24 completed, 7 unknown, 5 recruiting, 5 terminated. 14 Phase 2, 12 Not applicable, 11 Phase 3, 3 Phase 4, 2 Phase 1.
Follow Hepatorenal Syndrome: new trials by email Literature Review of Hepatorenal Syndrome trials Research Report on Hepatorenal Syndrome
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Renal Histopathology and Transcriptomic Analysis in Hepatorenal Syndrome During Liver Transplantation renal biopsy - Hepatorenal Syndrome, Liver Regeneration, AKI - Acute Kidney Injury | Not applicable | Not yet recruiting | The University of Hong Kong | 42 | 2026-01-01 | 2025-12-24 |
| Comparison of Terlipressin Versus Octreotide in Patients With Hepatorenal Syndrome terlipressin, Octreotide (drug) - Hepatorenal Syndrome | Not applicable | Completed | Lahore General Hospital | 60 | 2025-05-01 | 2026-03-10 |
| Initial Resuscitation for Acute Kidney Injury in Cirrhosis Recommendation: No Further Resuscitation, Recommendation: Resuscitation with Crystalloid, Recommendation: Resuscitation with Colloid - Cirrhosis, Liver, Acute Kidney Injury | Not applicable | Recruiting | Massachusetts General Hospital | 50 | 2024-09-12 | 2026-03-13 |
| Endothelin Receptor Antagonism With Ambrisentan to Treat Hepatorenal Syndrome Ambrisentan, Terlipressin - Hepatorenal Syndrome, Liver Cirrhosis | Phase 2 | Active not recruiting | Noorik Biopharmaceuticals AG | 54 | 2024-04-17 | 2026-04-13 |
| Terlipressin in Combined Hepatorenal Syndrome in Patients With Signs of Chronic Renal Disease terlipressin or noradrenalin plus albumin - Liver Cirrhosis, Hepato-Renal Syndrome | Completed | University Hospital Freiburg | 490 | 2024-03-03 | 2025-12-05 | |
| NEPH-ROSIS (NEPHrology in CirRhOSIS) Pilot Trial: A Trial to Treat Acute Kidney Injury Among Hospitalized Cirrhosis Patients MAP-Target Algorithm - Acute Kidney Injury, Cirrhosis | Phase 2 / Phase 3 | Terminated | University of California, San Francisco | 14 | 2024-02-01 | 2026-09-24 |
| Study to Evaluate R2R01 Plus Terlipressin Versus Terlipressin Alone in Patients With Hepatorenal Syndrome R2R01, Terlipressin - Hepatorenal Syndrome, Acute Kidney Injury | Phase 2 | Unknown | River 2 Renal Corp. | 95 | 2023-06-30 | 2023-10-03 |
| A Retrospective Analysis of Outcomes in Patients With Hepatorenal Syndrome at Methodist Dallas Medical Center Hepatorenal Syndrome outcome in Patients at Methodist Health systems - Hepatorenal Syndrome | Recruiting | Methodist Health System | 500 | 2023-05-13 | 2026-05-01 | |
| HRS-AKI Treatment With TIPS in Patients With Cirrhosis TIPS, Standard of Care - Cirrhosis, Liver, Hepatorenal Syndrome | Not applicable | Recruiting | Jena University Hospital | 124 | 2022-11-29 | 2024-11-18 |
| International Registry of Acute Kidney Injury in Cirrhosis: The GLOBAL AKI Project Crystalloids, albumin, vasoconstrictors, diuretics, renal replacement therapy - Liver Cirrhosis, Acute Kidney Injury | Completed | Azienda Ospedaliera di Padova | 1456 | 2022-07-01 | 2024-01-30 | |
| Statin Impact on Hepatic Decompensation Atorvastatin 20mg, Placebo - Quality of Life, the Incidence of Whole Complications Resultant From Decompensated Liver | Phase 2 / Phase 3 | Completed | Tanta University | 100 | 2022-06-15 | 2026-09-14 |
| The Selective Cytopheretic Device (SCD) for Acute Kidney Injury (AKI) and Hepatorenal Syndrome (HRS) Type I Selective Cytopheretic Device - Acute Kidney Injury, Hepatorenal Syndrome | Not applicable | Suspended | Lenar Yessayan | 10 | 2022-06-09 | 2026-10-02 |
| A Study of OCE-205 in Participants With Cirrhosis With Ascites Who Developed Hepatorenal Syndrome-Acute Kidney Injury OCE-205, Placebo - Cirrhosis, Ascites | Phase 2 | Completed | Ocelot Bio, Inc | 47 | 2022-04-28 | 2023-12-15 |
| Point-of-Care Echocardiography to Assess Impact of Dynamic Cardiac Function, Renal and Cardiac Biomarkers in Cirrhosis With Hepatorenal Syndrome-Acute Kidney Injury Echocardiographic assessment - Hepatorenal Syndrome, Cirrhosis, Liver | Unknown | Post Graduate Institute of Medical Education and Research, Chandigarh | 75 | 2021-12-15 | 2023-05-01 | |
| Fractional Excretion of Urea for the Differential Diagnosis of Acute Kidney Injury in Cirrhosis Acute Kidney Injury | Unknown | Sohag University | 100 | 2021-09-04 | 2022-10-28 | |
| Angiotensin 2 for Hepatorenal Syndrome Angiotensin II, Midodrine, Octreotide - Hepatorenal Syndrome, Cirrhosis | Phase 2 | Withdrawn | University of California, Los Angeles | 2021-07-01 | 2024-03-06 | |
| Faecal Microbiota Transplantation for Liver Cirrhosis Faecal microbiota transplantation, Placebo - Liver Cirrhosis | Phase 2 / Phase 3 | Recruiting | University of Aarhus | 220 | 2021-07-01 | 2025-01-24 |
| Terlipressin for HRS-AKI in Liver Transplant Candidates (INFUSE) Terlipressin - Hepatorenal Syndrome | Phase 3 | Completed | University of Pennsylvania | 50 | 2020-12-11 | 2024-10-09 |
| Efficacy of Early Terlipressin Plus Albumin Therapy in Comparison to Standard Treatment for HRS-AKI in Acute-on-chronic Liver Failure. Terlipressin, Albumin - Acute-On-Chronic Liver Failure, Hepatorenal Syndrome | Not applicable | Completed | Institute of Liver and Biliary Sciences, India | 70 | 2020-06-22 | 2023-04-06 |
| Nor-epinephrine Versus Midodrine/Octreotide in Patients With Hepatorenal Syndrome Midodrine/Octreotide, Nor-epinephrine - Hepato-Renal Syndrome | Not applicable | Completed | National Hepatology & Tropical Medicine Research Institute | 91 | 2018-04-15 | 2020-08-21 |
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Fibrosis (20) · Acute Kidney Injury (18) · Ascites (10) · Liver Cirrhosis (10) · Renal Insufficiency (6) · Hypertension, Portal (4) · Acute-On-Chronic Liver Failure (3) · Hepatitis, Alcoholic (3) · Liver Diseases (3) · Kidney Cortex Necrosis (2) · Adrenal Insufficiency (1) · Brain Diseases (1) · Gastrointestinal Hemorrhage (1) · Hepatic Encephalopathy (1)
Digestive System Diseases (48) · Female Urogenital Diseases (48) · Female Urogenital Diseases and Pregnancy Complications (48) · Kidney Diseases (48) · Male Urogenital Diseases (48) · Urogenital Diseases (48) · Urologic Diseases (48) · Liver Diseases (45) · Pathologic Processes (28) · Pathological Conditions, Signs and Symptoms (28) · Renal Insufficiency (18) · Fibrosis (8) · Hepatic Insufficiency (4) · Liver Failure (4) · Alcohol-Induced Disorders (3)
Terlipressin (16) · Albumins (9) · Midodrine (6) · Octreotide (6) · Crystalloid Solutions (2) · Norepinephrine (2) · Amoxicillin (1) · Amoxicillin-Potassium Clavulanate Combination (1) · Angiotensin I (1) · Angiotensin II (1) · Atorvastatin (1) · Blood Specimen Collection (1) · Colloids (1) · Diuretics (1) · Fecal Microbiota Transplantation (1)
Hospital Clinic of Barcelona (4) · Mallinckrodt (3) · Institute of Liver and Biliary Sciences, India (2) · The University of Hong Kong (2) · University of Turin, Italy (2) · Anna Cruceta (1) · Assistance Publique - Hôpitaux de Paris (1) · Azienda Ospedaliera di Padova (1) · Cumberland Pharmaceuticals (1) · Hospices Civils de Lyon (1) · Hvidovre University Hospital (1) · Jena University Hospital (1) · La Jolla Pharmaceutical Company (1) · Lahey Clinic (1) · Lahore General Hospital (1)
United States (16) · India (6) · Spain (6) · Canada (4) · Egypt (4) · France (4) · Italy (4) · Denmark (3) · Germany (3) · Brazil (2) · China (2) · Hong Kong (2) · South Korea (2) · Argentina (1) · Austria (1)
Alberto Q Farias, Associate professor (1) · Arun J. Sanyal, M.D. (1) · Brendan McGuire, MD (1) · Carlo Alessandria, MD (1) · Cristina Ripoll, MD (1) · Cristina Ripoll, Prof. Dr. (1) · Desmond Yap, MD (1) · Dominik Bettinger, MD (1) · Edith Fleischmann, M.D. (1) · Eman A Sabet, Professor (1)
PMID 36633470, PMID 37143199, PMID 37302573, PMID 40704461, PMID 25638527, PMID 28370090, PMID 17560680, PMID 18471513, PMID 22521351, PMID 24277679, PMID 24375576, PMID 24613364, PMID 24700173, PMID 25183658, PMID 26042740, PMID 26141259, PMID 26484442, PMID 26896734, PMID 27464593, PMID 27475248, PMID 27876501, PMID 28406940, PMID 28842294, PMID 29140542, PMID 29369449, PMID 29973706, PMID 31096099, PMID 33657294, PMID 37020315, PMID 37159035, PMID 37976391, PMID 38235907, PMID 39938959, PMID 40058397, PMID 40658810, PMID 40677691, PMID 41200852, PMID 41265546, PMID 41865069, PMID 42813964
2014 (1), K23DK128567 (1)