Helicobacter Infections: Clinical Trials

30 completed, 7 unknown, 6 recruiting, 3 terminated. 15 Phase 4, 9 Phase 3, 7 Not applicable, 6 Phase 2, 2 Phase 1.

By phase and status

Phase	Trials	Status
Phase 4	15	Completed 11, Not yet recruiting 2, Unknown 1, Withdrawn 1
Phase 3	9	Unknown 4, Completed 3, Recruiting 1, Terminated 1
Not applicable	7	Recruiting 2, Active not recruiting 1, Completed 1, Terminated 1, Unknown 1, Withdrawn 1
Phase 2	6	Completed 3, Recruiting 1, Terminated 1, Unknown 1
Phase 1	2	Completed 1, Terminated 1

Follow Helicobacter Infections: new trials by email Literature Review of Helicobacter Infections trials Research Report on Helicobacter Infections

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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
Efficacy Comparison of 10-Day High-Dose Versus 14-Day Standard-Dose Vonoprazan Plus Amoxicillin in Helicobacter Pylori Eradication: A Multicenter Non-Inferiority Randomized Controlled Trial 10-day group, 14-day group - Helicobacter Infection, Vonoprazan	Phase 4	Not yet recruiting	Shandong University	232	2026-09-30	2026-09-29
Keverprazan-Minocycline Dual Therapy of Different Durations Versus Bismuth Quadruple Therapy for Helicobacter Pylori Eradication. Minocycline, Keverprazan, Amoxicillin - Helicobacter Infection	Phase 3	Recruiting	Nanjing First Hospital, Nanjing Medical University	612	2026-07-15	2026-10-29
Vonoprazan vs Proton Pump Inhibitor With Vitamin D or Probiotics Based Triple Therapy for Eradication of Helicobacter Pylori Infection Vonoparazan, Vitamin D, Probiotic - HELICOBACTER PYLORI INFECTIONS, Helicobacter Infection	Phase 2	Recruiting	Tanta University	132	2026-02-15	2026-09-09
Clinical Trial to Evaluate the Efficacy of Probit-Based Triple Therapy for Helicobacter Pylori Eradication This study aims to evaluate the efficacy and safety of a 14-day triple therapy regimen consisting of Zastaprazan 20 mg, clarithromycin, and amoxicillin for the eradication of Helicobacter pylori. - Helicobacter Infection	Phase 4	Not yet recruiting	Samsung Medical Center	103	2025-12-01	2025-08-14
An Observational Study for Gastric Cancer in Carriers of High Risk Helicobacter Pylori observational study - Gastric (Stomach) Cancer, Helicobacter Infection		Recruiting	Fudan University	3000	2025-07-01	2026-02-25
The Prevalence and the Pathophysiological Role of Non-Helicobacter Pylori Helicobacter Spp. in Well-defined Gastric Diseases and (Pre-) Malignancies Functional Dyspepsia, Gastritis		Recruiting	Universiteit Antwerpen	150	2025-02-24	2026-08-18
Helicobacter Pylori Infection and Gastric Diseases in Lao PDR: First Community-Wide Population-Based Study Gastric Cancer Screening, Prevention and Control		Completed	Zero Helicobacter IGAN Network	1251	2023-12-18	2026-01-14
Helicobacter Pylori Prevalence in Southern Region of Romania Infections, Helicobacter		Completed	Carol Davila University of Medicine and Pharmacy	708	2023-04-01	2024-08-21
Effectiveness of Rifabutin for Treatment of Helicobacter Pylori Rifabutin, Amoxicillin, Esomeprazole - Helicobacter Infections, Resistance Bacterial	Phase 3	Unknown	Rabin Medical Center	300	2021-05-01	2021-03-10
Association Between Helicobacter Pylori and Inflammatory Bowel Disease Helicobacter Infections		Completed	Assiut University	50	2019-02-01	2021-06-30
A Unique Regimen for Treatment of Helicobacter Pylori Infection Quadruple therapy, Classic treatment - Helicobacter Infections	Phase 3	Unknown	Sherief Abd-Elsalam	600	2018-04-01	2018-04-10
A Comparison of Four Different Treatment Regimens of Helicobacter Pylori in Chinese Children triple therapy, sequential therapy, bismuth quadruple therapy - Helicobacter Infections	Not applicable	Recruiting	Ying HUANG	1440	2017-09-20	2025-02-28
Comparison Efficacy of 14-day Concomitant Therapy:Clarithromycin vs.Levofloxacin in Eradication of H.Pylori Clarithromycin 500Mg Oral Tablet, Levofloxacin 500Mg Oral Tablet - Helicobacter Pylori Gastrointestinal Tract Infection	Phase 4	Withdrawn	Damascus Hospital		2017-06-01	2018-12-07
Intraluminal Therapy for Helicobacter Pylori Infection Lansoprazole, Amoxicillin, Clarithromycin - Helicobacter Pylori Infection	Phase 4	Completed	Mackay Memorial Hospital	100	2017-04-28	2018-05-02
Specimen Collection Study for H. Pylori Testing Helicobacter Infections		Completed	Biomerica	98	2017-02-27	2022-03-18
Comparison of Daily Single Dose Triple and Conventional Triple Therapies for Helicobacter Pylori Infection Nexium, Tinafas, Tavanex - Helicobacter Infection	Phase 4	Completed	Zahra Vahdat Shariatpanahi	212	2016-09-01	2017-06-08
The Effect of Probiotic Combination on Helicobacter Pylori Infection in Children Gastrus, Placebo - Helicobacter Infections	Not applicable	Withdrawn	University Medical Centre Ljubljana		2016-01-01	2017-08-22
Comparison Efficacy of 14-day Triple Therapy: Clarithromycin vs. Levofloxacin on Eradication of H. Pylori Clarithromycin, Levofloxacin - Helicobacter Pylori Gastrointestinal Tract Infection	Phase 4	Unknown	Damascus Hospital	74	2015-12-01	2017-03-21
Dual Therapy With High Doses of Ilaprazole and Amoxicillin for Helicobacter Pylori Infection Ilaprazole + Amoxicillin - Helicobacter Infections	Phase 4	Completed	Il-Yang Pharm. Co., Ltd.	90	2014-12-01	2015-11-03
The Efficacy of the 7 Days Tailored Therapy as 2nd Rescue Therapy for Eradication of H. Pylori Infection H. pylori culture and antimicrobial susceptibility testing, 14 days empirical bismuth quadruple therapy (Proton pump inhibitor), Metronidazole - Helicobacter Infection	Not applicable	Terminated	Seoul National University Bundang Hospital	370	2014-08-01	2023-04-13

Showing 20 of 51. Sign in to see all of them.

Narrower conditions

Stomach Neoplasms (6)  ·  Gastritis (5)  ·  Infections (3)  ·  Bacterial Infections (2)  ·  Cardiovascular Diseases (2)  ·  Chlamydia Infections (2)  ·  Coronary Disease (2)  ·  Cytomegalovirus Infections (2)  ·  Duodenal Ulcer (2)  ·  Gastritis, Atrophic (2)  ·  Heart Diseases (2)  ·  Inflammation (2)  ·  Myocardial Infarction (2)  ·  Peptic Ulcer (2)

Broader conditions

Bacterial Infections and Mycoses (51)  ·  Gram-Negative Bacterial Infections (50)  ·  Bacterial Infections (49)  ·  Infections (48)  ·  Digestive System Diseases (11)  ·  Gastrointestinal Diseases (10)  ·  Stomach Diseases (9)  ·  Digestive System Neoplasms (6)  ·  Gastroenteritis (6)  ·  Gastrointestinal Neoplasms (6)  ·  Neoplasms (6)  ·  Neoplasms by Site (6)  ·  Duodenal Diseases (4)  ·  Intestinal Diseases (4)  ·  Pathological Conditions, Signs and Symptoms (4)

Interventions

Amoxicillin (20)  ·  Clarithromycin (14)  ·  Metronidazole (8)  ·  Esomeprazole (7)  ·  Lansoprazole (4)  ·  Rabeprazole (4)  ·  Tetracycline (4)  ·  Levofloxacin (3)  ·  Moxifloxacin (3)  ·  Omeprazole (3)  ·  Proton Pump Inhibitors (3)  ·  Tinidazole (3)  ·  Pantoprazole (2)  ·  ilaprazole (2)  ·  Bismuth (1)

Sponsors

Seoul National University Bundang Hospital (5)  ·  Asan Medical Center (2)  ·  Damascus Hospital (2)  ·  Hamamatsu University (2)  ·  Il-Yang Pharm. Co., Ltd. (2)  ·  MerLion Pharmaceuticals GmbH (2)  ·  National Heart, Lung, and Blood Institute (NHLBI) (2)  ·  National Taiwan University Hospital (2)  ·  American University of Beirut Medical Center (1)  ·  Assiut University (1)  ·  Atlantia Food Clinical Trials (1)  ·  Biomerica (1)  ·  Carol Davila University of Medicine and Pharmacy (1)  ·  Coordinación de Investigación en Salud, Mexico (1)  ·  Dallas VA Medical Center (1)

Countries

South Korea (8)  ·  United States (7)  ·  China (4)  ·  Taiwan (4)  ·  Egypt (3)  ·  Belgium (2)  ·  Germany (2)  ·  Japan (2)  ·  Syria (2)  ·  United Kingdom (2)  ·  Croatia (1)  ·  Finland (1)  ·  Iran (1)  ·  Ireland (1)  ·  Israel (1)

Top investigators

Nayoung Kim, M.D., Ph. D (3)  ·  Ala' I Sharara, MD (1)  ·  Alaa El Abdelmonem, Doctorate of internal medicine (1)  ·  Antone R Opekun, PA-C (1)  ·  Asem Elfert, Prof (1)  ·  Ayman Yousry, Prof (1)  ·  Bahaa Os Taha, Master of internal medicine (1)  ·  Benjamin D. Gold, M.D. (1)  ·  Byron Cryer, MD (1)  ·  Ching-Kuan Liu, MD, PhD (1)  ·  Cinzia Papadia, MD (1)  ·  David L Putnam, PhD (1)  ·  David Y Graham, MD (1)  ·  Deng-Chyang Wu, MD PhD (1)  ·  Dongsoo Lee, MD, PhD. (1)

Results publications

PMID 11197288, PMID 16441468, PMID 20427390, PMID 21336156, PMID 21336159, PMID 21345487, PMID 21762268, PMID 24050512, PMID 24296423, PMID 25460556, PMID 26452405, PMID 30635887, PMID 30734357, PMID 31067538, PMID 32153909, PMID 32365359, PMID 32545856, PMID 33037845

NIH funding

R01HL058755 (1), R01HL062233 (1), R44DK055935 (1)