27 completed, 12 recruiting, 7 unknown, 5 not yet recruiting. 55 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 55 | Completed 27, Recruiting 12, Unknown 7, Not yet recruiting 5, Active not recruiting 1, Enrolling by invitation 1, Terminated 1, Withdrawn 1 |
Follow Lethargy: new trials by email Literature Review of Lethargy trials Research Report on Lethargy
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Network-based tDCS for Apathy transcranial direct current stimulation, sham stimulation - Apathy, Brain Stimulation | Not applicable | Not yet recruiting | Hebrew SeniorLife | 20 | 2026-11-10 | 2026-10-28 |
| The Volunteering-in-Place Program for Apathetic Assisted Living Residents With ADRD Volunteering in Place Program, Recreational activity - Apathy in Dementia | Not applicable | Recruiting | University of Maryland, Baltimore | 200 | 2026-10-01 | 2026-10-05 |
| Motivational Intervention for Patients With Schizophrenia Positive Emotion Program for Schizophrenia (PEPS), a psychotherapeutic intervention, - Schizo-affective Disorder, Non Organic Psychosis | Not applicable | Not yet recruiting | University of Geneva, Switzerland | 88 | 2026-10-01 | 2026-10-01 |
| Accelerated rTMS for Apathy in Parkinson's Disease Accelerated intermittent theta-burst stimulation (iTBS) rTMS to left dorsomedial prefrontal cortex (dmPFC) - Parkinson Disease, Apathy | Not applicable | Recruiting | Medical University of South Carolina | 30 | 2026-09-09 | 2026-11-05 |
| SENS'REM - SENSoriality and Multi-Sensory Emotional Reminiscences: a Pilot Study Multisensory Virtual Reality Reminiscence Intervention - Apathy, Apathy in Dementia | Not applicable | Not yet recruiting | Centre Hospitalier Universitaire de Nice | 10 | 2026-09-01 | 2026-05-26 |
| Robotic Technologies for APATHy in Dementia: a Randomised Controlled Trial (RAPHAel) telepresence robotic system, Pepper robot connected to a CAIR server, Occupational Therapy - Apathy, Apathy in Dementia | Not applicable | Recruiting | Giovanna Zamboni | 75 | 2026-04-28 | 2026-05-05 |
| Neural Bases of Motivation Cortico-cortical paired-associative stimulation (ccPAS), Bifocal transcranial alternating current stimulation (tACS), Combining transcranial temporal interference stimulation (tTIS) and oscillatory TMS - Healthy Volunteers, Motivation | Not applicable | Recruiting | Hospices Civils de Lyon | 204 | 2026-01-14 | 2026-01-22 |
| Targeting Network Dysfunction in Apathy of Late-life Depression Using Digital Therapeutics Targeted Cognitive Training Intervention, General Cognitive Training Intervention - Major Depressive Disorder, Apathy | Not applicable | Recruiting | AdventHealth | 84 | 2025-09-19 | 2026-11-06 |
| VC/VS for Apathy in PD Deep Brain Stimulation - Parkinson Disease, Deep Brain Stimulation | Not applicable | Not yet recruiting | Nora Vanegas | 5 | 2025-09-01 | 2025-05-31 |
| A Virtual Life Story Club Intervention to Improve Loneliness and Apathy in Community-Dwelling Older Adults Life Story Club - Apathy, Loneliness | Not applicable | Recruiting | Montefiore Medical Center | 50 | 2025-08-15 | 2026-09-25 |
| Chronic Anergic Depression IDentification - Magnetic Resonance Imaging Exploration in the Elderly of Traits Related to Onset Functional MRI with EEG per MRI - Late Life Depression | Not applicable | Recruiting | University Hospital, Strasbourg, France | 50 | 2025-07-17 | 2026-08-21 |
| Respiratory-gated Transcutaneous Auricular Vagus Nerve Stimulation for Improving Apathy in Parkinson's Disease Active RAVANS, Sham RAVANS - Parkinson Disease, Apathy | Not applicable | Recruiting | Anhui Medical University | 60 | 2025-05-01 | 2025-11-19 |
| A Randomized Double-Blind Active-Controlled Crossover Trial of Respiratory-Gated Versus Non-Gated Transcutaneous Auricular Vagus Nerve Stimulation for the Treatment of Motor and Non-Motor Symptoms in Parkinson's Disease Transcutaneous auricular vagus nerve stimulation - Parkinson Disease, Apathy | Not applicable | Enrolling by invitation | Anhui Medical University | 30 | 2024-10-01 | 2025-12-19 |
| Apathy in Parkinson Disease TMS Study Transcranial Magnetic Stimulation (TMS) - Parkinson Disease | Not applicable | Recruiting | University of North Carolina, Chapel Hill | 100 | 2024-05-01 | 2026-07-08 |
| Stratifying Psychoses for Personalized REpetitive TMS in Persistent NEgative Symptoms Alleviation Personalized rTMS - Schizophrenia, Persistent Negative Symptoms | Not applicable | Not yet recruiting | University Hospital, Strasbourg, France | 160 | 2024-03-01 | 2023-12-28 |
| Cognitive Stimulation Therapy and Olderly People With Mild Cognitive Impairment Cognitive Stimulation Therapy - Mild Cognitive Impairment | Not applicable | Completed | Ejdane Coskun | 60 | 2023-10-30 | 2024-01-23 |
| Cognitive Stimulation Therapy Cognitive Stimulation Therapy - Alzheimer Disease 10, Dementia | Not applicable | Completed | Hasan Kalyoncu University | 56 | 2023-05-01 | 2024-03-15 |
| Home-based Transcranial Direct Current Stimulation (tDCS) for Behavioral Symptoms in Alzheimer's Disease and Related Dementias (ADRD) active tDCS - Alzheimer Disease | Not applicable | Completed | The University of Texas Health Science Center, Houston | 3 | 2023-04-17 | 2025-10-10 |
| Lifestyle Intervention for Improving Insulin Resistance and Concern for Health Diet without soy, Diet with soy - Insulin Sensitivity, Apathy | Not applicable | Completed | Pennington Biomedical Research Center | 40 | 2023-02-13 | 2026-09-09 |
| rTMS for Apathy Clinical Trial rTMS, methylphenidate - Alzheimer Disease, Apathy in Dementia | Not applicable | Recruiting | Sunnybrook Health Sciences Centre | 10 | 2023-02-09 | 2026-04-13 |
Showing 20 of 55. Sign in to see all of them.
Dementia (14) · Parkinson Disease (10) · Alzheimer Disease (7) · Depression (7) · Schizophrenia (6) · Anxiety Disorders (4) · Cognitive Dysfunction (4) · Neurocognitive Disorders (4) · Psychotic Disorders (4) · Anhedonia (3) · Behavior (2) · Fatigue (2) · Frontotemporal Dementia (2) · Mental Disorders (2)
Neurobehavioral Manifestations (55) · Neurologic Manifestations (55) · Pathological Conditions, Signs and Symptoms (55) · Signs and Symptoms (55) · Nervous System Diseases (54) · Central Nervous System Diseases (34) · Brain Diseases (32) · Mental Disorders (31) · Neurodegenerative Diseases (20) · Neurocognitive Disorders (19) · Basal Ganglia Diseases (10) · Behavior (10) · Movement Disorders (10) · Parkinsonian Disorders (10) · Synucleinopathies (10)
Transcranial Direct Current Stimulation (4) · Methylphenidate (2) · Occupational Therapy (2) · Therapeutics (2) · Transcranial Magnetic Stimulation (2) · Actigraphy (1) · Advance Care Planning (1) · Amoxicillin (1) · Deep Brain Stimulation (1) · Diet (1) · Diffusion Tensor Imaging (1) · Heart Rate (1) · Leucyl Aminopeptidase (1) · Medication Review (1) · Patient Safety (1)
Centre Hospitalier Universitaire de Nice (5) · Hospices Civils de Lyon (3) · Institut National de la Santé Et de la Recherche Médicale, France (3) · University Hospital, Strasbourg, France (3) · Anhui Medical University (2) · Sunnybrook Health Sciences Centre (2) · University Health Network, Toronto (2) · University Hospital, Clermont-Ferrand (2) · University of Maryland, Baltimore (2) · AdventHealth (1) · Centre Hospitalier de Niort (1) · Ejdane Coskun (1) · Giovanna Zamboni (1) · Hasan Kalyoncu University (1) · Hebrew SeniorLife (1)
France (17) · United States (16) · Canada (5) · China (3) · Switzerland (3) · Turkey (Türkiye) (2) · Bangladesh (1) · Germany (1) · Italy (1) · Norway (1) · Poland (1) · Singapore (1)
Cyrus DeSouza, MD (2) · Andres M Lozano, MD, PhD (1) · Andrew M Goldfine, MD (1) · Anne-Julie Vaillant-Ciszewicz, PhD (1) · Antonio L Teixeira, MD (1) · Birgit Kleim, Prof. Dr. (1) · Candida J Rebello (1) · Carmela Tartaglia, MD (1) · Christine Gulla, MD (1) · Cletus Cheyuo, MD, PhD (1) · Daniel Lench (1)
PMID 31551908, PMID 35751676, PMID 36155506, PMID 36658040, PMID 20113526, PMID 29078755, PMID 29370766, PMID 30564163, PMID 30706561, PMID 30783071, PMID 31064365, PMID 31267124, PMID 32748494, PMID 32753339, PMID 33467876, PMID 33851004, PMID 34253099, PMID 34275457, PMID 34551782, PMID 35608793, PMID 35653896, PMID 35700600, PMID 36324159, PMID 39345385, PMID 40482961, PMID 41284918, PMID 41330571, PMID 42837535
2017 (1), 2018 (1), 2025 (1), K23MH129882 (1), K23MH132884 (1), R00AG065419 (1), R01AG062685 (1), R61AG088468 (1), UM1TR004400 (1)