41 completed, 23 unknown, 21 recruiting, 13 terminated. 27 Not applicable, 25 Phase 2, 11 Phase 1, 10 Phase 3, 6 Phase 4.
Follow Intestinal Polyposis: new trials by email Literature Review of Intestinal Polyposis trials Research Report on Intestinal Polyposis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Safety Study of ST316 in Participants With Familial Adenomatous Polyposis (FAP). ST316 IV - Familial Adenomatous Polyposis (FAP) | Phase 1 | Not yet recruiting | Sapience Therapeutics | 40 | 2027-01-04 | 2026-08-12 |
| Chinese Multicenter Registry for Peutz-Jeghers Syndrome Peutz-Jeghers Syndrome | Not yet recruiting | First People's Hospital of Hangzhou | 1000 | 2026-10-01 | 2026-10-22 | |
| Safety Study for the Use of Rapamycin in Children With Familial Adenomatous Polyposis Rapamycin - Familial Adenomatous Polyposis | Phase 2 | Not yet recruiting | University Hospital, Toulouse | 25 | 2026-09-01 | 2026-05-08 |
| Evaluation of the Ileo-anal Pouch in FAP (ENDOPOL) Chromoendoscopy (Indigo Carmine), Virtual Chromoendoscopy - Familial Adenomatous Polyposis (FAP), Pouches, Ileoanal | Not applicable | Recruiting | London North West Healthcare NHS Trust | 50 | 2026-07-09 | 2026-07-24 |
| Trial of Exercise Therapy in Familial Adenomatous Polyp (FAP) Exercise Therapy - Familial Adenomatous Polyposis | Not applicable | Recruiting | University of Michigan Rogel Cancer Center | 32 | 2026-05-13 | 2026-05-19 |
| An Investigational Drug (TPST-1495) in Patients With Familial Adenomatous Polyposis Biopsy Procedure, Biospecimen Collection, EP2/EP4 Antagonist TPST-1495 - Colorectal Carcinoma, Familial Adenomatous Polyposis | Phase 2 | Recruiting | National Cancer Institute (NCI) | 38 | 2026-03-31 | 2026-09-14 |
| Impact of Prior Identification and Education of Patients Requiring a Digestive Stoma for Fecal Diversion preoperative stoma identification and education - Colorectal Anastomosis, Endometrial | Not applicable | Not yet recruiting | Assistance Publique Hopitaux De Marseille | 100 | 2026-03-01 | 2025-11-18 |
| Safety and Efficacy of Tegavivint in Patients With Metastatic Colorectal Carcinoma Tegavivint - Metastatic Colorectal Carcinoma (mCRC), Colorectal Cancer (CRC) | Phase 1 / Phase 2 | Recruiting | HonorHealth Research Institute | 126 | 2026-02-17 | 2026-03-11 |
| Testing for Safety and Colorectal Cancer Preventive Effects of ONC201 Biopsy Procedure, Biospecimen Collection, Colonoscopy - Colorectal Adenomatous Polyp, Colorectal Carcinoma | Phase 1 | Recruiting | National Cancer Institute (NCI) | 36 | 2025-10-06 | 2026-10-15 |
| Clinical Validation of Sophia Genetics Assay Sophia Herditary Cancer Solution - Ovarian Cancer, Breast Cancer | Not yet recruiting | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 248 | 2025-09-15 | 2025-09-08 | |
| Phase 3 Trial of eRapa in Patients With Familial Adenomatous Polyposis eRapa (encapsulated rapamycin), Placebo - Familial Adenomatous Polyposis (FAP) | Phase 3 | Recruiting | Rapamycin Holdings Inc. | 168 | 2025-07-18 | 2026-06-02 |
| Ten Versus Fifteen Centimeter Pouch in IPAA Surgery 10 cm pouch, 15 cm pouch - Ulcerative Colitis, Familial Adenomatous Polyposis | Not applicable | Recruiting | Odense University Hospital | 120 | 2025-07-03 | 2025-07-09 |
| Celecoxib for Prevention of Progression in Peutz-Jeghers Syndrome Celecoxib 400mg, Placebo - Peutz-Jeghers Syndrome, Celecoxib | Not applicable | Recruiting | Air Force Military Medical University, China | 80 | 2025-02-01 | 2025-05-30 |
| Artificial Intelligence-assisted Colonoscopy in the Detection and Characterization of Colorectal Lesions Colonoscopy - Colorectal Cancer (CRC), Adenomatous Polyposis | Not applicable | Recruiting | Instituto do Cancer do Estado de São Paulo | 1000 | 2025-02-01 | 2026-06-23 |
| Microbial and Environmental Factors Associated With Polyps Development in Familial Adenomatous Polyposis (MicrobEnvironment in FAP) Sampling of feces and duodenal fluids - Familial Adenomatous Polyposis | Recruiting | Hospices Civils de Lyon | 100 | 2024-12-17 | 2026-05-27 | |
| Investigation of β-hydroxybutyrate Supplementation as Chemoprevention in Familial Adenomatous Polyposis R-1,3-Butanediol (10G-A), R-1,3-Butanediol (20G-A), R-1,3-Butanediol (30G-A) - FAP, Familial Adenomatous Polyposis | Not applicable | Enrolling by invitation | Abramson Cancer Center at Penn Medicine | 20 | 2024-09-20 | 2026-09-16 |
| Detection of Ileoanal Pouch/Reservoir Adenomas Adenomas detection rate with the different observation methods - Adenomatous Polyps | Unknown | Jean Christophe Saurin | 40 | 2024-09-09 | 2023-09-25 | |
| Chemopreventive Effect of Combination of Celecoxib and Metformin in Patients With Familial Adenomatous Polyposis celecoxib monotherapy, celecoxib and metformin combination - Familial Adenomatous Polyposis | Phase 3 | Unknown | Yonsei University | 28 | 2024-08-13 | 2024-08-09 |
| Familial Adenomatous Poliposys Italian Network (Rete Italiana Poliposi Adenomatosa Familiare) Familial Adenomatous Polyposis (FAP), Attenuated Familial Adenomatous Polyposis (AFAP) | Active not recruiting | Fondazione IRCCS Istituto Nazionale dei Tumori, Milano | 1500 | 2024-05-13 | 2026-03-10 | |
| Efficacy of Vitamin B1 in Familial Adenomatous Polyposis Patients. Vitamin B1 - Familial Adenomatous Polyposis (FAP) | Not applicable | Enrolling by invitation | Shanghai Zhongshan Hospital | 10 | 2024-01-08 | 2026-04-24 |
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Adenomatous Polyposis Coli (92) · Colorectal Neoplasms (22) · Peutz-Jeghers Syndrome (22) · Colorectal Neoplasms, Hereditary Nonpolyposis (15) · Colitis, Ulcerative (13) · Pancreatic Neoplasms (9) · Polyps (8) · Crohn Disease (7) · Adenoma (6) · Desmoid Tumors (5) · Duodenal Neoplasms (5) · Neoplasms (5) · Breast Neoplasms (4) · Colonic Neoplasms (4) · Dysplastic Nevus Syndrome (4)
Digestive System Diseases (114) · Gastrointestinal Diseases (114) · Intestinal Diseases (114) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (113) · Genetic Diseases, Inborn (111) · Neoplastic Syndromes, Hereditary (111) · Neoplasms (110) · Neoplasms by Site (107) · Digestive System Neoplasms (104) · Colonic Diseases (103) · Intestinal Neoplasms (102) · Neoplasms by Histologic Type (102) · Gastrointestinal Neoplasms (100) · Neoplasms, Glandular and Epithelial (93)
Celecoxib (8) · Biopsy (5) · Sirolimus (4) · Sulindac (4) · Curcumin (3) · Eflornithine (3) · Endoscopy (3) · Secretin (3) · Specimen Handling (3) · Colonoscopy (2) · Endoscopy, Digestive System (2) · Endoscopy, Gastrointestinal (2) · Erlotinib Hydrochloride (2) · Erythromycin (2) · Everolimus (2)
National Cancer Institute (NCI) (9) · Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) (5) · Johns Hopkins University (4) · Charite University, Berlin, Germany (3) · Fondazione IRCCS Istituto Nazionale dei Tumori, Milano (3) · Janssen Research & Development, LLC (3) · M.D. Anderson Cancer Center (3) · Yonsei University (3) · Cancer Prevention Pharmaceuticals, Inc. (2) · London North West Healthcare NHS Trust (2) · Peking Union Medical College Hospital (2) · Radboud University Medical Center (2) · Rapamycin Holdings Inc. (2) · S.L.A. Pharma AG (2) · Tel-Aviv Sourasky Medical Center (2)
United States (52) · Netherlands (12) · China (8) · Germany (8) · Puerto Rico (8) · France (7) · Italy (7) · Spain (6) · United Kingdom (6) · Denmark (5) · Israel (4) · South Korea (4) · Belgium (3) · Sweden (3) · Australia (2)
Niloy J Samadder (3) · Gary Shangold, MD (2) · Marco Vitellaro, MD (2) · Revital Kariv, MD (2) · Aimee Lucas, MD, MS (1) · Alexander G Raufi, MD (1) · Alfred M. Cohen, M.D. (1) · Andre Latchford, MBBS PhD FRCP (1) · Angela George (1) · Angelo Minucci (1) · Anthony J Senagore, MD, MBA, MS (1) · Arthur F Stucchi, PhD (1)
PMID 37119510, PMID 29802852, PMID 20018966, PMID 20234350, PMID 20348368, PMID 20458532, PMID 21899713, PMID 22154461, PMID 23114473, PMID 23200980, PMID 23919274, PMID 24245549, PMID 25481712, PMID 25792707, PMID 26528500, PMID 27002448, PMID 29371475, PMID 29423501, PMID 30012100, PMID 30538291, PMID 31197699, PMID 31676359, PMID 31898110, PMID 32893266, PMID 32905675, PMID 33161160, PMID 33376109, PMID 33509804, PMID 34149034, PMID 34253565, PMID 34261858, PMID 35477756, PMID 35636921, PMID 35962368, PMID 37099777, PMID 37201686, PMID 37787643, PMID 38422953, PMID 39956770, PMID 42544942
N01CN00042 (2), P30CA015083 (2), P30CA016672 (2), P30CA068485 (2), UG1CA242632 (2), 2019 (1), 2023 (1), P01CA073992 (1), P30CA006973 (1), P30CA014520 (1), P30CA046592 (1), R01CA106577 (1), R01CA134620 (1), R01CA176828 (1), R41CA126453 (1)