14 recruiting, 10 not yet recruiting, 9 completed, 3 active not recruiting. 26 Not applicable, 3 Phase 2, 2 Phase 1, 2 Phase 3.
Follow Generalized Anxiety Disorder (GAD): new trials by email Literature Review of Generalized Anxiety Disorder (GAD) trials Research Report on Generalized Anxiety Disorder (GAD)
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Miles for Mental Health Exercise - Generalized Anxiety Disorder (GAD), Depressive and Anxiety Disorders | Not applicable | Not yet recruiting | Emporia State University | 20 | 2026-11-10 | 2026-10-23 |
| Device for Treating Generalized Anxiety EXOMIND (BTL-699-2) Active treatment, EXOMIND (BTL-699-2) Sham treatment - Generalized Anxiety Disorder (GAD) | Not applicable | Recruiting | BTL Industries Ltd. | 40 | 2026-09-09 | 2026-09-18 |
| Acupuncture for Generalized Anxiety Disorder sham electro-acupuncture, 2Hz electro-acupuncture, 100Hz electro-acupuncture - Generalized Anxiety Disorder (GAD) | Not applicable | Not yet recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 120 | 2026-09-01 | 2026-09-02 |
| Multimodal Cohort Study of Generalized Anxiety Disorder Generalized Anxiety Disorder (GAD) | Not yet recruiting | Shanghai Mental Health Center | 400 | 2026-08-01 | 2026-08-13 | |
| Transcranial Alternating Current Stimulation to Enhance Mindfulness Therapy in Generalized Anxiety Disorder Synchronous Individualized Alpha-Frequency tACS, Desynchronous Individualized Alpha-Frequency tACS, Sham tACS - Generalized Anxiety Disorder (GAD) | Not applicable | Not yet recruiting | Central South University | 99 | 2026-06-01 | 2026-06-16 |
| MRI-Guided Accelerated cTBS for Generalized Anxiety Disorder continuous theta burst stimulation(cTBS) - Generalized Anxiety Disorder (GAD) | Not applicable | Not yet recruiting | Central South University | 75 | 2026-06-01 | 2026-06-11 |
| AI-Supported Therapy for Depression and Anxiety Compared With Standard CBT AI-Digital CBT, Cognitive Behavioural Therapy - Generalized Anxiety Disorder (GAD), Major Depressive Disorder (MDD) | Not applicable | Not yet recruiting | PsyScale | 400 | 2026-06-01 | 2026-06-04 |
| Personalized AI-Driven Models in Cognitive Behavioral Therapy for Anxiety Explicit CBT SAR Personalization for 6 weeks, Implicit CBT SAR Personalization for 6 weeks, Control CBT SAR for 6 weeks - Generalized Anxiety Disorder (GAD) | Not applicable | Recruiting | University of Southern California | 140 | 2026-03-30 | 2026-06-08 |
| Text Message Safety Behavior Fading for Pathological Worry Safety Behavior Fading for Pathological Worry, Progressive Muscle Relaxation (PMR) - Generalized Anxiety Disorder (GAD), Worrying | Not applicable | Active not recruiting | Florida State University | 300 | 2026-03-01 | 2026-09-28 |
| Effectiveness of Solution-Focused Therapy for Generalized Anxiety Disorder in Emerging Adults Solution-Focused Therapy - Generalized Anxiety Disorder (GAD) | Not applicable | Recruiting | International Islamic University, Islamabad | 50 | 2026-01-05 | 2026-09-01 |
| Stepped Care Treatment for Anxiety Resilience Relaxation and Mentorship Training (RMT), Stepped Care Targeting Exposure and Parenting for Anxiety (STEP-A) - Generalized Anxiety Disorder (GAD), Social Anxiety Disorder (SAD) | Not applicable | Recruiting | Andrew Wiese | 106 | 2026-01-05 | 2026-03-02 |
| An Examination of the Performance of QbMobile in Differential Diagnosis Associated With ADHD Symptoms Digital software application for cognitive performance and activity measurement (QbMobile, investigational device) - Bi-Polar Disorder, Autism Spectrum Disorder (ASD) | Suspended | Qbtech AB | 300 | 2026-01-01 | 2026-09-25 | |
| Cannabidiol-Assisted Learning for Managing Generalized Anxiety Disorder Low-Dose Cannabidiol, Placebo Matched to Moderate-Dose Cannabidiol, Moderate-Dose Cannabidiol - Generalized Anxiety Disorder (GAD), Anxiety Disorders | Phase 3 | Recruiting | Wayne State University | 90 | 2025-11-03 | 2026-10-21 |
| Therapy and Tech Study Chatbot Therapy - Generalized Anxiety Disorder (GAD), Major Depressive Disorder | Not applicable | Not yet recruiting | University of California, Irvine | 204 | 2025-11-01 | 2025-11-21 |
| Internet-Based Cognitive Behavioral Therapy With Treatment as Usual for Generalized Anxiety Disorder and Major Depressive Disorder in Taiwan (ICBT-TW) Internet-Based Cognitive Behavioral Therapy (ICBT), Treatment as Usual (TAU) Only - Generalized Anxiety Disorder (GAD), Major Depressive Disorder (MDD) | Not applicable | Not yet recruiting | National Health Research Institutes, Taiwan | 120 | 2025-09-20 | 2025-09-22 |
| Transdiagnostic Metacognitive Therapy Compared to Disorder-Specific Cognitive-Behavioral Therapy for Anxiety Disorders Transdiagnostic metacognitive therapy, Disorder-specific cognitive-behavioral therapy - Generalized Anxiety Disorder (GAD), Social Anxiety Disorder (SAD) | Not applicable | Recruiting | Karolinska Institutet | 86 | 2025-08-27 | 2026-03-27 |
| The Effect of Patient Preference for Treatment Model in Internet Delivered Cognitive Behavior Therapy for Generalized Anxiety Disorder Metacognitive Internet delivered Cognitive Behavior Therapy, Intolerance of uncertainty based Internet delivered Cognitive Behavior Therapy - Generalized Anxiety Disorder (GAD) | Not applicable | Recruiting | Karolinska Institutet | 440 | 2025-08-26 | 2025-10-01 |
| Metacognitive Therapy vs Unified Protocol for Patients With Comorbid Anxiety Disorders Metacognitive therapy (MCT), Unified protocol (UP) - Posttraumatic Stress Disorder (PTSD), Generalized Anxiety Disorder (GAD) | Not applicable | Not yet recruiting | Karolinska Institutet | 114 | 2025-08-01 | 2025-05-14 |
| Comparative Effectiveness of Internet-based Versus Parent-Coached Cognitive-Behavioral Therapy For Children and Adolescents With Anxiety and OCD Parent Coached Exposure Therapy, Family Based, Internet-Based Cognitive Behavioral Therapy - Obsessive Compulsive Disorder (OCD), Anxiety Disorder of Childhood or Adolescence | Not applicable | Active not recruiting | Baylor College of Medicine | 174 | 2025-07-01 | 2026-07-30 |
| Transcranial Alternating Current Stimulation for Generalized Anxiety Disorder and Insomnia: An Open-Label Pilot Study Transcranial Alternating Current Stimulation (tACS) - Generalized Anxiety Disorder (GAD), Chronic Insomnia | Not applicable | Recruiting | University of Sao Paulo | 30 | 2025-06-01 | 2026-06-23 |
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Generalized Anxiety Disorder (40) · Anxiety Disorders (10) · Depressive Disorder, Major (8) · Phobia, Social (7) · Bipolar Disorder (5) · Obsessive-Compulsive Disorder (5) · Panic Disorder (5) · Stress Disorders, Post-Traumatic (5) · Anxiety, Separation (4) · Mental Disorders (4) · Psychological Well-Being (3) · Alcoholism (2) · Anorexia Nervosa (2) · Bulimia Nervosa (2) · Depression (2)
Mental Disorders (36) · Anxiety Disorders (30) · Mood Disorders (11) · Behavior (9) · Depressive Disorder (8) · Phobic Disorders (7) · Stress Disorders, Traumatic (6) · Trauma and Stressor Related Disorders (6) · Bipolar and Related Disorders (5) · Neurodevelopmental Disorders (4) · Pathological Conditions, Signs and Symptoms (4) · Signs and Symptoms (4) · Behavioral Symptoms (3) · Nervous System Diseases (3) · Neurologic Manifestations (3)
Transcranial Direct Current Stimulation (2) · Autogenic Training (1) · Cannabidiol (1) · Cognitive Behavioral Therapy (1) · Drug Interactions (1) · Exercise (1) · Guanfacine (1) · Hybrid Renal Replacement Therapy (1) · Pharmaceutical Preparations (1) · Psilocybin (1) · Psychotherapy, Brief (1) · Single Person (1) · Therapeutics (1) · Transcranial Magnetic Stimulation (1)
AbbVie (3) · Karolinska Institutet (3) · Central South University (2) · The University of Hong Kong (2) · University of Texas Southwestern Medical Center (2) · Andrew Wiese (1) · BTL Industries Ltd. (1) · Baylor College of Medicine (1) · Centre for Addiction and Mental Health (1) · Charite University, Berlin, Germany (1) · Claudio N Soares (1) · Comenius University (1) · Edgemont Pharmaceuticals, LLC (1) · Emporia State University (1) · Florida State University (1)
United States (14) · China (4) · Sweden (3) · Canada (2) · Hong Kong (2) · Brazil (1) · Germany (1) · Iran (1) · Pakistan (1) · Puerto Rico (1) · Saudi Arabia (1) · Senegal (1) · Slovakia (1) · Turkey (Türkiye) (1)
Yan Zhang, PhD (2) · Yumeng Ju, PhD (2) · Ahmad Raza, M.D. (1) · Alexandra Brazinova, prof. MD PhD (1) · Anne Hilger, PhD (1) · Benoit H Mulsant, MD, MS, FRCPC, DLFAPA (1) · Carrie J McAdams, MD PhD (1) · Christine Rabinak, PhD, MBA (1) · Fariha Hayat, MS (1) · Hilary Marusak, PhD (1) · Jesse Cougle, Ph.D. (1) · Julianna Olah, B.Sc., M.A., M.Sc., Ph.D. (1) · Leslie Lundahl, PhD (1) · Mai A Ghabashi, PhD (1)
PMID 28165762, PMID 41276826, PMID 41661959
2025 (2), P20GM103418 (1), R01MH139134 (1), R33AT010606 (1), R61MH137105 (1)