5 completed, 5 recruiting, 4 not yet recruiting, 3 enrolling by invitation. 5 Not applicable, 3 Phase 2, 1 Early Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 5 | Completed 1, Enrolling by invitation 1, Not yet recruiting 1, Recruiting 1, Withdrawn 1 |
| Phase 2 | 3 | Completed 2, Recruiting 1 |
| Early Phase 1 | 1 | Recruiting 1 |
Follow Frontotemporal Dementia (FTD): new trials by email Literature Review of Frontotemporal Dementia (FTD) trials Research Report on Frontotemporal Dementia (FTD)
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Wearable Sensor Platform for Remote Monitoring of Individuals on the Frontotemporal Dementia Spectrum Frontotemporal Lobar Degeneration (FTLD), Frontotemporal Dementia (FTD) | Not yet recruiting | BioSensics | 60 | 2026-11-01 | 2026-10-13 | |
| Speech-Based Artificial Intelligence for Detection of Dementia in Danish Patients (DetectAI) Mini-mental State Examination, Addenbrooke's Cognitive Examination, Speech Task - Picture Description - Dementia (Diagnosis), Alzheimer Dementia (AD) | Not yet recruiting | Zealand University Hospital | 440 | 2026-11-01 | 2026-09-02 | |
| Digital Measurements of Motor and Voice Functions in FTD Frontotemporal Lobar Degeneration (FTLD), Frontotemporal Dementia (FTD) | Not yet recruiting | BioSensics | 20 | 2026-08-01 | 2026-04-28 | |
| Retrospective Observational Study of Blood-based Biomarkers in the Diagnosis and Monitoring of Patients With a Neurodegenerative Disease or Mental Disorder Alzheimer Disease, Dementia With Lewy Bodies (DLB) | Enrolling by invitation | Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau | 1799 | 2026-02-19 | 2026-02-23 | |
| Transcranial Alternating Current Stimulation in Frontotemporal Dementia Transcranial Alternating Current Stimulation, Sham Transcranial Alternating Current Stimulation - Transcranial Alternating Current Stimulation, Frontotemporal Dementia (FTD) | Not applicable | Recruiting | IRCCS Centro San Giovanni di Dio Fatebenefratelli | 30 | 2026-02-03 | 2026-09-24 |
| Prospective Observational Study of the Relationship Between Sociodemographic Factors, Blood-based Biomarkers and Psychiatric Symptoms in Neurodegenerative Diseases and Mental Disorders Major Depressive Disorder (MDD), Schizophenia Disorder | Enrolling by invitation | Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau | 1310 | 2026-02-01 | 2026-04-24 | |
| Deep Cervical Lymphaticovenous Anastomosis Surgery for Moderate-to-Advanced Dementia Patients Deep Cervical Lymphaticovenous Anastomosis(DLVA) - Alzheimer Disease, Lewy Body Dementia (LBD) | Not applicable | Not yet recruiting | RenJi Hospital | 85 | 2025-05-28 | 2025-05-28 |
| Vortioxetine for the Treatment of Mood and Cognitive Symptoms in Frontotemporal Dementia Vortioxetine - Fronto-temporal Dementia, Fronto-temporal Lobar Dementia | Phase 2 | Recruiting | Johns Hopkins University | 50 | 2025-03-20 | 2026-03-09 |
| Disease Biosignatures in ALS/FTD Spectrum: New Impactful Biological Perspectives Beyond Clinical Approaches ALS (Amyotrophic Lateral Sclerosis), FTD | Active not recruiting | Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta | 230 | 2025-02-27 | 2026-08-28 | |
| Discovery and Validation of Protein Structural Complexes in Circulating Biofluids As Novel Biomarkers for Early Diagnosis, Prognosis and Therapeutic Management of Patients Affected by Neurodegenerative Disorders Genetic: whole genome sequencing, whole exome sequencing - Parkinson Disease, Amyotrophic Lateral Sclerosis (ALS) | Recruiting | Neuromed IRCCS | 110 | 2025-02-04 | 2025-03-18 | |
| [18F]ACI-19626 PET in TDP-43 Proteinopathies [18F]ACI-19626 - Frontotemporal Dementia (FTD), Amyotrophic Lateral Sclerosis (ALS) | Early Phase 1 | Recruiting | AC Immune SA | 45 | 2025-01-21 | 2026-08-26 |
| Predict to Prevent PGRN Disease Clinical, behavioral and cognitive evaluation, blood sampling, brain MRI - Frontotemporal Dementia (FTD), GRN Related Frontotemporal Dementia | Not applicable | Withdrawn | Assistance Publique - Hôpitaux de Paris | 2025-01-01 | 2025-03-21 | |
| The Role of Advanced Electroencephalographic Data as Marker of Pathology and Prognosis in Primary Dementias Electroencephalogram, 3 Tesla MRI, Apolipoprotein E genetic test - Alzheimer Disease, Lewy Body Dementia (LBD) | Not applicable | Enrolling by invitation | IRCCS San Raffaele | 175 | 2021-11-05 | 2025-02-17 |
| A Biomarker-chip Assay in Preserved Red Blood Cells for the Diagnosis of Alzheimer's Disease Alzheimer's Disease (AD), Neurodegenerative Disease | Completed | Amoneta Diagnostics SAS | 150 | 2017-03-23 | 2025-12-29 | |
| Low-Dose Lithium for the Treatment of Behavioral Symptoms in Frontotemporal Dementia Lithium Carbonate, Placebo - Frontotemporal Dementia (FTD) | Phase 2 | Completed | Columbia University | 17 | 2017-01-27 | 2025-02-03 |
| A Medium Chain Triglyceride Intervention for Patients With Alzheimer Disease Ketogenic medium chain triglyceride drink (MCT drink), Placebo - Alzheimer's Disease, Primary Progressive Non-fluent Aphasia | Not applicable | Completed | University of British Columbia | 43 | 2016-09-01 | 2026-04-23 |
| Comprehensive Assessment of Neurodegeneration and Dementia Dementia, Mild Cognitive Impairment (MCI) | Recruiting | McGill University | 1573 | 2016-06-01 | 2026-01-20 | |
| Tau PET Imaging With 18F-AV-1451 in Subjects With MAPT Mutations 18F-AV-1451 - Frontotemporal Lobar Degeneration (FTLD), Frontotemporal Dementia (FTD) | Phase 2 | Completed | Columbia University | 7 | 2016-04-01 | 2019-12-06 |
| Advancing Research and Treatment for Frontotemporal Lobar Degeneration (ARTFL) FTLD, Progressive Supranuclear Palsy (PSP) | Completed | University of California, San Francisco | 1489 | 2014-09-01 | 2021-05-21 |
Frontotemporal Dementia (19) · Alzheimer Disease (9) · Lewy Body Disease (6) · Amyotrophic Lateral Sclerosis (5) · Dementia (5) · Frontotemporal Lobar Degeneration (5) · Parkinson Disease (5) · Cognitive Dysfunction (3) · Corticobasal Degeneration (3) · Depressive Disorder, Major (2) · Primary Progressive Nonfluent Aphasia (2) · Aphasia, Primary Progressive (1) · Charcot-Marie-Tooth disease, Type 1F (1) · Color Vision Defects (1) · Dementia, Vascular (1)
Brain Diseases (19) · Central Nervous System Diseases (19) · Metabolic Diseases (19) · Nervous System Diseases (19) · Neurocognitive Disorders (19) · Nutritional and Metabolic Diseases (19) · Proteostasis Deficiencies (19) · Mental Disorders (18) · Neurodegenerative Diseases (18) · TDP-43 Proteinopathies (18) · Dementia (14) · Frontotemporal Lobar Degeneration (14) · Tauopathies (12) · Basal Ganglia Diseases (8) · Movement Disorders (8)
Blood Specimen Collection (2) · 7-(6-fluoropyridin-3-yl)-5H-pyrido(4,3-b)indole (1) · Diploidy (1) · Electroencephalography (1) · Exome Sequencing (1) · Lithium Carbonate (1) · Spinal Puncture (1) · Transcranial Direct Current Stimulation (1) · Vortioxetine (1)
BioSensics (2) · Columbia University (2) · Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau (2) · AC Immune SA (1) · Amoneta Diagnostics SAS (1) · Assistance Publique - Hôpitaux de Paris (1) · Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta (1) · IRCCS Centro San Giovanni di Dio Fatebenefratelli (1) · IRCCS San Raffaele (1) · Johns Hopkins University (1) · McGill University (1) · Neuromed IRCCS (1) · RenJi Hospital (1) · University of British Columbia (1) · University of California, San Francisco (1)
United States (5) · Italy (4) · Canada (3) · Spain (2) · China (1) · Denmark (1) · Netherlands (1) · Switzerland (1)
Edward Huey, MD (2) · Adam L Boxer, MD, PhD (1) · Christopher Morrow, MD (1) · Elsmarieke van de Giessen, MD (1) · Haakon Nygaard, MD, PhD (1) · Howard Feldman, MD (1) · Jaspreet Bhangu, MB (1) · Massimo MF Filippi, MD (1) · Michael Borrie, MD (1) · Natalie Philips, PhD (1)
PMID 11976975, PMID 12092785, PMID 12566600, PMID 15753425, PMID 20633386, PMID 21325651, PMID 21396882, PMID 21810890, PMID 22689311, PMID 23963806, PMID 28709880, PMID 31925823, PMID 32987305, PMID 33017671, PMID 33827960, PMID 35492244, PMID 35607946, PMID 35790423, PMID 39136447
2017 (1), K23AG088248 (1), R01NS076837 (1), U54NS092089 (1)