17 completed, 13 recruiting, 8 unknown, 5 active not recruiting. 29 Not applicable, 4 Phase 1, 4 Phase 2, 2 Phase 3, 2 Phase 4.
Follow Heart Failure NYHA Class III: new trials by email Literature Review of Heart Failure NYHA Class III trials Research Report on Heart Failure NYHA Class III
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Barostim-Enabled NEurohormonal Intervention For Improving Treatment of Heart Failure Barostim System, Usual care medical management - Heart Failure, Heart Failure NYHA Class II | Not applicable | Recruiting | CVRx, Inc. | 2500 | 2026-04-24 | 2026-10-21 |
| Heart Failure Management for Patient With CIED Remotely Monitored SmartSignalHF, HF RM standard of care - Heart Failure, Heart Failure NYHA Class II | Not applicable | Recruiting | Implicity | 1132 | 2025-12-19 | 2026-03-31 |
| Narrative Intervention for Chronic Illness- Heart Failure Trial (NICI-HF) Narrative Intervention for Chronic Illness-Heart Failure, Attention Control - Heart Failure, Heart Failure NYHA Class III | Phase 1 / Phase 2 | Not yet recruiting | University of Colorado, Denver | 300 | 2025-09-01 | 2024-11-13 |
| REDUCED FUNCTIONALITY AND KINESIOPHOBIA IN PATIENTS WITH HEART FAILURE: USE OF ALTERNATIVE THERAPEUTIC STRATEGIES Low Frequency Neuromuscular Electrical Stimulation, Medium Frequency Neuromuscular Electrical Stimulation, Neuromuscular Electrical Stimulation without generating contractility - Heart Failure, Heart Failure NYHA Class III | Not applicable | Not yet recruiting | Universidade Federal do Rio Grande do Norte | 54 | 2025-08-18 | 2025-08-01 |
| Association Between the Sit-To-Stand Test and the Prognosis of Patients With Heart Failure 1-minute sit-to-stand test - Heart Failure, Heart Failure NYHA Class IV | Active not recruiting | Centro Universitário Augusto Motta | 68 | 2025-07-16 | 2026-07-14 | |
| Optimization of STAR STAR condition 1, STAR condition 2, STAR condition 3 - Heart Failure NYHA Class II, Heart Failure NYHA Class III | Not applicable | Not yet recruiting | UMC Utrecht | 320 | 2025-07-01 | 2025-07-15 |
| An Early Feasibility Study Evaluation of an Implant Free Interatrial Shunt to Improve Heart Failure PAS-C System - Heart Failure, Heart Failure NYHA Class III | Not applicable | Active not recruiting | InterShunt Technologies, Inc. | 20 | 2025-05-15 | 2026-05-27 |
| Whole Heart Radiotherapy for End-stage Heart Failure Whole Heart Radiation Therapy - Heart Failure NYHA Class III, Heart Failure NYHA Class IV | Phase 1 | Enrolling by invitation | McGill University Health Centre/Research Institute of the McGill University Health Centre | 6 | 2025-04-30 | 2025-05-14 |
| Sustaining Home Heart Failure Palliative Care in Rural Appalachia HF-FamPALhomeCARE - Heart Failure NYHA Class III, Heart Failure NYHA Class IV | Not applicable | Recruiting | West Virginia University | 208 | 2025-04-01 | 2026-03-09 |
| Real World Effectiveness of the Cordella Pulmonary Artery Sensor System in Patients With Chronic Heart Heart Failure Cordella PA Sensor System, Standard of Care Pharmacologic Therapy - Heart Failure NYHA Class III, Heart Failure | Recruiting | Endotronix, Inc. | 2150 | 2025-02-07 | 2025-11-19 | |
| Optimizing HFrEF Patients Using BaroStim and CardioMems BaroStim - Heart Failure NYHA Class III | Phase 2 / Phase 3 | Recruiting | Northwell Health | 15 | 2025-01-17 | 2026-02-10 |
| Atrial Appendage Micrograft Transplants to Assist Heart Repair After Cardiac Surgery Epicardial AAMs-patch transplantation, RNA-stabilized whole blood sampling, Plasma sampling - Ischemic Heart Disease, Ischemic Cardiomyopathy | Not applicable | Recruiting | Hospital District of Helsinki and Uusimaa | 50 | 2024-04-01 | 2024-04-19 |
| Comprehensive Hybrid Cardiac Rehabilitation Trial on Heart Failure Comprehensive Initial Assessment, Continuous evaluation, Interval Exercise - Heart Failure NYHA Class II, Heart Failure NYHA Class III | Not applicable | Recruiting | Universidad de La Frontera | 152 | 2024-04-01 | 2024-12-03 |
| Beneficial Effects of Vitamin D Combined With Oral Iron Supplementation in Patients With Chronic Heart Failure and Iron Deficiency Sucrosomial iron, Vitamin D, Ferric Carboxymaltose 50 MG/ML - Heart Failure, Iron-deficiency | Phase 4 | Unknown | University of Padova | 258 | 2024-01-15 | 2023-12-15 |
| PROACTIVE-HF-2 Trial Heart Failure NYHA Class II and III Cordella™ Pulmonary Artery Sensor System - Heart Failure NYHA Class II, Heart Failure NYHA Class III | Not applicable | Recruiting | Endotronix, Inc. | 1750 | 2023-11-29 | 2026-06-29 |
| Gender-Based Differences in Heart Failure Hospitalizations Among Patients With Heart Failure Treated With Spironolactone Spironolactone - Heart Failure, Heart Failure With Reduced Ejection Fraction | Completed | Ahmad Abdullah Salawi | 509 | 2023-10-01 | 2025-03-24 | |
| A Study to Improve Physician-Youth Communication and Medical Decision Making We Chatt communication tool, Usual/standard care - Heart Failure NYHA Class II, Heart Failure NYHA Class III | Not applicable | Completed | University of Michigan | 62 | 2023-09-14 | 2025-06-18 |
| Early Metabolic Adaptations to SGLT2 Inhibition in Heart Failure Heart Failure NYHA Class II, Heart Failure NYHA Class III | Active not recruiting | University of Pennsylvania | 40 | 2023-06-27 | 2026-06-04 | |
| Yoga Based Cardiac Rehabilitation in Heart Failure Failure Yoga-CaRe HF, Health Education - Heart Failure With Reduced Ejection Fraction, Heart Failure NYHA Class II | Not applicable | Recruiting | Centre for Chronic Disease Control, India | 3500 | 2023-04-24 | 2026-09-14 |
| Autologous Induced Pluripotent Stem Cells of Cardiac Lineage for Congenital Heart Disease iPSC-CL - Univentricular Heart, Congenital Heart Disease | Phase 1 | Recruiting | HeartWorks, Inc. | 50 | 2023-02-03 | 2026-03-13 |
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Heart Failure (36) · Heart Diseases (6) · Cardiovascular Diseases (5) · Motor Activity (5) · Heart Failure, Systolic (3) · Coitus (2) · Amyloid Neuropathies, Familial (1) · Anemia, Iron-Deficiency (1) · Bundle-Branch Block (1) · Coronary Artery Disease (1) · Diabetes Mellitus (1) · Dyspnea (1) · Heart Defects, Congenital (1) · Heart Failure, Diastolic (1) · Hypertrophy, Left Ventricular (1)
Cardiovascular Diseases (35) · Heart Diseases (34) · Behavior (7) · Pathological Conditions, Signs and Symptoms (4) · Metabolic Diseases (3) · Nutritional and Metabolic Diseases (3) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (2) · Hemic and Lymphatic Diseases (2) · Pathologic Processes (2) · Sexual Behavior (2) · Vascular Diseases (2) · Amyloid Neuropathies (1) · Amyloidosis (1) · Amyloidosis, Familial (1) · Anemia (1)
Activities of Daily Living (1) · BID protein, human (1) · Blood Specimen Collection (1) · Drug Therapy (1) · Echocardiography (1) · Echocardiography, Transesophageal (1) · Enalapril (1) · Exercise (1) · Furosemide (1) · Psychiatric Rehabilitation (1) · Resistance Training (1) · Saline Solution (1) · Sodium Channel Blockers (1) · Sodium Potassium Chloride Symporter Inhibitors (1) · Spironolactone (1)
Endotronix, Inc. (6) · Abbott Medical Devices (2) · Medtronic Cardiac Rhythm and Heart Failure (2) · West Virginia University (2) · Aalborg University (1) · Ahmad Abdullah Salawi (1) · Alexandria University (1) · BackBeat Medical Inc (1) · Biosistemak Institute for Health Systems Research (1) · Boston Scientific Corporation (1) · CVRx, Inc. (1) · Celestino Sardu (1) · Central Hospital, Nancy, France (1) · Centre for Chronic Disease Control, India (1) · Centro Universitário Augusto Motta (1)
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Edward Karst (3) · Andrea Sauerland (2) · Birthe Dinesen, PhD (1) · Christopher M Celano, MD (1) · Dorairaj Prabhakaran, MD DM (Cardiology) (1) · Elisabeth L Sattler, PhD, BSPharm (1) · Emma Birks, MD (1) · Esteban de Manuel (1) · Federico Capone, MD (1) · Gaetano Marrone (1) · Heleen Westland, PhD (1) · Ian J Gerard, MD, PhD (1) · Jamie Pelzel, MD (1) · Javed Butler, MD (1)
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K23HL145096 (1), R01NR021630 (1), R15NR018547 (1)