229 completed. 229 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 229 | Completed 229 |
Follow Heart Failure: new trials by email Literature Review of Heart Failure trials Research Report on Heart Failure
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Antithrombotic Activities of Sotagliflozin vs. Empagliflozin Sotagliflozin, Empagliflozin - Thrombosis | Phase 4 | Completed | Icahn School of Medicine at Mount Sinai | 17 | 2025-02-25 | 2026-04-30 |
| N-of-1 for Beta-Blockers in Cardiac Amyloidosis Beta blocker - Cardiac Amyloidosis, Heart Diseases | Phase 4 | Completed | Weill Medical College of Cornell University | 14 | 2024-01-31 | 2026-07-29 |
| The Fontan Dapagliflozin Pilot Study Dapagliflozin 10mg Tab - Heart Failure | Phase 4 | Completed | Johns Hopkins University | 29 | 2023-11-08 | 2026-07-22 |
| Henagliflozin Reducing Infarct Size After Priamry PCI in Patients With ST Segment Elevation Myocardial Infarction Henagliflozin - Myocardial Infarction, Heart Failure | Phase 4 | Completed | Qian geng | 248 | 2023-07-01 | 2025-12-02 |
| COPILOT-HF: Cooperative Program for ImpLementation of Optimal Therapy in Heart Failure SGLT2i, beta blocker, ARNI, MRA, MTD, Education-First - Heart Failure | Phase 4 | Completed | Brigham and Women's Hospital | 503 | 2023-05-05 | 2026-02-06 |
| The Effect of Vericiguat on Peripheral Vascular Function, Patient Health Status and Inflammation Vericiguat, Placebo - Heart Failure, Heart Failure With Reduced Ejection Fraction (HFrEF) | Phase 4 | Completed | Josef Stehlik | 26 | 2023-05-01 | 2025-10-08 |
| Intravenous Iron Sucrose for Acute Decompensated Heart Failure Patients With Reduced Ejection Fraction and Iron Deficiency Iron Sucrose IV, Standard Medical Therapy - Heart Failure With Reduced Ejection Fraction (HFrEF), Hospitalization | Phase 4 | Completed | Cheng-Hsin General Hospital | 76 | 2023-05-01 | 2024-11-25 |
| The Heart Failure Diuresis Efficacy Comparison (DEA-HF) Study IV Furosemide, IV Furosemide and PO Metolazone, IV Furosemide and IV Acetazolamide - Chronic Heart Failure, Diuretics Drug Reactions | Phase 4 | Completed | Rambam Health Care Campus | 42 | 2023-04-19 | 2024-05-21 |
| ORal IrON Supplementation with Ferric Maltol in Treating Iron Deficiency and Anaemia in Patients with Heart Failure (ORION-HF) Ferric maltol 30 mg (Feraccru®) - Heart Failure, Left-sided, Anemia, Iron Deficiency | Phase 4 | Completed | Hannover Medical School | 50 | 2023-02-21 | 2025-03-07 |
| Clinical Outcomes of Levosimendan Versus Dobutamine Versus Milrinone in Cases With Acute Decompensated Heart Failure With Impaired Renal Function Levosimendan, Dobutamine, Milrinone - Acute Decompensated Heart Failure (ADHF), Cardiorenal Syndrome (CRS) | Phase 4 | Completed | Ain Shams University | 60 | 2022-06-01 | 2026-09-21 |
| Sugammadex Titration in Cardiac Surgery Patients Sugammadex administration - Coronary Artery Disease, Valvular Heart Disease | Phase 4 | Completed | University of Washington | 100 | 2022-02-01 | 2024-03-21 |
| Sacubitril/Valsartan Versus Valsartan in Heart Failure Sacubitril / Valsartan Oral Tablet, Valsartan 80 mg - Heart Failure | Phase 4 | Completed | Damanhour University | 80 | 2022-01-01 | 2023-06-27 |
| Impact of Empagliflozin on Functional Capacity in Heart Failure with Preserved Ejection Fraction Empagliflozin 10 MG - Heart Failure with Preserved Ejection Fraction, Heart Failure, Diastolic | Phase 4 | Completed | University of Texas Southwestern Medical Center | 8 | 2021-11-09 | 2024-09-19 |
| Efficacy of Metformin as add-on Therapy in Non-Diabetic Heart Failure Patients Metformin Hydrochloride - Heart Failure | Phase 4 | Completed | Cairo University | 70 | 2021-07-21 | 2023-07-19 |
| Mechanisms Underlying Hypotensive Response to ARB/NEP Inhibition - Aim 3 LCZ 696, Placebo, Para-aminohippurate - Heart Failure | Phase 4 | Completed | Yale University | 46 | 2021-05-27 | 2026-10-27 |
| Effect of Dual Bronchodilation With Umeclidinium/Vilanterol on Patients With COPD, Hyperinflation and Heart Failure Umeclidinium/vilanterol, Placebo - Copd, Heart Failure | Phase 4 | Completed | Luis Puente Maestu | 60 | 2021-05-21 | 2026-09-21 |
| Impact of Beta-blockers on Physical Function in HFpEF Beta blockers - Heart Failure, Heart Failure, Diastolic | Phase 4 | Completed | Weill Medical College of Cornell University | 9 | 2021-04-01 | 2023-09-08 |
| Pilot Deprescribing N-of-1 Trials for Beta-blockers in HFpEF Beta blockers - Heart Failure, Heart Failure, Diastolic | Phase 4 | Completed | Weill Medical College of Cornell University | 9 | 2021-04-01 | 2024-04-09 |
| Dapagliflozin on Volume Vascular Outcomes. Dapagliflozin, Placebo - Heart Failure，Congestive | Phase 4 | Completed | Frank Ruschitzka | 80 | 2021-02-15 | 2024-11-12 |
| Sodium-glucose Cotransporter Type 2 Inhibitors for Acute Cardiorenal Syndrome Prevention Standard list of drugs used for acute decompensation of CHF (loop diuretics, vasodilators, digoxin, inotropic agents, vasopressors), plus dapagliflozin (Forxiga; MP-002596) - Congestive Heart Failure | Phase 4 | Completed | I.M. Sechenov First Moscow State Medical University | 370 | 2021-01-01 | 2022-12-07 |
Showing 20 of 229. Sign in to see all of them.
Heart Failure, Systolic (13) · Diabetes Mellitus, Type 2 (11) · Heart Failure, Diastolic (11) · Diabetes Mellitus (9) · Iron Deficiencies (8) · Hypertension (7) · Atrial Fibrillation (6) · Insulin Resistance (6) · Motor Activity (6) · Myocardial Infarction (6) · Heart Diseases (5) · Sleep Apnea Syndromes (5) · Anemia, Iron-Deficiency (4) · Arrhythmias, Cardiac (4)
Cardiovascular Diseases (225) · Heart Diseases (224) · Pathological Conditions, Signs and Symptoms (45) · Nutritional and Metabolic Diseases (37) · Metabolic Diseases (34) · Pathologic Processes (31) · Glucose Metabolism Disorders (24) · Vascular Diseases (24) · Endocrine System Diseases (23) · Respiratory Tract Diseases (16) · Diabetes Mellitus (11) · Nervous System Diseases (11) · Signs and Symptoms (11) · Arrhythmias, Cardiac (10)
sacubitril and valsartan sodium hydrate drug combination (20) · Valsartan (14) · Furosemide (13) · dapagliflozin (11) · Carvedilol (9) · Enalapril (8) · sacubitril (8) · Adrenergic beta-Antagonists (7) · Simendan (7) · Spironolactone (7) · empagliflozin (7) · Bisoprolol (6) · Ivabradine (6) · Nebivolol (5) · Tolvaptan (5)
Novartis Pharmaceuticals (9) · Medtronic Cardiac Rhythm and Heart Failure (6) · Biotronik SE & Co. KG (5) · Abbott Medical Devices (4) · Boston Scientific Corporation (4) · Centro Cardiologico Monzino (4) · Tottori University Hospital (4) · University of Campania Luigi Vanvitelli (4) · Duke University (3) · Fundación para la Investigación del Hospital Clínico de Valencia (3) · Hasselt University (3) · Johns Hopkins University (3) · Montreal Heart Institute (3) · Saint Luke's Health System (3) · US Department of Veterans Affairs (3)
United States (79) · Germany (20) · Italy (20) · Canada (15) · Spain (14) · United Kingdom (12) · Switzerland (11) · Denmark (9) · Netherlands (9) · France (8) · Brazil (7) · Egypt (7) · Japan (7) · Russia (7) · Czechia (6)
Mikhail Kosiborod, MD (3) · Piergiuseppe Agostoni, MD, PhD (3) · Gennaro Cice, MD (2) · Kirkwood F Adams, MD (2) · Marvin W Kronenberg, MD (2) · Nicolas Rodondi, MD MAS (2) · Parag Goyal, MD (2) · Adam H Miller (1) · Aharon Abbo, MD (1) · Ahmed El-Sherbeni (1) · Ahmed M Kamel, MSc. (1) · Akihiro Isogawa, M.D. (1) · Alan Hull, MD (1) · Alberto Zanchetti (1)
PMID 34693515, PMID 31081589, PMID 24331202, PMID 30739055, PMID 35115085, PMID 37203441, PMID 39421941, PMID 10647758, PMID 11578717, PMID 11755288, PMID 14987587, PMID 15136775, PMID 15450041, PMID 15531765, PMID 15583088, PMID 17174643, PMID 17383291, PMID 17448416, PMID 17643576, PMID 17646603, PMID 17707182, PMID 17980248, PMID 17996820, PMID 18178411, PMID 18436120, PMID 18443260, PMID 18474343, PMID 18487210, PMID 18565859, PMID 18617067, PMID 18652942, PMID 18760124, PMID 18926148, PMID 19234987, PMID 19264750, PMID 19433997, PMID 19464409, PMID 19464412, PMID 19564557, PMID 19576329, PMID 19673667, PMID 19723695, PMID 19789402, PMID 19808270, PMID 19933411, PMID 20009044, PMID 20051294, PMID 20152220, PMID 20211302, PMID 20299607
2008 (2), 2009 (2), 2014 (2), 2015 (2), 2016 (2), 2017 (1), 2019 (1), K23HL085097 (1), K76AG064428 (1), R01HL084525 (1), R21AG053512 (1), R24AG064025 (1), U01HL084904 (1), U01HL130163 (1)