29 completed, 11 recruiting, 5 terminated, 5 unknown. 14 Phase 2, 13 Phase 3, 7 Not applicable, 4 Phase 4, 3 Phase 1.
Follow Pituitary ACTH Hypersecretion: new trials by email Literature Review of Pituitary ACTH Hypersecretion trials Research Report on Pituitary ACTH Hypersecretion
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| PRESTO: A Phase III Randomised Controlled Trial of Dose-escalated Proton Beam Therapy Versus Standard of Care Radiotherapy for Functioning Pituitary Tumours Standard dose Intensity-Modulated Radiation Therapy (IMRT), Standard dose Proton Beam Therapy (PBT), Escalated dose Proton Beam Therapy (PBT) - Acromegaly Due to Pituitary Adenoma, Cushing's Disease | Phase 3 | Not yet recruiting | University College, London | 82 | 2026-09-01 | 2026-10-01 |
| Use of [18F]FET PET-MRI to Improve Detection of Pituitary Adenomas in Cushing's Disease [18F]FET PET-MRI - Cushing Disease | Not applicable | Enrolling by invitation | University Hospital, Basel, Switzerland | 43 | 2026-06-04 | 2026-07-06 |
| Combination Osilodrostat and Cabergoline in Cushing's Disease osilodrostat, osilodrostat and cabergoline - Cushing Disease Due to Increased ACTH Secretion | Phase 4 | Enrolling by invitation | University of Basrah | 50 | 2026-05-11 | 2026-05-22 |
| FET PET/CT Imaging To Localize Pituitary Adenomas In Cushing Disease Fluoro-O-(2) fluoroethyl-L-tyrosine (FET) PET - Cushing Disease, Pituitary Adenoma | Early Phase 1 | Recruiting | Mayo Clinic | 50 | 2026-04-27 | 2026-06-22 |
| DDAVP for Pituitary Adenoma Desmopressin acetate - Cushing's Disease, Pituitary Adenoma | Not applicable | Recruiting | National Institute of Neurological Disorders and Stroke (NINDS) | 22 | 2026-03-09 | 2026-04-09 |
| Effect of Vorinostat on ACTH Producing Pituitary Adenomas in Cushing s Disease Vorinostat - Cushing's Disease | Phase 2 | Withdrawn | National Institute of Neurological Disorders and Stroke (NINDS) | 2025-04-11 | 2025-04-15 | |
| Fimepinostat, Combination HDAC and Pi3-kinase Inhibitor Tumor-Directed Therapy for Cushing Disease Fimepinostat - Cushing Disease | Phase 2 | Recruiting | University of California, Los Angeles | 20 | 2025-01-16 | 2026-07-17 |
| Osilodrostat Therapy and 11C-methionine PET to Improve Corticotroph Adenoma Detection 11C-Methionine PET/CT - Cushing's Disease, Hypercortisolism | Not yet recruiting | Imperial College London | 15 | 2024-12-03 | 2024-12-03 | |
| A Trial of Lu AG13909 in Adult Participants With Cushing's Disease Lu AG13909 - Cushing's Disease | Phase 2 | Active not recruiting | H. Lundbeck A/S | 16 | 2024-06-19 | 2026-10-16 |
| Evaluation of Intraoperative Contrast Enhanced Ultrasound for the Identification of Pituitary Adenoma in Cushing's Disease Compared to Other Pituitary Tumors Contrast enhanced pituitary magnetic resonance imaging (MRI), Contrast enhanced ultrasound, Non-Contrast Ultrasound - Pituitary Adenoma, Cushing Disease | Recruiting | Mayo Clinic | 110 | 2024-06-19 | 2026-01-13 | |
| Evaluation of Positron Emission Tomography (PET) With [18F]FET for the Detection of ACTH-Secreting Corticotroph Pituitary Neuroendocrine Tumors. Data-only evaluation of [18F]FET PET, pituitary MRI, and biomarkers - Cushing Disease, ACTH-producing Pituitary Tumour | Recruiting | Hospices Civils de Lyon | 20 | 2023-11-23 | 2026-03-11 | |
| A Study to Evaluate the Safety and PK of CRN04894 for the Treatment of Cushing's Syndrome atumelnant - Cushing Syndrome, Cushing Disease | Phase 1 / Phase 2 | Completed | Crinetics Pharmaceuticals Inc. | 19 | 2023-10-12 | 2026-10-14 |
| SPI-62 as a Treatment for Adrenocorticotropic Hormone-dependent Cushing's Syndrome SPI-62, Placebo - Cushing's Syndrome I, Cushing Disease Due to Increased ACTH Secretion | Phase 2 | Completed | Sparrow Pharmaceuticals | 26 | 2022-09-01 | 2025-10-08 |
| Modified Desmopressin (mDesmo) Using Cold-Kit for PET/CT Cushing Syndrome | Recruiting | Post Graduate Institute of Medical Education and Research, Chandigarh | 100 | 2022-08-15 | 2025-05-20 | |
| Hair Cortisol and Cushing's Disease Patient group, Remission control group, Bilateral surrenalectomy control group - Cushing Disease | Not applicable | Completed | University Hospital, Bordeaux | 51 | 2021-03-10 | 2023-07-18 |
| Postoperative Thrombosis Prevention in Patients With CD LMWH/Rivaroxaban, IPC - Cushing Disease, DVT | Not applicable | Active not recruiting | Huashan Hospital | 206 | 2020-12-01 | 2025-07-02 |
| Nailfold Capillaroscopy Evaluation in Cushing Syndrome Patients Cushing Syndrome, Hypercortisolism | Unknown | Marmara University | 200 | 2020-06-15 | 2020-06-16 | |
| Diagnostic Yield of Deep Learning Based Denoising MRI in Cushing's Disease MRI - Pituitary ACTH Secreting Adenoma | Terminated | Asan Medical Center | 15 | 2020-01-10 | 2024-05-14 | |
| Recovery From Cushing Syndrome and Mild Autonomous Cortisol Secretion (MACS) MUSE biofeedback - Cushing Syndrome | Recruiting | Mayo Clinic | 700 | 2019-07-25 | 2026-09-18 | |
| Discriminant Capacity and Thresholds of Salivary Cortisol in Chemiluminescence in the Diagnosis of Hypercorticisms Blood test, 24-hour Urine test, Saliva swab - Cushing Disease | Active not recruiting | Centre Hospitalier Universitaire de Nīmes | 380 | 2019-07-01 | 2025-11-17 |
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Cushing Syndrome (18) · ACTH Syndrome, Ectopic (10) · Pituitary Diseases (10) · Pituitary Neoplasms (10) · Acromegaly (6) · Adrenal Cortex Neoplasms (5) · Hypertension (4) · ACTH-Secreting Pituitary Adenoma (3) · Adrenal Insufficiency (3) · Adrenocortical Hyperfunction (3) · Choristoma (3) · Diabetes Mellitus, Type 2 (3) · Hirsutism (3) · Adrenocortical Carcinoma (2)
Brain Diseases (61) · Central Nervous System Diseases (61) · Endocrine System Diseases (61) · Hypothalamic Diseases (61) · Nervous System Diseases (61) · Hyperpituitarism (60) · Pituitary Diseases (51) · Adrenal Gland Diseases (22) · Neoplasms (22) · Adrenocortical Hyperfunction (18) · Endocrine Gland Neoplasms (18) · Neoplasms by Site (18) · Brain Neoplasms (10) · Central Nervous System Neoplasms (10) · Hypothalamic Neoplasms (10)
pasireotide (8) · Cabergoline (4) · Mifepristone (4) · Corlux (3) · Osilodrostat (3) · relacorilant (3) · 2-phenyl-6-(2'-(4'-(ethoxycarbonyl)thiazolyl))thiazolo(3,2-b)(1,2,4)triazole (1) · 4-amino-4'-hydroxylaminodiphenylsulfone (1) · Bexarotene (1) · Biomarkers (1) · Deamino Arginine Vasopressin (1) · Gefitinib (1) · Hematologic Tests (1) · Insulin (1) · Liraglutide (1)
Corcept Therapeutics (8) · Novartis Pharmaceuticals (8) · Mayo Clinic (3) · National Institute of Neurological Disorders and Stroke (NINDS) (3) · Cortendo AB (2) · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (2) · Hospices Civils de Lyon (2) · Huashan Hospital (2) · RECORDATI GROUP (2) · University of Roma La Sapienza (2) · Asan Medical Center (1) · Assistance Publique - Hôpitaux de Paris (1) · Cedars-Sinai Medical Center (1) · Centre Hospitalier Universitaire de Nīmes (1) · Crinetics Pharmaceuticals Inc. (1)
United States (37) · France (16) · Italy (15) · Germany (11) · Spain (11) · Netherlands (10) · Poland (10) · Canada (8) · Israel (8) · Romania (8) · Turkey (Türkiye) (8) · Belgium (7) · Brazil (7) · China (6) · Greece (6)
Prashant Chittiboina, M.D. (3) · Coleman Gross, MD (2) · Deborah P Merke, M.D. (2) · Abbas A Mansour (1) · Andrea M Isidori, MD, PhD (1) · Andreas G Moraitis, MD (1) · Andreas Moraitis, MD (1) · Anne Klibanski, MD (1) · Anthony Heaney, MD (1) · Antoine Tabarin, Pr (1) · Coleman Gross (1) · Coleman Gross, M.D. (1)
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