43 completed, 23 recruiting, 6 active not recruiting, 6 unknown. 67 Not applicable, 9 Phase 2, 4 Phase 4, 3 Phase 1, 1 Early Phase 1.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Deep Sleep in Older Adults SleepSpaceRx CBT-I-IoT-AI, SleepEZ CBTi, Sleep Hygiene IoT - Insomnia, Insomnia Chronic | Phase 2 | Recruiting | Proactive Life Inc | 180 | 2026-09-30 | 2026-10-20 |
| Efficacy and Safety of APSTZD in the Treatment of Insomnia Disorder APSTZD 1, APSTZD 2, APSTZD 3 - Insomnia, Insomnia Chronic | Phase 2 | Recruiting | Apsen Farmaceutica S.A. | 222 | 2026-08-05 | 2026-08-21 |
| Efficacy and Accuracy of an AI-Driven Sleep Earbud for Chronic Insomnia AI-driven Neuromodulation Music (NeuroRhythm), Standard Music (Sham Control) - Insomnia, Insomnia Chronic | Not applicable | Active not recruiting | The Chinese University of Hong Kong, Shenzhen | 25 | 2026-07-01 | 2026-08-04 |
| Physical Activity Interventions for Sleep Improvement and Sedative-Hypnotic Reduction in Middle-Aged and Older Adults: Investigating the Role of Sarcopenia resistance training, Relaxation training - Insomnia Chronic, Hypnotics and Sedatives | Not applicable | Enrolling by invitation | Chang Gung Memorial Hospital | 40 | 2026-07-01 | 2026-10-29 |
| Effective of Early Treatment of Insomnia on the Adherence of CPAP digital CBT-I, CPAP - Obstructive Sleep Apnea (OSA), Insomnia Chronic | Not applicable | Not yet recruiting | Centre Hospitalier Universitaire Vaudois | 120 | 2026-06-01 | 2026-04-29 |
| Mindfulness Meditation for Insomnia Instructed bedtime app-guided mindfulness meditation, Uninstructed app-guided mindfulness meditation, Sleep hygiene education - Sleep Initiation and Maintenance Disorders, Insomnia | Phase 1 / Phase 2 | Recruiting | Brigham and Women's Hospital | 30 | 2026-03-31 | 2026-06-23 |
| Sleep Learning Education and Empowerment for Older Korean Immigrants CBT-I based sleep intervention, Sleep Education - Insomnia Chronic | Not applicable | Recruiting | University of California, Los Angeles | 32 | 2026-02-24 | 2026-03-05 |
| The Effects of Insomnia Treatment on Overnight Regulation of Emotional Memories and Risk for Mental Disorders Immediate CBCTi, Delayed CBCTi - Insomnia Chronic, Anxiety | Not applicable | Recruiting | Woolcock Institute of Medical Research | 98 | 2026-01-06 | 2025-11-26 |
| Sleep Difficulties After Loss: Exploring the Beneficial Effect of Brief Behavioral Therapy for Insomnia in a Sample of Bereaved Individuals Brief Behavioral Therapy for Insomnia, Sleep Hygiene Therapy - Insomnia, Insomnia Chronic | Not applicable | Not yet recruiting | University of Aarhus | 58 | 2025-12-30 | 2025-11-17 |
| Efficacy of Trazodone to Treat Insomnia in Older Adults (TRADITION Study) Trazodone 25 mg - Insomnia Chronic, Older People | Phase 2 | Recruiting | Centre hospitalier de l'Université de Montréal (CHUM) | 40 | 2025-11-10 | 2025-12-08 |
| Chinese Medicine in Treating Insomnia Modified Suan ZaoRen Tang-TianWang BuXin Dan, Placebo - Insomnia Chronic | Phase 2 | Recruiting | Chinese University of Hong Kong | 76 | 2025-09-25 | 2026-07-27 |
| Effect of Acupuncture on Chronic Nonspecific Neck Pain and Insomnia Acupuncture, sham acupuncture - Neck Pain Chronic, Insomnia Chronic | Not applicable | Not yet recruiting | Guang'anmen Hospital of China Academy of Chinese Medical Sciences | 124 | 2025-09-01 | 2025-07-15 |
| Nurse-supported Mobile App for Self-help CBT-I in Informal Cancer Caregivers Nurse-Supported Mobile App for Self-Help CBT-I, Sleep hygiene education - Insomnia Chronic, Cancer Caregivers | Not applicable | Completed | The University of Hong Kong | 208 | 2025-08-11 | 2026-10-19 |
| Sleep Treatment Education Program for Cancer Survivors: STEP-Together The Sleep Treatment Education Program Together (STEP-Together), Coaching Session - Insomnia, Insomnia Chronic | Not applicable | Enrolling by invitation | Dana-Farber Cancer Institute | 100 | 2025-06-25 | 2026-08-04 |
| Comparative Efficacy of BRT and CBT-I for Insomnia Cognitive behavioral therapy for insomnia (CBT-I), Bedtime restriction (BRT) - Insomnia Disorders, Insomnia Disorder | Not applicable | Recruiting | Christoph Nissen | 160 | 2025-03-10 | 2025-02-17 |
| Assessment of Usability and Preliminary Effectiveness of a Digital Sleep Aid in an Italian Sample Digital Health Technology for Chronic Insomnia, Treatment as Usual (TAU) - Insomnia Chronic, Insomnia | Not applicable | Recruiting | Universita di Verona | 50 | 2025-03-10 | 2025-04-17 |
| Tailored Treatment of Insomnia in Social and Health Care Sector Shift Workers in Occupational Health Care Cognitive behavioral therapy for insomnia, Sleep hygiene counselling - Insomnia Chronic, Shift Work Sleep Disorder | Not applicable | Active not recruiting | Finnish Institute of Occupational Health | 84 | 2025-02-17 | 2026-04-13 |
| The Impact of Light, Electrical, and Magnetic Neuroregulation Interventions on Sleep-wake Disorders Transcranial Magnetic Stimulation - Insomnia Chronic, Narcolepsy | Not applicable | Recruiting | Second Affiliated Hospital of Soochow University | 20 | 2025-02-01 | 2025-02-14 |
| Efficacy and Safety of Transcranial Magnetic Stimulation in Treatment of Insomnia with Subjective Cognitive Decline rTMS, Sham Comparator - Insomnia Chronic, Subjective Cognitive Decline (SCD) | Not applicable | Not yet recruiting | Fujian Medical University Union Hospital | 66 | 2025-01-01 | 2024-11-29 |
| Digital CBT-I for Chronic Insomnia digital CBT-I - Insomnia Chronic, Insomnia Disorder | Not applicable | Not yet recruiting | WELT corp | 120 | 2025-01-01 | 2024-11-19 |
Showing 20 of 88. Sign in to see all of them.
Sleep Initiation and Maintenance Disorders (88) · Sleep Wake Disorders (10) · Anxiety Disorders (7) · Depression (7) · Chronic Pain (5) · Cognitive Dysfunction (4) · Parasomnias (3) · Autism Spectrum Disorder (2) · Hypertension (2) · Motor Activity (2) · Oppositional Defiant Disorder (2) · Osteoarthritis (2) · Sleep Apnea, Obstructive (2) · Stress Disorders, Post-Traumatic (2) · Asthma (1)
Dyssomnias (88) · Nervous System Diseases (88) · Sleep Disorders, Intrinsic (88) · Mental Disorders (87) · Sleep Wake Disorders (78) · Pathological Conditions, Signs and Symptoms (19) · Signs and Symptoms (17) · Neurologic Manifestations (16) · Behavior (11) · Behavioral Symptoms (8) · Neurocognitive Disorders (5) · Brain Diseases (4) · Central Nervous System Diseases (4) · Cognition Disorders (4) · Neurodevelopmental Disorders (4)
Cognitive Behavioral Therapy (12) · Exercise (2) · Relaxation Therapy (2) · Therapeutics (2) · Trazodone (2) · zopiclone (2) · Acupuncture Therapy (1) · Blood Glucose Self-Monitoring (1) · Chloral Hydrate (1) · Clonidine (1) · Digital Health (1) · Electroacupuncture (1) · Fecal Microbiota Transplantation (1) · Hygiene (1) · Hypnotics and Sedatives (1)
University of Pennsylvania (5) · University of Aarhus (3) · University of Missouri-Columbia (3) · University of South Florida (3) · Chang Gung Memorial Hospital (2) · Diakonhjemmet Hospital (2) · The Hong Kong Polytechnic University (2) · University of California, Los Angeles (2) · University of Pittsburgh (2) · University of Washington (2) · Xuanwu Hospital, Beijing (2) · Aarhus University Hospital (1) · Apsen Farmaceutica S.A. (1) · Azienda Ospedaliero, Universitaria Pisana (1) · Balearic Islands Health Service (Ibsalut) (1)
United States (33) · China (10) · Canada (6) · Denmark (4) · Norway (4) · Brazil (3) · Hong Kong (3) · Italy (3) · Taiwan (3) · Finland (2) · France (2) · Switzerland (2) · United Kingdom (2) · Australia (1) · Belgium (1)
Jean Tang, PhD (2) · Philip Gehrman, PhD (2) · Robert Zachariae, DMSc, MSc (2) · Alexa Kane (1) · Alexander D Castro-Pavlik, PhD-student, MSc in Psychology (1) · Alexandros Vgontzas, MD (1) · Alice KY Siu, MMed, FRCSEd(ORL) (1) · Andrew Kubala, MS (1) · Barbara Cagnie, PhD (1) · Benicio N Frey, MD, MSc, PhD (1) · Christina McCrae (1) · Christina McCrae, PhD (1) · Christina S McCrae, PhD (1) · Christopher Recklitis, PhD, MPH (1)
PMID 11556941, PMID 17974868, PMID 1798888, PMID 18041487, PMID 18364524, PMID 19544753, PMID 21145786, PMID 21532953, PMID 22294820, PMID 24238871, PMID 24571603, PMID 25257144, PMID 25874938, PMID 25931250, PMID 26294268, PMID 26446111, PMID 28777364, PMID 28851459, PMID 28992829, PMID 29482814, PMID 29514705, PMID 30195661, PMID 30353817, PMID 30389347, PMID 31203649, PMID 31410909, PMID 33863276, PMID 34321944, PMID 34433593, PMID 35313849, PMID 35426736, PMID 35633158, PMID 35940841, PMID 36045710, PMID 36085009, PMID 37434109, PMID 37616032, PMID 38485134, PMID 38980675, PMID 39120902, PMID 39292452, PMID 40063947, PMID 40636932, PMID 40866978, PMID 42026772, PMID 42110592, PMID 42199304, PMID 8561380
1UG3HL161342-01A1 (1), 2025 (1), K23AT012475 (1), R01AG054521 (1), R01HL165115 (1), R03HL135213 (1), R21AG086817 (1), R21NR017446 (1), R34DA047466 (1), R43AG097205 (1)