21 completed, 4 recruiting, 4 unknown, 3 terminated. 12 Not applicable, 7 Phase 2, 3 Phase 4, 2 Early Phase 1, 1 Phase 1.
Follow Heart Failure With Normal Ejection Fraction: new trials by email Literature Review of Heart Failure With Normal Ejection Fraction trials Research Report on Heart Failure With Normal Ejection Fraction
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Chronic Exogenous Ketosis in HFpEF Exogenous Ketone Drink, Placebo - Heart Failure With Preserved Ejection Fraction (HFPEF), Heart Failure With Normal Ejection Fraction | Phase 2 | Enrolling by invitation | Duke University | 20 | 2025-07-28 | 2026-10-14 |
| Ablation Versus Medical Management of Atrial Fibrillation in HFpEF Pulmonary Vein Isolation - Atrial Fibrillation, Heart Failure With Normal Ejection Fraction | Not applicable | Terminated | Inova Health Care Services | 13 | 2023-07-10 | 2026-03-27 |
| Chlorhexidine Mouthwash and Oral Nitrate in Adults With Pulmonary Hypertension Nitrates, Chlorhexidine Gluconate Mouthwash, Placebo Mouthwash - Pulmonary Hypertension, Heart Failure With Normal Ejection Fraction | Phase 1 | Withdrawn | Gladwin, Mark, MD | 2022-12-01 | 2022-07-07 | |
| Iron Substitution With Ferric Carboxymaltose as Treatment Strategy for Heart Failure Patients With Preserved Ejection Fraction Ferric carboxymaltose, Placebo - Heart Failure With Normal Ejection Fraction, Iron-deficiency | Phase 4 | Withdrawn | Cantonal Hospital, Baselland | 2021-12-01 | 2022-07-28 | |
| High-intensity Interval Training in Heart Failure Patients With Preserved Ejection Fraction High-intensity interval training (HIT), Moderate-intensity contiuous training (MCT) - Heart Failure With Normal Ejection Fraction | Not applicable | Unknown | University of Basel | 86 | 2020-07-01 | 2023-02-13 |
| Unsaturated Fatty Acids to Improve Cardiorespiratory Fitness in Obesity and HFpEF UFA dietary recommendations - Obesity, Heart Failure With Normal Ejection Fraction | Not applicable | Completed | Virginia Commonwealth University | 30 | 2019-07-23 | 2024-07-03 |
| Open-Label Rollover Study of Levosimendan in PH-HFpEF Patients Levosimendan - Hypertension Pulmonary Secondary Heart Failure, Right Sided Heart Failure With Normal Ejection Fraction | Phase 2 | Completed | Tenax Therapeutics, Inc. | 35 | 2019-04-09 | 2026-04-22 |
| Flow Regulation by Opening the Septum in Patients With Heart Failure Trial AFR implantation, Sham procedure - Heart Failure With Normal Ejection Fraction | Not applicable | Unknown | Unity Health Toronto | 230 | 2019-01-01 | 2018-11-23 |
| Renal Hemodynamics in Patients With HFpEF Renal clearance examination - Heart Failure With Normal Ejection Fraction | Completed | University of Erlangen-Nürnberg Medical School | 40 | 2018-11-30 | 2019-07-10 | |
| Hemodynamic Evaluation of Levosimendan in Patients With PH-HFpEF Levosimendan, Matching Placebo - Hypertension Pulmonary Secondary, Heart Failure, Right Sided | Phase 2 | Completed | Tenax Therapeutics, Inc. | 44 | 2018-11-14 | 2024-11-20 |
| β-blockers Withdrawal in Patients With HFpEF and Chronotropic Incompetence: Effect on Functional Capacity (Preserve-HR) Controlled withdrawal of beta-blockers, Cardiopulmonary Exercise Testing - Heart Failure With Normal Ejection Fraction, Chronotropic Incompetence | Phase 4 | Completed | Fundación para la Investigación del Hospital Clínico de Valencia | 52 | 2018-10-01 | 2021-03-02 |
| Imaging Histone Deacetylase in the Heart 11C-Martinostat, PET-MRI - Heart Failure With Normal Ejection Fraction, Left Ventricular Hypertrophy | Not applicable | Recruiting | Massachusetts General Hospital | 96 | 2018-09-07 | 2025-12-22 |
| Hemodynamic-GUIDEd Management of Heart Failure CardioMEMS™ HF System - Heart Failure, Heart Failure, Systolic | Not applicable | Completed | Abbott Medical Devices | 2358 | 2018-03-15 | 2025-08-07 |
| Abnormal Vascular, Metabolic, and Neural Function During Exercise in Heart Failure With Preserved Ejection Fraction Exercise training - Heart Failure With Normal Ejection Fraction | Not applicable | Suspended | University of Texas Southwestern Medical Center | 22 | 2018-02-01 | 2026-07-22 |
| Validation of CMR Against Invasive Haemodynamics in Patients With HFpEF Comprehensive Cardiovascular magnetic resonance (CMR), Blood sampling, TTE (EchoErgo) - Heart Failure With Normal Ejection Fraction | Completed | Goethe University | 185 | 2018-01-14 | 2023-03-10 | |
| New Orleans Pulmonary Hypertension Biobank No intervention. Biospecimen collection only - Pulmonary Hypertension, Systemic Sclerosis | Recruiting | Louisiana State University Health Sciences Center in New Orleans | 450 | 2017-12-29 | 2021-09-10 | |
| Neuromodulation to Treat Patients With Heart Failure With Preserved Ejection Fraction low level transcutaneous vagus nerve stimulation - Heart Failure With Normal Ejection Fraction | Not applicable | Completed | University of Oklahoma | 52 | 2017-12-12 | 2026-01-23 |
| Inhaled Iloprost and Exercise Hemodynamics and Ventricular Performance in Heart Failure With Preserved Ejection Fraction Iloprost, Placebo - Heart Failure With Normal Ejection Fraction | Phase 4 | Unknown | National Taiwan University Hospital | 34 | 2017-11-29 | 2019-08-14 |
| Unsaturated Fatty Acids Enriched-diet to Improve Cardiorespiratory Fitness, Metabolic Flexibility and Glucose Tolerance in Obese Patients Increasing daily unsaturated fatty acid consumption - Heart Failure With Normal Ejection Fraction, Obesity | Not applicable | Completed | Virginia Commonwealth University | 16 | 2017-10-23 | 2019-04-18 |
| Effects of Iron Therapy in Heart Failure With Preserved Ejection Fraction and Iron Deficiency (PREFER-HF) Placebo, Ferric carboxymaltose, Ferroglycine Sulfate - Heart Failure With Normal Ejection Fraction, Ferropenic Anemia | Phase 3 | Completed | Institut de Recerca Biomèdica de Lleida | 72 | 2017-08-23 | 2025-05-21 |
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Heart Failure (14) · Heart Failure, Diastolic (5) · Hypertension, Pulmonary (4) · Anemia, Iron-Deficiency (2) · Inflammation (2) · Motor Activity (2) · Obesity (2) · Sleep Apnea Syndromes (2) · Aortic Valve Stenosis (1) · Atrial Fibrillation (1) · Bronchiolitis Obliterans Syndrome (1) · Diabetes Mellitus (1) · Heart Failure, Systolic (1) · Heart Murmurs (1) · Hypertrophy, Left Ventricular (1)
Cardiovascular Diseases (20) · Heart Diseases (18) · Respiratory Tract Diseases (7) · Nutritional and Metabolic Diseases (6) · Pathological Conditions, Signs and Symptoms (6) · Lung Diseases (5) · Hypertension (4) · Metabolic Diseases (4) · Vascular Diseases (4) · Pathologic Processes (3) · Signs and Symptoms (3) · Anemia (2) · Anemia, Hypochromic (2) · Apnea (2) · Behavior (2)
Exercise (2) · Simendan (2) · ferric carboxymaltose (2) · Biopsy (1) · Blood Specimen Collection (1) · Cell- and Tissue-Based Therapy (1) · Echocardiography (1) · Exercise Test (1) · High-Intensity Interval Training (1) · Iloprost (1) · Interleukin 1 Receptor Antagonist Protein (1) · Ketones (1) · Magnetic Resonance Spectroscopy (1) · Nitrates (1) · Sodium Chloride (1)
Massachusetts General Hospital (3) · Virginia Commonwealth University (3) · Tenax Therapeutics, Inc. (2) · Abbott Medical Devices (1) · Cantonal Hospital, Baselland (1) · CorAssist Cadiovascular Ltd. (1) · Corporal Michael J. Crescenz VA Medical Center (1) · Duke University (1) · Fundación para la Investigación del Hospital Clínico de Valencia (1) · Gladwin, Mark, MD (1) · Goethe University (1) · Hannover Medical School (1) · Heart Center Leipzig - University Hospital (1) · Imperial College London (1) · Inova Health Care Services (1)
United States (22) · Germany (5) · Spain (3) · Canada (2) · United Kingdom (2) · Austria (1) · Slovenia (1) · Switzerland (1) · Taiwan (1)
Salvatore Carbone, PhD (2) · Thomas Dieterle, MD (2) · Alison Morris, MD, MS (1) · Antonio Abbate, MD, PhD (1) · Benjamin Van Tassell, PharmD (1) · Bojan Vrtovec, MD, PhD (1) · Brett Atwater, MD (1) · Brian Houston, M.D. (1) · Charles B Eaton, MD, MS (1) · Christopher O'Connor, MD (1) · Diana Bonderman, MD (1) · Eike C Nagel, MD, PhD (1)
PMID 25533966, PMID 26449137, PMID 27081022, PMID 28360259, PMID 28475816, PMID 29449367, PMID 29551699, PMID 30354558, PMID 31053957, PMID 31479003, PMID 31748285, PMID 31849715, PMID 32073676, PMID 33559346, PMID 33839076, PMID 34461042, PMID 34630155, PMID 34663746, PMID 34716759, PMID 34794685, PMID 35023349, PMID 35266003, PMID 35775390, PMID 36456066, PMID 37286262, PMID 37707956, PMID 38225218, PMID 38324280, PMID 40223608, PMID 40622772, PMID 42206402, PMID 42762217
2014 (1), 2016 (1), 2017 (1), 2018 (1), 2019 (1), K23HL127099 (1), P01HL103455 (1), R01HL061912 (1), R01HL104018 (1), R34HL118348 (1)