43 completed, 23 recruiting, 11 unknown, 4 active not recruiting. 90 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 90 | Completed 43, Recruiting 23, Unknown 11, Active not recruiting 4, Enrolling by invitation 4, Withdrawn 3, Not yet recruiting 1, Terminated 1 |
Follow Frontotemporal Lobar Degeneration: new trials by email Literature Review of Frontotemporal Lobar Degeneration trials Research Report on Frontotemporal Lobar Degeneration
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Temporal Interference Stimulation Treatment in Patients With Cognitive Impairment Temporal Interference Stimulation, Sham Temporal Interference Stimulation, Targeted Cognitive Training - Amnestic Mild Cognitive Impairment - aMCI, AD-MCI | Not applicable | Recruiting | Tianjin Huanhu Hospital | 60 | 2026-07-01 | 2026-06-11 |
| Restoring Cervical Lymphatic Drainage in Alzheimer's Disease Cervical lymphovenous anastomosis (LVA) - Alzheimer, Alzheimer Dementia (AD) | Not applicable | Recruiting | University of Siena | 5 | 2026-07-01 | 2026-10-02 |
| Intervention for Communication Quality of Life in Primary Progressive Aphasia Multicomponent Lexical Retrieval Cascade Training, Multicomponent Video Implemented Script Training in Aphasia - Primary Progressive Aphasia(PPA), Semantic Dementia | Not applicable | Recruiting | Maya Henry | 30 | 2026-04-01 | 2026-04-21 |
| Transcranial Alternating Current Stimulation in Frontotemporal Dementia Transcranial Alternating Current Stimulation, Sham Transcranial Alternating Current Stimulation - Transcranial Alternating Current Stimulation, Frontotemporal Dementia (FTD) | Not applicable | Recruiting | IRCCS Centro San Giovanni di Dio Fatebenefratelli | 30 | 2026-02-03 | 2026-09-24 |
| Research Study for Patients With Neurological Diseases Which Evaluates the Patient Experience of the MemorEM Device MemorEM - Alzheimer Disease, Parkinson Disease | Not applicable | Enrolling by invitation | eQ8Health Corporation d/b/a CareONE Concierge | 1000 | 2025-12-01 | 2026-02-05 |
| Automated Language Analysis in Neurodegenerative Diseases: Application of Artificial Intelligence Models Speech and language Test to support clinical diagnosis - Alzheimer's Disease (AD), Frontotemporal Dementia (FTD) | Not applicable | Recruiting | Istituti Clinici Scientifici Maugeri SpA | 200 | 2025-10-20 | 2026-11-03 |
| Long Term Effect of Brain Stimulation in PPA TMS, tDCS, Sham TMS - Primary Progressive Aphasia(PPA) | Not applicable | Recruiting | Hospital San Carlos, Madrid | 80 | 2025-09-15 | 2026-04-23 |
| Single-centre Descriptive Study of Taste in Frontotemporal Lobar Degeneration Through the Analysis of Taste Evoked Potentials Blood test, Interrogation of the subject, Cognitive assessment - Frontotemporal Lobar Degeneration (FTLD) | Not applicable | Recruiting | Centre Hospitalier Universitaire Dijon | 20 | 2025-08-18 | 2025-08-24 |
| STELLA-FTD: Examination of a Behavior Change Intervention for FTD Family Care Partners STELLA-FTD Control, STELLA-FTD Test - Frontotemporal Dementia, Caregiver Burden | Not applicable | Recruiting | Oregon Health and Science University | 640 | 2025-06-23 | 2025-10-27 |
| Deep Cervical Lymphaticovenous Anastomosis Surgery for Moderate-to-Advanced Dementia Patients Deep Cervical Lymphaticovenous Anastomosis(DLVA) - Alzheimer Disease, Lewy Body Dementia (LBD) | Not applicable | Not yet recruiting | RenJi Hospital | 85 | 2025-05-28 | 2025-05-28 |
| ETASCAI Pilot Project Active 1 ETAS®, Active 2 ETAS®, Placebo - Cognition, Affect (Mental Function) | Not applicable | Completed | University of Reading | 45 | 2025-02-24 | 2025-11-19 |
| Repetitive Transcranial Magnetic Stimulation in Frontotemporal Lobar Degeneration Theta burst stimulation, Sham Theta burst stimulation - FTLD, FTD | Not applicable | Recruiting | Università degli Studi di Brescia | 120 | 2025-02-13 | 2026-01-05 |
| Social & Affective Cognition in Alzheimer's Disease & Associated Disorders SCANN - Alzheimer's Disease, Frontotemporal Degeneration (Semantic & Behavioral Variants) | Not applicable | Recruiting | University Hospital, Lille | 120 | 2025-01-28 | 2026-04-30 |
| Music, Social Attention, and Dementia Synchronous Rhythm Production, Solo Rhythm Production - Frontotemporal Dementia, Alzheimer Disease | Not applicable | Active not recruiting | University of California, San Francisco | 80 | 2025-01-10 | 2025-12-03 |
| Predict to Prevent PGRN Disease Clinical, behavioral and cognitive evaluation, blood sampling, brain MRI - Frontotemporal Dementia (FTD), GRN Related Frontotemporal Dementia | Not applicable | Withdrawn | Assistance Publique - Hôpitaux de Paris | 2025-01-01 | 2025-03-21 | |
| The Skin as a Window to the Central Nervous System in Frontotempolar Lombar Degeneration Skin biopsy - Frontotemporal Lobar Degeneration | Not applicable | Recruiting | Nantes University Hospital | 80 | 2024-12-17 | 2024-12-20 |
| Incremental Diagnostic Value of Tau-PET With [18F]RO948 vs Amyloid-PET in Patients With Cognitive Impairment PET/CT with RO958 (experimental) - Dementia, Alzheimer Disease | Not applicable | Recruiting | University Hospital, Geneva | 120 | 2024-12-03 | 2025-12-23 |
| Association of Transcranial Alternating Current Stimulation with Digital Cognitive Training for Cognitive Remediation in Older Adults Transcranial Alternating Current Stimulation, Digital Cognitive Training - Cognitive Dysfunction, Alzheimer Disease | Not applicable | Recruiting | Universidade Federal do Rio de Janeiro | 40 | 2024-12-02 | 2024-12-13 |
| Communication Bridge Pilot Study Communication Bridge - Primary Progressive Aphasia | Not applicable | Active not recruiting | University of Chicago | 12 | 2024-06-28 | 2025-08-07 |
| Using the EHR to Advance Genomic Medicine Across a Diverse Health System Behavioral nudge - Genetic Predisposition, Paraganglioma | Not applicable | Recruiting | University of Pennsylvania | 1000 | 2024-06-10 | 2026-08-14 |
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Frontotemporal Dementia (65) · Alzheimer Disease (49) · Dementia (34) · Lewy Body Disease (27) · Pick Disease of the Brain (21) · Aphasia, Primary Progressive (18) · Dementia, Vascular (18) · Cognitive Dysfunction (12) · Aphasia (11) · Parkinson Disease (10) · Neurodegenerative Diseases (9) · Primary Progressive Nonfluent Aphasia (9) · Caregiver Burden (8) · Mixed Dementias (7)
Central Nervous System Diseases (90) · Brain Diseases (89) · Mental Disorders (89) · Nervous System Diseases (89) · Neurocognitive Disorders (86) · Metabolic Diseases (76) · Nutritional and Metabolic Diseases (76) · Proteostasis Deficiencies (76) · TDP-43 Proteinopathies (76) · Neurodegenerative Diseases (75) · Dementia (56) · Tauopathies (52) · Pathological Conditions, Signs and Symptoms (44) · Basal Ganglia Diseases (32)
Transcranial Direct Current Stimulation (7) · Algorithms (2) · Blood Specimen Collection (2) · Mental Status and Dementia Tests (2) · Speech Therapy (2) · Transcranial Magnetic Stimulation (2) · Deep Brain Stimulation (1) · Electroencephalography (1) · Genetic Testing (1) · Hematologic Tests (1) · Language Therapy (1) · Mindfulness-Based Stress Reduction (1) · N-(2-((N-(4-phenoxypyridin-3-yl)acetamido)methyl)phenoxy)ethyl fluoride (1) · Neurofeedback (1) · Neuroimaging (1)
University of California, San Francisco (7) · Assistance Publique - Hôpitaux de Paris (5) · University of Pennsylvania (4) · University Health Network, Toronto (3) · University of Chicago (3) · University of Texas at Austin (3) · Drexel University (2) · Hospital San Carlos, Madrid (2) · IRCCS Centro San Giovanni di Dio Fatebenefratelli (2) · Institut National de la Santé Et de la Recherche Médicale, France (2) · Johns Hopkins University (2) · London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's (2) · Massachusetts General Hospital (2) · Mayo Clinic (2) · Oregon Health and Science University (2)
United States (35) · France (16) · Canada (10) · Italy (9) · Spain (3) · United Kingdom (3) · China (2) · Germany (2) · Australia (1) · Brazil (1) · Finland (1) · Sweden (1) · Switzerland (1) · Taiwan (1) · Turkey (Türkiye) (1)
Maya L Henry, PhD (3) · Carmela Tartaglia, MD (2) · Julie Fields, PhD, LP (2) · Katherine L Possin, PhD (2) · Aaron Colverson, PhD (1) · Aimee Mooney, MA, CCC-SLP (1) · Aimee Spector, PhD, DClinPsy (1) · Alberto Benussi, MD (1) · Allison Lindauer (1) · Allison Lindauer, PhD, APRN (1) · Andrea L Gilmore-Bykovskyi, PhD, RN (1) · Andres Lozano, MD, PhD (1) · Andres M Lozano, MD, PhD (1) · Argye Hillis, MD (1) · Barbara Borroni, MD (1)
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R01AG055425 (2), R01AG056715 (2), R44AG065088 (2), 2023 (1), K76AG060005 (1), R01AG057855 (1), R01AG061116 (1), R01AG061968 (1), R01AG074710 (1), R01AG078169 (1), R01AG084523 (1), R01DC016291 (1), R01NR016037 (1), R44AG059458 (1), R56DC016291 (1)