44 completed, 32 active not recruiting, 30 recruiting, 16 terminated. 62 Not applicable, 51 Phase 2, 21 Phase 1, 10 Phase 3, 2 Phase 4.
Follow Proton Therapy: new trials by email Literature Review of Proton Therapy trials Research Report on Proton Therapy
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| PRESTO: A Phase III Randomised Controlled Trial of Dose-escalated Proton Beam Therapy Versus Standard of Care Radiotherapy for Functioning Pituitary Tumours Standard dose Intensity-Modulated Radiation Therapy (IMRT), Standard dose Proton Beam Therapy (PBT), Escalated dose Proton Beam Therapy (PBT) - Acromegaly Due to Pituitary Adenoma, Cushing's Disease | Phase 3 | Not yet recruiting | University College, London | 82 | 2026-09-01 | 2026-10-01 |
| Integration of Adaptive Proton Therapy in Pediatric Solid Tumors and Hodgkin's Lymphoma Proton Therapy (Adaptive) - Pediatric Solid Tumors, Rhabdomyosarcoma | Not applicable | Recruiting | St. Jude Children's Research Hospital | 100 | 2026-08-20 | 2026-08-21 |
| Proton Therapy for Mediastinal Lymphoma (PROMLY) Proton therapy - Mediastinal Lymphoma, Hodgkin Disease Lymphoma | Not applicable | Recruiting | Copenhagen University Hospital, Rigshospitalet | 139 | 2026-05-01 | 2026-09-14 |
| Research on Real-time Proton Therapy Guidance Through Monitoring Proton Range Using All-digital PET proton therapy - Solid Tumor | Active not recruiting | Shuanghu Yuan | 30 | 2026-02-01 | 2026-03-10 | |
| Reduction of Gastrointestinal Toxicity in Prostate Cancer by Proton Spot Placement Spot Delete planning for proton therapy, Traditional proton treatment planning system - Prostate Cancer, Prostate Adenocarcinoma | Not applicable | Recruiting | Covenant Health Cancer Center | 500 | 2025-12-15 | 2025-12-18 |
| Phase I/ II Trial Combining PD-1 Inhibition and Neoadjuvant Proton or Photon Radiation Therapy in Recurrent Head and Neck Squamous Cell Carcinoma Proton therapy, Pembrolizumab - Head and Neck Cancer, Recurrent Head and Neck Squamous Cell Carcinoma | Phase 1 / Phase 2 | Recruiting | University of Cincinnati | 40 | 2025-10-08 | 2026-07-01 |
| Clinical Trial of the Safety and Efficacy of IBA Proton Therapy System PROTEUS® PLUS (Sichuan) Proton Beam Therapy (PBT) - Solid Tumor, Adult | Not applicable | Active not recruiting | Ion Beam Applications | 47 | 2025-08-19 | 2026-01-07 |
| Clinical Trial of the Safety and Efficacy of IBA Proton Therapy System PROTEUS® PLUS (Shenzhen) Proton Beam Therapy (PBT) - Solid Tumor, Adult | Not applicable | Active not recruiting | Ion Beam Applications | 47 | 2025-08-04 | 2026-01-16 |
| Proton Versus Photon Radiotherapy in Adults With Primary Brain Tumors Proton Beam Therapy, Photon Radiotherapy - Primary Brain Tumors, Diffuse Glioma | Not applicable | Recruiting | Tata Memorial Centre | 156 | 2025-07-01 | 2025-09-16 |
| PIRATES: Image-guided Hyper-fractioned Dose-escalation With Proton Therapy for Head and Neck Cancer Image guided hybrid hyper-fractioned dose escalation with proton therapy - Head and Neck Cancer, Oropharyngeal Cancer | Phase 1 | Recruiting | University Medical Center Groningen | 17 | 2025-05-01 | 2025-04-03 |
| Clinical Trial of the Safety and Efficacy of IBA Proton Therapy System PROTEUS® PLUS (Hebei) Proton Beam Therapy (PBT) - Solid Tumor, Adult | Not applicable | Active not recruiting | Ion Beam Applications | 47 | 2025-04-29 | 2026-02-27 |
| Proton Therapy for Recurrent Nasopharyngeal Carcinoma Proton therapy, Proton radiation therapy - Recurrent Nasopharyngeal Carcinoma | Not applicable | Recruiting | Guangzhou Concord Cancer Center | 52 | 2025-03-10 | 2026-03-09 |
| Pencil Beam Scanning Proton Beam Radiotherapy for the Management of Abdominal Neuroblastoma Proton Beam Therapy - Abdominal Neuroblastoma | Not applicable | Not yet recruiting | The Christie NHS Foundation Trust | 100 | 2025-03-01 | 2025-02-03 |
| Proton Beam Radiation Therapy After Treatment for Resected N2 Non-Small Cell Lung Cancer Biospecimen Collection, Proton Beam Radiation Therapy, Radiology, Treatment Planning - Resectable Lung Non-Small Cell Carcinoma | Phase 2 | Recruiting | Emory University | 10 | 2024-12-13 | 2026-09-16 |
| Investigating the Role of Adjuvant Proton Beam Therapy in Patients With Parotid Carcinoma Proton Beam Therapy - Parotid Cancer | Not applicable | Not yet recruiting | The Christie NHS Foundation Trust | 97 | 2024-11-01 | 2024-08-21 |
| Evaluation of Combined Modality Protons and Hepatic Transplantation for Hilar Cholangiocarcinoma Proton Beam Therapy, Concurrent oral capecitabine chemotherapy, Cisplatin & Gemcitabine intravenous chemotherapy - Cholangiocarcinoma | Not applicable | Not yet recruiting | The Christie NHS Foundation Trust | 30 | 2024-11-01 | 2024-08-21 |
| Varian ProBeam360° Proton Therapy System China Clinical Trial (Wuhan) Proton Radiation Therapy - Tumor, Solid | Not applicable | Completed | Varian, a Siemens Healthineers Company | 47 | 2024-09-05 | 2025-12-15 |
| Proton Therapy for Locally Advanced Cervical Cancer Proton therapy - Cervical Cancer, Proton Therapy | Phase 2 | Recruiting | University of Aarhus | 55 | 2024-05-20 | 2024-06-17 |
| Short Term Outcomes After PRoton and PhotoN RadiOtherapy for IDH Mutated Grade 2 and 3 Gliomas proton therapy, photon therapy - Glioma, Radiotherapy; Complications | Recruiting | Erasmus Medical Center | 320 | 2024-05-01 | 2024-10-15 | |
| Hemithoracic Irradiation With Proton Therapy in Malignant Pleural Mesothelioma Proton beam therapy - Malignant Pleural Mesothelioma | Not applicable | Recruiting | University College, London | 148 | 2024-03-28 | 2026-03-30 |
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Carcinoma, Non-Small-Cell Lung (14) · Prostatic Neoplasms (14) · Brain Neoplasms (12) · Glioma (7) · Sarcoma (7) · Meningioma (6) · Breast Neoplasms (5) · Esophageal Neoplasms (5) · Lung Neoplasms (5) · Pancreatic Neoplasms (5) · Carcinoma, Hepatocellular (4) · Glioblastoma (4) · Neoplasms (4) · Squamous Cell Carcinoma of Head and Neck (4) · Chondrosarcoma (3)
Massachusetts General Hospital (17) · M.D. Anderson Cancer Center (14) · Abramson Cancer Center at Penn Medicine (13) · St. Jude Children's Research Hospital (8) · University of Florida (8) · National Cancer Center, Korea (6) · Emory University (5) · Loma Linda University (5) · Mayo Clinic (5) · NRG Oncology (4) · Proton Collaborative Group (4) · University of Aarhus (4) · University of Zurich (4) · Washington University School of Medicine (4) · Ion Beam Applications (3)
United States (98) · South Korea (8) · China (7) · Germany (6) · Denmark (5) · Switzerland (5) · Canada (3) · Netherlands (3) · India (2) · Sweden (2) · United Kingdom (2) · Belgium (1) · France (1) · Israel (1) · Italy (1)
Gary Yang, MD (4) · Tae Hyun Kim, Ph.D (3) · Carlos Vargas, MD (2) · Curtiland Deville, MD (2) · Helen A Shih, MD (2) · Romaine C Nichols, MD (2) · Shannon MacDonald, MD (2) · Steven J Frank (2) · Thomas E. Merchant, DO, PhD (2) · Torunn Yock, MD (2) · Zhongxing Liao (2) · Adam P. Dicker, MD, PhD (1) · Alejandra Mendez Romero, MD PhD (1) · Anthony Zietman, MD (1)
PMID 33607632, PMID 41005671, PMID 16332601, PMID 20859129, PMID 21050498, PMID 21330656, PMID 21909812, PMID 23388559, PMID 24423462, PMID 24867540, PMID 25105369, PMID 25260491, PMID 26493095, PMID 26895711, PMID 27084653, PMID 27846903, PMID 28984517, PMID 29293386, PMID 30118397, PMID 30223877, PMID 30630500, PMID 30788166, PMID 31145418, PMID 31449469, PMID 31773043, PMID 31786276, PMID 31996395, PMID 32160096, PMID 32615102, PMID 32844399, PMID 32972877, PMID 33031846, PMID 33051340, PMID 33096027, PMID 33198942, PMID 33579340, PMID 33979653, PMID 34749885, PMID 34841093, PMID 35483358, PMID 35837200, PMID 36028065, PMID 36092320, PMID 36260832, PMID 36531700, PMID 37084748, PMID 37201756, PMID 37652304, PMID 37717786, PMID 38241600
P30CA138292 (5), U10CA180868 (5), P01CA021239 (4), U19CA021239 (4), U10CA021661 (2), 2019 (1), P30CA013330 (1), P30CA015704 (1), P50CA127001 (1), R03CA188162 (1), R56DE025248 (1), U10CA180820 (1), U10CA180822 (1)