116 completed, 59 unknown, 49 recruiting, 20 terminated. 65 Not applicable, 59 Phase 2, 30 Phase 1, 26 Phase 3, 9 Phase 4.
Follow Laminopathies: new trials by email Literature Review of Laminopathies trials Research Report on Laminopathies
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| BAG3-DCM Natural History Study Dilated Cardiomyopathy (DCM), Cardiovascular Diseases | Not yet recruiting | Rocket Pharmaceuticals Inc. | 30 | 2026-12-01 | 2026-10-19 | |
| Creating Stem Cells From a Progeria Patient's Blood to Test Candidate Treatments in the Lab Hutchinson-Gilford Progeria Syndrome | Not yet recruiting | Bundang CHA Hospital | 1 | 2026-10-01 | 2026-09-10 | |
| Sexual Quality of Life in Female Patients With Lipodystrophy Syndromes or Turner's Syndrome: a Case-control Study Lipodystrophy Congenital Generalized, Lipodystrophy, Familial Partial | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 1416 | 2026-10-01 | 2026-09-02 | |
| An AAV Gene Therapy Trial of AFTX-201 in Adults With BAG3-Associated Dilated Cardiomyopathy (DCM) AFTX-201 - Dilated Cardiomyopathy (DCM), BAG3 Mutation Associated Dilated Cardiomyopathy | Phase 1 / Phase 2 | Recruiting | Affinia Therapeutics | 22 | 2026-10-01 | 2026-10-21 |
| A Study Observing Disease Progression in a Patient With Hutchinson-Gilford Progeria Syndrome (HGPS) Hutchinson-Gilford Progeria Syndrome | Not yet recruiting | Bundang CHA Hospital | 1 | 2026-09-01 | 2026-09-24 | |
| Observational Study of Natural History of BAG3 Gene Mutation-Associated Dilated Cardiomyopathy in Chinese Adults Observational, None intervention - Dilated Cardiomyopathy | Recruiting | AstraZeneca | 10 | 2026-08-18 | 2026-10-22 | |
| Identification of Women With Severe Insulin Resistant Syndromes of Genetic Origin Among Patients With "Classic" Polycystic Ovary Syndrome (PCOS) Genetic analysis, Biological analysis, imaging test - Polycystic Ovary Syndrome, Familial Partial Lipodystrophy | Not applicable | Recruiting | Assistance Publique - Hôpitaux de Paris | 81 | 2026-07-21 | 2026-08-10 |
| RHYthm and Myocardial Function Relationship Evaluation in Heart Diseases speckle tracking echocardiography - Arrhythmia, Cardiomyopathy, Dilated | Recruiting | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 253 | 2026-06-23 | 2026-09-10 | |
| A Study With NVC-001 in Patients With LMNA-related Dilated Cardiomyopathy (SUNBEAM-LMNA) NVC-001 - Low Dose, NVC-001 - Intermediate Dose, NVC-001 - High Dose - LMNA-Related Dilated Cardiomyopathy | Phase 1 / Phase 2 | Recruiting | Nuevocor Pte. Ltd. | 21 | 2026-06-16 | 2026-08-07 |
| Safety and Efficacy of Second Infusion of FAP iCDC in End-stage Dilated Cardiomyopathy FAP immunosuppressive CAR-DC - Dilated Cardiomyopathy (DCM), Heart Failure | Phase 1 | Recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 5 | 2026-05-11 | 2026-07-02 |
| Effect of Sildenafil on Left Ventricular Function in Pediatric With Primary Dilated Cardiomyopathy Cardiomyopathy, Dilated | Not yet recruiting | Assiut University | 70 | 2026-05-10 | 2026-04-17 | |
| A Phase 1 AAV Gene Therapy Trial Evaluating Safety and Preliminary Efficacy of RP-A701 in Subjects With BAG3 Dilated Cardiomyopathy RP-A701 is a recombinant viral vector composed of an AAV serotype rh.74 (AAVrh.74) capsid encapsulating the transgene, BCL2-associated Athanogene 3 (BAG3) - Dilated Cardiomyopathy (DCM) | Phase 1 | Recruiting | Rocket Pharmaceuticals Inc. | 8 | 2026-04-17 | 2026-10-01 |
| Efficacy and Safety of Mibavademab in Adult and Pediatric Patients With Generalized Lipodystrophy Mibavademab, Placebo - Generalized Lipodystrophy | Phase 3 | Recruiting | Regeneron Pharmaceuticals | 28 | 2026-03-13 | 2026-09-11 |
| Mainstreaming Genetic Testing for Non-Ischemic Cardiomyopathy in Western Canada Health service delivery change - Nonischemic Cardiomyopathy, Dilated Cardiomyopathy (DCM) | Not applicable | Enrolling by invitation | Thomas Roston | 300 | 2026-02-02 | 2026-05-08 |
| Endocardial Delivery for Myocardial Regeneration Using Allogeneic iPSC-derived Cardiomyocyte Spheroids for HF With Systolic Dysfunction (EMERALD Study) HS-005 - Heart Failure, Ischemic Heart Failure | Phase 1 / Phase 2 | Recruiting | Heartseed Inc. | 14 | 2026-01-19 | 2026-10-22 |
| Prognostic Values of Coronary Microvascular Dysfunction in Patients With Dilated Cardiomyopathy coronary angiography - Dilated Cardiomyopathy (DCM) | Recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 330 | 2026-01-06 | 2025-12-19 | |
| A Study of AZD4063 in PLN R14del Dilated Cardiomyopathy AZD4063 - Dilated Cardiomyopathy | Phase 1 | Recruiting | AstraZeneca | 23 | 2025-12-01 | 2026-09-04 |
| the Clinical Outcome of Empagliflozin in Pediatric Heart Failure Patients Empagliflozin (EMPA), Standard medical treatment - Heart Failure | Phase 2 | Recruiting | Ain Shams University | 60 | 2025-12-01 | 2026-07-09 |
| Study of the Progression of Chronic Cardiovascular Conditions Cardiovascular Disease (CVD), Heart Failure | Recruiting | Prolaio | 5000 | 2025-10-30 | 2026-08-12 | |
| Multimodal Analysis of Endomyocardial Biopsies Heart Transplantation, Dilated Cardiomyopathy (DCM) | Recruiting | University Hospital, Essen | 216 | 2025-10-27 | 2026-01-22 |
Showing 20 of 277. Sign in to see all of them.
Cardiomyopathy, Dilated (242) · Heart Failure (92) · Cardiomyopathy, Hypertrophic (38) · Cardiomyopathies (35) · Lipodystrophy, Familial Partial (20) · Cardiomyopathy, Restrictive (14) · Arrhythmogenic Right Ventricular Dysplasia (13) · Death, Sudden, Cardiac (13) · Heart Diseases (12) · Progeria (12) · Cardiovascular Diseases (11) · Lipodystrophy (9) · Myocarditis (9) · Arrhythmias, Cardiac (7) · Coronary Disease (7)
Congenital, Hereditary, and Neonatal Diseases and Abnormalities (277) · Genetic Diseases, Inborn (276) · Cardiomegaly (241) · Cardiovascular Diseases (234) · Heart Diseases (232) · Cardiomyopathies (207) · Pathological Conditions, Signs and Symptoms (51) · Nutritional and Metabolic Diseases (47) · Metabolic Diseases (45) · Heart Valve Diseases (41) · Pathologic Processes (40) · Aortic Stenosis, Subvalvular (38) · Aortic Valve Disease (38) · Aortic Valve Stenosis (36)
lonafarnib (6) · ARRY-371797 (3) · Adrenergic beta-Antagonists (3) · Cardiac Resynchronization Therapy (3) · Carvedilol (3) · Drug Therapy (3) · Genetic Testing (3) · Granulocyte Colony-Stimulating Factor (3) · Pravastatin (3) · Standard of Care (3) · Zoledronic Acid (3) · Allopurinol (2) · Blood Coagulation Tests (2) · Blood Specimen Collection (2) · Hematologic Tests (2)
Imperial College London (9) · University Medical Centre Ljubljana (6) · LoneStar Heart, Inc. (4) · Ancora Heart, Inc. (3) · Assistance Publique Hopitaux De Marseille (3) · AstraZeneca (3) · Boston Children's Hospital (3) · Bundang CHA Hospital (3) · Centre Hospitalier Universitaire de la Réunion (3) · French Cardiology Society (3) · Göteborg University (3) · Hospital General Universitario Gregorio Marañon (3) · Institut National de la Santé Et de la Recherche Médicale, France (3) · Johns Hopkins University (3) · McGill University Health Centre/Research Institute of the McGill University Health Centre (3)
United States (77) · France (29) · United Kingdom (29) · Germany (23) · China (22) · Italy (19) · Spain (18) · Canada (17) · Netherlands (15) · Brazil (11) · Poland (8) · Denmark (7) · Slovenia (7) · Serbia (6) · Sweden (6)
James Ware (3) · Bojan Vrtovec, MD, PhD (2) · Ida Jovanovic, Prof,MD,PhD (2) · Javier Bermejo Thomas, MD, PhD (2) · Karim Wahbi, MD, PhD (2) · Mark W Kieran, MD, PhD (2) · Michael Burch, Prof,MD,PhD (2) · Michael R Bristow, MD PhD (2) · Michael Zapien, MS, CCRA (2) · Ray Hershberger, MD (2) · Steven E Lipshultz, MD (2)
PMID 36718638, PMID 38979608, PMID 17582361, PMID 22651868, PMID 22936827, PMID 23362308, PMID 24414062, PMID 24795390, PMID 25142002, PMID 26680013, PMID 27400896, PMID 28917683, PMID 36507973, PMID 36919608, PMID 37010012, PMID 42669063, PMID 10368877, PMID 11710893, PMID 12106931, PMID 12457625, PMID 14668703, PMID 14736546, PMID 15234411, PMID 16545646, PMID 17268122, PMID 17289576, PMID 17379833, PMID 17383291, PMID 17874006, PMID 18256394, PMID 18455424, PMID 18553028, PMID 19146917, PMID 19327618, PMID 19445426, PMID 19946241, PMID 20178563, PMID 20308616, PMID 21440864, PMID 21645332, PMID 21709064, PMID 22083160, PMID 22460337, PMID 22523306, PMID 22596155, PMID 22677278, PMID 22752073, PMID 22877814, PMID 22892122, PMID 23012407
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