92 completed, 37 recruiting, 32 unknown, 10 terminated. 39 Not applicable, 34 Phase 2, 25 Phase 3, 22 Phase 4, 15 Phase 1.
Follow Tick-Borne Diseases: new trials by email Literature Review of Tick-Borne Diseases trials Research Report on Tick-Borne Diseases
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Doxycycline Boosted Therapy in Lyme Borreliosis: DoBo Study. Hydroxychloroquin, Placebo, Doxycycline - Lyme Borreliosis, Nervous System | Phase 4 | Not yet recruiting | Radboud University Medical Center | 50 | 2027-03-01 | 2026-08-27 |
| The Precision Mito- Mito Map COMPASS Study Mito Map Energy Score and Home Functional Assessments - Mitochondrial Diseases, Myalgic Encephalomyelitis Chronic Fatigue Syndrome | Not yet recruiting | AI Agent Vault, Inc. d/b/a Precision Mito | 400 | 2026-11-01 | 2026-10-02 | |
| Natural History of Trisomy 8-Associated Autoinflammatory Disease (TRIAD) and Related Disorders Trisomy 8 Mosaicism, Trisomy 8 Associated Autoinflammatory Disease | Recruiting | National Institute of Allergy and Infectious Diseases (NIAID) | 750 | 2026-10-28 | 2026-10-23 | |
| Flow Cytometric Immune Monitoring of B. Afzelii-Specific T Lymphocytes Lyme Borreliosis, Lyme Disease | Not yet recruiting | University Hospital, Strasbourg, France | 20 | 2026-09-01 | 2026-07-14 | |
| UMIT-2 - Adaptive Phase IIb Platform Trial to Determine the Efficacy and Safety of Therapeutics for CCHF Favipiravir, Ribavin, Optimised Standard of Care - Crimean-Congo Hemorrhagic Fever | Phase 2 | Recruiting | Liverpool School of Tropical Medicine | 378 | 2026-06-04 | 2026-08-07 |
| Ceftriaxone for Post-Treatment Lyme Disease Ceftriaxone treatment, Placebo - Post-Treatment Lyme Disease Syndrome | Phase 1 / Phase 2 | Withdrawn | Hackensack Meridian Health | 2026-05-14 | 2026-05-18 | |
| Development Of A Rapid Diagnostic Test To Identify Crimean-Congo Haemorrhagic Fever At The Point-Of-Care Rapid Diagnostic Test - Crimean-Congo Haemorrhagic Fever | Not applicable | Recruiting | Liverpool School of Tropical Medicine | 492 | 2026-05-04 | 2026-06-09 |
| A Study to Evaluate the Safety, Reactogenicity, and Immunogenicity of mRNA-1982 to Prevent Lyme Disease in Healthy Participants (18 to 70 Years of Age) mRNA-1982, Placebo - Lyme Disease | Phase 2 | Active not recruiting | ModernaTX, Inc. | 366 | 2026-04-29 | 2026-08-03 |
| A Study to Learn About the Safety, Tolerability, and Immunogenicity of a Fifth Dose of 6-Valent OspA-Based Lyme Disease Vaccine VLA15, Placebo - Lyme Disease | Phase 3 | Recruiting | Pfizer | 1712 | 2026-04-08 | 2026-05-06 |
| A Study to Evaluate Safety and Efficacy of TP-05 in Healthy Participants With Tick Exposure TP-05 (lotilaner) Low Dose, TP-05 (lotilaner) High Dose, Placebo - Lyme Disease | Phase 2 | Active not recruiting | Tarsus Pharmaceuticals, Inc. | 722 | 2026-03-09 | 2026-07-09 |
| Borrelia Arthritis - a Hidden Cause of Arthritis in Danish Patients? Synovial fluid Borrelia burgdorferi PCR - Lyme Arthritis | Not yet recruiting | Fredrikke Christie Knudtzen | 350 | 2026-01-01 | 2026-01-20 | |
| First-in-Human Study Testing a New Antibody Treatment for Tick-Borne Encephalitis in Healthy Volunteers. Human monoclonal antibody TBE025, intravenous infusion - The Tick-borne Encephalitis Virus (TBEV) | Phase 1 | Not yet recruiting | Giuseppe Pantaleo | 18 | 2026-01-01 | 2026-01-29 |
| Risk Assessment of Community Spread of Multiple Endemic Infectious Diseases in a One Health Perspective Dengue, Chikungunya | Recruiting | Institut Pasteur du Cambodge | 10000 | 2025-12-18 | 2026-01-22 | |
| A Study to Learn About Different Dosing Schedules of a Lyme Disease Vaccine in Healthy Adults VLA15, Placebo - Lyme Borreliosis | Phase 3 | Active not recruiting | Pfizer | 207 | 2025-11-19 | 2026-05-06 |
| Human Babesiosis in Metropolitan France Human Babesiosis | Recruiting | University Hospital, Strasbourg, France | 100 | 2025-11-04 | 2026-01-16 | |
| Safety and Effectiveness of the BlinkER System in Participants With Facial Nerve Palsy BlinkER device. - Bell's Palsy, Ramsay Hunt Syndrome | Not applicable | Not yet recruiting | Neurotrigger Ltd | 80 | 2025-10-01 | 2025-06-10 |
| A Multicenter Real-life Study of Disseminated Borreliosis Cases Occurring in Patients Receiving Anti-CD20 Treatment in France Borrelia Infections | Recruiting | University Hospital, Strasbourg, France | 100 | 2025-08-29 | 2026-01-15 | |
| Effect of Saccharomyces Boulardii CNCM I-745 on Gut Microbiota in Patients Undergoing Antibiotic Therapy (in the Context of Erythema Migrans (Early Skin Form of Lyme Borreliosis)) Amoxicillin + Saccharomyces boulardii CNCM I-745, Amoxicillin + Placebo, Stool samples - Erythema Migrans of Lyme Disease | Phase 4 | Recruiting | Biocodex | 120 | 2025-07-16 | 2025-08-27 |
| Transcranial Direct Current Stimulation for Post Treatment Lyme Disease Transcranial Direct Current Stimulation (tDCS), Cognitive training - Post-Treatment Lyme Disease | Not applicable | Recruiting | Columbia University | 110 | 2025-07-14 | 2026-05-06 |
| Safety and Immunogenicity of a Self-Amplifying RNA Vaccine Against Crimean-Congo Hemorrhagic Fever 10 ug HDT 321, 25ug HDT-321, 50ug HDT-321 - Vaccine, Crimean-Congo Hemorrhagic Fever | Phase 1 | Recruiting | HDT Bio | 48 | 2025-07-10 | 2025-07-28 |
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Lyme Disease (94) · Encephalitis, Tick-Borne (50) · Post-Lyme Disease Syndrome (22) · Lyme Neuroborreliosis (19) · Glossitis, Benign Migratory (15) · Borrelia Infections (10) · Tick Bites (7) · Erythema Chronicum Migrans (6) · Hemorrhagic Fever, Crimean (6) · Tularemia (6) · Fatigue Syndrome, Chronic (5) · Relapsing Fever (5) · Arthritis, Rheumatoid (4) · Babesiosis (4)
Infections (193) · Vector Borne Diseases (193) · Bacterial Infections and Mycoses (132) · Gram-Negative Bacterial Infections (132) · Bacterial Infections (131) · Spirochaetales Infections (121) · Borrelia Infections (110) · Nervous System Diseases (79) · Central Nervous System Diseases (74) · Central Nervous System Infections (69) · Virus Diseases (66) · RNA Virus Infections (64) · Arbovirus Infections (56) · Brain Diseases (56)
Doxycycline (20) · Ceftriaxone (10) · Vaccines (9) · Blood Specimen Collection (6) · FSME-IMMUN vaccine (3) · Sodium Chloride (3) · Surveys and Questionnaires (3) · Amoxicillin (2) · Anti-Bacterial Agents (2) · Hydroxychloroquine (2) · Meditation (2) · lotilaner (2) · Acetaminophen (1) · Acyclovir (1) · Arthrocentesis (1)
Pfizer (27) · University Medical Centre Ljubljana (24) · National Institute of Allergy and Infectious Diseases (NIAID) (16) · University Hospital, Strasbourg, France (14) · U.S. Army Medical Research and Development Command (4) · Medical University of Vienna (3) · Novartis (3) · Research Foundation for Mental Hygiene, Inc. (3) · Brigham and Women's Hospital (2) · Central Hospital, Nancy, France (2) · Children's National Research Institute (2) · Columbia University (2) · Icahn School of Medicine at Mount Sinai (2) · Johns Hopkins University (2) · Liverpool School of Tropical Medicine (2)
United States (72) · France (23) · Slovenia (23) · Germany (15) · Austria (13) · Poland (11) · Sweden (7) · Czechia (5) · Switzerland (5) · Belgium (4) · Finland (4) · Canada (3) · China (3) · Denmark (3) · Netherlands (3)
Adriana R Marques, M.D. (8) · Brian A Fallon, MD (4) · Franc Strle, MD, PhD (4) · Franc Strle, MD (3) · Franc Strle, MD PhD (3) · Ryszard Konior, MD (3) · Dasa Stupica, MD, PhD (2) · Fredrikke C Knudtzen, MD (2) · Jerzy Brzostek, MD (2) · Jerzy Dziduch, MD (2)
PMID 30075748, PMID 21592984, PMID 28545923, PMID 38830375, PMID 39248571, PMID 16837678, PMID 18567539, PMID 22523260, PMID 24523212, PMID 25728316, PMID 27028911, PMID 27248436, PMID 27812090, PMID 28750854, PMID 28878005, PMID 29048514, PMID 29385444, PMID 29505880, PMID 30796143, PMID 30928173, PMID 31590634, PMID 31710647, PMID 32133487, PMID 32528467, PMID 32728481, PMID 34031759, PMID 34452033, PMID 35101266, PMID 35289310, PMID 35323885, PMID 35483736, PMID 35491421, PMID 35816681, PMID 36209759, PMID 36741404, PMID 37419129, PMID 38262807, PMID 38614954, PMID 39029481, PMID 40073309, PMID 40265182, PMID 40294611, PMID 41137175, PMID 41213278, PMID 41563326, PMID 41610944, PMID 41703273, PMID 41741501, PMID 42086599, PMID 42680745
2023 (3), 2009 (2), 2025 (2), 2008 (1), 2015 (1), P60AR036308 (1), R01AI031561 (1), R01OH010791 (1)