10 completed, 4 recruiting, 4 terminated, 3 unknown. 16 Not applicable, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 16 | Completed 8, Recruiting 2, Terminated 2, Unknown 2, Active not recruiting 1, Withdrawn 1 |
| Phase 2 | 1 | Completed 1 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Barostim-Enabled NEurohormonal Intervention For Improving Treatment of Heart Failure Barostim System, Usual care medical management - Heart Failure, Heart Failure NYHA Class II | Not applicable | Recruiting | CVRx, Inc. | 2500 | 2026-04-24 | 2026-10-21 |
| Impact of Barostimulation on Hemodynamics in Adults With Heart Failure Baroreflex Activation Therapy - HFrEF - Heart Failure With Reduced Ejection Fraction | Not applicable | Recruiting | Columbia University | 58 | 2026-03-30 | 2026-06-29 |
| Baroreflex Activation Therapy in Left Ventricular Assist Device Patients Study Baroreflex Activation Therapy (BAT) - Congestive Heart Failure | Not applicable | Withdrawn | Medical University of South Carolina | 2025-07-01 | 2025-07-23 | |
| Symptomatic CRT Patients: Real-World Experience - Barostim™ Advancing the Level of Clinical Evidence Barostim™ System - Heart Failure | Terminated | CVRx, Inc. | 5 | 2023-07-25 | 2025-04-08 | |
| BATwire Implant Kit Study BATwire Implant Kit - Heart Failure | Not applicable | Terminated | CVRx, Inc. | 93 | 2021-01-29 | 2026-10-01 |
| Real-World Experience - Barostim™ Advancing the Level of Clinical Evidence (REBALANCE Registry) Barostim™ System - Heart Failure | Terminated | CVRx, Inc. | 435 | 2020-06-26 | 2026-09-17 | |
| UK Registry for Baroreflex Activation Therapy Baroreflex Activation Therapy with Barostim Neo - Baroreflex Failure Syndrome, Hypertension, Resistant to Conventional Therapy | Not applicable | Terminated | Queen Mary University of London | 6 | 2018-11-01 | 2023-06-08 |
| BAROSTIM THERAPY™ In Heart Failure With Preserved Ejection Fraction BAROSTIM NEO™ System - Heart Failure | Completed | CVRx, Inc. | 11 | 2017-03-23 | 2026-09-11 | |
| BAROSTIM THERAPY™ in Heart Failure With Reduced Ejection Fraction Barostim Neo™ System - Heart Failure | Recruiting | CVRx, Inc. | 500 | 2016-12-13 | 2026-09-11 | |
| BAROSTIM THERAPY™ In Resistant Hypertension BAROSTIM NEO™ System - Hypertension | Recruiting | CVRx, Inc. | 500 | 2016-12-13 | 2026-09-11 | |
| Baroreflex Activation Therapy for Heart Failure BAROSTIM NEO® System, Medical Management - Heart Failure | Not applicable | Completed | CVRx, Inc. | 1090 | 2016-04-19 | 2026-03-10 |
| Effect Baroreflex Activation Therapy on the Carotid Body Hypertension Resistant To Conventional Therapy, Baroreflex | Unknown | Maastricht University Medical Center | 20 | 2013-10-01 | 2014-08-07 | |
| BAROSTIM NEO Hypertension Pivotal Trial BAROSTIM NEO System and Medical Management - Uncontrolled Hypertension | Not applicable | Completed | CVRx, Inc. | 10 | 2013-04-12 | 2026-09-11 |
| BAROSTIM® Hope for Heart Failure Study BAROSTIM NEO® System, Standard of care medical managment therapy for heart failure - Heart Failure | Not applicable | Unknown | CVRx, Inc. | 98 | 2012-11-01 | 2019-05-14 |
| Baroreflex Activation Therapy in Heart Failure Barostim Neo System - Heart Failure | Not applicable | Completed | CVRx, Inc. | 12 | 2011-11-01 | 2021-08-26 |
| BAROSTIM NEO System in the Treatment of Heart Failure BAROSTIM NEO System, Medical Management - Heart Failure | Not applicable | Unknown | CVRx, Inc. | 94 | 2011-08-01 | 2019-11-04 |
| Verification of the Efficacy and Safety of the BAROSTIM NEO System in the Treatment of Drug Resistant Hypertension BAROSTIM NEO System, Medical Management - High Blood Pressure | Not applicable | Active not recruiting | CVRx, Inc. | 40 | 2011-06-01 | 2026-09-10 |
| Rheos System for the Treatment of HFpEF Heart Failure Rheos® system - Heart Failure | Not applicable | Completed | CVRx, Inc. | 19 | 2009-08-01 | 2021-04-08 |
| Rheos® Diastolic Heart Failure Trial Rheos Baroreflex Activation Therapy System - Diastolic Heart Failure | Not applicable | Completed | CVRx, Inc. | 6 | 2008-07-01 | 2016-10-21 |
| Rheos® Pivotal Trial Rheos® Baroreflex Hypertension System - Hypertension | Not applicable | Completed | CVRx, Inc. | 591 | 2006-10-01 | 2017-03-20 |
Showing 20 of 23. Sign in to see all of them.
Heart Failure (13) · Hypertension (7) · Hypertension Resistant to Conventional Therapy (2) · Cardiovascular Diseases (1) · Heart Failure, Diastolic (1) · Heart Failure, Systolic (1)
Practice Management, Medical (3)
United States (10) · Germany (9) · Netherlands (6) · Italy (3) · Canada (2) · Switzerland (2) · United Kingdom (2) · Czechia (1) · France (1) · Latvia (1) · Poland (1)
Fred Weaver, MD (5) · Michael Zile, MD (4) · William Abraham, MD (4) · Faiez Zannad, MD (3) · JoAnn Lindenfield, MD (3) · Abraham Kroon, MD, PhD (1) · Bradley Knight, MD (1) · Burkert Pieske, PhD (1) · Edoardo G Gronda, MD, FESC (1) · George Bakris, MD (1) · Hannes Reuter, PhD (1) · Herbert Naegele, MD (1) · Hermann Haller, MD (1) · Johannes Sperzel, MD (1)
PMID 25982108, PMID 26011593, PMID 28065708, PMID 29705650, PMID 21300307, PMID 25331845, PMID 32616150, PMID 33992562