24 completed, 7 withdrawn, 6 active not recruiting, 5 recruiting. 35 Not applicable, 3 Phase 2, 2 Phase 1, 2 Phase 3.
Follow Knee: new trials by email Literature Review of Knee trials Research Report on Knee
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Restoration of Knee Extension After ACL Reconstruction Standard Physical Therapy, Ermi Knee Extensionater - Knee, ACL | Phase 1 | Not yet recruiting | University of Alabama at Birmingham | 58 | 2026-12-01 | 2026-10-15 |
| Autologous Adipose-Derived Stem Cell Injections for Knee Osteoarthritis Autologous Adipose-Derived Mesenchymal Stem Cells (ADMSCs), Cross-linked Hyaluronic Acid (Synovian) - Osteoarthritis, Knee | Not applicable | Recruiting | Yonsei University | 165 | 2026-09-03 | 2026-10-28 |
| The Effect of Lipedema on Knee Osteoarthritis Lipedema, Knee Osteoarthritis | Recruiting | Izmir Democracy University | 76 | 2026-07-07 | 2026-07-09 | |
| ORLINT & ORLEXT: Orthosis for Knee Orlint-Orlext orthosis device, Conventional orthosis device - Knee Brace, Knee | Not applicable | Not yet recruiting | University of Salamanca | 4 | 2026-07-01 | 2026-04-28 |
| sACB vs cACB in TKA Continuous ACB, Single-shot ACB - Arthroplasty, Replacement | Not applicable | Not yet recruiting | Yonsei University | 78 | 2026-05-18 | 2026-05-12 |
| CARTIZ Registry: Cartilage, Arthropathy and Imaging Under Tirzepatide in Zone-stratified Cohorts - A Four-Institute Mexican Observational Registry Tirzepatide - Psoriatic Arthritis, Osteoarthitis | Not yet recruiting | JULIO GRANADOS MONTIEL | 30 | 2026-05-01 | 2026-05-12 | |
| ATI Evidence-based Guide Investigating Clinical Services Primary Body Region (Arranged Most Common to Least), Lumbar/SI | Active not recruiting | ATI Holdings, LLC | 4000000 | 2026-02-24 | 2026-03-05 | |
| Hinge vs CCK Implants Condylar Constrained knee system. ( NexGen Legacy Condylar Constrained Knee by Zimmer Biomet), Rotating Hinge Knee ( NexGen Rotating Hinge Knee by Zimmer Biomet) - Revision Arthroplasty, Knee | Not applicable | Recruiting | Medstar Health Research Institute | 186 | 2026-02-01 | 2026-09-14 |
| The Effect of Continuous Care Counseling Based on the Roy Adaptation Model on Comfort and Quality of Life in Patients Undergoing Total Knee Arthroplasty Continuous Care Counseling Based on the Roy Adaptation Model - Osteoarthritis, Care Model | Not applicable | Completed | Cyprus International University | 60 | 2025-03-23 | 2026-10-09 |
| The Effect of Progressive Relaxation Exercises on Postoperative Pain progressive relaxation exercise - Arthroplasty, Replacement | Not applicable | Unknown | Bartın Unıversity | 96 | 2024-12-09 | 2024-07-30 |
| Amniotic Suspension Allograft Injection for Knee Osteoarthritis ASA injection 40 mg group, ASA injection 20 mg group, HA injection group - Knee, Osteoarthritis | Phase 3 | Recruiting | Chang Gung Memorial Hospital | 160 | 2024-10-21 | 2026-01-26 |
| Effect of Knee Mobilisation on Joint Position Sense and Tissues Pulse traction, Continuous traction, Sham therapy - Manual Therapy, Knee | Not applicable | Active not recruiting | The Jerzy Kukuczka Academy of Physical Education in Katowice | 126 | 2024-09-08 | 2025-02-21 |
| A Randomized Controlled Trial of the Sagittal Alignment Difference Between Mako Robotic TKA and Manual TKA Arthroplasty, Replacement | Unknown | Chinese PLA General Hospital | 100 | 2024-09-01 | 2024-07-30 | |
| WATERinMOTION Aquatic Therapy in Obese Men With Knee Osteoarthritis Aquatic Exercise, Land-Based Rehabilitation - Osteoarthritis, Knee | Not applicable | Enrolling by invitation | University of Sistan and Baluchestan | 100 | 2024-03-01 | 2025-04-27 |
| Development of Stance Control Orthotic Knee Joint For Improvement of KAFO Users Stance Control - Ankle Osteoarthritis, Knee | Unknown | Superior University | 2 | 2023-11-01 | 2024-05-08 | |
| Exploration of Knee Injuries Using 3 Tesla and 7 Tesla Magnetic Resonance Imaging at the University Hospital of Poitiers 7 Tesla MRI - Traumatic Knee Injury, Knee | Not applicable | Withdrawn | Poitiers University Hospital | 2023-06-15 | 2024-03-25 | |
| Blood Flow Restriction Therapy Combined With Neuromuscular Electrostimulation in Amateur Female Soccer Players Electrostimulation, Blood flow restriction therapy - Knee | Not applicable | Completed | Universidad de Extremadura | 20 | 2023-04-15 | 2023-12-12 |
| Precision Application of Clostridium Butyricm of Clinical Research on Osteoarthritis Western Ontario and McMaster University Osteoarthritis Index (WOMAC), Visual Analogue Scale (VAS), Kellgren Lawrence Grading Scale (KL score) - Osteoarthritis, Knee | Not applicable | Completed | China Medical University Hospital | 83 | 2023-04-01 | 2024-08-26 |
| Effects of Tissue Properties of the Superficial Anterior Myofascial Chain on the Development of Patellofemoral Pain Syndrome Observational - Patellofemoral Syndrome, Knee | Unknown | Istanbul Medeniyet University | 56 | 2022-09-20 | 2022-08-24 | |
| The Fast-track Centre for Hip and Knee Replacement Database Day-surgery, High-risk patient, Main Group - Hip, Knee | Completed | Copenhagen University Hospital, Rigshospitalet | 45000 | 2022-09-01 | 2026-07-09 |
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Osteoarthritis (16) · Osteoarthritis, Knee (7) · Joint Diseases (3) · Agnosia (2) · Arthritis (2) · Musculoskeletal Diseases (2) · Obesity (2) · Pain (2) · Rheumatic Diseases (2) · Arthritis, Psoriatic (1) · Atrial Fibrillation (1) · Chronic Pain (1) · Coronary Artery Disease (1) · Cutis Laxa (1) · Diabetes Mellitus (1)
Musculoskeletal Diseases (21) · Arthritis (19) · Joint Diseases (19) · Rheumatic Diseases (19) · Pathological Conditions, Signs and Symptoms (8) · Signs and Symptoms (7) · Nervous System Diseases (5) · Neurologic Manifestations (5) · Skin and Connective Tissue Diseases (5) · Connective Tissue Diseases (4) · Osteoarthritis (4) · Pathologic Processes (3) · Body Weight (2) · Neurobehavioral Manifestations (2) · Nutrition Disorders (2)
Hyaluronic Acid (2) · Ambulatory Surgical Procedures (1) · Aquatic Therapy (1) · Ascorbic Acid (1) · Blood Flow Restriction Therapy (1) · Botulinum Toxins, Type A (1) · Bupivacaine (1) · Injections, Intra-Articular (1) · Melatonin (1) · Naproxen (1) · Population Groups (1) · Tirzepatide (1) · Transcutaneous Electric Nerve Stimulation (1) · Watchful Waiting (1) · valdecoxib (1)
Smith & Nephew, Inc. (6) · Smith & Nephew Orthopaedics AG (2) · Stryker Orthopaedics (2) · The University of Tennessee, Knoxville (2) · Yonsei University (2) · ATI Holdings, LLC (1) · Bartın Unıversity (1) · Chang Gung Memorial Hospital (1) · China Medical University Hospital (1) · Chinese PLA General Hospital (1) · Copenhagen University Hospital, Rigshospitalet (1) · Cyprus International University (1) · DR R C Agrawal (1) · Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau (1) · Fundación Santa Fe de Bogota (1)
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Iain McNamara (2) · Agnieszka Polaczek, MSc (1) · Ajay Aggarwal, MD (1) · Alejandro G Della Valle, MD (1) · Alvin Ong, MD (1) · Amit Momaya, MD (1) · Andres Moron, PhD (1) · Astrid Yung (1) · Burcu Dikmen, PhD (1) · Chien-Wei Hsu, MD (1) · Christine Van den Broeck, Professor (1) · Craig Della Valle, MD (1) · David Markel, MD (1) · David Wasserstein, MD (1)
PMID 28701474, PMID 30170852, PMID 32154773, PMID 37845752, PMID 38658012, PMID 38878772, PMID 39566869, PMID 40404500, PMID 40407287, PMID 40903131, PMID 41188974, PMID 41387916, PMID 41406444, PMID 41666927, PMID 41903163, PMID 41928037, PMID 41944220, PMID 42010357
2019 (1)