6 completed, 1 enrolling by invitation. 7 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 7 | Completed 6, Enrolling by invitation 1 |
Follow Heart Failure With Normal Ejection Fraction: new trials by email Literature Review of Heart Failure With Normal Ejection Fraction trials Research Report on Heart Failure With Normal Ejection Fraction
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Chronic Exogenous Ketosis in HFpEF Exogenous Ketone Drink, Placebo - Heart Failure With Preserved Ejection Fraction (HFPEF), Heart Failure With Normal Ejection Fraction | Phase 2 | Enrolling by invitation | Duke University | 20 | 2025-07-28 | 2026-10-14 |
| Open-Label Rollover Study of Levosimendan in PH-HFpEF Patients Levosimendan - Hypertension Pulmonary Secondary Heart Failure, Right Sided Heart Failure With Normal Ejection Fraction | Phase 2 | Completed | Tenax Therapeutics, Inc. | 35 | 2019-04-09 | 2026-04-22 |
| Hemodynamic Evaluation of Levosimendan in Patients With PH-HFpEF Levosimendan, Matching Placebo - Hypertension Pulmonary Secondary, Heart Failure, Right Sided | Phase 2 | Completed | Tenax Therapeutics, Inc. | 44 | 2018-11-14 | 2024-11-20 |
| Pharmacodynamic Effects of Riociguat in Pulmonary Hypertension and Heart Failure With Preserved Ejection Fraction Riociguat, Placebo - Hypertension, Pulmonary, Heart Failure With Normal Ejection Fraction | Phase 2 | Completed | Medical University of Vienna | 118 | 2016-03-01 | 2020-11-04 |
| Cell Therapy in HFpEF Cell Therapy - Heart Failure With Normal Ejection Fraction | Phase 2 | Completed | University Medical Centre Ljubljana | 30 | 2016-01-01 | 2023-05-10 |
| Interleukin-1 Blockade in HF With Preserved EF Anakinra, Placebo - Heart Failure With Normal Ejection Fraction | Phase 2 | Completed | Virginia Commonwealth University | 31 | 2014-09-01 | 2018-06-19 |
| Effect of Inorganic Nitrates (Beetroot Juice) on Arterial Hemodynamics and Exercise Capacity Nitrate rich beetroot juice, Nitrate depleted beetroot juice - Heart Failure With Normal Ejection Fraction | Phase 2 | Completed | Corporal Michael J. Crescenz VA Medical Center | 17 | 2013-01-01 | 2015-04-28 |
Heart Failure (4) · Heart Failure, Diastolic (2) · Bronchiolitis Obliterans Syndrome (1) · Heart Murmurs (1) · Hypertension, Pulmonary (1) · Inflammation (1) · Ketosis (1) · Motor Activity (1)
Cardiovascular Diseases (5) · Heart Diseases (4) · Lung Diseases (2) · Respiratory Tract Diseases (2) · Acid-Base Imbalance (1) · Acidosis (1) · Behavior (1) · Bronchial Diseases (1) · Bronchiolitis (1) · Bronchiolitis Obliterans (1) · Bronchitis (1) · Graft vs Host Disease (1) · Hypertension (1) · Immune System Diseases (1) · Lung Diseases, Obstructive (1)
Simendan (2) · Cell- and Tissue-Based Therapy (1) · Interleukin 1 Receptor Antagonist Protein (1) · Ketones (1) · riociguat (1)
Tenax Therapeutics, Inc. (2) · Corporal Michael J. Crescenz VA Medical Center (1) · Duke University (1) · Medical University of Vienna (1) · University Medical Centre Ljubljana (1) · Virginia Commonwealth University (1)
United States (5) · Austria (1) · Slovenia (1)
Antonio Abbate, MD, PhD (1) · Benjamin Van Tassell, PharmD (1) · Bojan Vrtovec, MD, PhD (1) · Diana Bonderman, MD (1) · Johannes Kastner, MD (1) · Julio A Chirinos, MD, PhD (1) · Senthil Selvaraj, MD (1) · Stuart Rich, MD (1)
PMID 25533966, PMID 28475816, PMID 30354558, PMID 33839076, PMID 34716759, PMID 35775390
2014 (1), R34HL118348 (1)