5 recruiting, 4 completed. 9 Phase 2, 3 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 9 | Recruiting 5, Completed 4 |
| Phase 1 | 3 | Completed 2, Recruiting 1 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Deep Sleep in Older Adults SleepSpaceRx CBT-I-IoT-AI, SleepEZ CBTi, Sleep Hygiene IoT - Insomnia, Insomnia Chronic | Phase 2 | Recruiting | Proactive Life Inc | 180 | 2026-09-30 | 2026-10-20 |
| Efficacy and Safety of APSTZD in the Treatment of Insomnia Disorder APSTZD 1, APSTZD 2, APSTZD 3 - Insomnia, Insomnia Chronic | Phase 2 | Recruiting | Apsen Farmaceutica S.A. | 222 | 2026-08-05 | 2026-08-21 |
| Mindfulness Meditation for Insomnia Instructed bedtime app-guided mindfulness meditation, Uninstructed app-guided mindfulness meditation, Sleep hygiene education - Sleep Initiation and Maintenance Disorders, Insomnia | Phase 1 / Phase 2 | Recruiting | Brigham and Women's Hospital | 30 | 2026-03-31 | 2026-06-23 |
| Efficacy of Trazodone to Treat Insomnia in Older Adults (TRADITION Study) Trazodone 25 mg - Insomnia Chronic, Older People | Phase 2 | Recruiting | Centre hospitalier de l'Université de Montréal (CHUM) | 40 | 2025-11-10 | 2025-12-08 |
| Chinese Medicine in Treating Insomnia Modified Suan ZaoRen Tang-TianWang BuXin Dan, Placebo - Insomnia Chronic | Phase 2 | Recruiting | Chinese University of Hong Kong | 76 | 2025-09-25 | 2026-07-27 |
| The Efficacy and Safty of FMT in Patients With CID fecal microbiota, Placebo, synbiotics - Insomnia Chronic, Fecal Microbiota Transplantation | Phase 1 / Phase 2 | Completed | Peking University Sixth Hospital | 80 | 2023-10-08 | 2026-02-27 |
| Cannabinoids as a Treatment for Insomnia in Major Depression 25:1 CBD/THC, 5:1 CBD/THC, Placebo - Insomnia, Depressive Disorder, Major | Phase 2 | Completed | St. Joseph's Healthcare Hamilton | 14 | 2023-08-28 | 2026-01-22 |
| Montmorency Cherry Supplementation, Sleep, and Inflammation Montmorency cherry supplement, Control - Insomnia Chronic, Inflammation | Phase 1 / Phase 2 | Completed | Michigan State University | 34 | 2023-02-18 | 2025-09-08 |
| Effectiveness of BBT-I and Zopiclone for Chronic Insomnia Brief behavioral therapy, Zopiclone - Insomnia Chronic | Phase 2 | Completed | I.M. Sechenov First Moscow State Medical University | 42 | 2015-04-07 | 2019-09-16 |
Sleep Initiation and Maintenance Disorders (9) · Cognitive Dysfunction (2) · Depression (2) · Sleep Wake Disorders (2) · Anxiety Disorders (1) · Depressive Disorder, Major (1) · Inflammation (1) · Marijuana Abuse (1) · Psychological Well-Being (1)
Dyssomnias (9) · Mental Disorders (9) · Nervous System Diseases (9) · Sleep Disorders, Intrinsic (9) · Sleep Wake Disorders (7) · Pathological Conditions, Signs and Symptoms (3) · Behavior (2) · Behavioral Symptoms (2) · Cognition Disorders (2) · Neurocognitive Disorders (2) · Neurologic Manifestations (2) · Signs and Symptoms (2) · Chemically-Induced Disorders (1) · Depressive Disorder (1) · Mood Disorders (1)
Fecal Microbiota Transplantation (1) · Hypnotics and Sedatives (1) · Synbiotics (1) · Trazodone (1) · zopiclone (1)
Apsen Farmaceutica S.A. (1) · Brigham and Women's Hospital (1) · Centre hospitalier de l'Université de Montréal (CHUM) (1) · Chinese University of Hong Kong (1) · I.M. Sechenov First Moscow State Medical University (1) · Michigan State University (1) · Peking University Sixth Hospital (1) · Proactive Life Inc (1) · St. Joseph's Healthcare Hamilton (1)
United States (3) · Canada (2) · Brazil (1) · China (1) · Hong Kong (1)
Benicio N Frey, MD, MSc, PhD (1) · Daniel Taylor, PhD (1) · Nirushi Kuhathasan, PhD (1) · Polina Pchelina, PG student (1) · Zhixiu Lin (1)
2025 (1), K23AT012475 (1), R43AG097205 (1)