300 completed, 66 unknown, 46 terminated, 30 recruiting. 91 Phase 3, 71 Phase 2, 58 Phase 4, 54 Not applicable, 31 Phase 1.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| The AgRP and GH/IGF-1 Axis in Children Growth Hormone Deficiency | Not yet recruiting | Columbia University | 156 | 2027-06-10 | 2026-09-25 | |
| Evaluation of an Intensified Systematic Screening for Congenital Hypothyroidism in Premature Newborns Blood test - Congenital Hypothyroidism | Not yet recruiting | University Hospital, Lille | 1600 | 2027-03-01 | 2026-05-22 | |
| Phase 3 Long Term Safety Extension Study of LUM-201 in Children With Growth Hormone Deficiency LUM-201 - Growth Hormone Deficiency (GHD) | Phase 3 | Not yet recruiting | Lumos Pharma | 150 | 2027-02-01 | 2026-07-08 |
| PRESTO: A Phase III Randomised Controlled Trial of Dose-escalated Proton Beam Therapy Versus Standard of Care Radiotherapy for Functioning Pituitary Tumours Standard dose Intensity-Modulated Radiation Therapy (IMRT), Standard dose Proton Beam Therapy (PBT), Escalated dose Proton Beam Therapy (PBT) - Acromegaly Due to Pituitary Adenoma, Cushing's Disease | Phase 3 | Not yet recruiting | University College, London | 82 | 2026-09-01 | 2026-10-01 |
| A Study to Evaluate MAR002 for Acromegaly MAR002, Placebo - Acromegaly | Phase 2 | Recruiting | Marea Therapeutics | 72 | 2026-07-23 | 2026-09-11 |
| Evaluation of (Cardio)Metabolic and Auxological Outcomes of GHD Patients Under rhGH or LAGH With Stratification According to IGF-1 Levels metabolic and auxological outcomes - Growth Hormone Deficiency | Not applicable | Not yet recruiting | Cliniques universitaires Saint-Luc- Université Catholique de Louvain | 300 | 2026-07-01 | 2026-05-11 |
| Direct Versus Video Laryngoscopy in Patients With Acromegaly Acromegaly, Nonfunctioning Pituitary Adenoma | Not yet recruiting | Muzaffer GENCER | 40 | 2026-07-01 | 2026-06-22 | |
| A Phase 1 Study to Evaluate the Relative Bioavailability of Octreotide Acetate Tablets(T25) Compared to MYCAPSSA® and The Food Effect on Pharmacokinetics Of Octreotide Acetate Tablets(T25) T25-Fast, Mycapssa, T25-Fed - Acromegaly | Phase 1 | Completed | Triastek (Shanghai) Limited | 18 | 2026-06-25 | 2026-09-16 |
| Safety, Pharmacokinetic (PK) Profile and Efficacy of Inpegsomatropin Injection in Adults With Growth Hormone Deficiency Inpegsomatropin Injection, Placebo for Inpegsomatropin Injection - Adult Growth Hormone Deficiency | Phase 2 | Recruiting | Xiamen Amoytop Biotech Co., Ltd. | 36 | 2026-06-10 | 2026-07-22 |
| GB06 Phase III Trial for Pediatric Growth Hormone Deficiency GB06, Norditropin®FlexProTM - Growth Hormone Deficiency (GHD), Growth Hormone Deficiency in Children | Phase 3 | Recruiting | Kexing Biopharm Co., Ltd. | 192 | 2026-06-06 | 2026-06-10 |
| An Observational Study of Octreotide Subcutaneous Depot in Patients With Acromegaly Octreotide subcutaneous depot - Acromegaly | Recruiting | Camurus AB | 200 | 2026-06-05 | 2026-09-25 | |
| Phase 3 Study of LUM-201 in Children With Growth Hormone Deficiency LUM-201, Matched Placebo (Capsules) - Growth Hormone Deficiency (GHD) | Phase 3 | Recruiting | Lumos Pharma | 150 | 2026-05-20 | 2026-10-19 |
| Ultrasound Measurement of Thyroid Volume in Term Newborns Thyroid ultrasound - Thyroid Volume, Thyroid Ultrasound | Not yet recruiting | IRCCS Ospedale San Raffaele | 400 | 2026-05-01 | 2026-05-12 | |
| Ultrasound in Predicting Difficult Intubation in Acromegaly Patients observational study - Acromegaly Due to Pituitary Adenoma, Difficult Intubation | Not yet recruiting | Başakşehir Çam & Sakura City Hospital | 34 | 2025-12-25 | 2025-12-29 | |
| Infants With Primary Congenital Hypothyroidism and Development neurological status, sensory processing functions, Motor development - Congenital Hypothyroidism | Recruiting | Nigde Omer Halisdemir University | 40 | 2025-12-20 | 2026-02-12 | |
| A Study of GS3-007a for Oral Suspension in the Diagnosis of Adult Growth Hormone Deficiency (AGHD) GS3-007a dry suspension, Insulin - Adult Growth Hormone Deficiency (AGHD) | Phase 2 | Terminated | Changchun GeneScience Pharmaceutical Co., Ltd. | 120 | 2025-12-19 | 2026-05-22 |
| REMS25: Study on the Use of REMS Technology in Diseases Commonly Associated With Reduced Bone Mineral Density (BMD) REMS - Osteogenesis Imperfecta, Osteoporosis | Not applicable | Recruiting | Meyer Children's Hospital IRCCS | 100 | 2025-12-04 | 2026-02-17 |
| A Study to Assess the Efficacy and Safety of Debio 4126 in Participants With Acromegaly Previously Treated With Somatostatin Analogs Debio 4126, Placebo - Acromegaly | Phase 3 | Recruiting | Debiopharm International SA | 119 | 2025-11-26 | 2026-09-22 |
| Levothyroxine Dosing in Neonatal Congenital Hypothyroidism Levothyroxine - Congenital Hypothyroidism | Phase 4 | Completed | Menoufia University | 101 | 2025-11-02 | 2026-08-10 |
| ALXN2420 Versus Placebo in Combination With Somatostatin Analogs in Participants With Acromegaly ALXN2420, Placebo - Acromegaly | Phase 2 | Terminated | Alexion Pharmaceuticals, Inc. | 8 | 2025-10-28 | 2026-08-07 |
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Dwarfism, Pituitary (252) · Acromegaly (200) · Pituitary Neoplasms (27) · Congenital Hypothyroidism (26) · Pituitary Diseases (19) · Endocrine System Diseases (16) · Dwarfism (14) · Insulin Resistance (12) · Turner Syndrome (12) · Hypopituitarism (10) · Gigantism (8) · Failure to Thrive (7) · Obesity (7) · Prolactinoma (7)
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Human Growth Hormone (81) · Growth Hormone (45) · Octreotide (29) · lanreotide (21) · pegvisomant (20) · somapacitan (11) · pasireotide (10) · Blood Specimen Collection (9) · Injections (8) · Growth Hormone-Releasing Hormone (6) · Thyroxine (6) · Glucose Tolerance Test (5) · MOD-4023 (5) · Absorptiometry, Photon (4) · Cabergoline (4)
Ipsen (34) · Novo Nordisk A/S (27) · Pfizer (24) · Federico II University (15) · Novartis Pharmaceuticals (15) · Changchun GeneScience Pharmaceutical Co., Ltd. (13) · University of Aarhus (13) · Columbia University (12) · Cedars-Sinai Medical Center (10) · Merck KGaA, Darmstadt, Germany (9) · Massachusetts General Hospital (7) · Versartis Inc. (7) · Ascendis Pharma Endocrinology Division A/S (6) · Lumos Pharma (6) · Crinetics Pharmaceuticals Inc. (5)
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PMID 17259801, PMID 17984237, PMID 36380045, PMID 10690849, PMID 12641619, PMID 14769829, PMID 15613435, PMID 15827109, PMID 16449332, PMID 16487447, PMID 16537687, PMID 18395480, PMID 18445662, PMID 22508317, PMID 22788856, PMID 23658497, PMID 24291224, PMID 28566441, PMID 29671202, PMID 31305924, PMID 31972476, PMID 33571362, PMID 33709288, PMID 33754315, PMID 34173129, PMID 36792844, PMID 36947589, PMID 40418492, PMID 40919719, PMID 41701620, PMID 9808008, PMID 10022400, PMID 10199767, PMID 10199774, PMID 10372687, PMID 10405442, PMID 10453734, PMID 10469005, PMID 10598807, PMID 10753124, PMID 10792333, PMID 10999798, PMID 11134092, PMID 11203878, PMID 11207626, PMID 11273062, PMID 11344175, PMID 11397887, PMID 11531927, PMID 11580992
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