73 completed, 40 unknown, 21 recruiting, 8 active not recruiting. 32 Not applicable, 25 Phase 2, 10 Phase 3, 8 Phase 1, 6 Phase 4.
Follow Hypertrophic Cardiomyopathy: new trials by email Literature Review of Hypertrophic Cardiomyopathy trials Research Report on Hypertrophic Cardiomyopathy
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| NHLBI SESAME (SEptal Scoring Along Midline Endocardium) Multi-Center Prospective Study Using Improvised Off-Label Devices SESAME Procedure - Hypertrophic Cardiomyopathy, Left Ventricular Outflow Obstruction | Not applicable | Not yet recruiting | National Heart, Lung, and Blood Institute (NHLBI) | 200 | 2026-11-02 | 2026-10-28 |
| Echocardiographic Perspectives on Transient Mitral Regurgitation After Septal Myectomy Hypertrophic Cardiomyopathy | Not yet recruiting | University Health Network, Toronto | 150 | 2026-10-01 | 2026-10-14 | |
| Coronary Sinus Reducer Objective Impact on SymptoMs, Ischaemia and miCrovascular Resistance in Non-obstructive Hypertrophic CardioMyopathy Coronary sinus reducer, Placebo procedure - Hypertrophic Cardiomyopathy | Not applicable | Not yet recruiting | Imperial College London | 50 | 2026-10-01 | 2026-10-08 |
| A Study to Assess the Real-World Effectiveness of Mavacamten in Adult Patients With Obstructive Hypertrophic Cardiomyopathy in China Mavacamten - Hypertrophic Cardiomyopathy | Recruiting | Bristol-Myers Squibb | 500 | 2026-01-15 | 2026-06-18 | |
| Effect of Personalized Accelerated Pacing in Symptomatic Patients With Non-Obstructive Hypertrophic Cardiomyopathy myPACE+ algorithm - Non-obstructive Hypertrophic Cardiomyopathy, Hypertrophic Cardiomyopathy | Not applicable | Terminated | Montefiore Medical Center | 1 | 2025-10-02 | 2026-02-11 |
| A Clinical Study to Evaluate the Long-term Safety of HRS-1893 in Hypertrophic Cardiomyopathy HRS-1893 Tablet - Hypertrophic Cardiomyopathy | Phase 2 | Recruiting | Shandong Suncadia Medicine Co., Ltd. | 300 | 2025-07-04 | 2025-09-10 |
| A Trial of HRS-1893 in Healthy Volunteers HRS-1893 - Hypertrophic Cardiomyopathy | Early Phase 1 | Completed | Atridia Pty Ltd. | 20 | 2025-06-25 | 2025-11-18 |
| VIZ ACCESS HCM - Multi-Site Registry Viz HCM - Hypertrophic Cardiomyopathy | Terminated | Viz.ai, Inc. | 17 | 2025-06-13 | 2026-09-23 | |
| Evaluation of the Efficacy and Safety of Wearable ECG (AT-Patch) in Patients With Hypertrophic Cardiomyopathy Requiring 48-Hour Holter MonitoringEvaluation of the Efficacy and Safety of Wearable ECG (AT-Patch) in Patients With Hypertrophic Cardiomyopathy Requiring 48-Hour Holter Monitoring ATP-C135, ATP-C75 - Hypertrophic Cardiomyopathy | Phase 3 | Not yet recruiting | Yonsei University | 100 | 2025-03-01 | 2025-03-13 |
| Safety and Pharmacokinetics Study of HRS-1893 Tablets in Healthy Subjects and Those With Impaired Kidney Function HRS-1893 - Hypertrophic Cardiomyopathy | Phase 1 | Completed | Shandong Suncadia Medicine Co., Ltd. | 24 | 2025-02-11 | 2025-09-10 |
| NHLBI SESAME (SEptal Scoring Along Midline Endocardium) Early Feasibility Study Septal Scoring Along Midline Endocardium - Hypertrophic Cardiomyopathy, Left Ventricular Septal Hypertrophy | Not applicable | Terminated | National Heart, Lung, and Blood Institute (NHLBI) | 1 | 2024-12-18 | 2025-12-18 |
| Comparison of the Effects of Inspiratory Muscle Training and Baduanjin Exercises in Hypertrophic Cardiomyopathy Patients Inspiratory Muscle Training, Baduanjin Exercise - Hypertrophic Cardiomyopathy, Heart Diseases | Not applicable | Recruiting | Istanbul University - Cerrahpasa | 51 | 2024-10-25 | 2025-06-15 |
| Institutional Registry of Rare Diseases Rare Diseases, Amyloidosis | Recruiting | Hospital Italiano de Buenos Aires | 380 | 2024-07-01 | 2026-01-14 | |
| Hypertrophic Cardiomyopathy Federated Learning Implementation Platform Hypertrophic Cardiomyopathy | Unknown | American Heart Association | 1000 | 2024-06-05 | 2024-08-06 | |
| A Study of Artificial Intelligence ECG With ECG Devices to Detect Hypertrophic Cardiomyopathy Distinct From Athlete's 12-Lead ECG, Apple Smart Watch Single Lead ECG, AliveCor KardiaMobile 6-Lead ECG - Hypertrophic Cardiomyopathy | Active not recruiting | Mayo Clinic | 183 | 2024-05-07 | 2026-03-19 | |
| Assessment of Cardiac Function, Microvascular Function and Cardiac Perfusion in Different Disease Stages of Hypertrophic Cardiomyopathy Hypertrophic Cardiomyopathy, Hypertrophic Cardiomyopathy, Obstructive | Unknown | Amsterdam UMC, location VUmc | 100 | 2024-05-01 | 2024-05-06 | |
| A Retrospective Cohort Study of Mavacamten Patient Support Program in Canada Mavacamten - Hypertrophic Cardiomyopathy | Completed | Bristol-Myers Squibb | 683 | 2024-04-20 | 2026-06-12 | |
| A Study of EDG-7500 in Adults With Hypertrophic Cardiomyopathy (CIRRUS-HCM) EDG-7500 - Hypertrophic Cardiomyopathy | Phase 2 | Active not recruiting | Edgewise Therapeutics, Inc. | 79 | 2024-04-11 | 2026-07-31 |
| Echocardiography-guided Percutaneous Septal Radiofrequency Ablation for Obstructive HCM After Alcohol Septal Ablation Percutaneous Intramyocardial Septal Radiofrequency Ablation - Hypertrophic Cardiomyopathy | Unknown | Xijing Hospital | 12 | 2024-03-26 | 2024-07-11 | |
| Austrian Hypertrophic Cardiomyopathy Registry Hypertrophic Cardiomyopathy | Recruiting | Medical University of Graz | 1000 | 2024-03-08 | 2025-12-05 |
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Cardiomyopathy, Hypertrophic (160) · Cardiomyopathy, Dilated (16) · Cardiomyopathies (11) · Heart Failure (11) · Arrhythmogenic Right Ventricular Dysplasia (8) · Cardiomyopathy, Restrictive (8) · Coronary Artery Disease (7) · Hypertrophy (7) · Arrhythmias, Cardiac (6) · Hypertrophy, Left Ventricular (6) · Atrial Fibrillation (5) · Death, Sudden, Cardiac (5) · Heart Diseases (5) · Cardiomyopathy, Hypertrophic, Familial (4) · Cardiovascular Diseases (4)
Aortic Stenosis, Subvalvular (160) · Aortic Valve Disease (159) · Heart Valve Diseases (159) · Aortic Valve Stenosis (157) · Cardiovascular Diseases (156) · Heart Diseases (155) · Cardiomyopathies (149) · Pathological Conditions, Signs and Symptoms (40) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (30) · Genetic Diseases, Inborn (25) · Pathologic Processes (24) · Cardiomegaly (21) · Laminopathies (16) · Vascular Diseases (16) · Cardiovascular Abnormalities (15)
MYK-461 (7) · Echocardiography (3) · Exercise (3) · Losartan (3) · Perhexiline (3) · Blood Specimen Collection (2) · Electrocardiography (2) · Electrocardiography, Ambulatory (2) · Ethanol (2) · Metoprolol (2) · Spironolactone (2) · empagliflozin (2) · sacubitril and valsartan sodium hydrate drug combination (2) · Acetylcysteine (1) · Adenosine (1)
National Heart, Lung, and Blood Institute (NHLBI) (13) · Bristol-Myers Squibb (6) · Mayo Clinic (6) · Imperial College London (4) · Barts & The London NHS Trust (3) · The Cleveland Clinic (3) · University Hospital Birmingham (3) · University Hospital, Bordeaux (3) · University Hospital, Montpellier (3) · Xijing Hospital (3) · Assistance Publique - Hôpitaux de Paris (2) · Beijing Institute of Heart, Lung and Blood Vessel Diseases (2) · Brigham and Women's Hospital (2) · Duke University (2) · Far Eastern Memorial Hospital (2)
United States (56) · United Kingdom (22) · France (17) · China (16) · Canada (13) · Germany (8) · Italy (7) · Netherlands (6) · Australia (4) · Denmark (4) · Poland (4) · Czechia (3) · Israel (3) · Spain (3) · Sweden (3)
Jeffrey Geske, MD (2) · Milind Desai, MD (2) · Robert J Lederman, M.D. (2) · Steven E Lipshultz, MD (2) · Adolfo Fontenla, MD, PhD (1) · Adrian Gadano, MD (1) · Ali J. Marian, MD (1) · Anne-Sophie Polge, PH (1) · Benjamin D Levine, MD (1) · Bo Wang, Master (1) · Carolyn Y Ho, MD (1) · Carolyn Y. Ho, MD (1)
PMID 24621999, PMID 25533774, PMID 28912187, PMID 12957437, PMID 17572266, PMID 17582361, PMID 18164940, PMID 18403758, PMID 19074594, PMID 20837938, PMID 20921440, PMID 22075468, PMID 22932717, PMID 24361242, PMID 24414062, PMID 24674997, PMID 25176015, PMID 25387993, PMID 25533966, PMID 26299218, PMID 26661322, PMID 26680013, PMID 26874390, PMID 26898633, PMID 27059467, PMID 27247331, PMID 27265676, PMID 27326027, PMID 27437054, PMID 27590665, PMID 28306757, PMID 28400935, PMID 28547861, PMID 28662936, PMID 28682471, PMID 28917683, PMID 29018006, PMID 29161295, PMID 29249422, PMID 29321131, PMID 29540445, PMID 29604289, PMID 29754651, PMID 29797054, PMID 30018776, PMID 30316646, PMID 30725091, PMID 31333075, PMID 3160067, PMID 31745384
1RC1LM010526 (1), K23HL078901 (1), P50HL112349 (1), R01HL111459 (1), R01HL125918 (1), R01HL134885 (1), R01HL157238 (1), U01HL117006 (1)