74 completed, 47 unknown, 29 recruiting, 19 terminated. 59 Not applicable, 22 Phase 2, 16 Phase 4, 10 Phase 1, 9 Phase 3.
Follow Hypothalamic Neoplasms: new trials by email Literature Review of Hypothalamic Neoplasms trials Research Report on Hypothalamic Neoplasms
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Perimetry Based on Eye-movements in Patients With (Supra)Sellar Tumors SONDA - Pituitary Tumor, Visual Fields Hemianopsia | Not yet recruiting | University Medical Center Groningen | 30 | 2026-12-01 | 2026-07-23 | |
| China Treatment Trial for Tumor in Sellar Region With Unruptured Intracranial Aneurysm Tumor resection followed by aneurysm treatment, Aneurysm treatment followed by tumor resection, Observation - Unruptured Intracranial Aneurysms, Pituitary Neuroendocrine Tumor | Active not recruiting | Cheng sen | 608 | 2026-10-20 | 2026-10-21 | |
| PRESTO: A Phase III Randomised Controlled Trial of Dose-escalated Proton Beam Therapy Versus Standard of Care Radiotherapy for Functioning Pituitary Tumours Standard dose Intensity-Modulated Radiation Therapy (IMRT), Standard dose Proton Beam Therapy (PBT), Escalated dose Proton Beam Therapy (PBT) - Acromegaly Due to Pituitary Adenoma, Cushing's Disease | Phase 3 | Not yet recruiting | University College, London | 82 | 2026-09-01 | 2026-10-01 |
| Temozolomide in Aggressive Pituitary Neuroendocrine Tumors: A Latin American Multicenter Retrospective Cohort (TMZ-LATAM) temozolamide, Temozolamide - Pituitary Neoplasms | Not yet recruiting | University of Sao Paulo General Hospital | 80 | 2026-08-01 | 2026-07-10 | |
| Pilot Study Evaluating Panitumumab-IRDye800 as an Optical Imaging Agent to Detect Intracranial Lesions During Neurosurgical Procedures Panitumumab-IRDye800 - Meningioma, Glioblastoma | Early Phase 1 | Recruiting | Eben Rosenthal | 30 | 2026-07-07 | 2026-10-16 |
| Direct Versus Video Laryngoscopy in Patients With Acromegaly Acromegaly, Nonfunctioning Pituitary Adenoma | Not yet recruiting | Muzaffer GENCER | 40 | 2026-07-01 | 2026-06-22 | |
| AI in Endoscopic Transsphenoidal Surgery Live intra-op AI analysis of endoscopic video feed, with output displayed on supplementary monitor - Pituitary Adenoma | Early Phase 1 | Not yet recruiting | University College, London | 30 | 2026-06-01 | 2026-05-05 |
| Standardized Patient Education in Pituitary Surgery Standardized Pituitary Training - Pituitary Adenoma | Not applicable | Not yet recruiting | Uludag University | 102 | 2026-06-01 | 2026-06-01 |
| FET PET/CT Imaging To Localize Pituitary Adenomas In Cushing Disease Fluoro-O-(2) fluoroethyl-L-tyrosine (FET) PET - Cushing Disease, Pituitary Adenoma | Early Phase 1 | Recruiting | Mayo Clinic | 50 | 2026-04-27 | 2026-06-22 |
| DDAVP for Pituitary Adenoma Desmopressin acetate - Cushing's Disease, Pituitary Adenoma | Not applicable | Recruiting | National Institute of Neurological Disorders and Stroke (NINDS) | 22 | 2026-03-09 | 2026-04-09 |
| Clinical Trial of an Anti-Fog Drainage Device for Endoscopic Endonasal Sellar Region Tumor Surgery Anti-fog suction device-a 4 Fr multi-channel silicone catheter - Pituitary Adenoma, Craniopharyngioma | Not applicable | Recruiting | West China Hospital | 20 | 2026-03-01 | 2026-06-30 |
| Use of [18F] Fluoroethyl-L-tyrosine PET/MRI for Identifying Small Functional Pituitary Adenomas FET-PET/MRI - Pituitary Adenoma | Phase 1 | Recruiting | Mayo Clinic | 5 | 2026-01-08 | 2026-03-09 |
| How Estrogen Fluctuations Before Diagnosis Affect the Size Prolactin-secreting Tumors Standardized questionnaire - Prolactinoma, Macroprolactinoma | Completed | Hospices Civils de Lyon | 171 | 2026-01-06 | 2026-10-23 | |
| Prediction Model for Postoperative Headache After Transsphenoidal Pituitary Surgery Transsphenoidal Pituitary Surgery - Headache, Pituitary Adenoma | Active not recruiting | Beijing Tiantan Hospital | 500 | 2026-01-01 | 2026-03-03 | |
| Clinical Evaluation of [68Ga]Ga-NOTA-RF PET Imaging Targeting RFVT3 in Patients With Pituitary Tumors [68Ga]Ga-NOTA-RF - Pituitary Neoplasms | Early Phase 1 | Enrolling by invitation | Peking Union Medical College Hospital | 30 | 2025-11-17 | 2025-11-28 |
| Comparison of NeuroEXPLORER PET/CT Versus Standard-of-care PET/CT of the Head and Neck Region. Standard-of-care PET/CT, NeuroEXPLORER - Dementia, Movement Disorders | Not applicable | Enrolling by invitation | prof. dr. Koen Van Laere | 1600 | 2025-09-30 | 2026-05-19 |
| NoSeal Trial: Comparing Sealants Versus No Sealant for Preventing CSF Leak After Endonasal Skull Base Surgery Standard multilayer closure without sealant, Fibrin sealant application, Synthetic polyethylene glycol-based sealant - CerebroSpinal Fluid (CSF) Leak | Not applicable | Recruiting | Maria Sklodowska-Curie National Research Institute of Oncology | 225 | 2025-08-15 | 2025-10-14 |
| Proton Versus Photon Radiotherapy in Adults With Primary Brain Tumors Proton Beam Therapy, Photon Radiotherapy - Primary Brain Tumors, Diffuse Glioma | Not applicable | Recruiting | Tata Memorial Centre | 156 | 2025-07-01 | 2025-09-16 |
| The PROMISE Survey Prolactinoma, Pituitary Tumor | Active not recruiting | University Hospital, Basel, Switzerland | 530 | 2025-06-13 | 2026-01-08 | |
| KETO-TUMOR: a Study on Brain Tumors and Central Obesity Dietary intervention - Obese Patients, Hypothalamic Neoplasms | Not applicable | Recruiting | Meyer Children's Hospital IRCCS | 30 | 2025-05-08 | 2026-02-09 |
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Pituitary Neoplasms (192) · Acromegaly (23) · Pituitary Diseases (20) · Brain Neoplasms (18) · Meningioma (18) · Prolactinoma (13) · Craniopharyngioma (11) · Pituitary ACTH Hypersecretion (10) · Glioma (8) · Glioblastoma (7) · Growth Hormone-Secreting Pituitary Adenoma (7) · Medulloblastoma (7) · Neoplasms (7) · Astrocytoma (6) · Neuroectodermal Tumors, Primitive (6)
Brain Diseases (197) · Central Nervous System Diseases (197) · Hypothalamic Diseases (197) · Neoplasms by Site (197) · Nervous System Neoplasms (197) · Supratentorial Neoplasms (197) · Nervous System Diseases (196) · Endocrine System Diseases (193) · Central Nervous System Neoplasms (192) · Endocrine Gland Neoplasms (191) · Neoplasms (190) · Brain Neoplasms (179) · Pituitary Diseases (173) · Neoplasms by Histologic Type (50)
Cabergoline (7) · pasireotide (7) · Surgical Procedures, Operative (4) · Dexmedetomidine (3) · Hydrocortisone (3) · Propofol (3) · Proton Therapy (3) · Temozolomide (3) · Aminolevulinic Acid (2) · Desflurane (2) · Dexamethasone (2) · Human Growth Hormone (2) · Octreotide (2) · Radiosurgery (2) · Radiotherapy (2)
Huashan Hospital (8) · Novartis Pharmaceuticals (8) · Peking Union Medical College Hospital (6) · St. Joseph's Hospital and Medical Center, Phoenix (6) · Federico II University (5) · National Institute of Neurological Disorders and Stroke (NINDS) (5) · Beijing Tiantan Hospital (4) · Columbia University (4) · Mayo Clinic (4) · University Hospital, Basel, Switzerland (4) · Cedars-Sinai Medical Center (3) · Hospices Civils de Lyon (3) · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (3) · National Taiwan University Hospital (3) · Second Affiliated Hospital, Zhejiang University, School of Medicine (3)
United States (69) · China (31) · Italy (16) · France (15) · Turkey (Türkiye) (11) · Canada (10) · Germany (10) · South Korea (9) · Belgium (7) · Brazil (7) · United Kingdom (7) · Netherlands (6) · Switzerland (6) · Taiwan (6) · Argentina (5)
Andrew Little, MD (3) · Bing Xing, MD (3) · Gilda Cennamo (3) · Prashant Chittiboina, M.D. (3) · Wei Lian, MD (3) · Yao Zhao, M.D. (3) · Andrew S Little, MD (2) · Annamaria AL Colao, Prof. (2) · Anthony Heaney, MD (2) · Harry T Whelan, MD (2) · Jung Hee Kim, M.D (2) · Abel Huang, MD (1)
PMID 19556464, PMID 25209242, PMID 29343557, PMID 31062234, PMID 35954244, PMID 10022400, PMID 10199767, PMID 10199774, PMID 10372687, PMID 10469005, PMID 10690849, PMID 10999798, PMID 11207626, PMID 11273062, PMID 11344175, PMID 11397887, PMID 11531927, PMID 11889170, PMID 12843148, PMID 12924350, PMID 14764779, PMID 15070920, PMID 15126541, PMID 15355453, PMID 15579750, PMID 15585563, PMID 15613435, PMID 15671089, PMID 15827109, PMID 15886238, PMID 15886256, PMID 15985481, PMID 16373932, PMID 16449332, PMID 16487447, PMID 16509142, PMID 16537687, PMID 16690338, PMID 17244780, PMID 1738293, PMID 17695407, PMID 17862444, PMID 17984237, PMID 18593773, PMID 18728566, PMID 18780796, PMID 19240574, PMID 1973979, PMID 19970261, PMID 21748460
2004 (1), 2008 (1), 2014 (1), 2018 (1), 2025 (1), P30CA138292 (1), R01NS052274 (1), R01NS070600 (1), R56DK064720 (1), U01CA097452 (1)