Applied Biologics, LLC: Clinical Trials

5 recruiting, 2 unknown. 2 Not applicable, 2 Phase 4, 1 Phase 2, 1 Phase 3.

By phase and status

Phase	Trials	Status
Not applicable	2	Recruiting 1, Unknown 1
Phase 4	2	Recruiting 2
Phase 2	1	Unknown 1
Phase 3	1	Recruiting 1

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Trials newest first · largest first

Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
a Prospective, Multicenter, Randomized Controlled Trial, With a Non-randomized Sentinel Cohort, Evaluating the Efficacy of Bioxheal, a Single-layer Placental-derived Biologic in Nonhealing Diabetic Foot Ulcers Standard of Care, BIOxHEAL (human amniotic membrane allograft) - Diabetic Foot Ulcer, Amniotic Membrane Placental Allograft	Phase 3	Recruiting	Applied Biologics, LLC	253	2026-10-08	2026-10-16
Evaluating the Durability of Closure for Diabetic Foot Ulcers Following a Randomized, Controlled, Modified Platform Trial. Blue Drop Foot Scanner - Diabetic Foot Ulcers (DFU), Foot Ulcer Chronic		Recruiting	Applied Biologics, LLC	50	2025-10-16	2026-02-10
A Multicenter, Prospective, Controlled Clinical Trial Evaluating the Efficacy of a Single Layer Placental-based Allograft and Standard of Care in the Management of Nonhealing Diabetic Foot Ulcers XWRAP - Diabetic Foot, Foot Ulcer	Phase 4	Recruiting	Applied Biologics, LLC	60	2025-08-26	2026-02-11
A Multicenter, Prospective, Clinical Trial Evaluating a Single Layer Amniotic Membrane and Standard of Care Versus Matched Controls in the Management of Nonhealing Pressure Ulcers Standard of Care, XPURT + SOC - Pressure Ulcer, Ulcer, Pressure	Phase 4	Recruiting	Applied Biologics, LLC	100	2025-06-11	2026-02-11
Evaluating the Efficacy of a Single Layer Placental-based Allograft and Standard of Care Versus Standard of Care SLAM + SOC, SOC - Diabetic Foot Ulcer, Diabetic Foot	Not applicable	Recruiting	Applied Biologics, LLC	124	2024-09-20	2024-11-20
Safety & Efficacy FloGraft (Micronized Human Amnion Chorion Membrane)® in Adults With Pain Due to OA of the Knee mHACMb, placebo - Osteoarthritis, Knee	Phase 2	Unknown	Applied Biologics, LLC	320	2018-11-01	2018-09-28
Efficacy of an Amniotic Fluid Derived Allograft, (FlōGraft®) in Rotator Cuff Repairs: A Prospective Study Superiority of augmented repairs, Fat degeneration of supraspinatus muscle - Rotator Cuff Tear, Fatty Atrophy	Not applicable	Unknown	Applied Biologics, LLC	260	2017-03-24	2017-12-20

Conditions studied

Diabetic Foot (4)  ·  Foot Ulcer (3)  ·  Osteoarthritis, Knee (1)  ·  Pressure Ulcer (1)  ·  Rotator Cuff Injuries (1)  ·  Ulcer (1)

Interventions

Standard of Care (2)  ·  Sodium Chloride (1)

Countries

United States (7)

Top investigators

Charles Zelen, DPM (1)  ·  Edward Britt (1)  ·  Gregory Stocks, MD (1)