100 completed, 27 unknown, 26 terminated, 15 recruiting. 83 Phase 2, 47 Phase 3, 36 Phase 4, 26 Phase 1, 17 Not applicable.
Follow this drug Literature Review of Methylprednisolone Hemisuccinate trials Research Report on Methylprednisolone Hemisuccinate
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Intra Articular Injection of Peripheral Blood Mononuclear Cells for Knee Osteoarthritis High-dose PCP-PBMCs injection, Solu-Medrol, Low-dose PCP-PBMCs injection - Knee Osteoarthritis | Phase 2 / Phase 3 | Not yet recruiting | DuoGenic StemCells Corporation (DGSC) | 240 | 2026-09-30 | 2026-07-20 |
| Teprotumumab N01 Versus Methylprednisolone After Urgent Orbital Decompression for Dysthyroid Optic Neuropathy Teprotumumab N01, Intravenous Methylprednisolone (IVMP) - Thyroid Eye Disease, TED, Graves Ophthalmopathy | Phase 2 | Not yet recruiting | Sun Yat-sen University | 60 | 2026-08-01 | 2026-05-19 |
| IA Lidocaine and Methylprednisolone for Headache Associated With Subarachnoid Hemorrhage Lidocaine hydrochloride, Methylprednisolone sodium succinate - Headaches Associated With Subarachnoid Hemorrhage (SAH) | Phase 2 | Recruiting | Daniel Raper, MBBS | 25 | 2026-06-23 | 2026-07-08 |
| Evaluation of Corticosteroid Administration Following Impacted Third Molar Surgery Using 3-Dimensional Facial Analysis Surgical Extraction of Impacted Mandibular Third Molar, methylprednisolone sodium succinate, Dexamethasone Sodium Phosphate Injection - Impacted Mandibular Third Molar Extraction, Postoperative Pain Control | Not applicable | Completed | Irfan Üstündağ | 60 | 2026-03-02 | 2026-06-04 |
| Early Inflammatory-Immune Stratification and Precision Glucocorticoid Intervention in Acute Respiratory Failure Induced by Community-Acquired Pneumonia Methylprednisolone - Acute Respiratory Failure, Community-Acquired Pneumonia | Phase 1 / Phase 2 | Not yet recruiting | Qingyuan Zhan | 500 | 2026-02-01 | 2026-01-22 |
| Upadacitinib Combined With Corticosteroids vs Corticosteroid Monotherapy Induction for Inpatients and Outpatients With Acute Severe Ulcerative Colitis Oral Upadacitinib, Intravenous Methylprednisolone, Oral Upadacitinib Placebo - Ulcerative Colitis Acute | Phase 4 | Recruiting | Berinstein, Jeffrey | 110 | 2026-01-16 | 2026-02-02 |
| Study of Gecacitinib-corticosteroid as First-line Therapy for Grade II-IV Acute Graft Versus Host Disease Gecacitinib-Corticosteroid, Methylprednisolone sodium succinate - aGVHD | Phase 2 | Recruiting | Bin Gu | 25 | 2026-01-01 | 2026-09-23 |
| Methylprednisolone Sodium Succinate With Endovascular ThRombectomy for Large Ischemic STroke Methylprednisolone sodium succinate, Placebo - Ischemic Stroke, Acute | Not applicable | Not yet recruiting | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | 912 | 2025-10-01 | 2025-09-16 |
| A Comparative Study Between Dexmedetomidine Versus Methylprednisolone on Induced Inflammatory Response in Patients Undergoing On-pump CABG Normal saline, Dexmedetomidine, Methylprednisolone - Coronary Artery Disease, Systemic Inflammatory Response Syndrome | Phase 1 / Phase 2 | Unknown | Ain Shams University | 60 | 2025-09-01 | 2025-08-06 |
| Methylprednisolone for Stroke With Large Infarct Core and Post-stroke Lymphocytopenia Methylprednisolone sodium succinate, Normal Saline - Large Infarct Core, Post-stroke Lymphocytopenia | Phase 3 | Recruiting | YiLin | 200 | 2025-09-01 | 2025-10-01 |
| MAGIC Ruxolitinib for aGVHD Ruxolitinib, Methylprednisolone - Acute Graft-versus-host Disease, Allogeneic Bone Marrow Transplantation | Phase 2 | Recruiting | John Levine | 98 | 2025-05-14 | 2026-03-23 |
| Neuroendoscopic Hematoma Evacuation Combined With Methylprednisolone Sodium Succinate in the Treatment of Basal Ganglia Intracerebral Hemorrhage at the Early Stage Simple neuroendoscopic hematoma evacuation, Neuroendoscopic hematoma evacuation combined with sodium methylprednisolone succinate - Stroke, Intracerebral Hemorrhage Basal Ganglia | Phase 4 | Not yet recruiting | Yong Jiang | 100 | 2025-05-01 | 2025-04-13 |
| Neuroendoscopic Hematoma Evacuation Combined With Methylprednisolone Sodium Succinate in the Treatment of Lobar Intracerebral Hemorrhage at the Early Stage. Simple neuroendoscopic hematoma evacuation, Neuroendoscopic hematoma evacuation combined with sodium methylprednisolone succinate - Stroke, Intracerebral Hemorrhage Lobar | Phase 4 | Not yet recruiting | Yong Jiang | 396 | 2025-05-01 | 2025-04-13 |
| Methylprednisolone Adjunctive to Endovascular Thrombectomy for Stroke Methylprednisolone sodium succinate, Placebo - Acute Ischemic Stroke, Large Infarct Core | Phase 3 | Active not recruiting | Wan-Jin Chen | 928 | 2024-08-01 | 2025-12-03 |
| Comparing Methylprednisolone And Hyaluronic Acid To Reduce Wisdom Tooth Surgery Complications Methyl Prednisolone (MP), Hyaluronic Acid (HA) - Wisdom Tooth Removal, Post Operative Complications | Phase 3 | Enrolling by invitation | Sana'a University | 40 | 2024-06-27 | 2026-04-30 |
| MYTHS-MR Trial (MYocarditis THerapy With Steroids in Patients With Mildly Reduced Ejection Fraction) Methylprednisolone 125 MG, IV saline solution 0.9% - Acute Myocarditis | Phase 3 | Recruiting | University Hospital, Antwerp | 174 | 2024-05-24 | 2025-04-17 |
| The Efficacy of Intravenous Pulse in Attaining Remission in Refractory Juvenile Idiopathic Arthritis Solumedrol - Refractory Juvenile Idiopathic Arthritis (Despite 2 DMARDs Still Active) | Phase 3 | Unknown | Sohag University | 215 | 2024-05-01 | 2024-06-17 |
| Pulse Steroid Injection in Refractory Rheumatoid Arthritis Solumedrol - Active Rheumatoid Arthritis | Phase 3 | Unknown | Sohag University | 268 | 2024-05-01 | 2024-06-13 |
| Particulate vs. Non-Particulate Steroid for Sacroiliac Joint Injection Dexamethasone, Methylprednisolone, 2% Lidocaine HCl Injection - Sacroiliac Joint Dysfunction, Sacro-Iliac Spondylosis | Phase 4 | Recruiting | University of New Mexico | 230 | 2024-03-27 | 2025-11-06 |
| Localized Injection of Lidocaine and Glucocorticoid for Headache Treatment Phase 1 Lidocaine hydrochloride, Methylprednisolone sodium succinate - Refractory Migraine | Phase 1 | Completed | The Cooper Health System | 10 | 2024-03-15 | 2025-11-04 |
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Leukemia (12) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (12) · Leukemia, Myeloid, Acute (9) · Osteoarthritis (8) · COVID-19 (7) · Lymphoma (7) · Lymphoma, Non-Hodgkin (7) · Burkitt Lymphoma (6) · Graft vs Host Disease (6) · Lymphoma, Follicular (6) · Lymphoma, Large B-Cell, Diffuse (6) · Myelodysplastic Syndromes (6) · Blast Crisis (5) · Graves Ophthalmopathy (5) · Lymphoma, Mantle-Cell (5)
M.D. Anderson Cancer Center (11) · Copenhagen University Hospital, Rigshospitalet (7) · Stanford University (7) · Northwestern University (6) · National Institute of Allergy and Infectious Diseases (NIAID) (5) · Children's Oncology Group (3) · National Taiwan University Hospital (3) · Washington University School of Medicine (3) · A. Manzoni Hospital (2) · Ain Shams University (2) · Assiut University (2) · Berinstein, Jeffrey (2) · Case Comprehensive Cancer Center (2) · Cedars-Sinai Medical Center (2) · Emory University (2)
United States (88) · Denmark (19) · China (14) · Italy (10) · Canada (9) · Belgium (8) · Egypt (8) · France (6) · Taiwan (6) · Germany (5) · Switzerland (5) · Netherlands (4) · Sweden (4) · United Kingdom (4) · Austria (3)
Richard Burt, MD (6) · Viktoria Lindberg-Larsen, MD (6) · Wen-Kai Weng (3) · Jeffrey Berinstein, MD, MSc (2) · Robert Lowsky (2) · Rodica Morariu-Zamfir, MD (2) · Sergio Giralt, MD (2) · Alaa F Fathy, researcher (1) · Alexandra L Goodyear, MD, MS (1) · Amal Y Al-Eryani (1) · Amin Alousi, MD (1) · Antonello Pani, MD (1) · Arnaldo P Barbosa (1)
PMID 11919310, PMID 12359731, PMID 14667752, PMID 15851648, PMID 17452226, PMID 17533019, PMID 17978307, PMID 19005182, PMID 19571790, PMID 19571791, PMID 20148887, PMID 20671616, PMID 21044725, PMID 21606384, PMID 21610239, PMID 21852672, PMID 22174345, PMID 22438229, PMID 22563089, PMID 22797672, PMID 22805100, PMID 23361904, PMID 23369458, PMID 23587468, PMID 23774314, PMID 23870160, PMID 24029421, PMID 24674813, PMID 25018935, PMID 25058803, PMID 25058804, PMID 25115430, PMID 25253674, PMID 25343233, PMID 25505035, PMID 25585823, PMID 25791027, PMID 26231455, PMID 26446165, PMID 26477577, PMID 26630142, PMID 2665875, PMID 26688484, PMID 27287853, PMID 27403440, PMID 27477797, PMID 28341274, PMID 28422025, PMID 28609319, PMID 28627134
P30CA016672 (4), 2015 (3), 2017 (2), U10CA098543 (2), 2005 (1), 2009 (1), 2014 (1), 2018 (1), K23DK134764 (1), P01CA018029 (1), P01CA039542 (1), P01CA049605 (1), P30CA012197 (1), P30CA023074 (1), P30CA036727 (1)