9 completed, 9 unknown, 7 terminated, 6 recruiting. 40 Phase 2, 10 Phase 1, 4 Phase 3.
Follow Liver Failure, Acute: new trials by email Literature Review of Liver Failure, Acute trials Research Report on Liver Failure, Acute
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| National Collaborative Centre for Hepatic Regenerative Medicine (NC-CHRM): Evaluating Mesenchymal Stem Cell Therapy in Non-viral Acute on Chronic Liver Failure (ACLF) Patient- Phase-II Trial ucMSC and Standard medical treatment, Standard medical treatment - Acute-On-Chronic Liver Failure | Phase 2 | Not yet recruiting | Institute of Liver and Biliary Sciences, India | 100 | 2027-01-01 | 2025-08-20 |
| RENEW: Study of Porcine Liver Support in Participants With Acute-on-Chronic Liver Failure metra® Extracorporeal Liver Cross-Circulation (ELC) system (OrganOx), EGEN-5784 (genetically engineered porcine liver) - Acute on Chronic Liver Failure (ACLF), Hepatic Encephalopathy (HE) | Phase 1 / Phase 2 | Not yet recruiting | eGenesis, INC | 20 | 2026-10-01 | 2026-09-21 |
| Phase 2 Study of 500 mg BID NTZ on Top of Standard of Care in Patients With Acute Decompensation of Liver Cirrhosis at High Risk of Progression to Acute-on-Chronic Liver Failure or Established Acute-on-Chronic Liver Failure NTZ 500mg BID on top of SOC - Acute Decompensation of Liver Cirrhosis, Established Acute-on-Chronic Liver Failure | Phase 2 | Not yet recruiting | Genfit | 16 | 2026-10-01 | 2026-07-09 |
| A-TANGO Phase 2 Study Placebo, TAK-242, G-CSF (Filgrastim) - Acute-On-Chronic Liver Failure, Alcoholic Hepatitis | Phase 2 | Recruiting | Yaqrit Ltd | 78 | 2026-06-29 | 2026-09-21 |
| Chinese Phase II Trail of AS1501 in Acute-on-chronic Liver Failure (ACLF) Patients AS1501 for injection - Acute-On-Chronic Liver Failure | Phase 2 | Recruiting | Shenzhen Third People's Hospital | 96 | 2026-06-15 | 2026-07-17 |
| A Study to See if an Investigational Medicine Called VS-01 Can Help and How Safe it is in the Treatment of Patients With Overt Hepatic Encephalopathy VS-01 on top of SOC (Active Treatment Group), SOC - Hepatic Encephalopathy, Acute on Chronic Liver Failure (ACLF) | Phase 2 | Terminated | Genfit | 3 | 2025-08-25 | 2026-01-12 |
| Umbilical Cord-derived Mesenchymal Stem Cell Infusion for Treating ACLF Low-dose experimental group, High-dose experimental group, Low-dose placebo control group - Acute-On-Chronic Liver Failure | Phase 2 / Phase 3 | Not yet recruiting | National Engineering Center of Cell Products | 96 | 2025-04-15 | 2025-03-19 |
| Efficacy and Safety of Continuous Infusion of Terlipressin vs Bolus Terlipressin in ACLF Patients With Acute Esophageal Variceal Bleed Terlipressin Injectable Product - Acute on Chronic Liver Failure | Phase 2 / Phase 3 | Not yet recruiting | Institute of Liver and Biliary Sciences, India | 60 | 2025-02-10 | 2025-02-07 |
| A Novel COMBinATorial Therapy With Albumin and Enoxaparin in Patients With Decompensated Cirrhosis at High-risk of Poor Outcome (COMBAT Trial). Human albumin, Enoxaparin, Standard medical treatment - Liver Cirrhosis, Decompensated Cirrhosis of Liver | Phase 2 | Recruiting | European Foundation for Study of Chronic Liver Failure | 90 | 2024-07-01 | 2026-09-11 |
| Human Umbilical Cord Mesenchymal Stem Cell Transplantation for The Treatment of Acute-on-Chronic Liver Failure standard medical treatment, Placebo, hUC-MSC - Acute-On-Chronic Liver Failure | Phase 1 / Phase 2 | Recruiting | Beijing 302 Hospital | 150 | 2023-09-30 | 2024-05-07 |
| The Safety and Efficacy of MSC-EVs in Acute/Acute-on-Chronic Liver Failure MSC-EVs - Acute-On-Chronic Liver Failure, Acute Liver Failure | Phase 1 / Phase 2 | Withdrawn | Third Affiliated Hospital, Sun Yat-Sen University | 2023-09-01 | 2023-10-12 | |
| Efficacy, Safety and Tolerability of VS-01 in Adult Patients With Acute-on-Chronic Liver Failure and Ascites (UNVEIL-IT)® VS-01 on top of SOC, SOC (Control Group) - Acute-On-Chronic Liver Failure, Ascites | Phase 2 | Terminated | Genfit | 15 | 2023-07-02 | 2026-07-23 |
| To Evaluate the Efficacy and Safety of TYNADOTE® in the Treatment of Acetaminophen Overdose TYNADOTE, Placebo Oral Tablet - Hepatitis | Phase 2 | Recruiting | Sinew Pharma Inc. | 24 | 2023-05-01 | 2024-01-10 |
| F573 for Injection for the Treatment of Liver Injury/Failure F573 for injection, Sterilizing water for injection - Acute Liver Failure, Acute-On-Chronic Liver Failure | Phase 2 | Recruiting | Beijing Continent Pharmaceutical Co, Ltd. | 97 | 2023-03-24 | 2025-11-19 |
| Efficacy and Safety of BMSCs (CG-BM1) for ACLF Patients Bone marrow mesenchymal stem cells (low dose), Solvent of CG-BM1, Bone marrow mesenchymal stem cells (medium dose) - Acute-On-Chronic Liver Failure | Phase 1 / Phase 2 | Completed | GuangZhou Cellgenes Biotechnology Co., Ltd. | 100 | 2023-03-01 | 2026-10-21 |
| Hepatocyte Microbeads for Acute Liver Failure HMB002 - Acute Liver Failure | Phase 1 / Phase 2 | Unknown | King's College Hospital NHS Trust | 17 | 2022-09-01 | 2022-08-08 |
| TReatment for ImmUne Mediated PathopHysiology High-dose methylprednisolone, Equine anti-thymocyte globulin, Prednisolone - Acute Liver Failure, Fulminant Hepatic Failure | Phase 2 | Active not recruiting | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | 44 | 2022-02-09 | 2026-08-12 |
| Safety of UC-MSC Transfusion for ACLF Patients Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) - Acute-On-Chronic Liver Failure | Phase 2 | Unknown | Hai Li | 16 | 2021-09-30 | 2021-07-21 |
| TAK-242 in Patients With Acute Alcoholic Hepatitis TAK-242, Placebo - Acute-On-Chronic Liver Failure | Phase 2 | Terminated | Akaza Bioscience Ltd | 4 | 2020-11-12 | 2026-10-14 |
| Study to Evaluate the Efficacy and Safety of HepaStem in Patients With Acute on Chronic Liver Failure (ACLF) HepaStem, Placebo - Acute on Chronic Liver Failure | Phase 2 | Terminated | Cellaion SA | 133 | 2020-01-21 | 2024-05-22 |
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Acute-On-Chronic Liver Failure (24) · Liver Failure (8) · Liver Diseases (6) · Fibrosis (5) · Hepatic Encephalopathy (4) · Hepatitis, Alcoholic (4) · Brain Diseases (2) · Hepatitis B (2) · Kidney Diseases (2) · Liver Cirrhosis (2) · Renal Insufficiency (2) · Ascites (1) · Bacterial Infections (1) · Carcinoma, Hepatocellular (1)
Digestive System Diseases (40) · Hepatic Insufficiency (39) · Liver Diseases (34) · Liver Failure (32) · Pathologic Processes (8) · Pathological Conditions, Signs and Symptoms (8) · Central Nervous System Diseases (6) · Hepatitis (6) · Nervous System Diseases (6) · Chemically-Induced Disorders (5) · Alcohol-Induced Disorders (4) · Alcohol-Related Disorders (4) · Brain Diseases (4) · Brain Diseases, Metabolic (4)
Injections (2) · Standard of Care (2) · ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate (2) · 3-(2-(2-tert-butylphenylaminooxalyl)aminopropionylamino)-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid (1) · ALF-5755 (1) · Acetylcysteine (1) · Antilymphocyte Serum (1) · Control Groups (1) · Diphenhydramine (1) · Drug Delivery Systems (1) · Enoxaparin (1) · Filgrastim (1) · Granulocyte Colony-Stimulating Factor (1) · Methylprednisolone (1) · Methylprednisolone Hemisuccinate (1)
Vital Therapies, Inc. (4) · Genfit (3) · Cellaion SA (2) · Institute of Liver and Biliary Sciences, India (2) · Akaza Bioscience Ltd (1) · Alfact Innovation (1) · All India Institute of Medical Sciences (1) · Assistance Publique - Hôpitaux de Paris (1) · Azienda Ospedaliera di Padova (1) · Beijing 302 Hospital (1) · Beijing Continent Pharmaceutical Co, Ltd. (1) · Conatus Pharmaceuticals Inc. (1) · European Foundation for Study of Chronic Liver Failure (1) · GuangZhou Cellgenes Biotechnology Co., Ltd. (1) · HLB Cell Co., Ltd. (1)
United States (10) · China (8) · France (7) · Germany (5) · Belgium (4) · Italy (4) · Spain (4) · United Kingdom (4) · India (3) · Austria (2) · Bulgaria (1) · Denmark (1) · Estonia (1) · Georgia (1) · Hungary (1)
Robert A Ashley (2) · Amit Singhal, M.D. (1) · Angel Alsina, MD (1) · Anil Dhawan, Professor (1) · Averell Sherker, MD (1) · David J Reich, MD (1) · Dong Hyun Sinn, MD, Ph.D (1) · Dr. Shiv Kumar Sarin, DM (1) · Ed Doo, MD (1) · Estella M Alonso, MD (1) · Francesco D'Amico, MD (1) · Hai Li (1) · Jan Stange, MD, Ph.D. (1)
PMID 37183883, PMID 19505424, PMID 22859317, PMID 26983031, PMID 28284916, PMID 33011075, PMID 38409886, PMID 38925694
U01DK058369 (2), 2019 (1), 2025 (1), U01DK062436 (1)