical 5% Niacinamide for Skin Cancer Prevention in Transplant Recipients Topical niacinamide 5% cream, Sunscreen - Skin Cancer, Cutaneous Squamous Cell Carcinoma (CSCC) | Early Phase 1 | Recruiting | Marissa Lobl | 20 | 2026-05-01 | 2026-06-05 |
| Outcomes Associated With Tirbanibulin for Large Field Application on the Face in the U.S (CLEAR) Tirbanibulin - Actinic Keratosis (AK) | Recruiting | Avant Health LLC | 30 | 2026-04-02 | 2026-06-18 | |
| Actinic Keratoses Treated With 5-fluorouracil Plus Aluminum 5% 5-fluorouracil (5-FU) powder, 5% 5-fluorouracil (5-FU) powder PLUS 15% Aluminum Chloride Hexahydrate (ACH) - Actinic Keratoses | Phase 1 | Recruiting | West Virginia University | 32 | 2026-02-06 | 2026-04-22 |
| Evaluate RLS-1496 Topical Cream for Actinic Keratosis RLS-1496 1.0% cream - Actinic Keratosis (AK) | Phase 1 / Phase 2 | Active not recruiting | Rubedo Life Sciences, Inc. | 24 | 2026-02-03 | 2026-08-12 |
| Immunotherapy After Transplantation for Skin Cancer Prevention in Organ Transplant Recipients Calcipotriol Only Product in Cutaneous Dose Form, Vaseline, Topical 5FU - Immunotherapy, Cutaneous Squamous Cell Carcinoma | Phase 2 | Withdrawn | Massachusetts General Hospital | 2026-01-01 | 2025-05-07 | |
| Immunotherapy Before Transplantation for Skin Cancer Prevention in Organ Transplant Recipients Calcipotriol Only Product in Cutaneous Dose Form, Vaseline, Topical 5FU - Cutaneous Squamous Cell Carcinoma, Actinic Keratoses | Phase 2 | Withdrawn | Massachusetts General Hospital | 2026-01-01 | 2025-05-07 | |
| A Phase Ib Study of HW211026 Ointment in Patients With Actinic Keratosis. HW211026, Placebo - Actinic Keratosis (AK) | Phase 1 | Recruiting | Hubei Bio-Pharmaceutical Industrial Technological Institute Inc. | 40 | 2025-12-25 | 2026-01-06 |
| Study of Reformulated Levulan Kerastick Plus PDT for Actinic Keratosis on Upper Extremities Reformulated Levulan Kerastick containing aminolevulinic acid hydrochloride (ALA HCl), 20%, Vehicle, Blue Light Photodynamic Therapy Illuminator device, BLU-U® model 4170E. - Actinic Keratosis | Phase 3 | Recruiting | Sun Pharmaceutical Industries, Inc. | 260 | 2025-11-29 | 2026-04-22 |
| Study of Reformulated Levulan Kerastick Plus PDT for Actinic Keratosis on Face and Scalp Reformulated Levulan Kerastick containing aminolevulinic acid hydrochloride (ALA HCl), 20%, Vehicle containing excipients only (VEH) without active ingredient, Blue Light Photodynamic Therapy Illuminator device, BLU-U® model 4170E - Actinic Keratosis | Phase 3 | Recruiting | Sun Pharmaceutical Industries, Inc. | 160 | 2025-11-19 | 2026-04-22 |
| Study of the Photoprotection and Prevention of Actinic Damage With Anthelios Fluide 100 KA+ UVMune 400 in Patients With Multiple Actinic Keratoses Tested product group, Control group - Actinic Keratosis (AK) | Not applicable | Recruiting | Cosmetique Active International | 80 | 2025-07-01 | 2026-01-12 |
| Activation of Ameluz With BBL HEROic for the Treatment of Actinic Keratoses and Photodamage Ameluz, Sciton HEROic - Actinic Keratoses, Photodamage | Phase 1 | Completed | Sherrif Ibrahim | 10 | 2025-06-27 | 2026-01-02 |
| The Effect of Topical Imipramine on Photodynamic Therapy-Mediated Immunosuppression on Forearms or Face on US Veterans Imipramine, Control Vehicle - Actinic Keratosis, Imipramine | Phase 2 | Recruiting | VA Office of Research and Development | 48 | 2025-04-01 | 2025-12-22 |
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Carcinoma, Basal Cell (17) · Precancerous Conditions (17) · Carcinoma, Squamous Cell (15) · Keratosis (15) · Skin Neoplasms (13) · Skin Diseases (11) · Bowen's Disease (4) · Melanoma (4) · Melanosis (4) · Neoplasms (4) · Warts (3) · Disease (2) · Molluscum Contagiosum (2) · Pain (2)
Skin and Connective Tissue Diseases (340) · Neoplasms (336) · Skin Diseases (329) · Keratosis (325) · Precancerous Conditions (323) · Neoplasms by Histologic Type (31) · Carcinoma (29) · Neoplasms, Glandular and Epithelial (29) · Neoplasms by Site (18) · Neoplasms, Squamous Cell (18) · Neoplasms, Basal Cell (17) · Pathological Conditions, Signs and Symptoms (7) · Pigmentation Disorders (6) · Nevi and Melanomas (5) · Carcinoma, Squamous Cell (4)
3-ingenyl angelate (42) · Aminolevulinic Acid (34) · Imiquimod (29) · Fluorouracil (24) · Photochemotherapy (23) · methyl 5-aminolevulinate (14) · Cryotherapy (12) · Diclofenac (12) · Gels (12) · tirbanibulin (8) · Solutions (7) · BF-200 ALA (6) · calcipotriene (6) · LEO 43204 (5) · Ointments (5)
LEO Pharma (31) · Peplin (21) · Almirall, S.A. (14) · DUSA Pharmaceuticals, Inc. (10) · Galderma R&D (10) · Graceway Pharmaceuticals, LLC (8) · Maastricht University Medical Center (7) · University of California, Davis (7) · Actavis Inc. (6) · Biofrontera Bioscience GmbH (6) · Northwestern University (6) · Bispebjerg Hospital (5) · Dong-A University (5) · G&E Herbal Biotechnology Co., LTD (5) · Icahn School of Medicine at Mount Sinai (5)
United States (164) · Germany (52) · Australia (20) · France (17) · United Kingdom (15) · Netherlands (14) · Italy (12) · Denmark (11) · Spain (10) · Brazil (8) · Canada (8) · Switzerland (8) · Austria (7) · South Korea (6) · China (5)
Stuart Marcus, MD, PhD (9) · Murad Alam, MD (5) · Klara Mosterd, prof.dr. (4) · C. William Hanke, MD (3) · Edward Maytin, MD, PhD (3) · Eugene Bauer, MD (3) · Gary Goldenberg, MD (3) · Jane Fang, MD (3) · Sharon Levy, MD (3) · Assi Levi, MD (2) · Claus Garbe, MD (2) · Daniel M Siegel, MD (2) · Janelle Katsamas (2) · Jeffrey B Travers, MD, PhD (2) · Jonothan S Dosik, MD (2)
PMID 22417254, PMID 23553119, PMID 38125671, PMID 24765228, PMID 25584134, PMID 25950503, PMID 26300464, PMID 33196758, PMID 33567191, PMID 35314199, PMID 10607349, PMID 11493098, PMID 11966728, PMID 12533168, PMID 15097955, PMID 15168956, PMID 17488399, PMID 17488400, PMID 17822489, PMID 18067627, PMID 18955209, PMID 19221274, PMID 19467365, PMID 20133013, PMID 20231500, PMID 20514316, PMID 20518784, PMID 20725550, PMID 20729935, PMID 21115882, PMID 21283921, PMID 21753882, PMID 22025453, PMID 22055282, PMID 22136038, PMID 22329784, PMID 22527424, PMID 22714759, PMID 23252768, PMID 23510990, PMID 23815349, PMID 24033340, PMID 24037822, PMID 24068130, PMID 24509965, PMID 24589500, PMID 24672213, PMID 24818175, PMID 24892649, PMID 24918567
2014 (3), 2015 (2), P01CA027502 (2), P30CA023074 (2), 2005 (1), 2016 (1), 2017 (1), 2023 (1), P30CA043703 (1), R21CA156227 (1), R44CA250727 (1), UG1CA242596 (1)