14 completed. 14 Phase 2, 2 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 14 | Completed 14 |
| Phase 1 | 2 | Completed 2 |
Follow Head Injuries, Closed: new trials by email Literature Review of Head Injuries, Closed trials Research Report on Head Injuries, Closed
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| BCAAs in Concussion 2.0 BCAA, Placebo - Concussion, Brain, Concussion, Mild | Phase 2 | Completed | Akiva Cohen | 17 | 2025-04-01 | 2026-09-03 |
| Hyperbaric Oxygen Effects on Persistent Post-concussive Symptoms Hyperbaric oxygen at 1.5 ATA, Sham treatment - Persistent Post-concussive Syndrome, Concussion Post Syndrome | Phase 2 | Completed | Essentia Health | 20 | 2022-06-28 | 2026-10-15 |
| Ghrelin (OXE--103) for Acute Concussion Management Ghrelin (OXE-103), Placebo - Concussion, Brain, Traumatic Brain Injury | Phase 2 | Completed | Michael Rippee | 23 | 2020-10-20 | 2024-05-21 |
| Efficacy and Tolerability of Erenumab in the Prophylactic Treatment of Persistent Post-Traumatic Headache AMG 334 - Post-Traumatic Headache, Mild Traumatic Brain Injury | Phase 2 | Completed | Danish Headache Center | 100 | 2019-04-05 | 2020-02-10 |
| Hyperbaric Oxygen for Traumatic and Non-traumatic Brain Injury Hyperbaric Oxygen, Minimal pressure air - Brain Injury, Chronic | Phase 2 | Completed | Lindell Weaver | 49 | 2017-09-06 | 2022-08-04 |
| rTMS Treatment of Persistent Headache and Post Concussion Symptoms Attributed to Mild Traumatic Injury to the Head rTMS - Real Air Film Coil, rTMS - Sham Coil - Brain Injuries, Traumatic, Concussion, Brain | Phase 1 / Phase 2 | Completed | University of Calgary | 20 | 2017-04-15 | 2019-04-22 |
| Chronic Postconcussive Headache: A Placebo-Controlled Treatment Trial of Prazosin prazosin hydrochloride, placebo - Posttraumatic Headache, Combat Disorders | Phase 1 / Phase 2 | Completed | VA Office of Research and Development | 89 | 2016-01-04 | 2026-03-30 |
| BCAA Supplementation for Concussion Branched Chain Amino Acids, Placebo solution - Brain Concussion | Phase 2 | Completed | Children's Hospital of Philadelphia | 42 | 2014-01-01 | 2024-05-14 |
| Sildenafil for Cerebrovascular Dysfunction in Chronic Traumatic Brain Injury. Sildenafil - Traumatic Brain Injury, Post-concussive Syndrome | Phase 2 | Completed | Uniformed Services University of the Health Sciences | 59 | 2013-01-01 | 2016-01-01 |
| mTBI Mechanisms of Action of HBO2 for Persistent Post-Concussive Symptoms Hyperbaric oxygen (HBO2) at 1.5 atms, Sham control 1.2 atms - Traumatic Brain Injury With Brief Loss of Consciousness, Post-Concussion Syndrome | Phase 2 | Completed | U.S. Army Medical Research and Development Command | 71 | 2012-09-11 | 2018-11-21 |
| Interactive Training in Sports Concussion Prevention and Management Brain 101 website, Control - Concussion | Phase 2 | Completed | Oregon Center for Applied Science, Inc. | 25 | 2011-08-01 | 2013-11-08 |
| Hyperbaric Oxygen Therapy (HBO2) for Persistent Post-concussive Symptoms After Mild Traumatic Brain Injury (mTBI) hyperbaric oxygen, sham hyperbaric air - Post-concussive Symptoms, Traumatic Brain Injury | Phase 2 | Completed | U.S. Army Medical Research and Development Command | 79 | 2011-02-01 | 2014-09-05 |
| Hyperbaric Oxygen Therapy (HBO2T) for Post-Concussive Symptoms (PSC) After Mild Traumatic Brain Injury (mTBI) Hyperbaric Oxygen Therapy - Mild Traumatic Brain Injury, Post-Concussive Syndrome | Phase 2 | Completed | Virginia Commonwealth University | 60 | 2010-06-01 | 2013-08-27 |
| An Intervention Program to Reduce to the Risk of Persistent Symptoms After Concussion Treatment as usual, Cognitive-behavioural therapy - Mild Traumatic Brain Injury | Phase 2 | Completed | University of British Columbia | 28 | 2009-06-01 | 2018-11-06 |
Brain Concussion (10) · Post-Concussion Syndrome (9) · Brain Injuries, Traumatic (6) · Headache (3) · Post-Traumatic Headache (3) · Brain Injuries (1) · Brain Injury, Chronic (1) · Charcot-Marie-Tooth disease, Type 1F (1) · Combat Disorders (1) · Headache Disorders (1) · Hypercapnia (1) · Stress Disorders, Post-Traumatic (1)
Craniocerebral Trauma (14) · Nervous System Diseases (14) · Trauma, Nervous System (14) · Wounds and Injuries (14) · Wounds, Nonpenetrating (14) · Brain Diseases (13) · Central Nervous System Diseases (13) · Brain Injuries (12) · Brain Injuries, Traumatic (6) · Brain Concussion (4) · Pathological Conditions, Signs and Symptoms (4) · Signs and Symptoms (4) · Headache Disorders, Secondary (3) · Neurologic Manifestations (3)
Hyperbaric Oxygenation (3) · Amino Acids (1) · Cognitive Behavioral Therapy (1) · Ghrelin (1) · Oxyhemoglobins (1) · Prazosin (1) · Sildenafil Citrate (1) · Therapeutics (1) · Transcranial Magnetic Stimulation (1) · erenumab (1)
U.S. Army Medical Research and Development Command (2) · Akiva Cohen (1) · Children's Hospital of Philadelphia (1) · Danish Headache Center (1) · Essentia Health (1) · Lindell Weaver (1) · Michael Rippee (1) · Oregon Center for Applied Science, Inc. (1) · Uniformed Services University of the Health Sciences (1) · University of British Columbia (1) · University of Calgary (1) · VA Office of Research and Development (1) · Virginia Commonwealth University (1)
United States (11) · Canada (2) · Denmark (1)
Alice Rose (1) · Allen Thornton (1) · Ann E Glang, PhD (1) · Brad Hallam (1) · Brett Hart, MD (1) · Chantel Debert, MD MSc FRCPC (1) · Cynthia L Mayer, DO (1) · Daniel Corwin, MD (1) · David X Cifu, MD (1) · Eric Wassermann, MD (1) · Heather Underwood (1) · Justin O Alicea (1) · Kevin Whitfield (1) · Lindell K. Weaver, MD (1) · Lindell Weaver, MD (1)
PMID 31394602, PMID 31394603, PMID 25401463, PMID 25438964, PMID 28768069, PMID 28768070, PMID 28768071, PMID 28768072, PMID 28768073, PMID 28768075, PMID 28771392, PMID 29734566, PMID 30098189, PMID 30099354, PMID 31394600, PMID 31394601, PMID 31530227, PMID 32493206, PMID 34873185, PMID 38468511
1IK2RX001136-01A2 (1), 2018 (1), R44HD056610 (1)