175 completed, 45 unknown, 25 recruiting, 25 terminated. 50 Phase 3, 45 Phase 2, 34 Phase 4, 31 Not applicable, 18 Phase 1.
Follow Hyperpituitarism: new trials by email Literature Review of Hyperpituitarism trials Research Report on Hyperpituitarism
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Hypoproteic Diet in Acromegaly Usual clinical practice + hypoproteic diet - Acromegaly | Not applicable | Suspended | Azienda Ospedaliero Universitaria Maggiore della Carita | 12 | 2026-12-01 | 2026-10-29 |
| PRESTO: A Phase III Randomised Controlled Trial of Dose-escalated Proton Beam Therapy Versus Standard of Care Radiotherapy for Functioning Pituitary Tumours Standard dose Intensity-Modulated Radiation Therapy (IMRT), Standard dose Proton Beam Therapy (PBT), Escalated dose Proton Beam Therapy (PBT) - Acromegaly Due to Pituitary Adenoma, Cushing's Disease | Phase 3 | Not yet recruiting | University College, London | 82 | 2026-09-01 | 2026-10-01 |
| A Study to Evaluate MAR002 for Acromegaly MAR002, Placebo - Acromegaly | Phase 2 | Recruiting | Marea Therapeutics | 72 | 2026-07-23 | 2026-09-11 |
| Adrenal Diseases in the Population of Modena: A Clinical-Epidemiological Database of Patients Referred to the Adrenal Disorders Outpatient Clinic of the Clinical Unit of Endocrinology at the Modena University Hospital (AOU Modena) Cushing s Syndrome, Cushing Disease | Recruiting | Azienda Ospedaliero-Universitaria di Modena | 2000 | 2026-07-09 | 2026-11-09 | |
| Direct Versus Video Laryngoscopy in Patients With Acromegaly Acromegaly, Nonfunctioning Pituitary Adenoma | Not yet recruiting | Muzaffer GENCER | 40 | 2026-07-01 | 2026-06-22 | |
| A Phase 1 Study to Evaluate the Relative Bioavailability of Octreotide Acetate Tablets(T25) Compared to MYCAPSSA® and The Food Effect on Pharmacokinetics Of Octreotide Acetate Tablets(T25) T25-Fast, Mycapssa, T25-Fed - Acromegaly | Phase 1 | Completed | Triastek (Shanghai) Limited | 18 | 2026-06-25 | 2026-09-16 |
| An Observational Study of Octreotide Subcutaneous Depot in Patients With Acromegaly Octreotide subcutaneous depot - Acromegaly | Recruiting | Camurus AB | 200 | 2026-06-05 | 2026-10-27 | |
| Use of [18F]FET PET-MRI to Improve Detection of Pituitary Adenomas in Cushing's Disease [18F]FET PET-MRI - Cushing Disease | Not applicable | Enrolling by invitation | University Hospital, Basel, Switzerland | 43 | 2026-06-04 | 2026-07-06 |
| Combination Osilodrostat and Cabergoline in Cushing's Disease osilodrostat, osilodrostat and cabergoline - Cushing Disease Due to Increased ACTH Secretion | Phase 4 | Enrolling by invitation | University of Basrah | 50 | 2026-05-11 | 2026-05-22 |
| FET PET/CT Imaging To Localize Pituitary Adenomas In Cushing Disease Fluoro-O-(2) fluoroethyl-L-tyrosine (FET) PET - Cushing Disease, Pituitary Adenoma | Early Phase 1 | Recruiting | Mayo Clinic | 50 | 2026-04-27 | 2026-10-30 |
| A Phase 1 Clinical Trial of NTQ6179 Tablets in Healthy Volunteers NTQ6179, NTQ6179 placebo - Acromegaly | Phase 1 | Recruiting | Nanjing Chia-tai Tianqing Pharmaceutical | 56 | 2026-04-23 | 2026-11-03 |
| DDAVP for Pituitary Adenoma Desmopressin acetate - Cushing's Disease, Pituitary Adenoma | Not applicable | Recruiting | National Institute of Neurological Disorders and Stroke (NINDS) | 22 | 2026-03-09 | 2026-04-09 |
| Safety and Potency of a High Cabergoline Dosage in Microprolactinomas Cabergoline - Prolactinoma, Prolactin Excess | Phase 3 | Recruiting | University of Sao Paulo General Hospital | 70 | 2026-03-04 | 2026-03-13 |
| Ultrasound in Predicting Difficult Intubation in Acromegaly Patients observational study - Acromegaly Due to Pituitary Adenoma, Difficult Intubation | Not yet recruiting | Başakşehir Çam & Sakura City Hospital | 34 | 2025-12-25 | 2025-12-29 | |
| A Study to Assess the Efficacy and Safety of Debio 4126 in Participants With Acromegaly Previously Treated With Somatostatin Analogs Debio 4126, Placebo - Acromegaly | Phase 3 | Recruiting | Debiopharm International SA | 119 | 2025-11-26 | 2026-10-23 |
| ALXN2420 Versus Placebo in Combination With Somatostatin Analogs in Participants With Acromegaly ALXN2420, Placebo - Acromegaly | Phase 2 | Terminated | Alexion Pharmaceuticals, Inc. | 8 | 2025-10-28 | 2026-08-07 |
| Metabolic Outcomes in Patients With Prolactinomas Under Dopamine Agonist Treatment Cabergoline (Dopamine Agonist) - Prolactinoma | Phase 4 | Recruiting | University Hospital, Basel, Switzerland | 60 | 2025-09-16 | 2025-09-23 |
| A Phase III Clinical Study of Cabergoline Tablets Compared With Bromocriptine Mesylate Tablets Cabergoline tablets, Bromocriptine mesylate tablets - Hyperprolactinemia | Phase 3 | Recruiting | Changchun GeneScience Pharmaceutical Co., Ltd. | 382 | 2025-09-12 | 2025-10-02 |
| Effects of Pasireotide Lar Therapy on Bone Metabolism morphometric spine radiography - Acromegaly Due to Pituitary Adenoma, Acromegaly | Recruiting | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 120 | 2025-09-08 | 2025-09-18 | |
| Study of MAR002 in Healthy Men MAR002, Placebo - Acromegaly | Phase 1 | Recruiting | Marea Therapeutics | 45 | 2025-08-11 | 2026-01-12 |
Showing 20 of 297. Sign in to see all of them.
Acromegaly (201) · Pituitary ACTH Hypersecretion (62) · Hyperprolactinemia (39) · Pituitary Neoplasms (31) · Cushing Syndrome (21) · Pituitary Diseases (18) · ACTH Syndrome, Ectopic (11) · Prolactinoma (11) · Schizophrenia (10) · Gigantism (8) · Insulin Resistance (8) · Adrenal Cortex Neoplasms (6) · Dwarfism, Pituitary (6) · Adrenal Insufficiency (5) · Adrenocortical Hyperfunction (5)
Brain Diseases (297) · Central Nervous System Diseases (297) · Hypothalamic Diseases (297) · Nervous System Diseases (297) · Endocrine System Diseases (294) · Pituitary Diseases (279) · Musculoskeletal Diseases (204) · Bone Diseases, Endocrine (203) · Bone Diseases (202) · Neoplasms (57) · Endocrine Gland Neoplasms (46) · Neoplasms by Site (46) · Central Nervous System Neoplasms (31) · Hypothalamic Neoplasms (31)
Octreotide (29) · lanreotide (21) · pegvisomant (19) · pasireotide (16) · Cabergoline (13) · Aripiprazole (5) · Glucose Tolerance Test (5) · Mifepristone (4) · Absorptiometry, Photon (3) · Corlux (3) · Hematologic Tests (3) · Injections (3) · Osilodrostat (3) · Somatostatin (3) · relacorilant (3)
Ipsen (34) · Novartis Pharmaceuticals (22) · Cedars-Sinai Medical Center (12) · University of Aarhus (10) · Pfizer (9) · Corcept Therapeutics (8) · Massachusetts General Hospital (7) · Crinetics Pharmaceuticals Inc. (6) · Columbia University (5) · Federico II University (5) · Huashan Hospital (5) · Assistance Publique - Hôpitaux de Paris (4) · Camurus AB (4) · Ambrilia Biopharma, Inc. (3) · Chiasma, Inc. (3)
United States (107) · Italy (60) · France (53) · Germany (44) · United Kingdom (38) · Poland (35) · Spain (33) · Hungary (29) · Brazil (28) · Denmark (27) · China (26) · Netherlands (26) · Romania (25) · Belgium (21) · Russia (19)
Shlomo Melmed, MD (4) · Annamaria Colao, MD (3) · Prashant Chittiboina, M.D. (3) · Raphael Naudin, M.D. (3) · Anne Klibanski, MD (2) · Coleman Gross, MD (2) · Deborah P Merke, M.D. (2) · John Carmichael, MD (2) · Karen Miller, MD (2)
PMID 17259801, PMID 17984237, PMID 10690849, PMID 12641619, PMID 14769829, PMID 15613435, PMID 15827109, PMID 16449332, PMID 16487447, PMID 16537687, PMID 18445662, PMID 25013998, PMID 26507877, PMID 27405306, PMID 34173129, PMID 35058882, PMID 36792844, PMID 40418492, PMID 41052284, PMID 41701620, PMID 9808008, PMID 10469005, PMID 10753124, PMID 10792333, PMID 10999798, PMID 11397887, PMID 11788630, PMID 12843148, PMID 1430082, PMID 14764779, PMID 1478121, PMID 15070920, PMID 15080776, PMID 15080778, PMID 15099442, PMID 15272916, PMID 15362960, PMID 15531475, PMID 15649100, PMID 15687336, PMID 15817912, PMID 15886238, PMID 15886256, PMID 16181243, PMID 16322377, PMID 16373932, PMID 16584510, PMID 16899562, PMID 16918950, PMID 17167139
2004 (4), 2019 (4), 2009 (3), 2014 (3), 2015 (3), 2005 (2), 2017 (2), 2018 (2), 2023 (1), 2025 (1), K23MH085005 (1), R21DK112093 (1), R56DK064720 (1)