10 completed, 4 recruiting, 3 unknown, 2 not yet recruiting. 8 Not applicable, 4 Phase 4, 1 Phase 2, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 8 | Completed 5, Active not recruiting 1, Recruiting 1, Terminated 1 |
| Phase 4 | 4 | Recruiting 2, Completed 1, Enrolling by invitation 1 |
| Phase 2 | 1 | Completed 1 |
| Phase 3 | 1 | Completed 1 |
Follow Major Surgery: new trials by email Literature Review of Major Surgery trials Research Report on Major Surgery
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Postoperative Complications in Major Surgery Patients with postoperative complications - Major Surgery | Not yet recruiting | Hospital Departamental de Villavicencio | 364 | 2026-08-01 | 2026-06-02 | |
| LANdiolol to Avoid TAchycardia in Patients at Risk for Cardiovascular Events Undergoing Major Non-cardiac Surgery Landiolol - Perioperative Myocardial Injury, Autonomic Dysfunction | Phase 4 | Recruiting | Insel Gruppe AG, University Hospital Bern | 114 | 2026-04-24 | 2026-05-05 |
| Submental Tissue Oxygenation and Arterial Lactate in Major Surgery No intervention. This is a prospective observational study. Near-infrared spectroscopy measurements are performed for monitoring purposes only and do not influence clinical management. - Microcirculatory Dysfunction, Tissue Hypoperfusion | Not yet recruiting | Bursa Sevket Yilmaz Training and Research Hospital | 150 | 2026-02-15 | 2026-02-10 | |
| Analgesic Efficacy of Intravenous Ketamine as a Continuous Infusion vs PCA in the Management of Acute Postoperative Pain in Major Orthopedic Surgery. Ketamine infusion, PCA Ketamine - Pain, Postoperative, Opioid Use | Phase 4 | Recruiting | Universidad de Antioquia | 120 | 2025-03-01 | 2025-04-11 |
| Outcomes of Patient Blood Management in Patients Undergoing Major Surgery Allogeneic transfusion, Patient Blood Management - Major Surgery | Completed | Helios Klinik Gotha/Ohrdruf | 25979 | 2024-09-01 | 2025-04-20 | |
| Prehabilitation in Oncological Patients Undergoing Major Gastrointestinal Surgery (PROGRESS) Multimodal prehabilitation Program - Oncological Patients, Major Surgery | Not applicable | Active not recruiting | Università Vita-Salute San Raffaele | 400 | 2024-05-16 | 2026-05-11 |
| Morbidity and Mortality: Surgery and Standardized Transmission in Operating Room Training with AnesList© - Major Surgery | Recruiting | Assistance Publique - Hôpitaux de Paris | 1120 | 2023-09-08 | 2025-11-19 | |
| Perioperative TPN Improves Surgical Outcomes TPN-N7 Baxter - Parenteral Nutrition, Major Surgery | Completed | Nepal Medical College and Teaching Hospital | 150 | 2022-10-01 | 2024-08-27 | |
| Multimodal Prehabilitation for Surgery in the Elderly: a Randomised, Prospective, Multicenter, Multidisciplinary Trial Multimodal Prehabilitation - Frail Elderly Syndrome, Major Surgery | Not applicable | Recruiting | Insel Gruppe AG, University Hospital Bern | 466 | 2022-02-01 | 2024-11-01 |
| Intravenous Oliceridine and Opioid-related Complications Oliceridine - Major Surgery | Phase 4 | Completed | The Cleveland Clinic | 204 | 2021-09-15 | 2026-05-14 |
| The GUARDIAN Trial - Induction Agent Sub-Study Routine Blood Pressure Management, Tight Blood Pressure Management, Etomidate Induction - Major Surgery | Phase 4 | Enrolling by invitation | The University of Texas Health Science Center, Houston | 6254 | 2021-07-25 | 2025-08-29 |
| Esketamine and Perioperative Depressive Symptoms Esketamine, Normal saline - Depressive Symptoms, Esketamine | Phase 2 / Phase 3 | Completed | Beijing Tiantan Hospital | 435 | 2021-02-19 | 2025-08-01 |
| Impact of an Anesthesia Care Handover-Checklist on Adverse Perioperative Outcome AnCHor-Checklist implementation - Major Surgery | Unknown | University Hospital Heidelberg | 300 | 2020-10-29 | 2020-11-03 | |
| Long-term Enlarged Survival After an Enhanced Recovery Protocol (LESAS). PRI (Enhanced Recovery after surgery protocol) - Major Surgery | Unknown | Grupo Español de Rehabilitación Multimodal | 750 | 2020-09-01 | 2022-01-14 | |
| Anesthesia-handover Checklist and Perioperative Outcomes in Elderly Oral handover, Checklist handover - Elderly Patients, Major Surgery | Not applicable | Completed | Peking University First Hospital | 1421 | 2020-07-16 | 2024-12-02 |
| Different Intra-abdominal Pressures and Optic Nerve Size Intraabdominal pressure and optic nerve diameters - Major Surgery, Intraabdominal Hypertension | Completed | Trakya University | 78 | 2018-06-15 | 2020-09-21 | |
| Implementation of Enhanced Recovery Protocol in Spain ERAS program - Major Surgery | Unknown | Grupo Español de Rehabilitación Multimodal | 2000 | 2016-07-15 | 2022-01-14 | |
| TXA Study in Major Burn Surgery Tranexamic Acid, Placebo Comparator - Tranexamic Acid, Burn | Not applicable | Terminated | Corewell Health West | 25 | 2016-04-01 | 2021-08-23 |
| REAnimation Low Immune Status Markers Blood sampling - Septic Shock, Severe Trauma | Not applicable | Completed | Hospices Civils de Lyon | 552 | 2015-12-11 | 2025-12-19 |
| TXA Study in Major Oncologic Surgery Tranexamic Acid, Placebo - Tranexamic Acid, Cancer | Not applicable | Completed | Corewell Health West | 76 | 2012-06-12 | 2023-08-07 |
Showing 20 of 22. Sign in to see all of them.
Burns (2) · Neoplasms (2) · Anemia (1) · Coronary Artery Disease (1) · Cross Infection (1) · Depression (1) · Emergence Delirium (1) · Hyperlactatemia (1) · Hyperphagia (1) · Intra-Abdominal Hypertension (1) · Malnutrition (1) · Motor Activity (1) · Pain (1) · Pain, Postoperative (1) · Postoperative Complications (1)
Pathological Conditions, Signs and Symptoms (6) · Pathologic Processes (4) · Signs and Symptoms (4) · Behavior (2) · Cardiovascular Diseases (2) · Nervous System Diseases (2) · Neurologic Manifestations (2) · Nutritional and Metabolic Diseases (2) · Postoperative Complications (2) · Vascular Diseases (2) · Arterial Occlusive Diseases (1) · Arteriosclerosis (1) · Autonomic Nervous System Diseases (1) · Behavioral Symptoms (1) · Compartment Syndromes (1)
Tranexamic Acid (2) · ((3-methoxythiophen-2-yl)methyl)((2-(9-(pyridin-2-yl)-6-oxaspiro(4.5)decan-9-yl)ethyl))amine (1) · Blood Specimen Collection (1) · Esketamine (1) · Folic Acid (1) · Nitrous Oxide (1) · Saline Solution (1) · Standard of Care (1) · Vitamin B 12 (1) · landiolol (1) · placental ribonuclease inhibitor (1)
Corewell Health West (2) · Grupo Español de Rehabilitación Multimodal (2) · Insel Gruppe AG, University Hospital Bern (2) · Peking University First Hospital (2) · Assistance Publique - Hôpitaux de Paris (1) · Beijing Tiantan Hospital (1) · Bursa Sevket Yilmaz Training and Research Hospital (1) · Helios Klinik Gotha/Ohrdruf (1) · Hospices Civils de Lyon (1) · Hospital Departamental de Villavicencio (1) · Nepal Medical College and Teaching Hospital (1) · The Cleveland Clinic (1) · The University of Texas Health Science Center, Houston (1) · Trakya University (1) · Universidad de Antioquia (1)
United States (5) · China (4) · Colombia (2) · France (2) · Germany (2) · Spain (2) · Switzerland (2) · Turkey (Türkiye) (2) · Greece (1) · Italy (1) · Japan (1) · Nepal (1)
Daniel I Sessler, MD (2) · Dong-Xin Wang, MD, PhD (2) · Dominique A Engel, Dr (1) · Elizabeth Steensma, MD (1) · Fabian D Casas, Professor (1) · Gerald P Wright, MD (1) · Jan Larmann, MD PhD (1) · Jose M Calvo, Dr (1) · Jose M Ramirez, Prof. (1) · Peter Nagele, MD (1) · Petra Seeber (1)
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