19 completed, 9 unknown, 8 recruiting, 4 not yet recruiting. 33 Not applicable, 4 Phase 4, 2 Phase 3, 1 Early Phase 1, 1 Phase 2.
Follow Hyaluronic Acid: new trials by email Literature Review of Hyaluronic Acid trials Research Report on Hyaluronic Acid
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Hyaluronic Acid as an Adjunct to Non-Surgical Periodontal Therapy in Smokers Scaling and Root Planing, Hyaluronic Acid (HYADENT BG) - Hyaluronic Acid, Periodontal Therapy | Not applicable | Recruiting | Marmara University | 23 | 2026-07-13 | 2026-08-18 |
| Intraarticular Injection of Botox and Hyaluronic Acid in Knee Osteoarthritis Hyaluronic acid, Botulinum toxin type A - Intraarticular Injection, Botox | Not applicable | Recruiting | Tanta University | 50 | 2026-06-24 | 2026-06-25 |
| Adjunctive Hyaluronic Acid Gel in Non-Surgical Periodontal Treatment of Patients With Diabetes Mellitus Scaling and root planing, Hyaluronic Acid (HYADENT BG) - Periodontitis, Diabetes Mellitus | Not applicable | Not yet recruiting | Marmara University | 23 | 2026-06-01 | 2026-06-08 |
| The Efficacy and Safety of a Single-Dose Hyaluronic Acid Injection in the Treatment of Knee Osteoarthritis Intra-articular hyaluronic acid injection - Knee Osteoarthristis, Hyaluronic Acid | Not yet recruiting | Fatih Sultan Mehmet Training and Research Hospital | 133 | 2026-05-01 | 2026-04-29 | |
| Is Cross-linked Hyaluronic Acid a Biologic Alternative for Alveolar Ridge Preservation? DBBM + FGG, Hyaluronic acid + collagen sponge + FGG - Alveolar Bone Resorption, Alveolar Ridge Enlargement | Not applicable | Not yet recruiting | Medical University of Vienna | 48 | 2026-04-01 | 2026-03-27 |
| Evaluation of Hyaluronic Acid and Chlorhexidine Gel as an Adjunct to Minimally Invasive Non-surgical Therapy in the Treatment of Stage III and IV Periodontitis MINST + CHX+HA gel, MINST - Periodontology, Periodontal Disease | Not applicable | Active not recruiting | Cairo University | 72 | 2026-03-01 | 2026-08-07 |
| Effect of TXA on Reducing Bruising After Filler Injection Hyaluronic Acid (HA), Tranexamic Acid (TXA), Saline (placebo) - Facial Filler Injections, Hyaluronic Acid | Phase 2 | Recruiting | University of Wisconsin, Madison | 40 | 2025-12-05 | 2026-07-23 |
| Post-Menopause Skin Rejuvenation Study Restylane SkinBoosters Vital, Sculptra Aesthetic - Aesthetic, Menopause | Phase 4 | Completed | Erevna Innovations Inc. | 50 | 2025-08-14 | 2026-10-26 |
| A Modern, Non-surgical Method for Treating Papillary Deficiencies is the Use of Hyaluronic Acid, Which Have Demonstrated Encouraging Outcome. Subperiosteal Hyaluronic Acid Injection Overlay Technique with the Idea of Merging Hyaluronic Acid Injection with Surgical Intervention to Reconstruct Idp Subperiosteal hyaluronic acid injection overlay technique, Tunneling with connective tissue graft. - Interdental Papillae Reconstruction, Hyaluronic Acid | Not applicable | Not yet recruiting | Cairo University | 38 | 2025-07-01 | 2025-03-21 |
| Clinical Evaluation of Platelet Rich Fibrin Membrane With or Without Hyaluronic Acid Along With Coronally Advanced Flap in the Treatment of Rt1 Gingival Recession root coverage with multilayered PRF, root coverage with multilayered PRF and hyaluronic acid - PRF, Gingival Recession | Not applicable | Active not recruiting | Gulf Medical University | 30 | 2025-07-01 | 2026-06-23 |
| Comparison of Skin Condition After Hyaluronic Acid Application on Dry vs. Moist Skin Topical Hyaluronic Acid - Skin Hydration, Hyaluronic Acid | Not applicable | Completed | University of Split, School of Medicine | 23 | 2025-06-18 | 2025-07-22 |
| Hyaluronic Acid and Polynucleotides in Ridge Preservation regeneration of post extraction socket with biomaterials - Socket Preservation, Implant-supported Single Crowns | Not applicable | Recruiting | University of Parma | 40 | 2025-06-09 | 2025-09-08 |
| The Effect of Hyaluronic Acid Injection on TNF-Alpha and IL-1β in Knee Osteoarthritis Hyaluronic Acid injections, Saline -- placebo comparator - Knee Osteoarthritis, Hyaluronic Acid | Not applicable | Recruiting | Istanbul University | 50 | 2025-05-12 | 2026-09-03 |
| Palatal Mucosa Wound Healing Following Antimicrobial Gel Application Gel containing postbiotics, lactoferrin, aloe barbadensis leaf juice powder and sodium hyaluronate, Placebo gel - Wound Healing, Palate; Wound | Not applicable | Active not recruiting | University of Roma La Sapienza | 13 | 2024-12-22 | 2025-04-23 |
| Efficacy of 0.28% Sodium Hyaluronate Eye Drops in Patient With Moderate to Severe Dry Eye 0.28% Sodium Hyaluronate , preservative free eye drops, 0.18% Sodium Hyaluronate , preservative free eye drops - Dry Eye Disease (DED), Tear Break-Up Time | Phase 4 | Enrolling by invitation | Department of Medical Services Ministry of Public Health of Thailand | 84 | 2024-09-01 | 2025-03-06 |
| Oral Supplementation Compared With Hyaluronic Acid Infiltration in Rotator Cuff Tendinopathies Collagen, Hyaluronic Acid, Vitamin C, and Manganese, Intra-articular infiltration - Tendinitis of Shoulder, Hyaluronic Acid | Not applicable | Unknown | I.R.C.C.S. Fondazione Santa Lucia | 50 | 2024-08-10 | 2024-08-29 |
| Cross-linked and Non-cross-linked Hyaluronic Acid in Subdeltoid Bursitis cross-linked hyaluronic acid, non-cross-linked hyaluronic acid - Subdeltoid Bursitis, Hyaluronic Acid | Phase 4 | Unknown | Taipei Medical University | 52 | 2024-07-25 | 2024-07-19 |
| Comparing Methylprednisolone And Hyaluronic Acid To Reduce Wisdom Tooth Surgery Complications Methyl Prednisolone (MP), Hyaluronic Acid (HA) - Wisdom Tooth Removal, Post Operative Complications | Phase 3 | Enrolling by invitation | Sana'a University | 40 | 2024-06-27 | 2026-04-30 |
| Transcutaneous Pulsed Radiofrequency Application Plus Genicular Nerve Block Versus Intraarticular Hyaluronic Acid Injection for Management of Chronic Pain in Knee Osteoarthritis. Hyaluronic acid, Transcutaneous pulsed radiofrequency - Transcutaneous, Pulsed Radiofrequency | Not applicable | Completed | Tanta University | 80 | 2023-08-01 | 2024-11-29 |
| Arthrocentesis Alone Versus Arthrocentesis With Hyaluronic Acid Injection arthrocentesis alone, arthrocentesis with hyaluronic acid injection - Temporomandibular Joint Dysfunction Syndrome, Arthrocenteses | Not applicable | Unknown | Assiut University | 42 | 2023-08-01 | 2023-07-27 |
Showing 20 of 46. Sign in to see all of them.
Osteoarthritis, Knee (7) · Periodontitis (5) · Gingival Recession (3) · Dry Eye Syndromes (2) · Wounds and Injuries (2) · Breast Neoplasms (1) · Chronic Pain (1) · Diabetes Mellitus (1) · Esophageal Neoplasms (1) · Gingivitis (1) · Nails, Ingrown (1) · Pain, Postoperative (1) · Patient Satisfaction (1) · Penile Induration (1) · Periodontal Diseases (1)
Musculoskeletal Diseases (10) · Joint Diseases (9) · Stomatognathic Diseases (9) · Arthritis (7) · Mouth Diseases (7) · Osteoarthritis (7) · Rheumatic Diseases (7) · Periodontal Diseases (6) · Gingival Diseases (4) · Neurologic Manifestations (3) · Pain (3) · Pathological Conditions, Signs and Symptoms (3) · Periodontal Atrophy (3) · Signs and Symptoms (3) · Skin and Connective Tissue Diseases (3)
Hyaluronic Acid (17) · Root Planing (2) · Tooth Exfoliation (2) · Arthrocentesis (1) · Ascorbic Acid (1) · Biopsy (1) · Botulinum Toxins, Type A (1) · Collagen (1) · Injections, Intra-Articular (1) · Lasers, Semiconductor (1) · Manganese (1) · Methylprednisolone (1) · Methylprednisolone Hemisuccinate (1) · Ozone (1) · Physical Therapy Modalities (1)
SciVision Biotech Inc. (6) · Maxigen Biotech Inc. (4) · Cairo University (3) · Marmara University (2) · Tanta University (2) · University of Roma La Sapienza (2) · Assiut University (1) · Batman University (1) · Benha University (1) · Bezmialem Vakif University (1) · Centre Hospitalier Universitaire, Amiens (1) · Department of Medical Services Ministry of Public Health of Thailand (1) · Erevna Innovations Inc. (1) · Fatih Sultan Mehmet Training and Research Hospital (1) · Germans Trias i Pujol Hospital (1)
Taiwan (9) · Turkey (Türkiye) (6) · Egypt (5) · Italy (4) · Spain (3) · China (2) · Croatia (2) · United Arab Emirates (2) · Brazil (1) · Canada (1) · France (1) · Thailand (1) · United States (1) · Yemen (1)
Amal Y Al-Eryani (1) · Ana Badovinac, assoc prof (1) · Andrea Pilloni, MD,DDS,MS (1) · Andreas Nikolis, MD, PhD (1) · Ariadna Huertas Zurriaga, RN (1) · Cheng Fong Chen (1) · Daniel Cho, MD, PhD (1) · Danijel Domic, Dr.med.dent. (1) · Gabriel Gijon-Nogueron, PhD (1) · Isabel Granados Navarrete, RN (1) · Joan Blanco Blanco, RN (1)
PMID 12140209, PMID 14508260, PMID 14723108, PMID 15976462, PMID 16900272, PMID 16973668, PMID 17172891, PMID 18691081, PMID 19034126, PMID 21529354, PMID 27243353, PMID 27561497, PMID 27929721, PMID 28397148, PMID 28736342, PMID 28797892, PMID 28827614, PMID 29958008, PMID 30036099, PMID 34454466, PMID 41436701, PMID 8534643, PMID 9260563, PMID 9627665